Richard G. Wise
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View article: Exploring the contribution of gray matter microstructure to R1 contrast via multi-compartment diffusion modelling in the healthy brain
Exploring the contribution of gray matter microstructure to R1 contrast via multi-compartment diffusion modelling in the healthy brain Open
The Soma And Neurite Density Imaging (SANDI) model enhances MRI-derived water diffusion metrics sensitivity to gray matter (GM) microstructural complexity. We investigated the hypothesis that the diffusion metrics derived from the SANDI th…
View article: Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations
Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations Open
Velocity-selective arterial spin labelling (VSASL) MRI is insensitive to prolonged arterial transit time. This is an advantage over other arterial spin labelling schemes, where long arterial transit times can lead to bias. Therefore, VSASL…
View article: Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study
Body size and intracranial volume interact with the structure of the central nervous system: A multi-center in vivo neuroimaging study Open
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject’s sex and age. However, corrections for body …
View article: Changes of brain parenchyma free water fraction reflect tissue damage and impaired processing speed in multiple sclerosis
Changes of brain parenchyma free water fraction reflect tissue damage and impaired processing speed in multiple sclerosis Open
Free water fraction (FWF) represents the amount of water per unit volume of brain parenchyma, which is not bound to macromolecules. Its excess in multiple sclerosis (MS) is related to increased tissue loss. The use of mcDESPOT (multicompon…
View article: Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations
Velocity-selective arterial spin labelling bolus duration measurements: Implications for consensus recommendations Open
Velocity-selective arterial spin labelling (VSASL) MRI is insensitive to arterial transit time. This is an advantage over other perfusion measurements, where long arterial transit times can lead to bias. Therefore, VSASL can be used to stu…
View article: Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study
Body size interacts with the structure of the central nervous system: A multi-center in vivo neuroimaging study Open
Clinical research emphasizes the implementation of rigorous and reproducible study designs that rely on between-group matching or controlling for sources of biological variation such as subject’s sex and age. However, corrections for body …
View article: Breath-hold calibrated fMRI mapping of absolute cerebral metabolic rate of oxygen metabolism (CMRO2): An assessment of the accuracy and repeatability in a healthy adult population
Breath-hold calibrated fMRI mapping of absolute cerebral metabolic rate of oxygen metabolism (CMRO2): An assessment of the accuracy and repeatability in a healthy adult population Open
We previously introduced a calibrated fMRI framework that utilises respiratory modulation with only a single gas (CO2) to map the grey matter (GM) cerebral metabolic rate of oxygen consumption (CMRO2). The method decouples and estimates th…
View article: Evidence for a sustained cerebrovascular response following motor practice
Evidence for a sustained cerebrovascular response following motor practice Open
Motor tasks have been extensively used to probe neuroplasticity and the changes in MRI signals are often associated with changes in performance. Changes in performance have been linked to alterations in resting-state fluctuations of BOLD s…
View article: Corrigendum: Towards high-resolution quantitative assessment of vascular dysfunction
Corrigendum: Towards high-resolution quantitative assessment of vascular dysfunction Open
Corrigendum on: Guidi M, Giulietti G, Biondetti E, Wise R and Giove F (2023), Towards high resolution quantitative assessment of vascular dysfunction. Front. Phys. 11:1248021. doi: 10.3389/fphy.2023.1248021Incorrect Funding In the publishe…
View article: Breath-hold BOLD fMRI without CO2 sampling enables estimation of venous cerebral blood volume: potential use in normalization of stimulus-evoked BOLD fMRI data
Breath-hold BOLD fMRI without CO2 sampling enables estimation of venous cerebral blood volume: potential use in normalization of stimulus-evoked BOLD fMRI data Open
BOLD fMRI signal has been used in conjunction with vasodilatory stimulation as a marker of cerebrovascular reactivity (CVR): the relative change in cerebral blood flow (CBF) arising from a unit change in the vasodilatory stimulus. Using nu…
View article: Changes in brain perfusion with training-related visuomotor improvement in MS
Changes in brain perfusion with training-related visuomotor improvement in MS Open
Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system. A better understanding of the mechanisms supporting brain plasticity in MS would help to develop targeted interventions to promote recovery. A total o…
View article: Towards high-resolution quantitative assessment of vascular dysfunction
Towards high-resolution quantitative assessment of vascular dysfunction Open
Neurovascular alterations are increasingly recognized as a key feature of many brain diseases. They can manifest as a reduction in resting cerebral blood flow or cerebrovascular reactivity (CVR) in the whole brain or in specific regions, d…
View article: Assessment of brainstem function and haemodynamics by MRI: challenges and clinical prospects
Assessment of brainstem function and haemodynamics by MRI: challenges and clinical prospects Open
MRI offers techniques for non-invasively measuring a range of aspects of brain tissue function. Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) is widely used to assess neural activity, based on the br…
View article: Analysis of the Impacts of Freight Subsidisation on Transport Mode Selection: An Assessment of the Tasmanian Freight Equalisation Scheme
Analysis of the Impacts of Freight Subsidisation on Transport Mode Selection: An Assessment of the Tasmanian Freight Equalisation Scheme Open
The objective of this research is to identify the key selection criteria that form the basis of a shipper’s selection of freight transport mode. The study is undertaken in the context of sea freight. The study is localised to Tasmanian shi…
View article: Pathophysiology of <scp>multiple sclerosis</scp> damage and repair: Linking cerebral hypoperfusion to the development of irreversible tissue loss in <scp>multiple sclerosis</scp> using <scp>magnetic resonance imaging</scp>
Pathophysiology of <span>multiple sclerosis</span> damage and repair: Linking cerebral hypoperfusion to the development of irreversible tissue loss in <span>multiple sclerosis</span> using <span>magnetic resonance imaging</span> Open
Background and purpose Reduced cerebral perfusion has been observed in multiple sclerosis (MS) and may contribute to tissue loss both acutely and chronically. Here, we test the hypothesis that hypoperfusion occurs in MS and relates to the …
View article: Cerebral blood flow patterns in preterm and term neonates assessed with <scp>pseudo‐continuous</scp> arterial spin labeling perfusion <scp>MRI</scp>
Cerebral blood flow patterns in preterm and term neonates assessed with <span>pseudo‐continuous</span> arterial spin labeling perfusion <span>MRI</span> Open
In preterm (PT) infants, regional cerebral blood flow (CBF) disturbances may predispose to abnormal brain maturation even without overt brain injury. Therefore, it would be informative to determine the spatial distribution of grey matter (…
View article: Editorial board ‐ TOC
Editorial board ‐ TOC Open
COVER ILLUSTRATIONGraph theory analysis reveals enhanced strength centrality in the left amygdala of vocalists and pianists, which indicates a high degree of interconnectivity between the left amygdala and other brain regions.This suggests…
View article: Hippocampal Dosimetry and Neurocognitive Function in Patients Undergoing Stereotactic Radiosurgery for Brain Metastases
Hippocampal Dosimetry and Neurocognitive Function in Patients Undergoing Stereotactic Radiosurgery for Brain Metastases Open
AIMS To measure neurocognitive function (NCF) and correlate with hippocampus dose in patients undergoing stereotactic radiosurgery (SRS) for 1-3 brain metastases. METHOD We conducted a prospective observational study measuring NCF before a…
View article: Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI
Reduced brain oxygen metabolism in patients with multiple sclerosis: Evidence from dual-calibrated functional MRI Open
Cerebral energy deficiency is increasingly recognised as an important feature of multiple sclerosis (MS). Until now, we have lacked non-invasive imaging methods to quantify energy utilisation and mitochondrial function in the human brain. …
View article: Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training
Changes in white matter microstructure and MRI-derived cerebral blood flow after 1-week of exercise training Open
Exercise is beneficial for brain health, inducing neuroplasticity and vascular plasticity in the hippocampus, which is possibly mediated by brain-derived neurotrophic factor (BDNF) levels. Here we investigated the short-term effects of exe…
View article: Contribution of Metabolomics to Multiple Sclerosis Diagnosis, Prognosis and Treatment
Contribution of Metabolomics to Multiple Sclerosis Diagnosis, Prognosis and Treatment Open
Metabolomics-based technologies map in vivo biochemical changes that may be used as early indicators of pathological abnormalities prior to the development of clinical symptoms in neurological conditions. Metabolomics may also reveal bioch…