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View article: Remarkable Response to Chemo-immunotherapy In Anaplastic Thyroid Cancer
Remarkable Response to Chemo-immunotherapy In Anaplastic Thyroid Cancer Open
Anaplastic thyroid cancer (ATC) is an aggressive and lethal malignancy with limited therapeutic options and poor prognosis. In recent years, the therapeutic arsenal of locally advanced or metastatic ATC has been expanded, with V-Raf murine…
View article: Accelerated Radiotherapy for Complicated Bone Metastases: SHARON Bone Randomized Phase III Trial Shows Non-Inferiority Compared to Standard Palliative Fractionation (NCT03503682)
Accelerated Radiotherapy for Complicated Bone Metastases: SHARON Bone Randomized Phase III Trial Shows Non-Inferiority Compared to Standard Palliative Fractionation (NCT03503682) Open
Objective: The SHARON (Short course RadiatiON therapy for palliative treatment) Bone trial is a phase III randomized non-inferiority multicentric study comparing symptom relief for complicated bone metastases (BMs) achieved through hypofra…
View article: Long-term outcomes of PSMA PET/CT-guided radiotherapy in biochemical failure patients post-radical prostatectomy: a 5-year follow-up analysis
Long-term outcomes of PSMA PET/CT-guided radiotherapy in biochemical failure patients post-radical prostatectomy: a 5-year follow-up analysis Open
Purpose To evaluate the role of PSMA PET/CT-guided salvage radiotherapy (sRT) in improving long-term biochemical recurrence-free survival (bRFS) in patients with biochemical recurrence (BCR) or PSA persistence (PERS) after radical prostate…
View article: Vaccine-Based Immunotherapy for Oropharyngeal and Nasopharyngeal Cancers
Vaccine-Based Immunotherapy for Oropharyngeal and Nasopharyngeal Cancers Open
Viral infections such as human papillomavirus (HPV) and Epstein–Barr virus (EBV) play a critical role in the onset of oropharyngeal (OPC) and nasopharyngeal cancer (NPC), respectively. Despite advancements in targeted therapies and immunot…
View article: Adequacy of Pain Management in Patients Referred for Radiation Therapy: A Subanalysis of the Multicenter ARISE-1 Study
Adequacy of Pain Management in Patients Referred for Radiation Therapy: A Subanalysis of the Multicenter ARISE-1 Study Open
Background: Pain is a prevalent symptom among cancer patients, and its management is crucial for improving their quality of life. However, pain management in cancer patients referred to radiotherapy (RT) departments is often inadequate, an…
View article: How smart is artificial intelligence in organs delineation? Testing a CE and FDA-approved Deep-Learning tool using multiple expert contours delineated on planning CT images
How smart is artificial intelligence in organs delineation? Testing a CE and FDA-approved Deep-Learning tool using multiple expert contours delineated on planning CT images Open
Background A CE- and FDA-approved cloud-based Deep learning (DL)-tool for automatic organs at risk (OARs) and clinical target volumes segmentation on computer tomography images is available. Before its implementation in the clinical practi…
View article: Adequacy of Pain Treatment in Radiotherapy Departments: Results of a Multicenter Study on 2104 Patients (Arise)
Adequacy of Pain Treatment in Radiotherapy Departments: Results of a Multicenter Study on 2104 Patients (Arise) Open
Aim: The frequent inadequacy of pain management in cancer patients is well known. Moreover, the quality of analgesic treatment in patients treated with radiotherapy (RT) has only been rarely assessed. In order to study the latter topic, we…
View article: Achieving Consensus for Management of Hormone-Sensitive, Low-Volume Metastatic Prostate Cancer in Italy
Achieving Consensus for Management of Hormone-Sensitive, Low-Volume Metastatic Prostate Cancer in Italy Open
Metastatic hormone-sensitive prostate cancer (mHSPC) is usually categorized as high- or low-volume disease. This is relevant because low- and high-volume metastatic disease are associated with different outcomes, and thus management of the…
View article: Memantine in the Prevention of Radiation-Induced Brain Damage: A Narrative Review
Memantine in the Prevention of Radiation-Induced Brain Damage: A Narrative Review Open
Preserving cognitive functions is a priority for most patients with brain metastases. Knowing the mechanisms of hyperglutamatergic neurotoxicity and the role of some hippocampal areas in cognitive decline (CD) led to testing both the antig…
View article: Lymph node ratio predicts efficacy of postoperative radiation therapy in nonmetastatic Merkel cell carcinoma: A population‐based analysis
Lymph node ratio predicts efficacy of postoperative radiation therapy in nonmetastatic Merkel cell carcinoma: A population‐based analysis Open
Background After radical resection of a nonmetastatic Merkel cell carcinoma (M0 MCC), postoperative radiation therapy (RT) is recommended as it improves survival. However, the role of RT in specific subgroups of M0 MCC is unclear. We sough…
View article: Large Cell Neuroendocrine Carcinoma of the Lung: Current Understanding and Challenges
Large Cell Neuroendocrine Carcinoma of the Lung: Current Understanding and Challenges Open
Large cell neuroendocrine carcinoma of the lung (LCNEC) is a rare and highly aggressive type of lung cancer, with a complex biology that shares similarities with both small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Th…
View article: A “SHort course Accelerated RadiatiON therapy” (SHARON) During and Beyond the COVID-19 Pandemic
A “SHort course Accelerated RadiatiON therapy” (SHARON) During and Beyond the COVID-19 Pandemic Open
The current pandemic situation posed significant problems for radiotherapy (RT) services. In addition to the need to treat COVID-positive patients, it is important to protect health workers and healthy patients from the infection. Although…
View article: CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report
CARE‑compliant stereotactic radiotherapy of urothelial nodal metastases: A case report Open
The aim of the present study was to report the case of a 58-year-old male patient with ureteral carcinoma who underwent ureteroileostomy treatment. At 2 years following surgery, six lymph node metastases (LNMs) were detected in the patient…
View article: Focused Ultrasound and RadioTHERapy for Non-Invasive Palliative Pain Treatment in Patients with Bone Metastasis: A Study Protocol for the Three Armed Randomized Controlled FURTHER-trial
Focused Ultrasound and RadioTHERapy for Non-Invasive Palliative Pain Treatment in Patients with Bone Metastasis: A Study Protocol for the Three Armed Randomized Controlled FURTHER-trial Open
Background Cancer Induced Bone Pain (CIBP), caused by bone metastases, is a common complication of cancer and strongly impairs quality of life (QoL). External Beam RadioTherapy (EBRT) is the current standard of care for treatment of CIBP. …
View article: Multimodal Strategy in Localized Merkel Cell Carcinoma: Where Are We and Where Are We Heading?
Multimodal Strategy in Localized Merkel Cell Carcinoma: Where Are We and Where Are We Heading? Open
Merkel cell carcinoma (MCC) is an aggressive neuroendocrine tumor of the skin whose incidence is rising. Multimodal treatment is crucial in the non-metastatic, potentially curable setting. However, the optimal management of patients with n…
View article: COVID-19 Pandemic-Adapted Radiotherapy Guidelines: Are They Really Followed?
COVID-19 Pandemic-Adapted Radiotherapy Guidelines: Are They Really Followed? Open
Background: In our department, we provided guidelines to the radiation oncologists (ROs) regarding the omission, delay, or shortening of radiotherapy (RT). The purpose was to reduce the patients’ exposure to the hospital environment and to…
View article: An Intensive Educational Intervention Significantly Improves the Adoption of Single Fractionation Radiotherapy in Uncomplicated Bone Metastases
An Intensive Educational Intervention Significantly Improves the Adoption of Single Fractionation Radiotherapy in Uncomplicated Bone Metastases Open
Introduction: An education strategy was employed in our department to increase the rate of patients with uncomplicated painful bone metastases undergoing single fractionation radiotherapy (SFRT). The purpose of this report is to analyze th…
View article: Simultaneous Integrated Radiotherapy Boost to the Dominant Intraprostatic Lesion: Final Results of a Phase I/II Trial
Simultaneous Integrated Radiotherapy Boost to the Dominant Intraprostatic Lesion: Final Results of a Phase I/II Trial Open
The treatment was well tolerated and achieved excellent results in terms of outcome in patients with low-intermediate Gleason's score and low risk of nodal metastasis.
View article: Radiotherapy of Prostate Carcinoma: A Comparison of the Predictive Role of EAU<i>Versus</i>NCCN Risk Stratification Systems
Radiotherapy of Prostate Carcinoma: A Comparison of the Predictive Role of EAU<i>Versus</i>NCCN Risk Stratification Systems Open
This analysis confirms the efficacy of both systems in definitive radiotherapy and suggests the utility of the NCCN also in salvage radiotherapy.
View article: MP53-16 EARLY SALVAGE RADIOTHERAPY FOR PATIENTS WITH ADVERSE PATHOLOGICAL FEATURES AFTER RADICAL PROSTATECTOMY: PRELIMINARY RESULTS FROM EASY-1 (EARLY SALVAGE RADIOTHERAPY-1) PROTOCOL
MP53-16 EARLY SALVAGE RADIOTHERAPY FOR PATIENTS WITH ADVERSE PATHOLOGICAL FEATURES AFTER RADICAL PROSTATECTOMY: PRELIMINARY RESULTS FROM EASY-1 (EARLY SALVAGE RADIOTHERAPY-1) PROTOCOL Open
You have accessJournal of UrologyProstate Cancer: Localized: Radiation Therapy (MP53)1 Apr 2020MP53-16 EARLY SALVAGE RADIOTHERAPY FOR PATIENTS WITH ADVERSE PATHOLOGICAL FEATURES AFTER RADICAL PROSTATECTOMY: PRELIMINARY RESULTS FROM EASY-1 …
View article: Radiotherapy Plus GnRH Analogue <i>Versus</i> High Dose Bicalutamide: A Case Control Study
Radiotherapy Plus GnRH Analogue <i>Versus</i> High Dose Bicalutamide: A Case Control Study Open
Bicalutamide may be offered as an adjuvant treatment to RT in patients who refuse GnRHa because of related side effects. Furthermore, our study justifies randomized trials comparing RT plus GnRHa and RT plus bicalutamide.