David G. Hunter
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View article: Mesoscale developmental rivalry in human extrastriate visual cortex
Mesoscale developmental rivalry in human extrastriate visual cortex Open
In humans and non-human primates, the extrastriate visual cortex contains fine-scale columns selectively responsive to motion, disparity, and color. However, the developmental interplay between these functional modules remains poorly under…
View article: Strabismus Surgery in Orthophoric Patients with Abduction Limitation
Strabismus Surgery in Orthophoric Patients with Abduction Limitation Open
Small, adjustable advancements of the lateral rectus muscles provided excellent results in our series of patients with lateral gaze esotropia caused by previous lateral rectus recessions. Despite large, early overcorrections, LI scores imp…
View article: Gene Identification for Ocular Congenital Cranial Motor Neuron Disorders Using Human Sequencing, Zebrafish Screening, and Protein Binding Microarrays.
Gene Identification for Ocular Congenital Cranial Motor Neuron Disorders Using Human Sequencing, Zebrafish Screening, and Protein Binding Microarrays. Open
This study nominates three strong novel candidate oCCDD genes (SEMA3F, OLIG2, and FRMD4B) and supports the functionality and putative pathogenicity of transcription factor candidate variants PHOX2A p.(Trp137Cys), MAFB p.(Glu223Lys), and OL…
View article: Decreased scene-selective activity within the posterior intraparietal cortex in amblyopic adults
Decreased scene-selective activity within the posterior intraparietal cortex in amblyopic adults Open
Introduction Amblyopia is a developmental disorder associated with reduced performance in visually guided tasks, including binocular navigation within natural environments. To help understand the underlying neurological disorder, we used f…
View article: Differential Impacts of Strabismic and Anisometropic Amblyopia on the Mesoscale Functional Organization of the Human Visual Cortex
Differential Impacts of Strabismic and Anisometropic Amblyopia on the Mesoscale Functional Organization of the Human Visual Cortex Open
We employed high-resolution fMRI to distinguish the impacts of anisometropia and strabismus amblyopia on the evoked ocular dominance (OD) response. Sixteen amblyopic participants (eight females) plus eight individuals with normal vision (o…
View article: Gene identification for ocular congenital cranial motor neuron disorders using human sequencing, zebrafish screening, and protein binding microarrays
Gene identification for ocular congenital cranial motor neuron disorders using human sequencing, zebrafish screening, and protein binding microarrays Open
Purpose To functionally evaluate novel human sequence-derived candidate genes and variants for unsolved ocular congenital cranial dysinnervation disorders (oCCDDs). Methods Through exome and genome sequencing of a genetically unsolved huma…
View article: Decreased scene-selective activity within the posterior intraparietal cortex in amblyopic adults
Decreased scene-selective activity within the posterior intraparietal cortex in amblyopic adults Open
Amblyopia is a developmental disorder associated with reduced performance in visually guided tasks, including binocular navigation within natural environments. To help understand the underlying neurological disorder, we used fMRI to test t…
View article: Peripheral Binocular Imbalance in Anisometropic and Strabismic Amblyopia
Peripheral Binocular Imbalance in Anisometropic and Strabismic Amblyopia Open
There is evidence of decreased binocularity deficits, or interocular suppression, in the periphery in anisometropic and strabismic amblyopia as compared with controls. Notably, those with strabismic amblyopia exhibited more significant per…
View article: Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders
Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders Open
Purpose To identify genetic etiologies and genotype/phenotype associations for unsolved ocular congenital cranial dysinnervation disorders (oCCDDs). Methods We coupled phenotyping with exome or genome sequencing of 467 pedigrees with genet…
View article: Presence of Copy Number Variants Associated With Esotropia in Patients With Exotropia
Presence of Copy Number Variants Associated With Esotropia in Patients With Exotropia Open
Importance Strabismus is a common ocular disorder of childhood. There is a clear genetic component to strabismus, but it is not known if esotropia and exotropia share genetic risk factors. Objective To determine whether genetic duplication…
View article: Using high-resolution functional MRI to differentiate impacts of strabismic and anisometropic amblyopia on evoked ocular dominance activity in humans
Using high-resolution functional MRI to differentiate impacts of strabismic and anisometropic amblyopia on evoked ocular dominance activity in humans Open
We employed high-resolution functional MRI (fMRI) to distinguish the impacts of anisometropia and strabismus (the two most frequent causes of amblyopia) on the evoked ocular dominance (OD) response. Sixteen amblyopic participants (8 female…
View article: The Incidence of Strabismus After Upper and Lower Blepharoplasty in the United States
The Incidence of Strabismus After Upper and Lower Blepharoplasty in the United States Open
Purpose: To compare the incidence of strabismus after upper and lower blepharoplasty in the United States. Methods: Retrospective cohort study of adults (age ≥18 years) in the IRIS Registry (Intelligent Research in Sight) who underwent ble…
View article: Gaps in the Vision Screening Pathway for School-Aged US Children
Gaps in the Vision Screening Pathway for School-Aged US Children Open
This cross-sectional study uses a nationally representative survey of the US pediatric population to identify gaps in the vision screening pathway.
View article: Surgical Approach and Reoperation Risk in Intermittent Exotropia in the IRIS Registry
Surgical Approach and Reoperation Risk in Intermittent Exotropia in the IRIS Registry Open
Importance There is no consensus on the optimal surgical treatment for children with intermittent exotropia (IXT). Objective To compare the 5-year reoperation rates for children with IXT treated with horizontal muscle strabismus surgery us…
View article: Vision Testing for Adolescents in the US
Vision Testing for Adolescents in the US Open
Importance Untreated refractive error contributes to the racial, ethnic, and socioeconomic disparities in visual function of adolescent children in the US. Objective To describe patterns in vision testing as a function of age among US adol…
View article: Vision Screening Among Children With Private Insurance: 2010–2019
Vision Screening Among Children With Private Insurance: 2010–2019 Open
OBJECTIVES To describe trends in vision screening based on insurance claims for young children in the United States. METHODS This cross-sectional study used administrative claims data from the 2010–2019 IBM MarketScan Commercial Claims and…
View article: Improving Estimates of the Geographic Distribution of Pediatric Ophthalmologists to Identify Underserved Regions
Improving Estimates of the Geographic Distribution of Pediatric Ophthalmologists to Identify Underserved Regions Open
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View article: Use and Costs of Instrument-Based Vision Screening for US Children Aged 12 to 36 Months
Use and Costs of Instrument-Based Vision Screening for US Children Aged 12 to 36 Months Open
This cohort study examines patterns and out-of-pocket costs of instrument-based screening among children 12 to 36 months.
View article: Factors Associated With Nasolacrimal Duct Probing Failure Among Children in the Intelligent Research in Sight Registry
Factors Associated With Nasolacrimal Duct Probing Failure Among Children in the Intelligent Research in Sight Registry Open
Importance Understanding the factors associated with nasolacrimal duct probing failure in young children may help inform practice patterns. Objective To identify factors associated with repeated nasolacrimal duct probing in young children.…
View article: Strategies for managing strabismus from oculomotor nerve palsy
Strategies for managing strabismus from oculomotor nerve palsy Open
Addressing ocular misalignment secondary to partial and complete oculomotor nerve palsy presents a special challenge to the strabismus surgeon, particularly when treating patients with binocular diplopia. We review the reported surgical op…
View article: Differentiating the impact of amblyopia on spatial frequency encoding within human V2/V3 thin and thick stripes
Differentiating the impact of amblyopia on spatial frequency encoding within human V2/V3 thin and thick stripes Open
Spatial frequency (SF) encoding in the human visual system is influenced by amblyopia. Amblyopic individuals struggle with low-contrast, high-SF stimuli, especially when presented monocularly to their amblyopic (suppressed) eye. To assess …