Explanipedia

Sustained Performance of Cardiac Arrest Prevention in Pediatric Cardiac Intensive Care Units Open

Dana Mueller, David K. Bailly, Mousumi Banerjee, Rebecca A. Bertrandt, Santiago Borasino , et al. · 2024

Importance The Pediatric Cardiac Critical Care Consortium (PC4) cardiac arrest prevention (CAP) quality improvement (QI) project facilitated a decreased in-hospital cardiac arrest (IHCA) incidence rate across multiple hospitals. The sustai…

Successful Resuscitation of Porcine Hearts After 12 and 24 h of Static Cold Storage With Normothermic Ex Situ Perfusion Open

Matthew Johnson, Kristopher A. Urrea, Brianna L. Spencer, Jasnoor Singh, Joseph B. Niman , et al. · 2024

Background. Heart transplantation is always an emergency because the transplant needs to occur within 6 h after procurement to prevent primary graft dysfunction. Static cold storage (SCS) is the gold-standard preservation method. This stud…

Rotational Intravascular Multidirectional Ultrasound Catheter for Sonothrombolysis of Retracted Clots: An in Vitro and in Vivo Study Open

Huaiyu Wu, Jinwook Kim, Bohua Zhang, Gabe E. Owens, Greyson Stocker , et al. · 2024

Thromboembolism in blood vessels poses a serious risk of stroke, heart attack, and even sudden death if not properly managed. Sonothrombolysis combined with ultrasound contrast agents has emerged as a promising approach for the effective t…

Development and Validation of a Multimedia Hypoplastic Left Heart Syndrome Assessment Tool for Pediatric Cardiology Fellows Open

Alyson R. Pierick, Sonal T. Owens, Ray Lowery, Gabe E. Owens, Kenneth E. Mah , et al. · 2024

Methods to Enhance Causal Inference for Assessing Impact of Clinical Informatics Platform Implementation Open

Michael Gaies, Mary K. Olive, Gabe E. Owens, John R. Charpie, Wenying Zhang , et al. · 2023

Background: Hospitals are increasingly likely to implement clinical informatics tools to improve quality of care, necessitating rigorous approaches to evaluate effectiveness. We leveraged a multi-institutional data repository and applied c…

A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis Open

Bohua Zhang, Huaiyu Wu, Howuk Kim, Phoebe J. Welch, Ashley Cornett , et al. · 2023

This research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method designed for treating cerebral venous sinus thrombosis (CVST). This is a topic of substantial importance since current treatment modalitie…

A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis Open

Bohua Zhang, Huaiyu Wu, Howuk Kim, Phoebe J. Welch, Ashley Cornett , et al. · 2022

This research aims to demonstrate a novel vortex ultrasound enabled endovascular thrombolysis method designed for treating cerebral venous sinus thrombosis (CVST). This is a topic of significant importance since current treatment modalitie…

Preventing Cardiac Arrest in the Pediatric Cardiac Intensive Care Unit Through Multicenter Collaboration Open

Jeffrey A. Alten, David S. Cooper, Darren Klugman, Tia T. Raymond, Sharyl Wooton , et al. · 2022

Importance Preventing in-hospital cardiac arrest (IHCA) likely represents an effective strategy to improve outcomes for critically ill patients, but feasibility of IHCA prevention remains unclear. Objective To determine whether a low-techn…

In Vivo Porcine Aged Deep Vein Thrombosis Model for Testing Ultrasound-based Thrombolysis Techniques Open

Greyson Stocker, Jiaqi Shi, Kimberly Ives, Adam D. Maxwell, Paul A. Dayton , et al. · 2021

Twenty-four-hour normothermic perfusion of isolated ex vivo hearts using plasma exchange Open

Lise Tchouta, Daniel H. Drake, Mark J. Hoenerhoff, Álvaro Rojas-Peña, Jonathan W. Haft , et al. · 2020

Predicting and Surviving Prolonged Critical Illness After Congenital Heart Surgery Open

Aaron DeWitt, Joseph W. Rossano, David K. Bailly, Priya Bhat, Nikhil K. Chanani , et al. · 2020

Objectives: Prolonged critical illness after congenital heart surgery disproportionately harms patients and the healthcare system, yet much remains unknown. We aimed to define prolonged critical illness, delineate between nonmodifiable and…

Three-dimensional US Fractional Moving Blood Volume: Validation of Renal Perfusion Quantification Open

Alec Welsh, J. Brian Fowlkes, S. Pintér, Kimberly Ives, Gabe E. Owens , et al. · 2019

Background Three-dimensional (3D) fractional moving blood volume (FMBV) derived from 3D power Doppler US has been proposed for noninvasive approximation of perfusion. However, 3D FMBV has never been applied in animals against a ground trut…

Functional Status Change Among Children With Extracorporeal Membrane Oxygenation to Support Cardiopulmonary Resuscitation in a Pediatric Cardiac ICU: A Single Institution Report* Open

Asaad Beshish, Mathew R. Baginski, Thomas J. Johnson, Barry K. Deatrick, Ryan P. Barbaro , et al. · 2018

Objectives: The purpose of this study is to describe the functional status of survivors from extracorporeal cardiopulmonary resuscitation instituted during in-hospital cardiac arrest using the Functional Status Scale. We aimed to determine…

Current monitoring and innovative predictive modeling to improve care in the pediatric cardiac intensive care unit Open

Mary K. Olive, Gabe E. Owens · 2018

The objectives of this review are (I) to describe the challenges associated with monitoring patients in the pediatric cardiac intensive care unit (PCICU) and (II) to discuss the use of innovative statistical and artificial intelligence (AI…

Extracorporeal Life Support as a Rescue Measure for Managing Life-Threatening Arrythmia and Brugada Syndrome Open

Asaad Beshish, Allison Weinberg, Waseem Ostwani, Gabe E. Owens · 2017

We describe the use of extracorporeal cardiopulmonary resuscitation (E-CPR) to transiently stabilize a 3-month-old patient who presented with ventricular tachyarrhythmias leading to spontaneous cardiac arrest. The patient required 4 days o…

Multiple ultrasound cavitation-enabled treatments for myocardial reduction Open

Douglas L. Miller, Xiaofang Lu, Chunyan Dou, Yiying Zhu, Mario L. Fabiilli , et al. · 2017

Non-Invasive Thrombolysis Using Microtripsy in a Porcine Deep Vein Thrombosis Model Open

Xi Zhang, Jonathan J. Macoskey, Kimberly Ives, Gabe E. Owens, Hitinder S. Gurm , et al. · 2017

Normothermic Ex Vivo Heart Perfusion: Effects of Live Animal Blood and Plasma Cross Circulation Open

Joseph T. Church, Fares Alghanem, Kristopher B. Deatrick, John M. Trahanas, Joseph Phillips , et al. · 2017

Prolonged normothermic ex vivo heart perfusion could transform cardiac transplantation. To help identify perfusate components that might enable long-term perfusion, we evaluated the effects of cross-circulated whole blood and cross-circula…

Achieving 12 Hour Normothermic Ex Situ Heart Perfusion: An Experience of 40 Porcine Hearts Open

John M. Trahanas, Lucas Witer, Fares Alghanem, Benjamin S. Bryner, Amit Iyengar , et al. · 2016

Although total body perfusion with extracorporeal life support (ECLS) can be maintained for weeks, individual organ perfusion beyond 12 hours has yet to be achieved clinically. Normothermic ex situ heart perfusion (ESHP) offers the potenti…

Histotripsy Thrombolysis on Retracted Clots Open

Xi Zhang, Gabe E. Owens, Charles A. Cain, Hitinder S. Gurm, Jonathan J. Macoskey , et al. · 2016

Maturation of Lesions Induced by Myocardial Cavitation-Enabled Therapy Open

Xiaofang Lu, Douglas L. Miller, Chunyan Dou, Yiying Zhu, Mario L. Fabiilli , et al. · 2016

Thrombolytic-Enhanced Extracorporeal Cardiopulmonary Resuscitation After Prolonged Cardiac Arrest Open

Elena Spinelli, Ryan P. Davis, Xiaodan Ren, Parth Sheth, Trevor R. Tooley , et al. · 2015

In a porcine model of prolonged cardiac arrest, t-ECPR improved cardiac resuscitability and reduced brain edema, without increasing bleeding complications. However, early electroencephalogram recovery and ischemic neuronal injury were not …

Use of Theranostic Strategies in Myocardial Cavitation-Enabled Therapy Open

Douglas L. Miller, Chunyan Dou, Xiaofang Lu, Yiying Zhu, Mario L. Fabiilli , et al. · 2015

Perceptions of 24/7 In-house Attending Coverage on Fellow Education and Autonomy in a Pediatric Cardiothoracic Intensive Care Unit Open

Sonal T. Owens, Gabe E. Owens, Shaili Rajput, John R. Charpie, Kelley M. Kidwell , et al. · 2015

Our prospective study, showing initial concerns about limiting the learning environment in transitioning to 24/7 in-house attending coverage did not result in diminished perceptions of the educational experience for our fellows but reveale…

2090472 Predictive Value of Left Ventricular Microbubble Echogenicity for Treatment Outcome During Myocardial Cavitation-Enabled Therapy Open

Douglas L. Miller, Chunyan Dou, Yiying Zhu, Xiaofang Lu, Gabe E. Owens , et al. · 2015

Real-Time Feedback of Histotripsy Thrombolysis Using Bubble-Induced Color Doppler Open

Xi Zhang, Ryan M. Miller, Kuang-Wei Lin, Albert M. Levin, Gabe E. Owens , et al. · 2015

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