Explanipedia

The Acute Stroke System of Treatment Across Canada: Findings from a National Stroke Centre Survey Open

Betty Adewusi, Andrew M. Demchuk, Grant Stotts, Renee Cashin, Marsha Eustace , et al. · 2025

Background: Stroke is a devastating disease, but the disability due to stroke can be avoided or reduced through timely access to treatment and care. This study surveyed all designated stroke centres across Canada to better understand the n…

P.027 Sex differences in symptomatic intracranial hemorrhage and procedural complications after endovascular thrombectomy: Analysis of the OPTIMISE registry Open

A Diallo, JA Rivillas, AY Poppe, Olena Bereznyakova, RH Swartz , et al. · 2025

Background: Studies have found similar rates of functional independence for men and women after endovascular thrombectomy (EVT). Less is known regarding EVT-related procedural complications and symptomatic intracerebral hemorrhage (sICH) b…

P.046 Impact of telemedicine evaluation among ischemic stroke patients transferred for endovascular thrombectomy: data from the OPTIMISE registry Open

Julie Barrette, Grégory Jacquin, RH Swartz, AH Katsanos, Jai Shankar , et al. · 2025

Background: Telemedicine evaluation for treatment of acute stroke patients with IV thrombolysis has been shown to be beneficial. Its usefulness for the evaluation of patients transferred from a primary stroke centre (PSC) to a comprehensiv…

Stroke Hospitalization Administration & Monitoring: Routine or COVID-19 Care (SHAMROCC) Open

Timothé Langlois‐Thérien, Michel Shamy, Brian Dewar, Tim Ramsay, Ronda Lun , et al. · 2025

Background Monitoring stroke patients in critical-care units for 24 h after thrombolysis or endovascular thrombectomy is considered standard of care in current guidelines but is not evidence-based. Due to the COVID-19 pandemic, our center …

Impact of the COVID-19 pandemic on outcomes of acute ischemic stroke patients treated with endovascular therapy: A multicenter Canadian study Open

Shenghua Zhu, Ammar Alam, Rebecca E. Thornhill, Vered Tsehmaister-Abitbul, Grant Stotts , et al. · 2025

Objective The novel coronavirus disease 2019 (COVID-19) pandemic led to the implementation of wide-ranging institutional infection control protocols. The purpose of this study is to determine the effect of the pandemic on outcomes of large…

A Multicentre Prospective Cohort Study to Identify High-Risk Transient Ischemic Attack/Minor Stroke Patients Benefitting from Echocardiography Open

Jeffrey J. Perry, Abdulaziz Alsadoon, Marie‐Joe Nemnom, Marco L.A. Sivilotti, Marcel Émond , et al. · 2024

Echocardiography is a very useful test in the investigations of patients with TIA/minor stroke. We identified high-risk clinical features-combined to create a clinical decision rule-to identify which patients with TIA/minor stroke are like…

Synthetic data in cancer and cerebrovascular disease research: A novel approach to big data Open

Ronda Lun, Deborah Siegal, Tim Ramsay, Grant Stotts, Dar Dowlatshahi · 2024

Objectives Synthetic datasets are artificially manufactured based on real health systems data but do not contain real patient information. We sought to validate the use of synthetic data in stroke and cancer research by conducting a compar…

P.10 Adding a neuroimaging safety net to the work up of status epilepticus at the Ottawa Hospital Open

R Gotfrit, Jill G. Zwicker, Grant Stotts, Tadeu A. Fantaneanu, RI Aviv , et al. · 2023

Background: CT angiogram of the head and neck (CTA) is not part of the routine work-up of status epilepticus (SE), which could miss acute ischemic stroke (AIS) as the cause. We hypothesized that healthcare savings from early treatment of o…

Stroke Hospitalization Administration & Monitoring: Routine Or Covid-19 Care (SHAMROCC) Open

Timothé Langlois‐Thérien, Michel Shamy, Brian Dewar, Tim Ramsay, Ronda Lun , et al. · 2023

BACKGROUND Monitoring stroke patients in critical-care units for 24 hours after thrombolysis or endovascular thrombectomy is considered standard of care but is not evidence-based. Due to the Covid-19 pandemic, our center modified its proto…

Ninety‐Day Stroke or Transient Ischemic Attack Recurrence in Patients Prescribed Anticoagulation in the Emergency Department With Atrial Fibrillation and a New Transient Ischemic Attack or Minor Stroke Open

Graham Wilson, Mukul Sharma, Debra Eagles, Marie‐Joe Nemnom, Marco L.A. Sivilotti , et al. · 2023

Background For patients with atrial fibrillation seen in the emergency department (ED) following a transient ischemic attack (TIA) or minor stroke, the impact of initiating oral anticoagulation immediately rather than deferring the decisio…

Time Course of Early Hematoma Expansion in Acute Spot-Sign Positive Intracerebral Hemorrhage: Prespecified Analysis of the SPOTLIGHT Randomized Clinical Trial Open

Fahad Al-Ajlan, David J. Gladstone, Dongbeom Song, Kevin E. Thorpe, Rick Swartz , et al. · 2023

Background: In the SPOTLIGHT trial (Spot Sign Selection of Intracerebral Hemorrhage to Guide Hemostatic Therapy), patients with a computed tomography (CT) angiography spot-sign positive acute intracerebral hemorrhage were randomized to rFV…

Spontaneous Recanalization of Internal Carotid Artery Occlusion Open

Sarah Y. Zhang, Dylan Blacquière, Brian Dewar, Grant Stotts, Dar Dowlatshahi · 2023

Introduction: Spontaneous recanalization of an occluded internal carotid artery (ICA) is thought to be unlikely. However, there has been a growing number of reports describing this phenomenon. Despite this, the frequency, time course, and …

Aetiology of extracranial carotid free-floating thrombus in a prospective multicentre cohort Open

Dar Dowlatshahi, Cheemun Lum, Bijoy K. Menon, Aditya Bharatha, Prasham Dave , et al. · 2022

Background Carotid free-floating thrombi (FFT) in patients with acute transient ischaemic attack (TIA)/stroke have a high risk of early recurrent stroke. Management depends on aetiology, which can include local plaque rupture, dissection, …

Risk of stroke is low after transient ischemic attack presentation with isolated dizziness Open

Anand K. Bery, Mukul Sharma, Marie‐Joe Nemnom, Peter Johns, Daniel Lelli , et al. · 2022

Cost-free pharmacotherapy in smokers with TIA or stroke: QUIT-MED randomised controlled trial Open

Robert D. Reid, Sophia Papadakis, Sophia Gocan, Aline Bourgoin, Mary Ann Laplante , et al. · 2022

Objective To examine whether cost-free (CF) smoking cessation medication was more effective than a prescription for cessation medication in patients after transient ischaemic attack (TIA) or stroke. Design Two-site randomised trial. Settin…

C.1 Time Metrics and Clinical Outcomes of Thrombectomy in Acute Stroke Patients Before and After Implementation of COVID-19 Infection Protocols in Nine Canadian Stroke Centres Open

Shuibo Zhu, V Tsehmaister-Abitbul, Grant Stotts, Robert Fahed, Hailey Pettem , et al. · 2021

Background: The coronavirus disease 2019 (COVID-19) pandemic has led an implementation of institutional infection control protocols. This study will determine the effects of these protocols on outcomes of acute ischemic stroke (AIS) patien…

Frequency and Patterns of Brain Infarction in Patients With Embolic Stroke of Undetermined Source: NAVIGATE ESUS Trial Open

Mukul Sharma, Eric E. Smith, Lesly A. Pearce, Ashkan Shoamanesh, Kanjana Perera , et al. · 2021

Background and Purpose: The spectrum of brain infarction in patients with embolic stroke of undetermined source (ESUS) has not been well characterized. Our objective was to define the frequency and pattern of brain infarcts detected by mag…

Prospective validation of Canadian TIA Score and comparison with ABCD2 and ABCD2i for subsequent stroke risk after transient ischaemic attack: multicentre prospective cohort study Open

Jeffrey J. Perry, Marco L.A. Sivilotti, Marcel Émond, Ian G. Stiell, Grant Stotts , et al. · 2021

Objective To validate the previously derived Canadian TIA Score to stratify subsequent stroke risk in a new cohort of emergency department patients with transient ischaemic attack. Design Prospective cohort study. Setting 13 Canadian emerg…

Prevalence and the predictive performance of the dynamic CT-angiography spot sign in an observational cohort with intracerebral hemorrhage Open

Dar Dowlatshahi, Hee Sahng Chung, Michael Reaume, Matthew J. Hogan, Dylan Blacquière , et al. · 2020

The CT-angiography (CTA) spot sign is a predictor of hematoma expansion (HE). We have previously reported on the use of dynamic CTA (dCTA) to detect spot sign, and to study its formation over the acquisition period. In this study, we repor…

Decreased Stroke Presentation Rates at a Comprehensive Stroke Center during COVID-19 Open

Dar Dowlatshahi, Grant Stotts, Aline Bourgoin, Sophia Gocan, Laura Dunn , et al. · 2020

We reviewed stroke care delivery during the COVID-19 pandemic at our stroke center and provincial telestroke system. We counted referrals to our prevention clinic, code strokes, thrombolysis, endovascular thrombectomies, and activations of…

Distribution and predictive performance of the temporal phase of dynamic spot sign appearance in acute intracerebral hemorrhage Open

Hee Sahng Chung, Santanu Chakraborty, Michael Reaume, Vignan Yogendrakumar, Matthew J. Hogan , et al. · 2020

Our exploratory analyses suggest that spot sign appearance in the arterial phase may be more likely associated with HE and poorer prognosis in ICH. This may be related to higher extravasation rates of arterial phase spot signs. However, fu…

Clinical Utility and Cost of Inpatient Transthoracic Echocardiography Following Acute Ischemic Stroke Open

Margaret Moores, Vignan Yogendrakumar, Olena Bereznyakova, Walid Alesefir, Kednapa Thavorn , et al. · 2020

Background and Purpose: It is unclear whether it is clinically necessary or cost-effective to routinely obtain a transthoracic echocardiogram (TTE) during inpatient admission for ischemic stroke. Methods: We assessed consecutive patients p…

Clinical Reasoning: Recurrent strokes secondary to unknown vasculopathy Open

Ronda Lun, Naomi Niznick, Ruth Padmore, Jonathan Mack, Michel Shamy , et al. · 2020

A healthy 84-year-old woman of Chinese ethnicity presented with multiple separate episodes of focal neurologic deficits (right-sided weakness with aphasia, as well as left-sided weakness) over 2 days, in the context of 3 months of subacute…

Early Dabigatran Treatment After Transient Ischemic Attack and Minor Ischemic Stroke Does Not Result in Hemorrhagic Transformation Open

Anas Alrohimi, Kelvin Ng, Dar Dowlatshahi, Brian Buck, Grant Stotts , et al. · 2020

Objectives: The optimal timing of anticoagulation after ischemic stroke in atrial fibrillation (AF) patients is unknown. Our aim was to demonstrate the feasibility and safety of initiating dabigatran therapy within 14 days of transient isc…

Can Emergency Physicians Perform Carotid Artery Point-of-Care Ultrasound to Detect Stenosis in Patients with TIA and Stroke? A Pilot Study Open

Robert Suttie, Michael Y. Woo, Lily Park, Marie‐Joe Nemnom, Grant Stotts , et al. · 2020

Carotid POCUS has low to moderate association with CTA for detection of carotid artery stenosis ≥ 50%. Further research and investigation is needed prior to widespread use of carotid POCUS in patients with acute cerebral ischemia. Addition…

Early vascular imaging and key system strategies expedite carotid revascularization after transient ischemic attack and stroke Open

Sophia Gocan, Aline Bourgoin, Rany Shamloul, Brammiya Sivakumar, Dar Dowlatshahi , et al. · 2020

Early/emergency response to stroke symptoms was pivotal in achieving best practice recommendations for rapid carotid revascularization, emphasizing the need for ongoing public awareness. Emergency and ambulatory strategies to facilitate ur…

Cohort Study of Features Used by Experts to Diagnose Transient Ischemic Attack Open

Tess Fitzpatrick, Sophia Gocan, Chu Qi Wang, Aline Bourgoin, Monica Taljaard , et al. · 2020

Background and Purpose: The diagnosis of transient ischemic attack (TIA) is largely dependent on a process of clinical decision-making that remains poorly characterized in the absence of a validated and accessible biomarker or imaging test…

Normal Systolic Blood Pressure at Presentation With Acute Ischemic Stroke Predicts Cardioembolic Etiology Open

Margaret Moores, Vignan Yogendrakumar, Olena Bereznyakova, Walid Alesefir, Hailey Pettem , et al. · 2020

Background Early insight into the possible etiology of ischemic stroke allows for early initiation of mechanism‐specific secondary stroke prevention. Initial systolic blood pressure during acute ischemic stroke may relate to stroke etiolog…

A Delayed Modified ICH Score Outperforms Baseline Scoring in Acute Intracerebral Hemorrhage Open

Ronda Lun, Vignan Yogendrakumar, Dylan Blacquière, Michel Shamy, Grant Stotts , et al. · 2019

The Modified Intracerebral Hemorrhage (MICH) score is a simple tool created to provide prognostication in basal ganglia hemorrhages. Current prognostic scores, including the MICH, are based on the assessment of baseline patient characteris…

PL01: Prospective multicenter validation of the Canadian TIA Score for predicting subsequent stroke within seven days Open

Jeffrey J. Perry, Marco L.A. Sivilotti, Marcel Émond, Andrew Worster, J. Lee , et al. · 2019

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