Marc H.G.P. Raaijmakers
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View article: Autologous stem cell transplantation versus consolidation chemotherapy as post-remission treatment in newly diagnosed favorable and intermediate risk patients with AML: A comparative analysis of HOVON-SAKK-Nordic trials
Autologous stem cell transplantation versus consolidation chemotherapy as post-remission treatment in newly diagnosed favorable and intermediate risk patients with AML: A comparative analysis of HOVON-SAKK-Nordic trials Open
Introduction High-dose chemotherapy followed by autologous stem cell transplantation (auto-HCT) or consolidation chemotherapy (CT) are post-remission therapy options for patients with acute myeloid leukemia (AML) who achieve complete remis…
View article: Germline LCP1 mutations cause immunodeficiency with neutropenia, monocytopenia, lymphopenia and defective cytokinesis
Germline LCP1 mutations cause immunodeficiency with neutropenia, monocytopenia, lymphopenia and defective cytokinesis Open
Severe congenital neutropenia (SCN) is characterized by neutropenia, recurrent infections and an increased leukemia risk. Multiple genetic defects underlying SCN have been identified, but a genetic diagnosis is still lacking in a significa…
View article: Targeting mitochondria mitigates chemotherapy-induced bone marrow dysfunction
Targeting mitochondria mitigates chemotherapy-induced bone marrow dysfunction Open
Summary Chemotherapy has revolutionized cancer treatment but its long-term impact on healthy tissues, particularly the rapidly dividing hematopoietic system, remains a significant concern. We show that the chemotherapeutic agent 5-fluorour…
View article: Immunotherapy for rapid bone marrow conditioning and leukemia depletion that allows efficient hematopoietic stem cell transplantation
Immunotherapy for rapid bone marrow conditioning and leukemia depletion that allows efficient hematopoietic stem cell transplantation Open
Hematopoietic stem cell transplantation (HSCT) is a life-saving procedure to treat hematopoietic disorders. Current bone marrow conditioning protocols create space for healthy donor stem cells by employing irradiation and/or chemotherapy, …
View article: Disease characteristics and outcomes of acute myeloid leukemia in germline <i>RUNX1</i> deficiency (Familial Platelet Disorder with associated Myeloid Malignancy)
Disease characteristics and outcomes of acute myeloid leukemia in germline <i>RUNX1</i> deficiency (Familial Platelet Disorder with associated Myeloid Malignancy) Open
Familial Platelet Disorder with associated Myeloid Malignancy (FPDMM, FPD/AML, RUNX1 ‐FPD), caused by monoallelic deleterious germline RUNX1 variants, is characterized by bleeding diathesis and predisposition for hematologic malignancies, …
View article: TGF-β1-SMAD2 Axis Regulates Hematopoiesis and β-Globin Gene Expression Via Super-Enhancer Associated Chromatin Reorganization
TGF-β1-SMAD2 Axis Regulates Hematopoiesis and β-Globin Gene Expression Via Super-Enhancer Associated Chromatin Reorganization Open
Introduction: Transforming growth factor beta 1 (TGF-β1) is an important regulator of hematopoiesis. This cytokine has been shown to be associated with bone marrow failure and ineffective hematopoiesis, even though the chromatin-mediated e…
View article: Hematological Phenotypes in GATA2 Deficiency Syndrome Arise from Secondary Injuries and Maladaptation to Proliferation
Hematological Phenotypes in GATA2 Deficiency Syndrome Arise from Secondary Injuries and Maladaptation to Proliferation Open
Introduction: GATA2 is a crucial transcription factor for hematopoietic stem and progenitor cell (HSPC) development. Germline mutations in GATA2 lead to monocytopenia, neutropenia, and B and NK cell lymphopenia, as well as an increased ris…
View article: Table S7 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S7 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S7 Gene list reflecting the inflammatory remodeling of stromal niches in AML
View article: Table S1 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S1 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S1 patient characteristics
View article: Table S4 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S4 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S4 Differentially expressed genes and transcriptional programs (GSEA Hallmark) in BMSCs from AML vs. BMSCs from NBM (scRNAseq)
View article: Table S2 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S2 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S2 Differentially expressed genes in the HSC (low-output) cluster 0 vs. (high-output) HSC/MPP clusters 1-4
View article: Table S6 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S6 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Supplementary Table 6. Differentially expressed genes in BMSCs from AML vs. BMSCs from NBM (purified BMSC RNAseq)
View article: Table S1 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S1 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S1 patient characteristics
View article: Supplementary Figure 1-9 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Supplementary Figure 1-9 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Fig S1-S9
View article: Supplementary Figure 1-9 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Supplementary Figure 1-9 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Fig S1-S9
View article: Table S2 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S2 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S2 Differentially expressed genes in the HSC (low-output) cluster 0 vs. (high-output) HSC/MPP clusters 1-4
View article: Table S5 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S5 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S5 Differentially expressed genes in residual normal/pre-leukemic HSCs in AML vs. HSCs from NBM (scRNAseq)
View article: Table S5 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S5 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S5 Differentially expressed genes in residual normal/pre-leukemic HSCs in AML vs. HSCs from NBM (scRNAseq)
View article: Table S3 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S3 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Supplementary Table 3. Differentially expressed genes in the NBM BMSC cluster 0 vs. other BMSC clusters
View article: Table S7 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S7 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S7 Gene list reflecting the inflammatory remodeling of stromal niches in AML
View article: Table S6 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S6 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Supplementary Table 6. Differentially expressed genes in BMSCs from AML vs. BMSCs from NBM (purified BMSC RNAseq)
View article: Table S4 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S4 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Table S4 Differentially expressed genes and transcriptional programs (GSEA Hallmark) in BMSCs from AML vs. BMSCs from NBM (scRNAseq)
View article: Table S3 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML
Table S3 from A SINGLE-CELL TAXONOMY PREDICTS INFLAMMATORY NICHE REMODELING TO DRIVE TISSUE FAILURE AND OUTCOME IN HUMAN AML Open
Supplementary Table 3. Differentially expressed genes in the NBM BMSC cluster 0 vs. other BMSC clusters
View article: Long‐term genetic and clinical remissions after cessation of azacitidine treatment in patients with VEXAS syndrome
Long‐term genetic and clinical remissions after cessation of azacitidine treatment in patients with VEXAS syndrome Open
VEXAS (vacuoles, E1 enzyme, X-linked, autoinflammatory, somatic) is an inflammatory syndrome caused by acquired mutations in the gene encoding ubiquitin like modifier activating enzyme 1 (UBA1) that is often fatal.1, 2 Allogeneic hematopoi…
View article: Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival?
Regional disparities in the use of intensive chemotherapy for AML in the Netherlands: does it influence survival? Open
Objective Acute myeloid leukaemia (AML) prognosis is enhanced with intensive remission induction chemotherapy (ICT) in eligible patients. However, ICT eligibility perceptions may differ among healthcare professionals. This nationwide, popu…
View article: Table S6 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML
Table S6 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML Open
Supplementary Table 6. Differentially expressed genes in BMSCs from AML vs. BMSCs from NBM (purified BMSC RNAseq)
View article: Table S4 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML
Table S4 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML Open
Table S4 Differentially expressed genes and transcriptional programs (GSEA Hallmark) in BMSCs from AML vs. BMSCs from NBM (scRNAseq)
View article: Table S2 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML
Table S2 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML Open
Table S2 Differentially expressed genes in the HSC (low-output) cluster 0 vs. (high-output) HSC/MPP clusters 1-4
View article: Supplementary Figure 1-9 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML
Supplementary Figure 1-9 from A Single-Cell Taxonomy Predicts Inflammatory Niche Remodeling to Drive Tissue Failure and Outcome in Human AML Open
Fig S1-S9