Rekha G. Panchal
YOU?
Author Swipe
View article: LONG-TERM DECLINE IN PICOPHYTOPLANKTON ABUNDANCE AND CARBON BIOMASS IN THE ARABIAN SEA: EVIDENCE FROM 1995 AND 2019
LONG-TERM DECLINE IN PICOPHYTOPLANKTON ABUNDANCE AND CARBON BIOMASS IN THE ARABIAN SEA: EVIDENCE FROM 1995 AND 2019 Open
Picophytoplankton play a critical role in marine primary production, particularly in oligotrophic regions such as the Arabian Sea. In this study, we assessed changes in the picophytoplankton abundance and carbon biomass of Prochlorococcus …
View article: Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route
Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route Open
Nipah virus, a zoonotic pathogen, can cause debilitating disease and death in humans. Currently, countermeasures are limited, with several in various stages of testing but none yet FDA-approved for human use. Evaluation of countermeasure c…
View article: Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route
Dose response comparison of Nipah virus strains Malaysia and Bangladesh in hamsters exposed by the intranasal or intraperitoneal route Open
Nipah virus, a zoonotic pathogen, can cause debilitating disease and death in humans. Currently, countermeasures are limited, with several in various stages of testing but none yet FDA-approved for human use. Evaluation of countermeasure c…
View article: G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis
G6PD deficiency triggers dopamine loss and the initiation of Parkinson’s disease pathogenesis Open
Loss of dopaminergic neurons in Parkinson's disease (PD) is preceded by loss of synaptic dopamine (DA) and accumulation of proteinaceous aggregates. Linking these deficits is critical to restoring DA signaling in PD. Using murine and human…
View article: Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease
Orally available nucleoside analog UMM-766 provides protection in a murine model of orthopox disease Open
Although smallpox has been eradicated, other orthopoxviruses continue to be a public health concern as exemplified by the ongoing Mpox (formerly monkeypox) global outbreak. While medical countermeasures (MCMs) previously approved by the Fo…
View article: Triggered pore-forming agents
Triggered pore-forming agents Open
An inactive pore-forming agent which is activated to lytic function by a condition such as pH, light, heat, reducing potential, or metal ion concentration, or substance such as a protease, at the surface of a cell.
View article: Modification of N-Hydroxycytidine Yields a Novel Lead Compound Exhibiting Activity Against the Venezuelan Equine Encephalitis Virus
Modification of N-Hydroxycytidine Yields a Novel Lead Compound Exhibiting Activity Against the Venezuelan Equine Encephalitis Virus Open
View article: A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With Bacillus anthracis
A Novel Toll-Like Receptor 2 Agonist Protects Mice in a Prophylactic Treatment Model Against Challenge With Bacillus anthracis Open
Current therapies for anthrax include the use of antibiotics (i.e., doxycycline, and ciprofloxacin), an anthrax vaccine (BioThrax) and Bacillus anthracis -specific, monoclonal antibody (mAb) (i.e., Raxibacumab and obiltoxaximab). In this s…
View article: Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity
Screening of a Focused Ubiquitin-Proteasome Pathway Inhibitor Library Identifies Small Molecules as Novel Modulators of Botulinum Neurotoxin Type A Toxicity Open
Botulinum neurotoxins (BoNTs) are known as the most potent bacterial toxins, which can cause potentially deadly disease botulism. BoNT Serotype A (BoNT/A) is the most studied serotype as it is responsible for most human botulism cases, and…
View article: In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens
In vitro and in vivo activity of GT-1, a novel siderophore cephalosporin, and GT-055, a broad-spectrum β-lactamase inhibitor, against biothreat and ESKAPE pathogens Open
Antimicrobial-resistance (AMR) has become an increasingly difficult issue to overcome for bacteria associated with both community- and hospital-acquired infections as well as potential biodefense threats. The need to identify new therapeut…
View article: Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells During Burkholderia mallei Infection Reveals a Role of Ezrin in Glanders Pathogenesis
Proteomic Analysis of Non-human Primate Peripheral Blood Mononuclear Cells During Burkholderia mallei Infection Reveals a Role of Ezrin in Glanders Pathogenesis Open
Burkholderia mallei , the causative agent of glanders, is a gram-negative intracellular bacterium. Depending on different routes of infection, the disease is manifested by pneumonia, septicemia, and chronic infections of the skin. B. malle…
View article: <i>In Vitro</i> Antibacterial Activity and <i>In Vivo</i> Efficacy of Sulbactam-Durlobactam against Pathogenic <i>Burkholderia</i> Species
<i>In Vitro</i> Antibacterial Activity and <i>In Vivo</i> Efficacy of Sulbactam-Durlobactam against Pathogenic <i>Burkholderia</i> Species Open
The Gram-negative bacterial genus Burkholderia includes several hard-to-treat human pathogens: two biothreat species, Burkholderia mallei (causing glanders) and B. pseudomallei (causing melioidosis), and the B. cepacia complex (BCC) and B.…
View article: Recent successes in therapeutics for Ebola virus disease: no time for complacency
Recent successes in therapeutics for Ebola virus disease: no time for complacency Open
View article: Combating biothreat pathogens: ongoing efforts for countermeasure development and unique challenges
Combating biothreat pathogens: ongoing efforts for countermeasure development and unique challenges Open
View article: 709. In Vitro Antibacterial Activity and In Vivo Efficacy of Sulbactam–Durlobactam (ETX2514SUL) Against Pathogenic Burkholderia Species
709. In Vitro Antibacterial Activity and In Vivo Efficacy of Sulbactam–Durlobactam (ETX2514SUL) Against Pathogenic Burkholderia Species Open
Background The genus Burkholderia contains several pathogenic species with distinct etiologies, including Burkholderia pseudomallei the biothreat pathogen responsible for melioidosis and Burkholderia mallei which causes glanders. β-Lactams…
View article: Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens
Aminomethyl spectinomycins: a novel antibacterial chemotype for biothreat pathogens Open
View article: <p>Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug</p>
Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug Open
Purpose: The rapid emergence of multidrug-resistant (MDR) bacteria and the lack of new therapies to eliminate them poses a major threat to global health. With the alarming rise in antimicrobial resistance (AMR), focus has now shifte…
View article: Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison
Characterization of the plasma proteome of nonhuman primates during Ebola virus disease or melioidosis: a host response comparison Open
View article: The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide
The Biophysical Interaction of the Danger-Associated Molecular Pattern (DAMP) Calreticulin with the Pattern-Associated Molecular Pattern (PAMP) Lipopolysaccharide Open
The endoplasmic reticulum (ER) chaperone protein, calreticulin (CRT), is essential for proper glycoprotein folding and maintaining cellular calcium homeostasis. During ER stress, CRT is overexpressed as part of the unfolded protein respons…
View article: Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action
Second generation of diazachrysenes: Protection of Ebola virus infected mice and mechanism of action Open
View article: Bioengineering of bacterial pathogens for noninvasive imaging and in vivo evaluation of therapeutics
Bioengineering of bacterial pathogens for noninvasive imaging and in vivo evaluation of therapeutics Open
View article: Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges
Mitigating the Impact of Antibacterial Drug Resistance through Host-Directed Therapies: Current Progress, Outlook, and Challenges Open
Increasing incidences of multidrug resistance in pathogenic bacteria threaten our ability to treat and manage bacterial infection. The development and FDA approval of novel antibiotics have slowed over the past decade; therefore, the adopt…
View article: Bacterial genome engineering and synthetic biology: combating pathogens
Bacterial genome engineering and synthetic biology: combating pathogens Open
View article: L1000CDS2: LINCS L1000 characteristic direction signatures search engine
L1000CDS2: LINCS L1000 characteristic direction signatures search engine Open
The library of integrated network-based cellular signatures (LINCS) L1000 data set currently comprises of over a million gene expression profiles of chemically perturbed human cell lines. Through unique several intrinsic and extrinsic benc…
View article: Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins
Biochip for the Detection of Bacillus anthracis Lethal Factor and Therapeutic Agents against Anthrax Toxins Open
Tethered lipid bilayer membranes (tBLMs) have been used in many applications, including biosensing and membrane protein structure studies. This report describes a biosensor for anthrax toxins that was fabricated through the self-assembly o…
View article: BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease
BCX4430 – A broad-spectrum antiviral adenosine nucleoside analog under development for the treatment of Ebola virus disease Open
View article: Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species
Characterization of the murine macrophage response to infection with virulent and avirulent Burkholderia species Open
These results characterize the phenotypic and immunological differences in the host innate response to pathogenic and avirulent Burkholderia strains and provide insight into the phenotypic alterations and molecular targets underlying host-…
View article: A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection
A reverse-phase protein microarray-based screen identifies host signaling dynamics upon Burkholderia spp. infection Open
Burkholderia is a diverse genus of gram-negative bacteria that causes high mortality rate in humans, equines and cattle. The lack of effective therapeutic treatments poses serious public health threats. Developing insights toward host-Burk…
View article: Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays
Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays Open
There is an urgent need to develop novel treatments to counter Botulinum neurotoxin (BoNT) poisoning. Currently, the majority of BoNT drug development efforts focus on directly inhibiting the proteolytic components of BoNT, i.e. light chai…
View article: Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging
Heat fixation inactivates viral and bacterial pathogens and is compatible with downstream MALDI mass spectrometry tissue imaging Open
We conclude that heat fixation inactivates viral and bacterial pathogens and is compatible with proteomic analysis by MALDI-MSI. This treatment will enable the use of infected tissue from studies performed in bio-safety level 3 laboratorie…