Gabin Drouard
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View article: Genetic Contributions to BMI Fluctuation and Its Associations With BMI and Its Trajectories Over Adolescence and Early Adulthood: A 25-Year Follow-Up Longitudinal Study of Finnish Twins
Genetic Contributions to BMI Fluctuation and Its Associations With BMI and Its Trajectories Over Adolescence and Early Adulthood: A 25-Year Follow-Up Longitudinal Study of Finnish Twins Open
We examined how BMI, BMI trajectories, and BMI fluctuation around these trajectories in adolescence were correlated with BMI trajectories and BMI fluctuation in early adulthood, as well as the genetic basis of these associations. BMI data …
View article: Genetic predisposition to high BMI and changes in BMI during adolescence modulate associations between adult BMI and plasma molecules involved in glucose metabolism
Genetic predisposition to high BMI and changes in BMI during adolescence modulate associations between adult BMI and plasma molecules involved in glucose metabolism Open
Introduction Glucose metabolism and related blood molecules are strongly associated with adult body mass index (BMI). However, it is unclear whether the magnitude of these associations differs in people whose BMI increased rapidly during a…
View article: Data-Driven Leisure-Time Physical Activity Trajectories of Over 46 Years and Their Associations with Cognition in Nonagenarians – A Cohort Study
Data-Driven Leisure-Time Physical Activity Trajectories of Over 46 Years and Their Associations with Cognition in Nonagenarians – A Cohort Study Open
Based on short follow-up studies, greater leisure-time physical activity (LTPA) has been associated with better cognition in old age, but more longitudinal studies are needed. Our aim was to identify long-term LTPA trajectories from midlif…
View article: Predicting Alzheimer’s Disease Phenotypes With Aging Clocks: An Exploratory Analysis
Predicting Alzheimer’s Disease Phenotypes With Aging Clocks: An Exploratory Analysis Open
Background The continuous aging of the world’s population urges the improvement of early diagnosis of age-related diseases, such as Alzheimer’s disease (AD). Blood proteomes can detect systemic and organ-specific disease-related changes an…
View article: Genetic contributions to BMI fluctuation and its associations with BMI and its trajectories over adolescence and early adulthood: a 25-year follow-up longitudinal study of Finnish twins.
Genetic contributions to BMI fluctuation and its associations with BMI and its trajectories over adolescence and early adulthood: a 25-year follow-up longitudinal study of Finnish twins. Open
Objective: We examined how BMI, BMI trajectories, and BMI fluctuation around these trajectories in adolescence were correlated with BMI trajectories and BMI fluctuation in early adulthood, as well as the genetic basis of these associations…
View article: A proteomic signature of healthspan
A proteomic signature of healthspan Open
The focus of aging research has shifted from increasing lifespan to enhancing healthspan to reduce the time spent living with disability. Despite significant efforts to develop biomarkers of aging, few studies have focused on biomarkers of…
View article: Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol‐Related Sociomedical Conditions
Protein Associations With Alcohol Consumption and Genetic Risk for Alcohol‐Related Sociomedical Conditions Open
Studies investigating proteomic associations with alcohol consumption and the genetic links of these proteins to alcohol‐related traits are scarce. The aims of our study were (1) to identify proteins associated with alcohol consumption and…
View article: Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts
Genetic and environmental effects on weight gain from young adulthood to old age and its association with body mass index at early young adulthood: an individual-based pooled analysis of 16 twin cohorts Open
Introduction Genetic factors contribute to weight gain, but how these effects change over adulthood is still unknown. We studied the impact of genetics on BMI change from young adulthood to old age and its relationship with BMI in early yo…
View article: Biological aging acceleration in major depressive disorder: a multi-omics, multi-modal analyses
Biological aging acceleration in major depressive disorder: a multi-omics, multi-modal analyses Open
View article: Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability
Twin Study Provides Heritability Estimates for 2321 Plasma Proteins and Assesses Missing SNP Heritability Open
Assessing how much variability in blood plasma proteins is due to genetic or environmental factors is essential for advancing personalized medicine. While large-scale studies have established SNP-based heritability (SNP-h2) esti…
View article: Mediterranean diet and obesity polygenic risk interaction on adiposity in European children: The <scp>IDEFICS</scp>/I.Family Study
Mediterranean diet and obesity polygenic risk interaction on adiposity in European children: The <span>IDEFICS</span>/I.Family Study Open
Summary Background and Objectives To examine whether changes in the Mediterranean Diet (MD) or any of its MD food groups modulate the genetic susceptibility to obesity in European youth, both in cross‐sectional and longitudinal analyses. M…
View article: Proteomic associations with fluctuation and long‐term changes in <scp>BMI</scp> : A 40‐year follow‐up study
Proteomic associations with fluctuation and long‐term changes in <span>BMI</span> : A 40‐year follow‐up study Open
Introduction While some studies have explored associations between weight change and blood proteins, most have been intervention‐based, offering limited insight into proteomic associations with long‐term weight gain. It remains unclear whe…
View article: Multi‐Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences
Multi‐Omic Associations of Epigenetic Age Acceleration Are Heterogeneously Shaped by Genetic and Environmental Influences Open
Connections between the multi‐ome and epigenetic age acceleration (EAA), and especially whether these are influenced by genetic or environmental factors, remain underexplored. We therefore quantified associations between the multi‐ome comp…
View article: Protein associations and protein–metabolite interactions with depressive symptoms and the p-factor
Protein associations and protein–metabolite interactions with depressive symptoms and the p-factor Open
Despite increasing mental health problems among young people, few studies have examined associations between plasma proteins and mental health. Interactions between proteins and metabolites in association with mental health problems remain…
View article: Trajectories of genetic risk across dimensions of alcohol use behaviors
Trajectories of genetic risk across dimensions of alcohol use behaviors Open
Background Alcohol use behaviors (AUBs) manifest in a variety of normative and problematic ways across the life course, all of which are heritable. Twin studies show that genetic influences on AUBs change across development, but this is us…
View article: Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study
Proteomic associations with fluctuation and long-term changes in BMI: A 40-year follow-up study Open
Introduction While some studies have explored associations between weight change and blood proteins, most have been intervention-based, offering limited insight into proteomic associations with long-term weight gain. It remains unclear whe…
View article: Associations between the mid-adolescent external exposome and proteomic biomarkers of mental health
Associations between the mid-adolescent external exposome and proteomic biomarkers of mental health Open
The exposome, encompassing all external and internal environmental factors, provides a comprehensive understanding of the complex etiology of mental health. This study investigated the relationship between the external exposome during mid-…
View article: Transcriptomic and Metabolomic Analyses in Monozygotic and Dizygotic Twins
Transcriptomic and Metabolomic Analyses in Monozygotic and Dizygotic Twins Open
Monozygotic (MZ) and dizygotic (DZ) twins are studied to understand genetic and environmental influences on complex traits, however the mechanisms behind twinning are not completely understood. (Epi)genomic studies identified SNPs associat…
View article: Genetic contributions to body mass index over adolescence and its associations with adult weight gain: a 25-year follow-up study of Finnish twins
Genetic contributions to body mass index over adolescence and its associations with adult weight gain: a 25-year follow-up study of Finnish twins Open
View article: Aldolase B and Angiotensinogen are associated with weekly chronic multisite spinal pain in men
Aldolase B and Angiotensinogen are associated with weekly chronic multisite spinal pain in men Open
Spinal pain problems increase with age, but already 21% of Finnish young adults suffer from a musculoskeletal disorder. Chronic widespread pain (CWP) significantly increases one’s disability level and up to 50% of people experiencing chron…
View article: Protein associations and protein–metabolite interactions with depressive symptoms and the p-factor
Protein associations and protein–metabolite interactions with depressive symptoms and the p-factor Open
Despite increasing mental health problems among young people, few studies have examined associations between plasma proteins and mental health, and interactions between proteins and metabolites in association with mental health problems re…
View article: Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles
Lifestyle differences between co-twins are associated with decreased similarity in their internal and external exposome profiles Open
View article: Relationships between the external exposome and proteome linked to mental health risk in adolescents
Relationships between the external exposome and proteome linked to mental health risk in adolescents Open
View article: Multi-omic associations of epigenetic age acceleration are heterogeneously shaped by genetic and environmental influences
Multi-omic associations of epigenetic age acceleration are heterogeneously shaped by genetic and environmental influences Open
Connections between the multi-ome and epigenetic age acceleration (EAA), and especially whether these are influenced by genetic or environmental factors, remain underexplored. We therefore quantified associations between the multi-ome comp…
View article: Transcriptomic and Metabolomic analyses in Monozygotic and Dizygotic twins
Transcriptomic and Metabolomic analyses in Monozygotic and Dizygotic twins Open
Monozygotic (MZ) and dizygotic (DZ) twins are studied to understand genetic and environmental influences on complex traits, however the mechanisms behind twinning are not completely understood. (Epi)genomic studies identified SNPs associat…
View article: Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data
Exploring machine learning strategies for predicting cardiovascular disease risk factors from multi-omic data Open
Background Machine learning (ML) classifiers are increasingly used for predicting cardiovascular disease (CVD) and related risk factors using omics data, although these outcomes often exhibit categorical nature and class imbalances. Howeve…
View article: Association between trajectories of the neighborhood social exposome and mental health in late adolescence: A FinnTwin12 cohort study
Association between trajectories of the neighborhood social exposome and mental health in late adolescence: A FinnTwin12 cohort study Open
Trajectories of the social neighborhood exposome modestly influenced late adolescent mental health. Tackling root causes of social inequalities through targeted programs for living conditions could improve adolescent mental health.
View article: Twin study provides heritability estimates for 2,321 plasma proteins and assesses missing SNP heritability
Twin study provides heritability estimates for 2,321 plasma proteins and assesses missing SNP heritability Open
Assessing how much of the variability in blood plasma proteins is due to genetic or environmental factors is essential for advancing personalized medicine. While large-scale studies have established SNP-based heritability (SNP-h 2 ) estima…
View article: Effect of Mediterranean Diet Adherence and Its Interaction with Genetic Susceptibility to Obesity on Adiposity in European Children: The IDEFICS/I.Family Study
Effect of Mediterranean Diet Adherence and Its Interaction with Genetic Susceptibility to Obesity on Adiposity in European Children: The IDEFICS/I.Family Study Open
The Mediterranean Diet (MD) has been associated with a better adiposity\nprofile in different cohorts of European children. However, these beneficial effects might be influenced\nby genetic variations, which could potentially modulate the …
View article: Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins
Longitudinal multi-omics study reveals common etiology underlying association between plasma proteome and BMI trajectories in adolescent and young adult twins Open
Background The influence of genetics and environment on the association of the plasma proteome with body mass index (BMI) and changes in BMI remains underexplored, and the links to other omics in these associations remain to be investigate…