Galina Velikova
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View article: Electronic patient-reported adverse event monitoring in academic early-phase clinical trials: A feasibility study
Electronic patient-reported adverse event monitoring in academic early-phase clinical trials: A feasibility study Open
Background: Adverse event monitoring is essential to monitor safety for oncology patients on early-phase clinical trials. Previous research considers that electronic patient-reported adverse events reporting is feasible and complementary t…
View article: Optimising a behavioural intervention to support endocrine therapy adherence for women with breast cancer: Protocol for the ROSETA optimisation randomised controlled trial
Optimising a behavioural intervention to support endocrine therapy adherence for women with breast cancer: Protocol for the ROSETA optimisation randomised controlled trial Open
Background Adjuvant endocrine therapy (AET) reduces breast cancer recurrence and mortality. However, up to three quarters of women with breast cancer do not take AET as prescribed. Existing interventions to support adherence have shown lim…
View article: Cross-cultural adaptation of the locally recurrent rectal cancer – Quality of life questionnaire
Cross-cultural adaptation of the locally recurrent rectal cancer – Quality of life questionnaire Open
The LRRC-QoL has now undergone cross-cultural adaptation to enable its use in 10 languages and 16 countries. Its psychometric properties will be further examined through external validation in an international cohort.
View article: Opportunities and challenges in pooling health-related quality-of-life data for prediction modeling in breast cancer across Europe: lessons from the EORTC BALANCE project
Opportunities and challenges in pooling health-related quality-of-life data for prediction modeling in breast cancer across Europe: lessons from the EORTC BALANCE project Open
View article: Development of a unified system for assessing health related quality of life across the cancer care continuum: the EUonQoL Delphi study to identify priorities for quality of life domains
Development of a unified system for assessing health related quality of life across the cancer care continuum: the EUonQoL Delphi study to identify priorities for quality of life domains Open
View article: Machine Learning Models Predicting Hospital Admissions During Chemotherapy Utilising Longitudinal Symptom Severity Reports and Patient-Reported Outcome Measures
Machine Learning Models Predicting Hospital Admissions During Chemotherapy Utilising Longitudinal Symptom Severity Reports and Patient-Reported Outcome Measures Open
Chemotherapy toxicity can lead to acute hospital admissions, negatively impacting the healthcare system and patients’ well-being. Machine learning (ML) models identifying patients at risk of emergency admissions are often developed on data…
View article: A disease registry study to prospectively observe treatment patterns and outcomes in patients with HER2-positive unresectable LA/MBC: final results of the ESTHER study
A disease registry study to prospectively observe treatment patterns and outcomes in patients with HER2-positive unresectable LA/MBC: final results of the ESTHER study Open
Purpose There are multiple contemporary systemic therapy options for patients with HER2-positive advanced breast cancer. However, there are few longitudinal data regarding what proportion of patients go on to receive later lines of therapy…
View article: Acceptability of acceptance and commitment therapy for medication‐decision‐making and quality of life in women with breast cancer: A qualitative process evaluation
Acceptability of acceptance and commitment therapy for medication‐decision‐making and quality of life in women with breast cancer: A qualitative process evaluation Open
Objectives Adjuvant endocrine therapy (AET) reduces breast cancer recurrence, but side effects and distress impact adherence. We co‐designed an Acceptance and Commitment Therapy (ACT) intervention to support medication decision‐making and …
View article: Evaluating the Involvement of People With Cancer and Informal Caregivers in the Development Process of a New Set of Quality of Life Questionnaires
Evaluating the Involvement of People With Cancer and Informal Caregivers in the Development Process of a New Set of Quality of Life Questionnaires Open
Introduction There is a general need for sharing practical examples of Patient and Public Involvement (PPI) within the research field to learn from and inspire. The aim of this article is to describe our process evaluation of PPI within th…
View article: Using artificial intelligence to predict patient outcomes from patient-reported outcome measures: a scoping review
Using artificial intelligence to predict patient outcomes from patient-reported outcome measures: a scoping review Open
Purpose This scoping review aims to identify and summarise artificial intelligence (AI) methods applied to patient-reported outcome measures (PROMs) for prediction of patient outcomes, such as survival, quality of life, or treatment decisi…
View article: Flexibility in patient-reported outcome and health-related quality of life measurement: The EORTC Quality of Life Group measurement strategy
Flexibility in patient-reported outcome and health-related quality of life measurement: The EORTC Quality of Life Group measurement strategy Open
The development of the first European Organisation for Research and Treatment of Cancer (EORTC) Quality of Life Group (QLG) health-related quality of life (HRQoL) questionnaires contributed to the systematic uptake of HRQoL as an endpoint …
View article: Prognostic value of baseline EORTC QLQ-C30 scores for overall survival across 46 clinical trials covering 17 cancer types: a validation study
Prognostic value of baseline EORTC QLQ-C30 scores for overall survival across 46 clinical trials covering 17 cancer types: a validation study Open
View article: Correction: Examining the Effectiveness of Electronic Patient-Reported Outcomes in People With Cancer: Systematic Review and Meta-Analysis
Correction: Examining the Effectiveness of Electronic Patient-Reported Outcomes in People With Cancer: Systematic Review and Meta-Analysis Open
[This corrects the article DOI: 10.2196/49089.].
View article: Survivorship issues in long‐term survivors of locally recurrent rectal cancer: A qualitative study
Survivorship issues in long‐term survivors of locally recurrent rectal cancer: A qualitative study Open
Aim There are increasing numbers of long‐term survivors following curative treatment for locally recurrent rectal cancer (LRRC); however, their experiences remain relatively underreported. The aim of this qualitative study was to identify …
View article: 11 Cross-Cultural Adaptation and External Validation of the Locally Recurrent Rectal Cancer – Quality of Life (LRRC-QoL) Measure
11 Cross-Cultural Adaptation and External Validation of the Locally Recurrent Rectal Cancer – Quality of Life (LRRC-QoL) Measure Open
Background Establishing an international measure of health-related quality of life (HrQoL) for patients with LRRC is central to understanding its impact from a patient perspective. The aim of this study was to cross-culturally adapt and ex…
View article: Evaluation of the psychometric properties of patient-reported outcome measures of health-related quality of life across the European cancer continuum: a systematic review protocol using COSMIN methodology
Evaluation of the psychometric properties of patient-reported outcome measures of health-related quality of life across the European cancer continuum: a systematic review protocol using COSMIN methodology Open
Introduction Over the past decades, there has been increasing recognition that assessing patients with cancer’s health-related quality of life (HRQoL) is pivotal to delivering optimal patient-centred healthcare. However, with the increasin…
View article: Frailty and outcomes in adults undergoing systemic anticancer treatment: a systematic review and meta-analysis
Frailty and outcomes in adults undergoing systemic anticancer treatment: a systematic review and meta-analysis Open
Background It is increasingly recognized that frailty should be assessed and considered in treatment decision making in patients with cancer. This review and meta-analysis synthesizes existing evidence evaluating the association between ba…
View article: An international Phase IV field study - psychometric properties of the updated module on assessing quality of life of patients with breast cancer EORTC QLQ-BR42
An international Phase IV field study - psychometric properties of the updated module on assessing quality of life of patients with breast cancer EORTC QLQ-BR42 Open
View article: Systematic review of the needs and health-related quality of life domains relevant to people surviving cancer in Europe
Systematic review of the needs and health-related quality of life domains relevant to people surviving cancer in Europe Open
View article: Supporting endocrine therapy adherence in women with breast cancer: findings from the ROSETA pilot fractional factorial randomized trial
Supporting endocrine therapy adherence in women with breast cancer: findings from the ROSETA pilot fractional factorial randomized trial Open
Background Adherence to adjuvant endocrine therapy (AET) in women with breast cancer is poor. Multicomponent intervention packages are needed to address adherence barriers. Optimizing these packages prior to definitive evaluation can incre…
View article: International Validation of the Locally Recurrent Rectal Cancer – Quality of Life (LRRC-QoL) Patient Reported Outcome Measure
International Validation of the Locally Recurrent Rectal Cancer – Quality of Life (LRRC-QoL) Patient Reported Outcome Measure Open
View article: Assessing multidimensional fidelity in a pilot optimization trial: A process evaluation of four intervention components supporting medication adherence in women with breast cancer
Assessing multidimensional fidelity in a pilot optimization trial: A process evaluation of four intervention components supporting medication adherence in women with breast cancer Open
Adherence to adjuvant endocrine therapy in women with breast cancer is low. We conducted a 24-1 fractional factorial pilot optimization trial to test four intervention components supporting medication adherence [text messages, information …
View article: Quality of life, healthcare usage and finances of UK cancer survivors five years post-diagnosis: a matched controlled study
Quality of life, healthcare usage and finances of UK cancer survivors five years post-diagnosis: a matched controlled study Open
Purpose Assessing the long-term impact of cancer on people’s lives is challenging due to confounding issues such as aging and comorbidities. We aimed to investigate this impact by comparing the outcomes of cancer survivors with a matched c…
View article: Patient and clinician perspectives of an eHealth intervention for supporting cancer treatment in the UK: mixed methods evaluation of the eRAPID randomised controlled trial
Patient and clinician perspectives of an eHealth intervention for supporting cancer treatment in the UK: mixed methods evaluation of the eRAPID randomised controlled trial Open
Objectives During 2015–2018, a randomised controlled trial (RCT) evaluated eRAPID, an eHealth intervention designed to capture patient-reported symptoms online during cancer treatment. eRAPID provides patients with advice on when to self-m…
View article: Truth and dare: patients dare to tell the truth when using PROMs in clinical practice
Truth and dare: patients dare to tell the truth when using PROMs in clinical practice Open
Purpose As patient-reported outcome measures (PROMs) are increasingly used in clinical practice for screening, monitoring, and management, the potential for response bias has been raised (e.g., over-reporting problems for attention, under-…
View article: Truth and dare: patients dare to tell the truth when using PROMs in clinical practice
Truth and dare: patients dare to tell the truth when using PROMs in clinical practice Open
View article: Registry-based study comparing health-related quality of life between patients with primary rectal cancer and locally recurrent rectal cancer
Registry-based study comparing health-related quality of life between patients with primary rectal cancer and locally recurrent rectal cancer Open
Patients with LRRC reported significantly worse overall scores in the FACT-C CCS from both a statistical and clinical perspective, demonstrating the ability of the FACT-C to distinguish between these patient groups and the benefits of the …
View article: Improving completion rates of patient-reported outcome measures in cancer clinical trials: Scoping review investigating the implications for trial designs
Improving completion rates of patient-reported outcome measures in cancer clinical trials: Scoping review investigating the implications for trial designs Open
View article: Correction to: Psychosocial factors associated with quality of life in cancer survivors: umbrella review
Correction to: Psychosocial factors associated with quality of life in cancer survivors: umbrella review Open
View article: Acceptability of Four Intervention Components Supporting Medication Adherence in Women with Breast Cancer: a Process Evaluation of a Fractional Factorial Pilot Optimization Trial
Acceptability of Four Intervention Components Supporting Medication Adherence in Women with Breast Cancer: a Process Evaluation of a Fractional Factorial Pilot Optimization Trial Open