Sangamesh G. Kumbar
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View article: DDDR-02. PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide
DDDR-02. PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide Open
BACKGROUND Glioblastoma shows a dismal prognosis despite the multimodal therapies that include maximal surgical resection, radiation, and chemotherapy. Although temozolomide (TMZ) is the standard chemotherapy for glioblastoma, tumor cells …
View article: Synergistic effects of electrical and chemical cues with biodegradable scaffolds for large peripheral nerve defect regeneration
Synergistic effects of electrical and chemical cues with biodegradable scaffolds for large peripheral nerve defect regeneration Open
View article: PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide
PRMT5 inhibition sensitizes glioblastoma tumor models to temozolomide Open
View article: Engineered Osteochondral Scaffolds with Bioactive Cartilage Zone for Enhanced Articular Cartilage Regeneration
Engineered Osteochondral Scaffolds with Bioactive Cartilage Zone for Enhanced Articular Cartilage Regeneration Open
Despite progress, osteochondral (OC) tissue engineering strategies face limitations in terms of articular cartilage layer development and its integration with the underlying bone tissue. The main objective of this study is to develop a zon…
View article: Innovative spiral nerve conduits: Addressing nutrient transport and cellular activity for critical-sized nerve defects
Innovative spiral nerve conduits: Addressing nutrient transport and cellular activity for critical-sized nerve defects Open
Large-gap nerve defects require nerve guide conduits (NGCs) for complete regeneration and muscle innervation. Many NGCs have been developed using various scaffold designs and tissue engineering strategies to promote axon regeneration. Stil…
View article: Advancements in stimulation therapies for peripheral nerve regeneration
Advancements in stimulation therapies for peripheral nerve regeneration Open
Soft-tissue injuries affecting muscles, nerves, vasculature, tendons, and ligaments often diminish the quality of life due to pain, loss of function, and financial burdens. Both natural healing and surgical interventions can result in scar…
View article: Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications
Stimuli-responsive peptide assemblies: Design, self-assembly, modulation, and biomedical applications Open
View article: Hydrogel-Based Strategies for Intervertebral Disc Regeneration: Advances, Challenges and Clinical Prospects
Hydrogel-Based Strategies for Intervertebral Disc Regeneration: Advances, Challenges and Clinical Prospects Open
Millions of people worldwide suffer from low back pain and disability associated with intervertebral disc (IVD) degeneration. IVD degeneration is highly correlated with aging, as the nucleus pulposus (NP) dehydrates and the annulus fibrosu…
View article: Innovative Spiral Nerve Conduits: Addressing Nutrient Transport and Cellular Activity for Critical-Sized Nerve Defects
Innovative Spiral Nerve Conduits: Addressing Nutrient Transport and Cellular Activity for Critical-Sized Nerve Defects Open
View article: Innovative Spiral Nerve Conduits: Addressing Nutrient Transport and Cellular Activity for Critical-Sized Nerve Defects
Innovative Spiral Nerve Conduits: Addressing Nutrient Transport and Cellular Activity for Critical-Sized Nerve Defects Open
View article: Editorial Board, Aims & Scope, Table of Contents
Editorial Board, Aims & Scope, Table of Contents Open
View article: Issue Information
Issue Information Open
An anti
View article: FKBP38 Regulates Self-Renewal and Survival of GBM Neurospheres
FKBP38 Regulates Self-Renewal and Survival of GBM Neurospheres Open
Glioblastoma is the most common malignant primary brain tumor. The outcome is dismal, despite the multimodal therapeutic approach that includes surgical resection, followed by radiation and chemotherapy. The quest for novel therapeutic tar…
View article: Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects
Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects Open
View article: Novel high‐strength polyester composite scaffolds for bone regeneration
Novel high‐strength polyester composite scaffolds for bone regeneration Open
Repair of critical‐sized bone defects, particularly in load‐bearing areas, is a major clinical problem that requires surgical intervention and implantation of biological or engineered grafts. For load‐bearing sites, it is essential to use …
View article: Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment
Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment Open
View article: Novel Injectable Fluorescent Polymeric Nanocarriers for Intervertebral Disc Application
Novel Injectable Fluorescent Polymeric Nanocarriers for Intervertebral Disc Application Open
Damage to intervertebral discs (IVD) can lead to chronic pain and disability, and no current treatments can fully restore their function. Some non-surgical treatments have shown promise; however, these approaches are generally limited by b…
View article: Fluorescent liposomal nanocarriers for targeted drug delivery in ischemic stroke therapy
Fluorescent liposomal nanocarriers for targeted drug delivery in ischemic stroke therapy Open
Ischemic Stroke causes acute CNS disorders. This article represents an injectable liposomal nanoparticle formulation of 5-BDBD and Nile red for treatment of Ischemic Stroke.
View article: Smart orthopedic biomaterials and implants
Smart orthopedic biomaterials and implants Open
View article: Progress and challenges of graphene and its congeners for biomedical applications
Progress and challenges of graphene and its congeners for biomedical applications Open
View article: ENAH regulates survival, self-renewal, and migration of patient-derived primary glioblastoma neurospheres
ENAH regulates survival, self-renewal, and migration of patient-derived primary glioblastoma neurospheres Open
Purpose: Glioblastoma (GBM) is the most common primary malignant brain tumor in adults. Despite standard treatment, the median survival of GBM patients is only 15 months. Enabled homolog (ENAH) is a member of the Ena/VASP protein family an…
View article: Insulin-Functionalized Bioactive Fiber Matrices with Bone Marrow-Derived Stem Cells in Rat Achilles Tendon Regeneration
Insulin-Functionalized Bioactive Fiber Matrices with Bone Marrow-Derived Stem Cells in Rat Achilles Tendon Regeneration Open
Approximately half of annual musculoskeletal injuries in the US involve tendon tears. The naturally hypocellular and hypovascular tendon environment makes tendons injury-prone and heal slowly. Tendon tissue engineering strategies often use…
View article: Amorphous silica fiber matrix biomaterials: An analysis of material synthesis and characterization for tissue engineering
Amorphous silica fiber matrix biomaterials: An analysis of material synthesis and characterization for tissue engineering Open
View article: Machine Learning Techniques in Structure-Property Optimization of Polymeric Scaffolds for Tissue Engineering
Machine Learning Techniques in Structure-Property Optimization of Polymeric Scaffolds for Tissue Engineering Open
Biomaterials and biomedical implants have revolutionized the way medicine is practiced. Technologies, such as 3D printing and electrospinning, are currently employed to create novel biomaterials. Most of the synthesis techniques are ad-hoc…
View article: Pegylated insulin‐like growth factor‐1 biotherapeutic delivery promotes rotator cuff regeneration in a rat model
Pegylated insulin‐like growth factor‐1 biotherapeutic delivery promotes rotator cuff regeneration in a rat model Open
Tears in the rotator cuff are challenging to repair because of the complex, hypocellular, hypovascular, and movement‐active nature of the tendon and its enthesis. Insulin‐like Growth Factor‐1 (IGF‐1) is a promising therapeutic for this rep…
View article: Bioactive Nanofiber Matrix Formulations for the Delivery of Exendin-4 for Tendon Regeneration: In Vitro and in Vivo Assessment
Bioactive Nanofiber Matrix Formulations for the Delivery of Exendin-4 for Tendon Regeneration: In Vitro and in Vivo Assessment Open
View article: Targeting protein arginine methyltransferase 5 sensitizes glioblastoma to trametinib
Targeting protein arginine methyltransferase 5 sensitizes glioblastoma to trametinib Open
Background The prognosis of glioblastoma (GBM) remains dismal because therapeutic approaches have limited effectiveness. A new targeted treatment using MEK inhibitors, including trametinib, has been proposed to improve GBM therapy. Trameti…
View article: 3D bioprinting and photocrosslinking: emerging strategies & future perspectives
3D bioprinting and photocrosslinking: emerging strategies & future perspectives Open
View article: Kinetic degradation and biocompatibility evaluation of <scp>polycaprolactone‐based</scp> biologics delivery matrices for regenerative engineering of the rotator cuff
Kinetic degradation and biocompatibility evaluation of <span>polycaprolactone‐based</span> biologics delivery matrices for regenerative engineering of the rotator cuff Open
Whereas synthetic biodegradable polymers have been successfully applied for the delivery of biologics in other tissues, the anatomical complexity, poor blood supply, and reduced clearance of degradation byproducts in the rotator cuff creat…
View article: Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration: In vivo structural and functional assessment
Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration: In vivo structural and functional assessment Open