Giovanna Guidoboni
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View article: Integrating artificial intelligence in ophthalmology: a pilot study of clinical understanding and adoption
Integrating artificial intelligence in ophthalmology: a pilot study of clinical understanding and adoption Open
Purpose: The purpose of this pilot study was to explore the current understanding and application of artificial intelligence (AI) within clinical ophthalmology. Design: This study used a qualitative research approach. One-on-one interviews…
View article: Fostering STEM competency in high-school students by bridging engineering and ophthalmology through eye research
Fostering STEM competency in high-school students by bridging engineering and ophthalmology through eye research Open
Recent data across the globe indicates a decline in stem competency among secondary education students. Despite persistent interest in STEM fields this decrease in preparedness could yield detrimental effects for both future scientists and…
View article: Eye2Heart : a validated lumped-parameter model bridging cardiovascular and ocular dynamics.
Eye2Heart : a validated lumped-parameter model bridging cardiovascular and ocular dynamics. Open
The cardiovascular and ocular systems are intricately connected, with hemodynamic interactions playing a crucial role in both physiological regulation and pathological conditions. However, existing models often treat these systems separate…
View article: Comparing Interface Conditions for a <scp>3D</scp>–<scp>0D</scp> Multiscale Interface Coupling With Applications in Tissue Perfusion
Comparing Interface Conditions for a <span>3D</span>–<span>0D</span> Multiscale Interface Coupling With Applications in Tissue Perfusion Open
Many pathologies are related to hemodynamic changes occurring at the microvascular level, where small vessels pierce the tissue, perfusing it with blood. Since there is a large number of vessels of small caliber, it is impractical to model…
View article: Reduced-Order Model for Cell Volume Homeostasis: Application to Aqueous Humor Production
Reduced-Order Model for Cell Volume Homeostasis: Application to Aqueous Humor Production Open
The ability of a cell to keep its volume constant irrespective of intra- and extracellular conditions is essential for cellular homeostasis and survival. The purpose of this study is to elaborate a theoretical model of cell volume homeosta…
View article: Reduced-Order Model for Cell Volume Homeostasis: Application to Aqueous Humor Production
Reduced-Order Model for Cell Volume Homeostasis: Application to Aqueous Humor Production Open
The ability of a cell to keep its volume constant irrespective of intra- and extracellular conditions is essential for cellular homeostasis and survival. The purpose of this study is to elaborate a theoretical model of cell volume homeosta…
View article: Analysis of Waveform Parameters in the Retinal Vasculature via Mathematical Modeling and Data Analytics Methods
Analysis of Waveform Parameters in the Retinal Vasculature via Mathematical Modeling and Data Analytics Methods Open
View article: Using Multi-Layer Perceptron Driven Diagnosis to Compare Biomarkers for Primary Open Angle Glaucoma
Using Multi-Layer Perceptron Driven Diagnosis to Compare Biomarkers for Primary Open Angle Glaucoma Open
Neural network models indicate that OCTA optic nerve head vascular biomarkers are equally useful for ML diagnosis of POAG when compared to OCT structural biomarker features alone.
View article: The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease
The Eye as the Window to the Heart: Optical Coherence Tomography Angiography Biomarkers as Indicators of Cardiovascular Disease Open
Alterations in microvasculature represent some of the earliest pathological processes across a wide variety of human diseases. In many organs, however, inaccessibility and difficulty in directly imaging tissues prevent the assessment of mi…
View article: Analysis of the Contribution of Cardiovascular Compartments to the Ballistocardiogram Signal Using Mathematical Modeling
Analysis of the Contribution of Cardiovascular Compartments to the Ballistocardiogram Signal Using Mathematical Modeling Open
International audience
View article: The ocular mathematical virtual simulator: A validated multiscale model for hemodynamics and biomechanics in the human eye
The ocular mathematical virtual simulator: A validated multiscale model for hemodynamics and biomechanics in the human eye Open
We present our continuous efforts from a modeling and numerical viewpoint to develop a powerful and flexible mathematical and computational framework called Ocular Mathematical Virtual Simulator (OMVS). The OMVS aims to solve problems aris…
View article: Cardiovascular sex-differences: insights via physiology-based modeling and potential for noninvasive sensing via ballistocardiography
Cardiovascular sex-differences: insights via physiology-based modeling and potential for noninvasive sensing via ballistocardiography Open
In this study, anatomical and functional differences between men and women in their cardiovascular systems and how these differences manifest in blood circulation are theoretically and experimentally investigated. A validated mathematical …
View article: The role of conventional and unconventional adaptive routes in lowering of intraocular pressure: Theoretical model and simulation
The role of conventional and unconventional adaptive routes in lowering of intraocular pressure: Theoretical model and simulation Open
In this article, we propose a theoretical model leveraging the analogy between fluid and electric variables to investigate the relation among aqueous humor (AH) circulation and drainage and intraocular pressure (IOP), the principal establi…
View article: Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent
Heterogeneity of Ocular Hemodynamic Biomarkers among Open Angle Glaucoma Patients of African and European Descent Open
This study investigated the heterogeneity of ocular hemodynamic biomarkers in early open angle glaucoma (OAG) patients and healthy controls of African (AD) and European descent (ED). Sixty OAG patients (38 ED, 22 AD) and 65 healthy control…
View article: Artificial Intelligence to Aid Glaucoma Diagnosis and Monitoring: State of the Art and New Directions
Artificial Intelligence to Aid Glaucoma Diagnosis and Monitoring: State of the Art and New Directions Open
Recent developments in the use of artificial intelligence in the diagnosis and monitoring of glaucoma are discussed. To set the context and fix terminology, a brief historic overview of artificial intelligence is provided, along with some …
View article: Precision medicine and glaucoma management: how mathematical modeling and artificial intelligence help in clinical practice
Precision medicine and glaucoma management: how mathematical modeling and artificial intelligence help in clinical practice Open
View article: Mathematical modeling of the lower urinary tract: A review
Mathematical modeling of the lower urinary tract: A review Open
Aims Understand what progress has been made toward a functionally predictive lower urinary tract (LUT) model, identify knowledge gaps, and develop from them a path forward. Methods We surveyed prominent mathematical models of the basic LUT…
View article: Numerical simulation and analysis of multiscale interface coupling between a poroelastic medium and a lumped hydraulic circuit: Comparison between functional iteration and operator splitting methods
Numerical simulation and analysis of multiscale interface coupling between a poroelastic medium and a lumped hydraulic circuit: Comparison between functional iteration and operator splitting methods Open
View article: Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics
Physiology-Enhanced Data Analytics to Evaluate the Effect of Altitude on Intraocular Pressure and Ocular Hemodynamics Open
Altitude affects intraocular pressure (IOP); however, the underlying mechanisms involved and its relationship with ocular hemodynamics remain unknown. Herein, a validated mathematical modeling approach was used for a physiology-enhanced (p…
View article: Mechanism-Driven Modeling to Aid Non-invasive Monitoring of Cardiac Function via Ballistocardiography
Mechanism-Driven Modeling to Aid Non-invasive Monitoring of Cardiac Function via Ballistocardiography Open
Left ventricular (LV) catheterization provides LV pressure-volume (P-V) loops and it represents the gold standard for cardiac function monitoring. This technique, however, is invasive and this limits its applicability in clinical and in-ho…
View article: Combining Physiology-Based Modeling and Evolutionary Algorithms for Personalized, Noninvasive Cardiovascular Assessment Based on Electrocardiography and Ballistocardiography
Combining Physiology-Based Modeling and Evolutionary Algorithms for Personalized, Noninvasive Cardiovascular Assessment Based on Electrocardiography and Ballistocardiography Open
Purpose: This study proposes a novel approach to obtain personalized estimates of cardiovascular parameters by combining (i) electrocardiography and ballistocardiography for noninvasive cardiovascular monitoring, (ii) a physiology-based ma…
View article: A multi-scale/multi-physics model for the theoretical study of the vascular configuration of retinal capillary plexuses based on OCTA data
A multi-scale/multi-physics model for the theoretical study of the vascular configuration of retinal capillary plexuses based on OCTA data Open
The retinal tissue is highly metabolically active and is responsible for translating the visual stimuli into electrical signals to be delivered to the brain. A complex vascular structure ensures an adequate supply of blood and oxygen, whic…
View article: Cubature Kalman Filter Based Training of Hybrid Differential Equation Recurrent Neural Network Physiological Dynamic Models
Cubature Kalman Filter Based Training of Hybrid Differential Equation Recurrent Neural Network Physiological Dynamic Models Open
Modeling biological dynamical systems is challenging due to the interdependence of different system components, some of which are not fully understood. To fill existing gaps in our ability to mechanistically model physiological systems, we…
View article: Cubature Kalman Filter Based Training of Hybrid Differential Equation Recurrent Neural Network Physiological Dynamic Models
Cubature Kalman Filter Based Training of Hybrid Differential Equation Recurrent Neural Network Physiological Dynamic Models Open
Modeling biological dynamical systems is challenging due to the interdependence of different system components, some of which are not fully understood. To fill existing gaps in our ability to mechanistically model physiological systems, we…
View article: Letter from the Editors
Letter from the Editors Open
Intelligence in Ophthalmology (MAIO)The new title of the journal reflects, embraces, and supports the tremendous innovation that advanced applications of modeling and artificial intelligence (AI) in mathematics, statistics, computer scienc…
View article: Fluid and protein exchange in microvascular networks: Importance of modelling heterogeneity in geometrical and biophysical properties
Fluid and protein exchange in microvascular networks: Importance of modelling heterogeneity in geometrical and biophysical properties Open
Key points Microvascular network architecture defines coupling of fluid and protein exchange. Network arrangements markedly reduce capillary hydrostatic pressures and resting fluid movement at the same time as increasing the capacity for c…
View article: Ocular Blood Flow as It Relates to Race and Disease on Glaucoma
Ocular Blood Flow as It Relates to Race and Disease on Glaucoma Open
View article: Physics-based modeling of Age-related Macular Degeneration—A theoretical approach to quantify retinal and choroidal contributions to macular oxygenation
Physics-based modeling of Age-related Macular Degeneration—A theoretical approach to quantify retinal and choroidal contributions to macular oxygenation Open
View article: Physiology-enhanced data analytics to evaluate the role of ocular hemodynamics in glaucoma progression
Physiology-enhanced data analytics to evaluate the role of ocular hemodynamics in glaucoma progression Open
View article: Differences in retinal capillary blood flow and visual function in healthy male and female subjects of African and European descent
Differences in retinal capillary blood flow and visual function in healthy male and female subjects of African and European descent Open