Giovanni Zanframundo
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View article: Elderly-onset systemic sclerosis defines a distinct clinical subset: analysis from the SPRING registry of the Italian Society for Rheumatology
Elderly-onset systemic sclerosis defines a distinct clinical subset: analysis from the SPRING registry of the Italian Society for Rheumatology Open
Elderly-onset identifies a distinct clinical subset of SSc, mainly characterized by mild cutaneous and peripheral vascular involvement, but showing a greater burden of pulmonary vascular disease and increased mortality compared to the age-…
View article: Gastrointestinal involvement in very early and established systemic sclerosis: insights from the SPRING-SIR national Italian registry
Gastrointestinal involvement in very early and established systemic sclerosis: insights from the SPRING-SIR national Italian registry Open
Objectives To describe the prevalence of gastrointestinal (GI) symptoms in SSc and Very Early Diagnosis of SSc (VEDOSS), identify clinical and serological features associated with GI involvement and explore a cranio-caudal pattern of sympt…
View article: First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry
First‐line diagnostic tests to intercept primary heart involvement in systemic sclerosis: Clinical associations from the SPRING‐SIR registry Open
Introduction Primary heart involvement (pHI) is an overlooked and poorly characterised complication of systemic sclerosis (SSc), associated with the risk of heart failure, arrhythmia and death. Despite consensus definition by the World Scl…
View article: Menopause in systemic sclerosis: the impact on clinical presentation in a multicenter cross-sectional analysis from the National Registry of the Italian Society for Rheumatology (SPRING-SIR)
Menopause in systemic sclerosis: the impact on clinical presentation in a multicenter cross-sectional analysis from the National Registry of the Italian Society for Rheumatology (SPRING-SIR) Open
Background: Hormonal changes in menopause might interact with the presentation of underlying autoimmune diseases, such as systemic sclerosis (SSc). Objectives: Our study aimed to evaluate the association of (1) current menopausal status, (…
View article: ABS0574 CHARACTERIZING AND PREDICTING GASTROINTESTINAL INVOLVEMENT IN SYSTEMIC SCLEROSIS: DATA FROM THE NATIONAL SYSTEMIC SCLEROSIS PROGRESSION INVESTIGATION (SPRING) REGISTRY OF THE ITALIAN SOCIETY FOR RHEUMATOLOGY
ABS0574 CHARACTERIZING AND PREDICTING GASTROINTESTINAL INVOLVEMENT IN SYSTEMIC SCLEROSIS: DATA FROM THE NATIONAL SYSTEMIC SCLEROSIS PROGRESSION INVESTIGATION (SPRING) REGISTRY OF THE ITALIAN SOCIETY FOR RHEUMATOLOGY Open
View article: Prevalence and clinical relevance of digital ulcers in systemic sclerosis patients from the real-life: the experience of the SPRING Registry of the Italian Society for Rheumatology
Prevalence and clinical relevance of digital ulcers in systemic sclerosis patients from the real-life: the experience of the SPRING Registry of the Italian Society for Rheumatology Open
Introduction Digital ulcers (DU) are one of the most frequent manifestations in systemic sclerosis (SSc). The presence of DU seems to be a sentinel sign of internal organ involvement and is related to a poor prognosis of the disease. The a…
View article: The role of multicriteria decision analysis in the development of candidate classification criteria for antisynthetase syndrome: analysis from the CLASS project
The role of multicriteria decision analysis in the development of candidate classification criteria for antisynthetase syndrome: analysis from the CLASS project Open
The MCDA-driven candidate classification criteria were consistent with published ASSD literature and yielded high accuracy and validity.
View article: Pulmonary arterial hypertension in systemic lupus erythematosus: identification of risk factors and haemodynamics characteristics in a multicentre retrospective cohort
Pulmonary arterial hypertension in systemic lupus erythematosus: identification of risk factors and haemodynamics characteristics in a multicentre retrospective cohort Open
Objectives The aim of our work was to identify specific patterns in clinical features and nailfold capillary changes that may help in screening for pulmonary arterial hypertension (PAH) in patients with systemic lupus erythematosus (SLE). …
View article: Clinical Characteristics of Anti‐Synthetase Syndrome: Analysis From the Classification Criteria for Anti‐Synthetase Syndrome Project
Clinical Characteristics of Anti‐Synthetase Syndrome: Analysis From the Classification Criteria for Anti‐Synthetase Syndrome Project Open
Objective Anti‐synthetase syndrome (ASSD) is a rare systemic autoimmune rheumatic disease (SARD) with significant heterogeneity and no shared classification criteria. We aimed to identify clinical and serological features associated with A…
View article: Agreement between local and central anti-synthetase antibodies detection: results from the Classification Criteria of Anti-Synthetase Syndrome project biobank
Agreement between local and central anti-synthetase antibodies detection: results from the Classification Criteria of Anti-Synthetase Syndrome project biobank Open
Our study evaluates the performance of real-world identification of anti-synthetase antibodies in a large cohort of multi-national patients with ASSD and controls. Our analysis reinforces the reliability of real-world anti-Jo1 detection me…
View article: P39 Analysis of nailfold capillaroscopy findings and clinical features of patients with systemic lupus erythematosus and pulmonary arterial hypertension
P39 Analysis of nailfold capillaroscopy findings and clinical features of patients with systemic lupus erythematosus and pulmonary arterial hypertension Open
Objective The aim of our work is to analyze the clinical and demographic features and nailfold capillary changes in patients with SLE-related PAH compared to a group of SLE patients without PAH. Methods We identified and selected 20 patien…
View article: Issues in the classification of myositis patients: an ongoing process
Issues in the classification of myositis patients: an ongoing process Open
View article: Practice pattern for the use of intravenous iloprost for the treatment of peripheral vasculopathy in systemic sclerosis: A case–control study from the Italian national multicenter “SPRING” (Systemic Sclerosis Progression InvestiGation) Registry
Practice pattern for the use of intravenous iloprost for the treatment of peripheral vasculopathy in systemic sclerosis: A case–control study from the Italian national multicenter “SPRING” (Systemic Sclerosis Progression InvestiGation) Registry Open
Background: Intravenous iloprost has been widely used for the treatment of systemic sclerosis peripheral vasculopathy. No agreement has been found on the regimen and the dosage of intravenous iloprost in different scleroderma subset condit…
View article: Impact of COVID-19 and vaccination campaign on 1,755 systemic sclerosis patients during first three years of pandemic. Possible risks for individuals with impaired immunoreactivity to vaccine, ongoing immunomodulating treatments, and disease-related lung involvement during the next pandemic phase
Impact of COVID-19 and vaccination campaign on 1,755 systemic sclerosis patients during first three years of pandemic. Possible risks for individuals with impaired immunoreactivity to vaccine, ongoing immunomodulating treatments, and disease-related lung involvement during the next pandemic phase Open
View article: High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey
High fatigue scores in patients with idiopathic inflammatory myopathies: a multigroup comparative study from the COVAD e-survey Open
Idiopathic inflammatory myopathies (IIMs) confer a significant risk of disability and poor quality of life, though fatigue, an important contributing factor, remains under-reported in these individuals. We aimed to compare and analyze diff…
View article: AB0607 ANALYSIS OF NAILFOLD CAPILLAROSCOPY FINDINGS AND CLINICAL FEATURES OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND PULMONARY ARTERIAL HYPERTENSION
AB0607 ANALYSIS OF NAILFOLD CAPILLAROSCOPY FINDINGS AND CLINICAL FEATURES OF PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS AND PULMONARY ARTERIAL HYPERTENSION Open
View article: POS0124 SURVIVAL ANALYSIS IN CONNECTIVE TISSUE DISEASES WITH INTERSTITIAL LUNG DISEASE COMPARED TO IDIOPATHIC PULMONARY FIBROSIS: MULTICENTRE ITALIAN STUDY
POS0124 SURVIVAL ANALYSIS IN CONNECTIVE TISSUE DISEASES WITH INTERSTITIAL LUNG DISEASE COMPARED TO IDIOPATHIC PULMONARY FIBROSIS: MULTICENTRE ITALIAN STUDY Open
View article: POS1293 STRAIN OF THE RIGHT VENTRICLE AS A TOOL OF EARLY DETECTION OF PULMONARY VASCULATURE ABNORMALITY IN SYSTEMIC SCLEROSIS
POS1293 STRAIN OF THE RIGHT VENTRICLE AS A TOOL OF EARLY DETECTION OF PULMONARY VASCULATURE ABNORMALITY IN SYSTEMIC SCLEROSIS Open
View article: AB0817 CLINICAL ASSOCIATION OF ANTI-RO52 ANTIBODIES IN SYSTEMIC SCLEROSIS: A SINGLE CENTRE COHORT PRELIMINARY ANALYSIS
AB0817 CLINICAL ASSOCIATION OF ANTI-RO52 ANTIBODIES IN SYSTEMIC SCLEROSIS: A SINGLE CENTRE COHORT PRELIMINARY ANALYSIS Open
Background Anti-Ro52 antibodies may be detected in several Rheumatic disorders, with different clinical significances. They may occur also in systemic sclerosis (SSc), but with clinical correlates not completely established, with some repo…
View article: Systemic sclerosis sine scleroderma: clinical and serological features and relationship with other cutaneous subsets in a large series of patients from the national registry ‘SPRING’ of the Italian Society for Rheumatology
Systemic sclerosis sine scleroderma: clinical and serological features and relationship with other cutaneous subsets in a large series of patients from the national registry ‘SPRING’ of the Italian Society for Rheumatology Open
Objective To describe demographic, clinical and laboratory features of systemic sclerosis sine scleroderma (ssSSc) in a large multicentre systemic sclerosis (SSc) cohort. Methods Data involving 1808 SSc patients from Italian Systemic scler…
View article: Idiopathic inflammatory myopathies and COVID-19: an intriguing liaison?
Idiopathic inflammatory myopathies and COVID-19: an intriguing liaison? Open
View article: Adhesive capsulitis after COVID-19 vaccine injection: a peculiar case treated with combined bursa distention and glenohumeral capsular hydrodilatation
Adhesive capsulitis after COVID-19 vaccine injection: a peculiar case treated with combined bursa distention and glenohumeral capsular hydrodilatation Open
View article: A Proof-of-Concept Analysis of Plasma-Derived Exosomal microRNAs in Interstitial Pulmonary Fibrosis Secondary to Antisynthetase Syndrome
A Proof-of-Concept Analysis of Plasma-Derived Exosomal microRNAs in Interstitial Pulmonary Fibrosis Secondary to Antisynthetase Syndrome Open
Antisynthetase syndrome (ASSD) is an autoimmune disease characterized by the positivity of autoantibodies against different aminoacyl transfer RNA (tRNA) synthetases. Morbidity and mortality of this disease are highly affected by interstit…
View article: Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. The experience of the Italian SIR-SPRING registry and review of the world literature
Geographical heterogeneity of clinical and serological phenotypes of systemic sclerosis observed at tertiary referral centres. The experience of the Italian SIR-SPRING registry and review of the world literature Open
View article: Clinical and radiological features of lung disorders related to connective-tissue diseases: a pictorial essay
Clinical and radiological features of lung disorders related to connective-tissue diseases: a pictorial essay Open
Connective tissue diseases (CTDs) include a spectrum of disorders that affect the connective tissue of the human body; they include autoimmune disorders characterized by immune-mediated chronic inflammation and the development of fibrosis.…
View article: Prevalence and Death Rate of COVID-19 in Autoimmune Systemic Diseases in theFirst Three Pandemic Waves. Relationship with Disease Subgroups and OngoingTherapies
Prevalence and Death Rate of COVID-19 in Autoimmune Systemic Diseases in theFirst Three Pandemic Waves. Relationship with Disease Subgroups and OngoingTherapies Open
Objective: Autoimmune systemic diseases (ASD) represent a predisposing condition to COVID-19. Our prospective, observational multicenter telephone survey study aimed to investigate the prevalence, prognostic factors, and outcomes of COVID-…
View article: Impact of low-dose acetylsalicylic acid on pregnancy outcome in systemic lupus erythematosus: results from a multicentre study
Impact of low-dose acetylsalicylic acid on pregnancy outcome in systemic lupus erythematosus: results from a multicentre study Open
Objective It is still a matter of debate whether low-dose acetylsalicylic acid (LDASA) should be prescribed to all patients with SLE during pregnancy. This study aimed at investigating the impact of LDASA on pregnancy outcomes in patients …
View article: Clinical evolution of antisynthetase syndrome after SARS-CoV2 infection: a 6-month follow-up analysis
Clinical evolution of antisynthetase syndrome after SARS-CoV2 infection: a 6-month follow-up analysis Open
View article: Anti-Ro52 antibodies positivity in antisynthetase syndrome: a single centre cohort study
Anti-Ro52 antibodies positivity in antisynthetase syndrome: a single centre cohort study Open
Anti-Ro52 antibodies affect time course and clinical characteristics of ASSD. Although ILD is significantly more associated to anti-Ro52 antibodies, no difference in mortality was observed compared to anti-Ro52 negative patients.
View article: A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies
A New Method for the Assessment of Myalgia in Interstitial Lung Disease: Association with Positivity for Myositis-Specific and Myositis-Associated Antibodies Open
In this study, it was found that myositis-specific and myositis-associated antibodies (MSAs and MAAs) improved the recognition of idiopathic inflammatory myopathies (IIMs) in interstitial lung disease (ILD) patients. The objective of this …