Gary W. Miller
YOU?
Author Swipe
View article: Computational Pipeline for Accelerating the Design of Glycomimetics
Computational Pipeline for Accelerating the Design of Glycomimetics Open
To accelerate the rational design of glycomimetic inhibitors, based on derivatization of a carbohydrate ligand, we introduce a computational pipeline that automates the creation and modeling of analogs and computes their interaction energi…
View article: Mixture of organic pollutants is associated with cognitive aging
Mixture of organic pollutants is associated with cognitive aging Open
INTRODUCTION Environmental organic pollutants impact brain function and cognitive aging, but the effects of real-world complex mixtures of these pollutants is unexplored. METHODS Using data collected at two time points from 170 cognitively…
View article: Developmental pyrethroid exposure disrupts molecular pathways for circadian rhythms and synaptic plasticity in mouse brain
Developmental pyrethroid exposure disrupts molecular pathways for circadian rhythms and synaptic plasticity in mouse brain Open
View article: CoxMDS: Multiple Data Splitting for High-dimensional Mediation Analysis with Survival Outcomes in Epigenome-wide Studies
CoxMDS: Multiple Data Splitting for High-dimensional Mediation Analysis with Survival Outcomes in Epigenome-wide Studies Open
Causal mediation analysis investigates whether the effect of an exposure on an outcome operates through intermediate variables known as mediators. Although progress has been made in high-dimensional mediation analysis, current methods do n…
View article: Developmental pyrethroid exposure disrupts molecular pathways for circadian rhythms and synaptic plasticity in mouse brain.
Developmental pyrethroid exposure disrupts molecular pathways for circadian rhythms and synaptic plasticity in mouse brain. Open
View article: Assessing Type 2 Diabetes and GLP-1 agonist response trajectories with a proteogenomic atlas of disease progression
Assessing Type 2 Diabetes and GLP-1 agonist response trajectories with a proteogenomic atlas of disease progression Open
Mapping patient progression from a healthy metabolic state to Type 2 Diabetes (T2D) provides opportunities for precision medicine-driven preventative interventions. We constructed the Metabolic Atlas of Progression to Diabetes (MAP-D), lev…
View article: The plasma proteome and breast cancer risk
The plasma proteome and breast cancer risk Open
While our results should be interpreted with caution, if replicated in larger prospective cohorts, these findings will have translational significance, attesting to the power of high-throughput profiling of circulating protein markers in i…
View article: Leveraging open cheminformatics tools for non-targeted metabolomics analysis of C. elegans: a workflow comparison and application to strains related to xenobiotic metabolism and neurodegeneration
Leveraging open cheminformatics tools for non-targeted metabolomics analysis of C. elegans: a workflow comparison and application to strains related to xenobiotic metabolism and neurodegeneration Open
View article: Leveraging open cheminformatics tools for non-targeted metabolomics analysis of C. elegans: a workflow comparison and application to strains related to xenobiotic metabolism and neurodegeneration
Leveraging open cheminformatics tools for non-targeted metabolomics analysis of C. elegans: a workflow comparison and application to strains related to xenobiotic metabolism and neurodegeneration Open
Caenorhabditis elegans (C. elegans) is a well-established nematode model for studying metabolism and neurodegenerative disorders, such as Alzheimer’s (AD) and Parkinson’s disease (PD). Non-targeted metabolomics via liquid chromatography co…
View article: Integrating exposomics into biomedicine
Integrating exposomics into biomedicine Open
Assessing a full range of environmental exposures will improve human health
View article: Interactive Panel Summaries of the 2024 Voice AI Symposium
Interactive Panel Summaries of the 2024 Voice AI Symposium Open
The 2024 Voice AI Symposium presented by the Bridge2AI-Voice Consortium, was a 2-day event which took place May 1st-May 2nd in Tampa, FL. The event included four interactive panel sessions, which are summarized here. All four interactive p…
View article: Preclinical Alzheimer's disease shows alterations in circulating neuronal‐derived extracellular vesicle microRNAs in a multiethnic cohort
Preclinical Alzheimer's disease shows alterations in circulating neuronal‐derived extracellular vesicle microRNAs in a multiethnic cohort Open
INTRODUCTION Alzheimer's disease (AD) is the leading cause of dementia, affecting around 50 million individuals worldwide. Brain‐derived extracellular vesicles (EVs) can cross the blood–brain barrier carrying neuron‐specific molecules, suc…
View article: Genetic Regulation of the Metabolome Differs by Sex, Alzheimer’s Disease Stage, and Plasma Biomarker Status
Genetic Regulation of the Metabolome Differs by Sex, Alzheimer’s Disease Stage, and Plasma Biomarker Status Open
We investigated genetic regulators of circulating plasma metabolites to identify pathways underlying biochemical changes in clinical and biomarker-assisted diagnosis of Alzheimer’s disease (AD). We computed metabolite quantitative trait lo…
View article: Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain
Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain Open
Here, we provide the first evidence that low-dose developmental exposure to a pyrethroid pesticide, deltamethrin, results in molecular disruptions in the adult mouse brain in pathways regulating circadian rhythms and neuronal growth (MAP k…
View article: Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain
Developmental pyrethroid exposure disrupts molecular pathways for MAP kinase and circadian rhythms in mouse brain Open
Neurodevelopmental disorders (NDDs) are a category of pervasive disorders of the developing nervous system with few or no recognized biomarkers. A significant portion of the risk for NDDs, including attention deficit hyperactivity disorder…
View article: Research gaps and unmet challenges to study the impact of chemicals on neurodegenerative diseases
Research gaps and unmet challenges to study the impact of chemicals on neurodegenerative diseases Open
Chemicals are ubiquitous in modern life. More than 100,000 chemicals are currently used worldwide, and the production continues to increase. Measuring with accuracy all the components of the chemical exposome represents a tremendous challe…
View article: Current epidemiological and experimental evidence relating the chemical exposome to Alzheimer’s disease
Current epidemiological and experimental evidence relating the chemical exposome to Alzheimer’s disease Open
This critical overview aims to provide one of the most comprehensive synthesis of epidemiological and experimental evidence relating the chemical exposome to Alzheimer’s Disease (AD). We have focused on chemical pollutants that mostly resu…
View article: Deciphering proteins in Alzheimer’s disease: A new Mendelian randomization method integrated with AlphaFold3 for 3D structure prediction
Deciphering proteins in Alzheimer’s disease: A new Mendelian randomization method integrated with AlphaFold3 for 3D structure prediction Open
Hidden confounding biases hinder identifying causal protein biomarkers for Alzheimer's disease in non-randomized studies. While Mendelian randomization (MR) can mitigate these biases using protein quantitative trait loci (pQTLs) as instrum…
View article: Gut Microbial Metabolites and Future Risk of Parkinson's Disease: A Metabolome‐Wide Association Study
Gut Microbial Metabolites and Future Risk of Parkinson's Disease: A Metabolome‐Wide Association Study Open
Background Alterations in gut microbiota are observed in Parkinson's disease (PD). Previous studies on microbiota‐derived metabolites in PD were small‐scale and post‐diagnosis, raising concerns about reverse causality. Objectives Our goal …
View article: The effect of air pollution on hospitalizations with Parkinson’s disease among medicare beneficiaries nationwide
The effect of air pollution on hospitalizations with Parkinson’s disease among medicare beneficiaries nationwide Open
We examined the effect of annual exposure to fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3), on the rate of first hospitalization with a PD-related diagnosis (hospitalization with P…
View article: Plasma metabolomics profiles and breast cancer risk
Plasma metabolomics profiles and breast cancer risk Open
If replicated in larger prospective cohorts, these findings offer promising new ways to identify exposures related to BC and improve BC risk prediction.
View article: Glial <i>swip-10</i> controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis
Glial <i>swip-10</i> controls systemic mitochondrial function, oxidative stress, and neuronal viability via copper ion homeostasis Open
Cuprous copper [Cu(I)] is an essential cofactor for enzymes that support many fundamental cellular functions including mitochondrial respiration and suppression of oxidative stress. Neurons are particularly reliant on mitochondrial product…
View article: Seminar: Functional Exposomics and Mechanisms of Toxicity—Insights from Model Systems and NAMs
Seminar: Functional Exposomics and Mechanisms of Toxicity—Insights from Model Systems and NAMs Open
We visit the definition of the functional exposome and exposomics and discuss a need to leverage alternative models as opposed to mammalian animals for delineating exposome-wide health effects. Under the "three Rs" principle of reduction, …
View article: Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression
Alzheimer's disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression Open
INTRODUCTION Normal pressure hydrocephalus (NPH) patients undergoing cortical shunting frequently show early Alzheimer's disease (AD) pathology on cortical biopsy, which is predictive of progression to clinical AD. The objective of this st…
View article: Effect of altered production and storage of dopamine on development and behavior in C. elegans
Effect of altered production and storage of dopamine on development and behavior in C. elegans Open
Introduction The nematode, Caenorhabditis elegans ( C. elegans ), is an advantageous model for studying developmental toxicology due to its well-defined developmental stages and homology to humans. It has been established that across speci…
View article: Circulating small molecules are associated with exposure to uranium and radon in people living near a former uranium processing site
Circulating small molecules are associated with exposure to uranium and radon in people living near a former uranium processing site Open
View article: Tricyclic and tetracyclic antidepressants upregulate VMAT2 activity and rescue disease-causing VMAT2 variants
Tricyclic and tetracyclic antidepressants upregulate VMAT2 activity and rescue disease-causing VMAT2 variants Open
View article: High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage
High-Resolution Mass Spectrometry for Human Exposomics: Expanding Chemical Space Coverage Open
In the modern "omics" era, measurement of the human exposome is a critical missing link between genetic drivers and disease outcomes. High-resolution mass spectrometry (HRMS), routinely used in proteomics and metabolomics, has emerged as a…
View article: Alzheimer’s disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression
Alzheimer’s disease CSF biomarkers correlate with early pathology and alterations in neuronal and glial gene expression Open
INTRODUCTION Normal pressure hydrocephalus (NPH) patients undergoing cortical shunting frequently show early AD pathology on cortical biopsy, which is predictive of progression to clinical AD. The objective of this study was to use samples…
View article: Developmental pyrethroid exposure in mouse leads to disrupted brain metabolism in adulthood
Developmental pyrethroid exposure in mouse leads to disrupted brain metabolism in adulthood Open