Jagadeesh Kumar Gangasani
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View article: Investigation of Proteome-Tetrazine Reactivity for a Highly Selective Tetrazine Ligation in Live Cells
Investigation of Proteome-Tetrazine Reactivity for a Highly Selective Tetrazine Ligation in Live Cells Open
Tetrazine has been widely used in bio-orthogonal click chemistry for diverse biological applications due to its short reaction time and excellent bio-orthogonality. For efficient click reaction, the stability of tetrazine in physiological …
View article: Exploration of the cytotoxic and microtubule disruption potential of novel imidazo[1,5- <i>a</i> ]pyridine-based chalcones
Exploration of the cytotoxic and microtubule disruption potential of novel imidazo[1,5- <i>a</i> ]pyridine-based chalcones Open
Design, synthesis, characterization of a series of imidazo[1,5- a ]pyridine-chalcones and evaluated their cytotoxicity. Apoptotic induction, ROS-mediated mitochondrial damage, immuno-fluorescence, microtubule disruption and docking were al…
View article: Targeting Phosphatidyl-inositol-4-Phosphate-5-Kinase ameliorates hepatic cancer by inhibiting PI3K/Akt/mTOR and autophagy mechanism and enhancing ROS-mediated apoptosis
Targeting Phosphatidyl-inositol-4-Phosphate-5-Kinase ameliorates hepatic cancer by inhibiting PI3K/Akt/mTOR and autophagy mechanism and enhancing ROS-mediated apoptosis Open
Background Hepatic cancer cells control Reactive Oxygen Species (ROS) and lipid kinases to grow. PIP5K, a lipid kinase, modulates the proliferation and Autophagy; however, its role remains HCC progression is uncertain. This study examined …
View article: Mesua Assamica (King & Prain) Kosterm. Bark Ethanolic Extract Attenuates Rheumatoid Arthritis Via Down-Regulating Tlr4/Nf-Κb/Cox-2/Inos and Activation of Nrf2/Ho-1 Pathways: A Comprehensive Study on In-Vitro and In-Vivo Models
Mesua Assamica (King & Prain) Kosterm. Bark Ethanolic Extract Attenuates Rheumatoid Arthritis Via Down-Regulating Tlr4/Nf-Κb/Cox-2/Inos and Activation of Nrf2/Ho-1 Pathways: A Comprehensive Study on In-Vitro and In-Vivo Models Open
View article: AKR1B1 drives hyperglycemia-induced metabolic reprogramming in MASLD-associated hepatocellular carcinoma
AKR1B1 drives hyperglycemia-induced metabolic reprogramming in MASLD-associated hepatocellular carcinoma Open
This research work highlights AKR1B1 as a druggable target in metabolic dysfunction-associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC), which could provide the basis for the development of new chemotherapeutic ag…
View article: AKR1B1 drives hyperglycemia-induced metabolic reprogramming in NAFLD-associated carcinogenesis and progression of hepatocellular carcinoma
AKR1B1 drives hyperglycemia-induced metabolic reprogramming in NAFLD-associated carcinogenesis and progression of hepatocellular carcinoma Open
Objective Emergent epidemiological evidence suggests that the progression of NAFLD/NASH-associated HCC positively correlates with the patient's glycemic index. However, the mechanism behind this progressive pathological alteration is poorl…
View article: Discovery of Potential Microtubule Disruption Agents: Design, Synthesis, And Biological Evaluation of Novel Imidazo[1,5-a]Pyridine Based Chalcone Conjugates
Discovery of Potential Microtubule Disruption Agents: Design, Synthesis, And Biological Evaluation of Novel Imidazo[1,5-a]Pyridine Based Chalcone Conjugates Open
View article: Litsea salicifolia Roxb. bark ethanolic extract attenuates rheumatoid arthritis by inhibiting TLR4/NF-κB and activating SIRT1-Nrf2/HO-1 signaling axis: In-vitro and in-vivo evaluations
Litsea salicifolia Roxb. bark ethanolic extract attenuates rheumatoid arthritis by inhibiting TLR4/NF-κB and activating SIRT1-Nrf2/HO-1 signaling axis: In-vitro and in-vivo evaluations Open
Background: Litsea salicifolia Roxb. (LS) is a pioneer medicinal plant that can be found in tropical and subtropical countries like India, China and Japan. LS is traditionally used for treating chronic pulmonary inflammatory diseases like …
View article: Nutraceutical prospects of Houttuynia cordata against the infectious viruses
Nutraceutical prospects of Houttuynia cordata against the infectious viruses Open
View article: Molecular Dissection of Tumor-Selective Cytotoxicity of Novel Epalrestat Analog (NARI-29) for Treating or Preventing Colitis-Associated Cancer: Special Focus on Oxidative Stress Mediated Death Receptor Signaling
Molecular Dissection of Tumor-Selective Cytotoxicity of Novel Epalrestat Analog (NARI-29) for Treating or Preventing Colitis-Associated Cancer: Special Focus on Oxidative Stress Mediated Death Receptor Signaling Open
View article: Polyphenolic-Rich Compounds From Dillenia pentagyna (Roxb.) Attenuates the Doxorubicin-Induced Cardiotoxicity: A High-Frequency Ultrasonography Assisted Approach
Polyphenolic-Rich Compounds From Dillenia pentagyna (Roxb.) Attenuates the Doxorubicin-Induced Cardiotoxicity: A High-Frequency Ultrasonography Assisted Approach Open
Cardiovascular complications are the foremost concern in patients undergoing anticancer therapy . There is an unmet need to address the problems arising from the drug-induced toxicity for the long-term benefit of the patients undergoing ch…
View article: Perillyl Alcohol Inhibits Keratinocyte Proliferation and Attenuates Imiquimod-Induced Psoriasis Like Skin-Inflammation by Modulating NF-κB and STAT3 Signaling Pathways
Perillyl Alcohol Inhibits Keratinocyte Proliferation and Attenuates Imiquimod-Induced Psoriasis Like Skin-Inflammation by Modulating NF-κB and STAT3 Signaling Pathways Open
View article: Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function
Description of a Novel Phosphodiesterase (PDE)-3 Inhibitor Protecting Mice From Ischemic Stroke Independent From Platelet Function Open
Background and Purpose— Acetylsalicylic acid and clopidogrel are the 2 main antithrombotic drugs for secondary prevention in patients with ischemic stroke (IS) without indication for anticoagulation. Because of their limited efficacy and p…
View article: CCDC 1507059: Experimental Crystal Structure Determination
CCDC 1507059: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Erratum to: Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents
Erratum to: Synthesis and characterization of new s-triazine bearing benzimidazole and benzothiazole derivatives as anticancer agents Open
View article: CCDC 977396: Experimental Crystal Structure Determination
CCDC 977396: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …