Gabor C. Petzold
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View article: Cognitive performance in patients with ischemic stroke and additional myocardial injury – results from the multicenter prospective observational PRAISE study
Cognitive performance in patients with ischemic stroke and additional myocardial injury – results from the multicenter prospective observational PRAISE study Open
View article: Region-specific drivers of CSF mobility measured with MRI in humans
Region-specific drivers of CSF mobility measured with MRI in humans Open
Many neurological diseases are characterized by the accumulation of toxic proteins in the brain. This accumulation has been associated with improper clearance from the parenchyma. Recent discoveries highlighted perivascular spaces, which a…
View article: Mortality within three months after nonfatal ischemic stroke treated by mechanical thrombectomy in routine care—data from the German Stroke Registry
Mortality within three months after nonfatal ischemic stroke treated by mechanical thrombectomy in routine care—data from the German Stroke Registry Open
Background Mechanical thrombectomy (MT) is a highly effective treatment for large vessel occlusion (LVO) ischemic stroke. However, a substantial share of patients have lethal outcome within 3 months. Individualization of outcome prognostic…
View article: Correction: Validity of the test for attentional performance in neurological post-COVID condition
Correction: Validity of the test for attentional performance in neurological post-COVID condition Open
View article: Anxiety in Myasthenia Gravis Patients Throughout the COVID‐19 Pandemic–Prevalence, Risk Factors, and Association With Vaccination Status
Anxiety in Myasthenia Gravis Patients Throughout the COVID‐19 Pandemic–Prevalence, Risk Factors, and Association With Vaccination Status Open
Introduction A high prevalence of COVID‐19‐related anxiety was observed among the general population during the COVID‐19 pandemic. Patients with myasthenia gravis (MG) might be at higher risk for COVID‐19‐related anxiety due to immunosuppr…
View article: Brain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy
Brain Atrophy Does Not Predict Clinical Progression in Progressive Supranuclear Palsy Open
Background Clinical progression rate is the typical primary endpoint measure in progressive supranuclear palsy (PSP) clinical trials. Objectives This longitudinal multicohort study investigated whether baseline clinical severity and region…
View article: Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study
Risk factors for dementia and cognitive impairment within 5 years after stroke: a prospective multicentre cohort study Open
View article: Circulating cytokine levels and 5-year vascular recurrence after stroke: A multicenter prospective cohort study
Circulating cytokine levels and 5-year vascular recurrence after stroke: A multicenter prospective cohort study Open
Background and objectives: Anti-inflammatory therapies are tested in randomized trials for secondary stroke prevention. Detecting inflammatory biomarkers that predict vascular recurrence could optimize patient selection for these trials. M…
View article: Associations between digital speech features of automated cognitive tasks and trajectories of brain atrophy and cognitive decline in early Alzheimer's disease
Associations between digital speech features of automated cognitive tasks and trajectories of brain atrophy and cognitive decline in early Alzheimer's disease Open
Background Speech-based features extracted from telephone-based cognitive tasks show promise for detecting cognitive decline in prodromal and manifest dementia. Little is known about the cerebral underpinnings of these speech features. Obj…
View article: Validity of the test for attentional performance in neurological post-COVID condition
Validity of the test for attentional performance in neurological post-COVID condition Open
View article: Intravenous thrombolysis before percutaneous coronary intervention in patients with non-ST-elevation acute coronary syndrome and acute ischaemic stroke: a subanalysis of the PRAISE study
Intravenous thrombolysis before percutaneous coronary intervention in patients with non-ST-elevation acute coronary syndrome and acute ischaemic stroke: a subanalysis of the PRAISE study Open
Background In patients with acute ischaemic stroke (AIS) and concomitant non-ST-elevation acute coronary syndrome (NSTE-ACS), the role of intravenous thrombolysis (IVT) before percutaneous coronary intervention (PCI) is unclear. Methods We…
View article: Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the <scp>Central Nervous System</scp> —A Multicenter Cohort Study in 163 Patients
Disease Characteristics and Treatments Associated with Outcome in Primary Angiitis of the <span>Central Nervous System</span> —A Multicenter Cohort Study in 163 Patients Open
Objective The aim was to determine patient, disease, and treatment characteristics associated with outcome in patients with primary angiitis of the central nervous system (PACNS) in a large multicenter German cohort. Methods In a retrospec…
View article: Portable ultra-low-field MRI in acute stroke care: A pilot study
Portable ultra-low-field MRI in acute stroke care: A pilot study Open
Introduction: Neuroimaging is a prerequisite for treatment of stroke patients, but it is not available all over the globe. Portable ultra-low field (pULF) MRI has the potential to improve access to neuroimaging and thus stroke care worldwi…
View article: Patterns and predictors of delayed functional independence and dependence after thrombectomy in large vessel occlusion stroke: A multicenter analysis
Patterns and predictors of delayed functional independence and dependence after thrombectomy in large vessel occlusion stroke: A multicenter analysis Open
Introduction: Predicting functional outcomes following endovascular treatment (EVT) for large-vessel occlusion stroke (LVOS) is challenging. Some patients achieve functional independence (modified Rankin Scale (mRS) 0 -2) at 90 days despit…
View article: Frailty’s influence on older stroke patients: Neurological outcome and mortality after endovascular treatment in stroke: A national German stroke registry analysis
Frailty’s influence on older stroke patients: Neurological outcome and mortality after endovascular treatment in stroke: A national German stroke registry analysis Open
Introduction: Frailty is a clinical syndrome particular in old patients with an increased risk of adverse health-care events. In geriatric stroke patients who received endovascular treatment, monocentric analyses have demonstrated that fra…
View article: <scp>Mini social cognition</scp> and <scp>emotional assessment</scp> : <scp>Diagnostic performance</scp> and <scp>neural correlates</scp> in behavioural‐variant <scp>frontotemporal dementia</scp>
<span>Mini social cognition</span> and <span>emotional assessment</span> : <span>Diagnostic performance</span> and <span>neural correlates</span> in behavioural‐variant <span>frontotemporal dementia</span> Open
We aimed at validating the Mini Social Cognition and Emotional Assessment (Mini‐SEA) in a German cohort of mildly impaired behavioural‐variant frontotemporal dementia (bvFTD) patients and healthy controls. The Mini‐SEA comprises the Facial…
View article: Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution
Three-photon in vivo imaging of neurons and glia in the medial prefrontal cortex with sub-cellular resolution Open
View article: Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins
Application of IVDr NMR spectroscopy to stratify Parkinson’s disease with absolute quantitation of blood serum metabolites and lipoproteins Open
The challenge of early detection and stratification in Parkinson’s disease (PD) is urgent due to the current emergence of mechanism-based disease-modifying treatments. In here, metabolomic and lipidomic parameters obtained by a standardize…
View article: Alternative splicing generates a Ribosomal Protein S24 isoform induced by neuroinflammation and neurodegeneration
Alternative splicing generates a Ribosomal Protein S24 isoform induced by neuroinflammation and neurodegeneration Open
Neuroinflammation, particularly that involving reactive microglia, the brain’s resident immune cells, is implicated in the pathogenesis of major neurodegenerative diseases. However, early markers of this process are in high demand. Multipl…
View article: General Anesthesia Versus Conscious Sedation in Thrombectomy Patients With Low NIHSS Anterior Circulation Stroke
General Anesthesia Versus Conscious Sedation in Thrombectomy Patients With Low NIHSS Anterior Circulation Stroke Open
BACKGROUND: The optimal anesthetic approach for patients with acute ischemic stroke with large vessel occlusion but low National Institutes of Health Stroke Scale receiving mechanical thrombectomy remains unclear. We aimed to evaluate the …
View article: Aetiology of Acute Respiratory Insufficiency in Patients With Ischaemic Stroke Studied by Chest <scp>CT</scp> Scan
Aetiology of Acute Respiratory Insufficiency in Patients With Ischaemic Stroke Studied by Chest <span>CT</span> Scan Open
Background Acute respiratory insufficiency (ARI) is considered a serious life‐threatening complication after ischaemic stroke. The aim of this study was to identify the most common aetiologies of ARI after stroke and their association with…
View article: Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence?
Time trends in mechanical thrombectomy (2017–2021): do real-world data reflect advances in evidence? Open
Background In recent years, we have witnessed a continuous, evidence-based expansion of indications for endovascular therapy (EVT) in the treatment of ischaemic stroke, driven by advancements in extended time windows and target vessel occl…
View article: A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy
A Short Cognitive and Neuropsychiatric Assessment Scale for Progressive Supranuclear Palsy Open
Background Patients with Progressive Supranuclear Palsy (PSP) suffer from several neuropsychological impairments. These mainly affect the frontal lobe and subcortical brain structures. However, a scale for the assessment of cognitive and n…
View article: Increase of nitrous oxide-induced neurological disorders – a German multicenter experience
Increase of nitrous oxide-induced neurological disorders – a German multicenter experience Open
Background Nitrous oxide (N₂O), commonly known as laughing gas, is widely recognized for its anesthetic and analgesic effects, and is frequently used in medical contexts. However, its misuse can lead to significant neurological complicatio…
View article: Excessive Supraventricular Ectopic Activity in Patients With Acute Ischemic Stroke Is Associated With Atrial Fibrillation Detection Within 24 Months After Stroke: A Predefined Analysis of the MonDAFIS Study
Excessive Supraventricular Ectopic Activity in Patients With Acute Ischemic Stroke Is Associated With Atrial Fibrillation Detection Within 24 Months After Stroke: A Predefined Analysis of the MonDAFIS Study Open
Background Excessive supraventricular ectopic activity (ESVEA) is regarded as a risk marker for later atrial fibrillation (AF) detection. Methods and Results The investigator‐initiated, prospective, open, multicenter MonDAFIS (Impact of St…
View article: Prospective Multicenter Evaluation of the <scp>MDS</scp> “Suggestive of <scp>PSP</scp>” Diagnostic Criteria
Prospective Multicenter Evaluation of the <span>MDS</span> “Suggestive of <span>PSP</span>” Diagnostic Criteria Open
Background The recent Movement Disorders Society (MDS)‐progressive supranuclear palsy (PSP) diagnostic criteria conceptualized three clinical diagnostic certainty levels: “suggestive of PSP” for sensitive early diagnosis based on subtle cl…
View article: Neuroinflammation in Alzheimer disease
Neuroinflammation in Alzheimer disease Open
Increasing evidence points to a pivotal role of immune processes in the pathogenesis of Alzheimer disease, which is the most prevalent neurodegenerative and dementia-causing disease of our time. Multiple lines of information provided by ex…
View article: Serum anti-NMDA receptor antibodies are linked to memory impairment 12 months after stroke
Serum anti-NMDA receptor antibodies are linked to memory impairment 12 months after stroke Open
View article: Region specific drivers of cerebrospinal fluid mobility as measured by high-resolution non-invasive MRI in humans
Region specific drivers of cerebrospinal fluid mobility as measured by high-resolution non-invasive MRI in humans Open
Highlights CSF-mobility can be measured in humans down to the level of perivascular spaces surrounding penetrating vessels using CSF-STREAM In perivascular spaces surrounding penetrating vessels, the cardiac and respiratory cycles have sim…
View article: Risk factors and clinical significance of post‐stroke incident ischemic lesions
Risk factors and clinical significance of post‐stroke incident ischemic lesions Open
INTRODUCTION While incident ischemic lesions (IILs) are not unusual on follow‐up magnetic resonance imaging (MRI) following stroke, their risk factors and prognostic significance remain unknown. METHODS In a prospective multicenter study o…