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View article: Dysregulation of the mTOR-FMRP pathway and synaptic plasticity in an environmental model of ASD
Dysregulation of the mTOR-FMRP pathway and synaptic plasticity in an environmental model of ASD Open
Autism Spectrum Disorder (ASD) is caused by genetic, epigenetic, and environmental factors. Mutations in the human FMR1 gene, encoding the Fragile X Messenger Ribonucleoprotein 1 (FMRP), cause the most common monogenic form of ASD, the Fra…
View article: Early dysregulation of GSK3β impairs mitochondrial activity in Fragile X Syndrome
Early dysregulation of GSK3β impairs mitochondrial activity in Fragile X Syndrome Open
The finely tuned regulation of mitochondria activity is essential for proper brain development. Fragile X Syndrome (FXS), the leading cause of inherited intellectual disability, is a neurodevelopmental disorder in which mitochondrial dysfu…
View article: FMRP expression in primary breast tumor cells correlates with recurrence and specific site of metastasis
FMRP expression in primary breast tumor cells correlates with recurrence and specific site of metastasis Open
Breast cancer is the most common cancer among women worldwide. Molecular and clinical evidence indicated that Fragile X Messenger Ribonucleoprotein 1 (FMRP) plays a role in different types of cancer, including breast cancer. FMRP is an RNA…
View article: FMRP modulates the Wnt signalling pathway in glioblastoma
FMRP modulates the Wnt signalling pathway in glioblastoma Open
Converging evidence indicates that the Fragile X Messenger Ribonucleoprotein (FMRP), which absent or mutated in Fragile X Syndrome (FXS), plays a role in many types of cancers. However, while FMRP roles in brain development and function ha…
View article: Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge
Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge Open
Intrahepatic cholangiocarcinoma (iCCA) is a rare malignancy of the intrahepatic biliary tract with a very poor prognosis. Although some clinicopathological parameters can be prognostic factors for iCCA, the molecular prognostic markers and…
View article: Protein synthesis levels are increased in a subset of individuals with fragile X syndrome
Protein synthesis levels are increased in a subset of individuals with fragile X syndrome Open
This article initially published with incomplete supplementary material. This error has now been corrected, and the correct supplementary material is published. The authors regret the error.
View article: Protein synthesis levels are increased in a subset of individuals with fragile X syndrome
Protein synthesis levels are increased in a subset of individuals with fragile X syndrome Open
Fragile X syndrome (FXS) is a monogenic form of intellectual disability and autism spectrum disorder caused by the absence of the fragile X mental retardation protein (FMRP). In biological models for the disease, this leads to upregulated …