Giuseppe Minniti
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View article: IMG-82. Positron emission tomography (PET) use among European Organisation for Research and Treatment of Cancer – Brain Tumour Group (EORTC-BTG) sites – a cross-sectional survey
IMG-82. Positron emission tomography (PET) use among European Organisation for Research and Treatment of Cancer – Brain Tumour Group (EORTC-BTG) sites – a cross-sectional survey Open
BACKGROUND Positron emission tomography (PET) is increasingly used in patients with brain tumors, yet its adoption varies across institutions. METHODS To assess the current landscape, a cross-sectional survey was conducted among European O…
View article: Repeated radiosurgery for recurrent or refractory trigeminal neuralgia: a systematic review and meta-analysis
Repeated radiosurgery for recurrent or refractory trigeminal neuralgia: a systematic review and meta-analysis Open
Stereotactic Radiosurgery (SRS) is a well-established component of the multimodal approach to treating trigeminal neuralgia (TN), a condition marked by frequent and recurrent episodes despite treatments. As a result, an increasing number o…
View article: Author Correction: Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care
Author Correction: Stereotactic radiosurgery for patients with brain metastases: current principles, expanding indications and opportunities for multidisciplinary care Open
View article: P03.09.B EANO, EORTC, EPTN AND ESNR CONSENSUS-BASED DEFINITION FOR POST-RADIOTHERAPY MRI ABNORMALITIES IN THE BRAIN: PRELIMINARY FINDINGS FROM AN INTERDISCIPLINARY DELPHI STUDY.
P03.09.B EANO, EORTC, EPTN AND ESNR CONSENSUS-BASED DEFINITION FOR POST-RADIOTHERAPY MRI ABNORMALITIES IN THE BRAIN: PRELIMINARY FINDINGS FROM AN INTERDISCIPLINARY DELPHI STUDY. Open
BACKGROUND Patients treated with radiotherapy for intracranial tumours can develop new abnormalities on follow-up MRI. However, there is significant heterogeneity in the terminology and definitions used to describe these post-radiotherapy …
View article: P12.25.B A GLOBAL PHASE 3, OPEN-LABEL, RANDOMIZED-CONTROLLED STUDY FOR NEWLY-DIAGNOSED, MGMT UNMETHYLATED GLIOBLASTOMA, COMPARING NIRAPARIB VS STANDARD OF CARE TEMOZOLOMIDE TREATMENT.
P12.25.B A GLOBAL PHASE 3, OPEN-LABEL, RANDOMIZED-CONTROLLED STUDY FOR NEWLY-DIAGNOSED, MGMT UNMETHYLATED GLIOBLASTOMA, COMPARING NIRAPARIB VS STANDARD OF CARE TEMOZOLOMIDE TREATMENT. Open
BACKGROUND Glioblastoma (GBM) is a universally deadly disease with dismal prognosis. The O6-methylguanine methyltransferase (MGMT) promoter methylation is both predictive in response to standard chemoradiation, as well as prognosis, and un…
View article: P17.15.A ASSOCIATION OF PROTON PUMP INHIBITOR USE WITH OUTCOME OF PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA
P17.15.A ASSOCIATION OF PROTON PUMP INHIBITOR USE WITH OUTCOME OF PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA Open
BACKGROUND Proton pump inhibitors (PPI) are often prescribed to prevent steroid-induced gastritis and peptic ulcer disease in patients with glioblastoma. Yet, these drugs may enhance the activity of aldehyde dehydrogenase 1 A1 (ALDH1A1) wh…
View article: Timing matters: overall treatment time, radiotherapy interruptions, and outcomes in glioblastomas—prognostic significance in different biological sub-groups
Timing matters: overall treatment time, radiotherapy interruptions, and outcomes in glioblastomas—prognostic significance in different biological sub-groups Open
Background Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, with a median overall survival (OS) rarely exceeding 15 months despite multimodal therapy. While established prognostic factors includ…
View article: Reirradiation in recurrent glioblastoma
Reirradiation in recurrent glioblastoma Open
Purpose of review Reirradiation has emerged as a potentially valuable treatment strategy for recurrent glioblastoma, a disease characterized by inevitable local progression despite aggressive multimodal first-line therapy. Recent advances …
View article: ESMO–ESTRO consensus statements on the safety of combining radiotherapy with immune checkpoint inhibitors, VEGF(R) inhibitors, or multitargeted tyrosine kinase inhibitors
ESMO–ESTRO consensus statements on the safety of combining radiotherapy with immune checkpoint inhibitors, VEGF(R) inhibitors, or multitargeted tyrosine kinase inhibitors Open
Generally, the expected toxicity of combining RT with ICIs is low, particularly for programmed death(-ligand) 1 inhibitors. For most combinations with VEGF(R) inhibitors and multitargeted TKIs, exercising caution is recommended. The eviden…
View article: [<sup>177</sup>Lu]Lu-DOTATATE for Recurrent Meningioma (LUMEN-1, EORTC-2334-BTG): Study Protocol for a Randomized Phase II Trial
[<sup>177</sup>Lu]Lu-DOTATATE for Recurrent Meningioma (LUMEN-1, EORTC-2334-BTG): Study Protocol for a Randomized Phase II Trial Open
There are no established treatment options for patients with meningioma recurring after surgery and radiotherapy. Somatostatin receptor type 2 (SSTR2) is highly expressed in meningiomas, and SSTR2-targeting radionuclide therapy with […
View article: Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas
Update to the RANO working group and EANO recommendations for the clinical use of PET imaging in gliomas Open
This Policy Review provides recommendations for the use of PET imaging in patients with gliomas and represents a joint effort of the Response Assessment in Neuro-Oncology (RANO) working group for PET and the European Association for Neuro-…
View article: Prognostic impact of small size sutureless prostheses: results for 241 patients from an international registry
Prognostic impact of small size sutureless prostheses: results for 241 patients from an international registry Open
Study number 587/2015.
View article: Timing Matters: Overall Treatment Time, Radiotherapy Interruptions, and Outcomes in glioblastomas – Prognostic Significance in Different Biological Sub- Groups
Timing Matters: Overall Treatment Time, Radiotherapy Interruptions, and Outcomes in glioblastomas – Prognostic Significance in Different Biological Sub- Groups Open
Background: Glioblastoma (GBM) is the most common and aggressive primary malignant brain tumor in adults, with a median overall survival (OS) rarely exceeding 15 months despite multimodal therapy. While established prognostic factors inclu…
View article: Prognostic value of 1D, 2D and volumetric tumor size increases in recurrent WHO grade 2 and 3 meningiomas: radiological <i>post-hoc</i> analysis of the EORTC-BTG-1320 trial
Prognostic value of 1D, 2D and volumetric tumor size increases in recurrent WHO grade 2 and 3 meningiomas: radiological <i>post-hoc</i> analysis of the EORTC-BTG-1320 trial Open
Background Although differential prognostic value of 1D, 2D and volumetric meningioma size assessment has been reported, RANO meningioma criteria rely on bidimensional measurements. Methods In this post-hoc analysis of the EORTC-BTG 1320 t…
View article: Tumor‐related epilepsy in glioma: A multidisciplinary overview
Tumor‐related epilepsy in glioma: A multidisciplinary overview Open
Seizures are a common and challenging symptom in brain tumors, affecting approximately 60% of patients. Tumor‐related epilepsy (TRE) in glioma patients requires personalized and dynamic management in a multidisciplinary environment, especi…
View article: Biomolecular Predictors of Recurrence Patterns and Survival in IDH-Wild-Type Glioblastoma: A Retrospective Analysis of Patients Treated with Radiotherapy and Temozolomide
Biomolecular Predictors of Recurrence Patterns and Survival in IDH-Wild-Type Glioblastoma: A Retrospective Analysis of Patients Treated with Radiotherapy and Temozolomide Open
Background and Aim: Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with poor prognosis despite maximal surgical resection, radiotherapy (RT), and temozolomide (TMZ) per the Stupp protocol. IDH-wild-type GBM, the p…
View article: Author Correction: RANO criteria for response assessment of brain metastases based on amino acid PET imaging
Author Correction: RANO criteria for response assessment of brain metastases based on amino acid PET imaging Open
View article: The effects of the introduction of the single-family room in neonatal intensive care and paediatric intensive care on the outcomes of paediatric patients, families, staff, and organizations: a mixed method systematic review protocol
The effects of the introduction of the single-family room in neonatal intensive care and paediatric intensive care on the outcomes of paediatric patients, families, staff, and organizations: a mixed method systematic review protocol Open
Introduction: the design of neonatal and paediatric neonatal intensive care significantly impacts the outcomes of the families, workers, and organizations. The aim of this review is to identify the effects of the introduction of the single…
View article: Availability and use of PET in patients with brain tumours – a European Organisation for Research and Treatment of Cancer - Brain Tumour Group (EORTC-BTG) survey
Availability and use of PET in patients with brain tumours – a European Organisation for Research and Treatment of Cancer - Brain Tumour Group (EORTC-BTG) survey Open
View article: RANO criteria for response assessment of brain metastases based on amino acid PET imaging
RANO criteria for response assessment of brain metastases based on amino acid PET imaging Open
View article: Integrating nutritional status and hematological biomarkers for enhanced prognosis prediction in glioma patients: A systematic review
Integrating nutritional status and hematological biomarkers for enhanced prognosis prediction in glioma patients: A systematic review Open
PNI, CONUT score and hematological biomarkers (e.g. albumin, globulin, neutrophils, lymphocytes) may serve as useful predictors in patients with gliomas, potentially influencing clinical decisions. Additional large-scale studies are requir…
View article: Analysis of Patients with Locally Advanced Rectal Cancer Given Neoadjuvant Radiochemotherapy with or Without Rt Dose Intensification: A Multicenter Retrospective Study – Atlantis Part Ii
Analysis of Patients with Locally Advanced Rectal Cancer Given Neoadjuvant Radiochemotherapy with or Without Rt Dose Intensification: A Multicenter Retrospective Study – Atlantis Part Ii Open
View article: TEMPORARY REMOVAL: ESTRO/EANO recommendation on reirradiation of glioblastoma
TEMPORARY REMOVAL: ESTRO/EANO recommendation on reirradiation of glioblastoma Open
View article: Reducing clinical target volume margins for multifocal glioblastoma: a multi-institutional analysis of patterns of recurrence and treatment response
Reducing clinical target volume margins for multifocal glioblastoma: a multi-institutional analysis of patterns of recurrence and treatment response Open
Purpose: No guidelines exist to delineate radiation therapy (RT) targets for the treatment of multiple glioblastoma (mGBM). This study analyzes margins around the gross tumor volume (GTV) to create a clinical target volume (CTV), comparing…
View article: PARP inhibitors in gliomas: Mechanisms of action, current trends and future perspectives
PARP inhibitors in gliomas: Mechanisms of action, current trends and future perspectives Open
Gliomas are the most common primary malignant brain tumours in adults. Despite decades of research into novel therapeutic approaches, the prognosis remains poor. PARP1-2 are critical for DNA repair, cell survival and genomic stability and …
View article: Multidisciplinary management strategies for recurrent brain metastasis after prior radiotherapy: An overview
Multidisciplinary management strategies for recurrent brain metastasis after prior radiotherapy: An overview Open
As cancer patients with intracranial metastatic disease experience increasingly prolonged survival, the diagnosis and management of recurrent brain metastasis pose significant challenges in clinical practice. Prior to deciding upon a manag…
View article: Predictive Value of Perilesional Edema Volume in Melanoma Brain Metastasis Response to Stereotactic Radiosurgery
Predictive Value of Perilesional Edema Volume in Melanoma Brain Metastasis Response to Stereotactic Radiosurgery Open
Background and aim: Stereotactic radiotherapy (SRT) is an established treatment for melanoma brain metastases (MBM). Recent evidence suggests that perilesional edema volume (PEV) might compromise the delivery and efficacy of radiotherapy t…
View article: Correction to: Predictive value of perilesional edema volume in melanoma brain metastasis response to stereotactic radiosurgery
Correction to: Predictive value of perilesional edema volume in melanoma brain metastasis response to stereotactic radiosurgery Open
View article: Predictive value of perilesional edema volume in melanoma brain metastasis response to stereotactic radiosurgery
Predictive value of perilesional edema volume in melanoma brain metastasis response to stereotactic radiosurgery Open
Background and aim Stereotactic radiotherapy (SRT) is an established treatment for melanoma brain metastases (MBM). Recent evidence suggests that perilesional edema volume (PEV) might compromise the delivery and efficacy of radiotherapy to…
View article: Challenges and Opportunities in Accessing Surgery for Glioblastoma in Low–Middle Income Countries: A Narrative Review
Challenges and Opportunities in Accessing Surgery for Glioblastoma in Low–Middle Income Countries: A Narrative Review Open
Glioblastoma: a highly aggressive brain tumor, presents substantial challenges in treatment and management, with surgical intervention playing a pivotal role in improving patient outcomes. Disparities in access to brain tumor surgery arise…