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View article: Testicular Anti-Müllerian Hormone Secretion Is Stimulated by Recombinant Human FSH in Patients with Congenital Hypogonadotropic Hypogonadism
Testicular Anti-Müllerian Hormone Secretion Is Stimulated by Recombinant Human FSH in Patients with Congenital Hypogonadotropic Hypogonadism Open
Serum anti-Mullerian hormone (AMH), a prepubertal Sertoli cell marker, declines during puberty as an early sign of testicular testosterone (T) production. When T synthesis or action is impaired, serum AMH is abnormally high in the first mo…
View article: Day-care, early common infections and childhood acute leukaemia: a multicentre French case–control study
Day-care, early common infections and childhood acute leukaemia: a multicentre French case–control study Open
We conducted a case–control study to investigate the role of early infections in the aetiology of childhood acute leukaemias. The study included 280 incident cases (240 acute lymphoblastic leukaemia and 40 acute non-lymphoblastic leukaemia…
View article: The Postmenopausal Ovary Is Not a Major Androgen-Producing Gland
The Postmenopausal Ovary Is Not a Major Androgen-Producing Gland Open
It is currently believed that the postmenopausal ovary remains a gonadotropin-driven, androgen-producing gland. However, the adrenal contribution to circulating androgen levels may explain some conflicting results previously reported. In a…
View article: Measurement of Plasma Free Luteinizing Hormoneβ -Subunit in Women
Measurement of Plasma Free Luteinizing Hormoneβ -Subunit in Women Open
Little is known about the physiological secretion of the free beta-subunit of LH (LHbeta). The aim of this study was to compare in women the secretion of LHbeta, using sensitive and specific two-site immunoassays, with dimeric LH and the f…
View article: Autoantibodies interacting with purified native thyrotropin receptor
Autoantibodies interacting with purified native thyrotropin receptor Open
Native thyrotropin receptor (TSHR) was purified by immunoaffinity chromatography from membrane extracts of stably transfected L cells. An ELISA test was devised to study anti‐TSHR autoantibodies directly. Comparison of native TSHR with bac…
View article: Antimüllerian Hormone in Patients with Hypogonadotropic Hypogonadism
Antimüllerian Hormone in Patients with Hypogonadotropic Hypogonadism Open
Antimullerian hormone (AMH) is produced by immature Sertoli cells until pubertal maturation. At puberty, elevation of serum testosterone correlates with a decrease in serum AMH. To further investigate the hormonal control of AMH secretion,…
View article: The Same Molecular Defects of the Gonadotropin-Releasing Hormone Receptor Determine a Variable Degree of Hypogonadism in Affected Kindred<sup>1</sup>
The Same Molecular Defects of the Gonadotropin-Releasing Hormone Receptor Determine a Variable Degree of Hypogonadism in Affected Kindred<sup>1</sup> Open
Detailed endocrinological studies were performed in the three affected kindred of a family carrying mutations of the GnRH receptor gene. All three were compound heterozygotes carrying on one allele the Arg262Gln mutation and on the other a…
View article: A Family with Hypogonadotropic Hypogonadism and Mutations in the Gonadotropin-Releasing Hormone Receptor
A Family with Hypogonadotropic Hypogonadism and Mutations in the Gonadotropin-Releasing Hormone Receptor Open
Hypogonadotropic hypogonadism is often associated with anosmia in a condition known as Kallmann's syndrome. The gene for the X-linked form of Kallmann's syndrome has been mapped to chromosome Xp22.3,1 and several mutations have been descri…
View article: Panhypopituitarism as a Model to Study the Metabolism of Dehydroepiandrosterone (DHEA) in Humans<sup>1</sup>
Panhypopituitarism as a Model to Study the Metabolism of Dehydroepiandrosterone (DHEA) in Humans<sup>1</sup> Open
The physiological importance and therapeutical interest of dehydroepiandrosterone (DHEA) and its sulfate ester (DHEAS) are still controversial. Panhypopituitarism is characterized by the absence of secretion of adrenal and gonadal steroids…
View article: Free Luteinizing-Hormone Beta-Subunit in Normal Subjects and Patients with Pituitary Adenomas
Free Luteinizing-Hormone Beta-Subunit in Normal Subjects and Patients with Pituitary Adenomas Open
Most clinically nonfunctioning pituitary adenomas (NFPA) are found to be gonadotropinomas when assessed by immunocytochemistry. However, they are rarely associated with increased basal plasma levels of FSH, LH and/or alpha-subunit. It has …
View article: The antigonadotropic activity of progestins (19-nortestosterone and 19-norprogesterone derivatives) is not mediated through the androgen receptor.
The antigonadotropic activity of progestins (19-nortestosterone and 19-norprogesterone derivatives) is not mediated through the androgen receptor. Open
To further study the mechanism of the antigonadotropic activity of progestins, the effects of a 19-nortestosterone derivative, norethisterone acetate (NETA), and a 19-norprogesterone derivative, nomegestrol acetate (NOMA), were compared. T…
View article: Different phenotypes in a family with androgen insensitivity caused by the same M780I point mutation in the androgen receptor gene.
Different phenotypes in a family with androgen insensitivity caused by the same M780I point mutation in the androgen receptor gene. Open
Mutations in the coding sequence of the androgen receptor (AR) gene result in a wild range of androgen insensitivity (AI) syndromes. Differences in the clinical expression of the same mutation in unrelated patients have been reported. Howe…
View article: The prevalence of colonic polyps in acromegaly: a colonoscopic and pathological study in 103 patients.
The prevalence of colonic polyps in acromegaly: a colonoscopic and pathological study in 103 patients. Open
Patients with acromegaly are reported to be at risk of developing adenomatous colonic polyps, which are considered to be preneoplastic lesions. This assumption is, however, usually drawn from results obtained in rather small series of pati…
View article: Androgen Insensitivity in Oligospermic Men: A Reappraisal**
Androgen Insensitivity in Oligospermic Men: A Reappraisal** Open
Androgen insensitivity has been reported to be present in as many as 40% of patients with severe oligospermia. In order to evaluate further the role of androgen resistance in male infertility we studied 24 men with severe oligospermia. Pla…
View article: Effect of carbimazole treatment on specific and non-specific immunological parameters in patients with Graves' disease.
Effect of carbimazole treatment on specific and non-specific immunological parameters in patients with Graves' disease. Open
Twenty-two patients with newly diagnosed Graves' disease (GD) were treated with carbimazole (CBZ) for 6 months. Thyroid stimulating immunoglobulins (TSI) and T cell subsets were studied prior to treatment and after 3 and 6 months of therap…
View article: Treatment of Acute Myeloblastic Leukaemia with RP 22050
Treatment of Acute Myeloblastic Leukaemia with RP 22050 Open
Fourty-four patients with acute myeloblastic leukaemia were treated with RP 22050, a new, semisynthetic derivative of daunorubicin. Complete remissions were achieved in 20 patients (45%). The median dose given was 23 mg/kg. The toxicity of…