М. G. Ryabkov
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View article: Distraction enterogenesis: effectiveness of experimental devices and clinical prospects
Distraction enterogenesis: effectiveness of experimental devices and clinical prospects Open
Objective. To identify perspective devices for distraction enterogenesis (DE) through analysis of their design, efficiency and complications. Material and methods. The PubMed, Google Scholar and eLibrary databases were screened regarding d…
View article: Experience of Surgical Treatment of Pressure Ulcers in Patients with Traumatic Spinal Cord Disease: Effectiveness and Risk of Complications
Experience of Surgical Treatment of Pressure Ulcers in Patients with Traumatic Spinal Cord Disease: Effectiveness and Risk of Complications Open
RELEVANCE One of the urgent issues in the complex treatment of patients with traumatic spinal cord disease is the treatment of pressure wounds. Despite the large number of suggested and applied methods, the results of surgical closure of p…
View article: Study of the Effectiveness of Skin Restoration Using a Biopolymer Hydrogel Scaffold with Encapsulated Mesenchymal Stem Cells
Study of the Effectiveness of Skin Restoration Using a Biopolymer Hydrogel Scaffold with Encapsulated Mesenchymal Stem Cells Open
Improving the restoration of skin defects of various etiologies continues to be an important medical challenge globally. This primarily applies to the treatment of chronic wounds and major burns, which create particularly complex and socia…
View article: Diagnosis of Colorectal Cancer and Adenomatous Polyps of the Colon Based on the Level of MicroRNA Expression in the Mucous Membrane (Pilot Clinical Study)
Diagnosis of Colorectal Cancer and Adenomatous Polyps of the Colon Based on the Level of MicroRNA Expression in the Mucous Membrane (Pilot Clinical Study) Open
The results of the study have shown that of four microRNAs, included into the test panel, hsa-miR-141-3p and hsa-miR-10b-5p were found to have the diagnostic value for identifying tumor colorectal lesions. Thus, our data will assume that s…
View article: Diagnosis of Skin Burn-Induced Colon Circulatory Disorders Using Optical Coherence Tomography Angiography and Laser Doppler Flowmetry (Experimental Study)
Diagnosis of Skin Burn-Induced Colon Circulatory Disorders Using Optical Coherence Tomography Angiography and Laser Doppler Flowmetry (Experimental Study) Open
The OCTA and LDF methods allowed us to establish experimentally that during the first 45 min thermal burn causes considerable disturbances of the blood flow in the colon wall, which normalizes only by day 14 if no therapy is administered. …
View article: Local Phage Therapy During Surgical Treatment of Burn Wounds Reduces the Risk of Colonization of the Skin of the Periwound Area by Pathogens of the ESKAPE Group
Local Phage Therapy During Surgical Treatment of Burn Wounds Reduces the Risk of Colonization of the Skin of the Periwound Area by Pathogens of the ESKAPE Group Open
Aim of study To study the effect of local phage therapy alone and in combination with systemic antibiotic therapy on the dynamics of microflora colonizing the skin of the periwound area during surgical treatment of infected burn wounds. Ma…
View article: Comparison of the Effectiveness of Methods for Obtaining and Application the Stromal-Vascular Fraction of Adipose Tissue in an Experimental Model of a Donor Wound in Burns
Comparison of the Effectiveness of Methods for Obtaining and Application the Stromal-Vascular Fraction of Adipose Tissue in an Experimental Model of a Donor Wound in Burns Open
Introduction . The optimal method of obtaining and application a stromal-vascular fraction (SVF) of adipose tissue in the treatment of donor wounds in burned patients has not been determined. Objective — to compare the effectiveness of the…
View article: Metabolism in the large intestine wall after injury of the thoracic spinal cord (experimental study)
Metabolism in the large intestine wall after injury of the thoracic spinal cord (experimental study) Open
Ailm : to assess metabolic processes in the serous layer of the large intestine in the acute period of spinal injury. Materials and Methods : the experiment was carried out on laboratory animals — Wistar rats (n = 20). Spinal injury was si…
View article: Immobilization of Bacteriophages in Ex Tempore Hydrogel for the Treatment of Burn Wound Infection
Immobilization of Bacteriophages in Ex Tempore Hydrogel for the Treatment of Burn Wound Infection Open
The resistance of bacteria to antibiotics is a major problem for anti-bacterial therapy. This problem may be solved by using bacteriophages—viruses that can attack and destroy bacteria, including antibiotic-resistant ones. In this article,…
View article: The Small Intestine in the Acute Period of Spinal Injury: Early Metabolic Disorders According to Fluorescence-Lifetime Imaging FLIM
The Small Intestine in the Acute Period of Spinal Injury: Early Metabolic Disorders According to Fluorescence-Lifetime Imaging FLIM Open
RELEVANCE A special place in the development of enteral insufficiency is given to dysproteinemia, which is one of the leading causes of the development of decubital ulcers in patients with spinal cord injury. Early enteral nutrition partia…
View article: Metabolism and Microstructure of the Small Intestine Wall in Patients With Colorectal Cancer
Metabolism and Microstructure of the Small Intestine Wall in Patients With Colorectal Cancer Open
RELEVANCE In patients with colorectal cancer (CRC), the normal small intestine, located outside the pathological focus, undergoes changes that may be the cause of digestive dysfunction after radical surgery to remove the tumor. The assessm…
View article: Effectiveness and Safety of Transplantation of the Stromal Vascular Fraction of Autologous Adipose Tissue for Wound Healing in the Donor Site in Patients with Third-Degree Skin Burns: A Randomized Trial
Effectiveness and Safety of Transplantation of the Stromal Vascular Fraction of Autologous Adipose Tissue for Wound Healing in the Donor Site in Patients with Third-Degree Skin Burns: A Randomized Trial Open
Transplantation of SVF autologous adipose tissue into the wound area in most clinical cases proceeded without complications. The area of epithelialization of wound areas af-ter the introduction of SVF did not change, although a significant…
View article: Biocompatibility Study of Hydrogel Biopolymer Scaffold with Encapsulated Mesenchymal Stem Cells
Biocompatibility Study of Hydrogel Biopolymer Scaffold with Encapsulated Mesenchymal Stem Cells Open
One of the key and actively developing areas of regenerative medicine is tissue-engineering. There is no doubt that the use of tissue-engineering products can have a significant impact on the efficiency of repair of damaged tissues and org…
View article: Optical Coherence Tomography Angiography of the Intestine: How to Prevent Motion Artifacts in Open and Laparoscopic Surgery?
Optical Coherence Tomography Angiography of the Intestine: How to Prevent Motion Artifacts in Open and Laparoscopic Surgery? Open
(1) Introduction. The problem that limits the intraoperative use of OCTA for the intestinal circulation diagnostics is the low informative value of OCTA images containing too many motion artifacts. The aim of this study is to evaluate the …
View article: Multimodal Optical Monitoring of Auto- and Allografts of Skin on a Burn Wound
Multimodal Optical Monitoring of Auto- and Allografts of Skin on a Burn Wound Open
The aim of the study was to investigate the dynamics of the state of allo- and autografts of skin on a wound using optical modalities: diffuse reflectance spectroscopy (DRS), optical coherence tomography (OCT), and laser Doppler flowmetry …
View article: Monitoring of the state of intramural intestinal vessels in acute mesenteric ischemia with optical coherence angiography
Monitoring of the state of intramural intestinal vessels in acute mesenteric ischemia with optical coherence angiography Open
Background. Objective data on the state of intramural microvessels are needed to select an effective therapy for the intestine reversibly damaged by mesenteric occlusion. Aim. To monitor the condition of the small intestine blood vessels i…
View article: Optical Coherence Tomography Angiography and Attenuation Imaging for Label-Free Observation of Functional Changes in the Intestine after Sympathectomy: A Pilot Study
Optical Coherence Tomography Angiography and Attenuation Imaging for Label-Free Observation of Functional Changes in the Intestine after Sympathectomy: A Pilot Study Open
We present in this study optical coherence tomography angiography (OCTA) and OCT attenuation imaging (OCTAI) for in vivo non-destructive visualization of intramural blood and lymphatic vessels of the intestine wall. Rabbit small intestine …
View article: Skin Micrograph Protector in a Burn Wound: Alloderm or Hydrogel Coating?
Skin Micrograph Protector in a Burn Wound: Alloderm or Hydrogel Coating? Open
AIM OF STUDY Was to compare the dynamics of engraftment of skin micrographs in a burn wound when using protectors from an allodermal graft and from a hydrogel coating. MATERIAL AND METHODS The experimental study was conducted on 18 rats wi…
View article: Epigenetic Markers of Colorectal Cancer: Clinical Data Analysis
Epigenetic Markers of Colorectal Cancer: Clinical Data Analysis Open
The aim of the study was to systematize the results of clinical application of epigenetic biomarkers "microRNA" and "DNA methylation" in early diagnosis and prognosis in patients with colorectal cancer.
Material and methods. Data review w…
View article: Effect of Surgical Technique on the Microstructure and Microcirculation of the Small Intestine Stump during Delayed Anastomosis: Multimodal OCT Data
Effect of Surgical Technique on the Microstructure and Microcirculation of the Small Intestine Stump during Delayed Anastomosis: Multimodal OCT Data Open
By using MM OCT, we found that in treating the remaining sections of the intestine after its emergency resection for acute mesenteric ischemia, the type of surgical technique determines the tissue structure in the period before the delayed…
View article: Laboratory Signs of Enteric Failure - Predictors of Pressure Ulcers in Traumatic Spinal Cord Disease
Laboratory Signs of Enteric Failure - Predictors of Pressure Ulcers in Traumatic Spinal Cord Disease Open
Relevance. Among the complications of traumatic spinal cord disease (SCD) pressure ulcers occupy a special place, with incidence reaching 68% and showing no tendency for decreasing. Literature reviews one of the main reasons for the format…
View article: Prospects of Intraoperative Multimodal OCT Application in Patients with Acute Mesenteric Ischemia
Prospects of Intraoperative Multimodal OCT Application in Patients with Acute Mesenteric Ischemia Open
Introduction: Despite the introduction of increasingly multifaceted diagnostic techniques and the general advances in emergency abdominal and vascular surgery, the outcome of treatment of patients with acute impaired intestinal circulation…
View article: New possibility of application of bacteriophages to prevent infectious complications in free skin grafting (bacteriophages in skin grafting)
New possibility of application of bacteriophages to prevent infectious complications in free skin grafting (bacteriophages in skin grafting) Open
Aim. To prevent infectious processes in the area of a recipient wound in free skin grafting with a split-graft.Materials and methods. A method was developed for immobilizing bacteriophages in the area of split thickness skin grafts through…
View article: Viability of Bacteriophages in the Complex Hydrogel Wound Dressings in vitro
Viability of Bacteriophages in the Complex Hydrogel Wound Dressings in vitro Open
The results suggest that bacteriophages immobilized in the hydrogel maintain their viability and lytic activity, and this activity persists when the phages are combined with succinic acid and lidocaine.
View article: Prospects of Intraoperative Multimodal OCT Application in Patients With Acute Mesenteric Ischemia
Prospects of Intraoperative Multimodal OCT Application in Patients With Acute Mesenteric Ischemia Open
Introduction: Despite the introduction of increasingly multifaceted diagnostic techniques and the general progress of emergency abdominal and vascular surgery, the outcome of treatment of patients with acute impaired intestinal circulation…
View article: Instrumental Non-Invasive Diagnostics of the Depth of Skin Burn:
Current Opportunities and Unsolved Problems
Instrumental Non-Invasive Diagnostics of the Depth of Skin Burn:
Current Opportunities and Unsolved Problems Open
Introduction. Burns of various etiologies are on the 3-4 place in frequency among all injuries, they are associated with a high percentage of complications, disability and mortality. Currently, a single algorithm for objective verification…
View article: Trans-Serosal Multimodal Optical Coherence Tomography for Visualization of Microstructure and Blood Circulation of the Small Intestine Wall
Trans-Serosal Multimodal Optical Coherence Tomography for Visualization of Microstructure and Blood Circulation of the Small Intestine Wall Open
Trans-serous MM OCT provides for in vivo visualization of microstructures critical for surgical gastroenterology: the intestinal wall layers including villi and blood vessels of each layer, as confirmed by histological analysis. Destructiv…
View article: Dosed tissue stretching in the preparation of the donor site for chronic wounds split-skin grafting
Dosed tissue stretching in the preparation of the donor site for chronic wounds split-skin grafting Open
Objective. Development of a new method for preparing an skin graft to hypoxia conditions in a recipient wound by tissue stretching of the donor site. Materials and methods. Scientific hypothesis: dosed tissue stretching and localized circu…
View article: The use of bacteriophages for prevention of infections in the surgical area at free skin grafting
The use of bacteriophages for prevention of infections in the surgical area at free skin grafting Open
Цель исследования: профилактика инфекционных осложнений в области кожной пластики путем иммобилизации актуальных для данной медицинской организации бактериофагов в области реципиентной раны.
View article: Application of adaptive tools in relaparotomy wound surgery
Application of adaptive tools in relaparotomy wound surgery Open
Aim. To evaluate the clinical effectiveness of the developed adaptive tools for mechanical treatment of wound surface and suturing of relaparotomy wounds. Methods. 55 patients aged 43 to 79 years after relaparotomy operated on for various …