Gernot Schabbauer
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View article: Deep MALDI-MS spatial omics guided by quantum cascade laser mid-infrared imaging microscopy
Deep MALDI-MS spatial omics guided by quantum cascade laser mid-infrared imaging microscopy Open
In spatial’omics, highly confident molecular identifications are indispensable for the investigation of complex biology and for spatial biomarker discovery. However, current mass spectrometry imaging (MSI)-based spatial ‘omics must comprom…
View article: Loss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma
Loss of SPHK1 fuels inflammation to drive KRAS-mutated lung adenocarcinoma Open
Inflammation is a widely recognized key contributor to KRAS-driven lung adenocarcinoma (LUAD). Tumor-associated macrophages (TAM) are an integral part of the tumor microenvironment and create a supportive niche that sustains inflammation-d…
View article: Metabolic support by macrophages sustains colonic epithelial homeostasis
Metabolic support by macrophages sustains colonic epithelial homeostasis Open
The intestinal epithelium has a high turnover rate and constantly renews itself through proliferation of intestinal crypt cells, which depends on insufficiently characterized signals from the microenvironment. Here, we showed that colonic …
View article: Data from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
Data from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth Open
Transient induction of the transcription factor early growth response protein-1 (EGR-1) plays a pivotal role in the transcriptional response of endothelial cells to the angiogenic growth factors vascular endothelial growth factor (VEGF) an…
View article: Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth Open
Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
View article: Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth Open
Supplementary Tables S1 & S2 from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
View article: Data from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth
Data from Sustained Expression of Early Growth Response Protein-1 Blocks Angiogenesis and Tumor Growth Open
Transient induction of the transcription factor early growth response protein-1 (EGR-1) plays a pivotal role in the transcriptional response of endothelial cells to the angiogenic growth factors vascular endothelial growth factor (VEGF) an…
View article: The human placenta shapes the phenotype of decidual macrophages
The human placenta shapes the phenotype of decidual macrophages Open
(Cell Reports 42, 111977; January 31, 2023) In the originally published version of this article, Figure 1A contained two identical immunofluorescence (IF) images. The IF picture showing vWF (magenta) and HLA-G (green) was erroneously repea…
View article: The human placenta shapes the phenotype of decidual macrophages
The human placenta shapes the phenotype of decidual macrophages Open
During human pregnancy, placenta-derived extravillous trophoblasts (EVTs) invade the decidua and communicate with maternal immune cells. The decidua distinguishes into basalis (decB) and parietalis (decP). The latter remains unaffected by …
View article: Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia
Platelet p110β mediates platelet-leukocyte interaction and curtails bacterial dissemination in pneumococcal pneumonia Open
Phosphatidylinositol 3-kinase catalytic subunit p110β is involved in tumorigenesis and hemostasis. However, it remains unclear if p110β also regulates platelet-mediated immune responses, which could have important consequences for immune m…
View article: Protocol to assess the tolerogenic properties of adoptively transferred dendritic cells during murine experimental autoimmune encephalomyelitis
Protocol to assess the tolerogenic properties of adoptively transferred dendritic cells during murine experimental autoimmune encephalomyelitis Open
By their capacity to induce peripheral T cell tolerance, dendritic cells (DCs) present a promising target cell and therapeutic strategy for treatment of several autoimmune diseases including multiple sclerosis (MS). This protocol describes…
View article: Determination of Extravasation Effects of Nal-Iri and Trabectedin and Evaluation of Treatment Options for Trabectedin Extravasation in a Preclinical Animal Model
Determination of Extravasation Effects of Nal-Iri and Trabectedin and Evaluation of Treatment Options for Trabectedin Extravasation in a Preclinical Animal Model Open
Background: Extravasation during chemotherapy administration can lead to dangerous adverse effects ranging from pain to tissue necrosis. Evidence-based data about prevention and treatment of extravasation injuries of some clinically used c…
View article: PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis
PI3K Signaling in Dendritic Cells Aggravates DSS-Induced Colitis Open
Aberrant innate immune responses to the gut microbiota are causally involved in the pathogenesis of inflammatory bowel diseases (IBD). The exact triggers and main signaling pathways activating innate immune cells and how they modulate adap…
View article: The human placenta shapes the phenotype of decidual macrophages
The human placenta shapes the phenotype of decidual macrophages Open
During human pregnancy, placenta-derived extravillous trophoblasts (EVT) invade the decidua and communicate with maternal immune cells. The decidua can be distinguished into basalis (decB) and parietalis (decP), the latter being unaffected…
View article: An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia
An immune-sympathetic neuron communication axis guides adipose tissue browning in cancer-associated cachexia Open
Cancer-associated cachexia (CAC) is a hypermetabolic syndrome characterized by unintended weight loss due to the atrophy of adipose tissue and skeletal muscle. A phenotypic switch from white to beige adipocytes, a phenomenon called brownin…
View article: JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction
JAK1 signaling in dendritic cells promotes peripheral tolerance in autoimmunity through PD-L1-mediated regulatory T cell induction Open
Dendritic cells (DCs) induce peripheral T cell tolerance, but cell-intrinsic signaling cascades governing their stable tolerogenesis remain poorly defined. Janus Kinase 1 (JAK1) transduces cytokine-receptor signaling, and JAK inhibitors (J…
View article: L-Arginine Depletion Improves Spinal Cord Injury via Immunomodulation and Nitric Oxide Reduction
L-Arginine Depletion Improves Spinal Cord Injury via Immunomodulation and Nitric Oxide Reduction Open
Background: Spinal cord injury (SCI) elicits robust neuroinflammation that eventually exacerbates the initial damage to the spinal cord. L-arginine is critical for the responsiveness of T cells, which are important contributors to neuroinf…
View article: Lipid scavenging macrophages and inflammation
Lipid scavenging macrophages and inflammation Open
Macrophages are professional phagocytes, indispensable for maintenance of tissue homeostasis and integrity. Depending on their resident tissue, macrophages are exposed to highly diverse metabolic environments. Adapted to their niche, they …
View article: Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages
Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages Open
Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering receptor expressed on myeloid cells 2 (TREM2) reportedly increases adiposity, wors…
View article: Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages
Beneficial Metabolic Effects of TREM2 in Obesity Are Uncoupled From Its Expression on Macrophages Open
Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering receptor expressed on myeloid cells 2 (TREM2) reportedly increases adiposity, wors…
View article: Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages
Beneficial Metabolic Effects of TREM2 in Obesity are Uncoupled from its Expression on Macrophages Open
Obesity-induced white adipose tissue (WAT) hypertrophy is associated with elevated adipose tissue macrophage (ATM) content. Overexpression of the triggering receptor expressed on myeloid cells 2 (TREM2) reportedly increases adiposity, wors…
View article: More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization
More than just protein building blocks: how amino acids and related metabolic pathways fuel macrophage polarization Open
Macrophages represent the first line of defence in innate immune responses and additionally serve important functions for the regulation of host inflammation and tissue homeostasis. The M1/M2 model describes the two extremes of macrophage …
View article: microRNA‐146a controls age‐related bone loss
microRNA‐146a controls age‐related bone loss Open
Bone loss is one of the consequences of aging, leading to diseases such as osteoporosis and increased susceptibility to fragility fractures and therefore considerable morbidity and mortality in humans. Here, we identify microRNA‐146a (miR‐…
View article: TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms
TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms Open
Objective Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic regenerative processes. The triggering receptor expressed on myeloid c…
View article: Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease
Enzymatic lipid oxidation by eosinophils propagates coagulation, hemostasis, and thrombotic disease Open
Blood coagulation is essential for physiological hemostasis but simultaneously contributes to thrombotic disease. However, molecular and cellular events controlling initiation and propagation of coagulation are still incompletely understoo…
View article: MiR-146a controls age related bone loss
MiR-146a controls age related bone loss Open
Bone loss is one of the consequences of aging, leading to diseases such as osteoporosis and increased susceptibility to fragility fractures and therefore considerable morbidity and mortality in humans. Here we identify microRNA 146a as an …