Gábor Wittmann
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View article: Variable transduction of thyroid hormone signaling in structures of the mouse brain
Variable transduction of thyroid hormone signaling in structures of the mouse brain Open
L-thyroxine (L-T4) monotherapy is the standard treatment for hypothyroidism, administered daily to normalize TSH levels. Once absorbed, T4 is converted to T3 to alleviate most symptoms. However, this treatment abnormally elevates plasma T4…
View article: Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus
Estrogen-Regulated Lateral Septal Kisspeptin Neurons Abundantly Project to GnRH Neurons and the Hypothalamic Supramammillary Nucleus Open
While hypothalamic kisspeptin (KP) neurons play well-established roles in the estrogen-dependent regulation of reproduction, little is known about extrahypothalamic KP-producing (KP LS ) neurons of the lateral septum. As established previo…
View article: The Musashi-1–type 2 deiodinase pathway regulates astrocyte proliferation
The Musashi-1–type 2 deiodinase pathway regulates astrocyte proliferation Open
Thyroid hormone (TH) is a critical regulator of cellular function and cell fate. The circulating TH level is relatively stable, while tissue TH action fluctuates according to cell type-specific mechanisms. Here, we focused on identifying m…
View article: Estrogen-dependent development and transcriptome regulation of the lateral septal kisspeptin system
Estrogen-dependent development and transcriptome regulation of the lateral septal kisspeptin system Open
While hypothalamic kisspeptin (KP) neurons play well-established roles in puberty and reproduction, kisspeptin neurons in the lateral septum (KP LS neurons) and other extrahypothalamic sites have received less attention. We found that the …
View article: Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice
Different Hypothalamic Mechanisms Control Decreased Circulating Thyroid Hormone Levels in Infection and Fasting-Induced Non-Thyroidal Illness Syndrome in Male Thyroid Hormone Action Indicator Mice Open
Background: Non-Thyroidal Illness Syndrome (NTIS) caused by infection or fasting is hallmarked by reduced circulating thyroid hormone (TH) levels. To better understand the role of local TH-action in the development of NTIS, we assessed tis…
View article: Origin of thyrotropin-releasing hormone neurons that innervate the tuberomammillary nuclei
Origin of thyrotropin-releasing hormone neurons that innervate the tuberomammillary nuclei Open
Hypophysiotropic thyrotropin-releasing hormone (TRH) neurons function as metabolic sensors that regulate the thyroid axis and energy homeostasis. Less is known about the role of other hypothalamic TRH neurons. As central administration of …
View article: Origin of thyrotropin-releasing hormone neurons that innervate the tuberomamillary nuclei
Origin of thyrotropin-releasing hormone neurons that innervate the tuberomamillary nuclei Open
Hypophysiotropic TRH neurons function as metabolic sensors that regulate the thyroid axis and energy homeostasis. Less is known about the role of other hypothalamic TRH neurons. As central administration of TRH decreases food intake and in…
View article: Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency
Adult-born proopiomelanocortin neurons derived from Rax-expressing precursors mitigate the metabolic effects of congenital hypothalamic proopiomelanocortin deficiency Open
These data demonstrate that Rax+ progenitors generate POMC neurons in sufficient numbers during adulthood to mitigate the metabolic abnormalities of hypothalamic POMC-deficient mice. The findings suggest that adult hypothalamic neurogenesi…
View article: <i>Rax</i> Expression Identifies a Novel Cell Type in the Adult Mouse Hypothalamus
<i>Rax</i> Expression Identifies a Novel Cell Type in the Adult Mouse Hypothalamus Open
Hypothalamic tanycytes are radial glia-like ependymal cells lining the ventrolateral walls and floor of the third ventricle. Recent data show that tanycytes are adult neural stem/progenitor cells, capable of generating neurons that populat…
View article: Cover Image, Volume 528, Issue 11
Cover Image, Volume 528, Issue 11 Open
The cover image is based on the Original Article Distributions of hypothalamic neuron populations coexpressing tyrosine hydroxylase and the vesicular GABA transporter in the mouse by Melissa J. Chee, Gabor Wittmann, Mikayla Payant et al., …
View article: SAT-605 Characterization of Dual Projection Patterns of Refeeding-Activated Neurons in the Parasubthalamic Nucleus
SAT-605 Characterization of Dual Projection Patterns of Refeeding-Activated Neurons in the Parasubthalamic Nucleus Open
We have observed that following a fast, animals terminate their food intake within 2h after refeeding accompanied by a pattern of neuronal activation as identified by c-fos immunostaining that involves a number of brain regions associated …
View article: OR16-03 Metabolic Effects Of Hypothalamic Pomc Neurons Generated Postnatally From Tanycytes On A Pomc Null Genetic Background
OR16-03 Metabolic Effects Of Hypothalamic Pomc Neurons Generated Postnatally From Tanycytes On A Pomc Null Genetic Background Open
Hypothalamic proopiomelanocortin (POMC) neurons are an integral part of the central melanocortin system and regulate feeding and energy balance in vertebrates. Tanycytes are radial glial-like cells lining the third ventricle that contain a…
View article: Distributions of hypothalamic neuron populations coexpressing tyrosine hydroxylase and the vesicular GABA transporter in the mouse
Distributions of hypothalamic neuron populations coexpressing tyrosine hydroxylase and the vesicular GABA transporter in the mouse Open
The hypothalamus contains catecholaminergic neurons marked by the expression of tyrosine hydroxylase (TH). As multiple chemical messengers coexist in each neuron, we determined if hypothalamic TH‐immunoreactive (ir) neurons express vesicul…
View article: Distributions of hypothalamic neuron populations co-expressing tyrosine hydroxylase and the vesicular GABA transporter in the mouse
Distributions of hypothalamic neuron populations co-expressing tyrosine hydroxylase and the vesicular GABA transporter in the mouse Open
The hypothalamus contains catecholaminergic neurons marked by the expression of tyrosine hydroxylase (TH). As multiple chemical messengers coexist in each neuron, we determined if hypothalamic TH-immunoreactive (ir) neurons express glutama…
View article: SUN-471 Corresponding Primary Transcript and mRNA Levels for Pomc and Prss56 Suggest Oscillating Transcriptions in Adult Rat Tanycytes
SUN-471 Corresponding Primary Transcript and mRNA Levels for Pomc and Prss56 Suggest Oscillating Transcriptions in Adult Rat Tanycytes Open
We recently reported mRNA and protein expression patterns in adult rat hypothalamic tanycytes that suggest oscillatory gene expression, demonstrating highly variable pro-opiomelanocortin (Pomc) mRNA and protein expression in these cells wi…
View article: Selective Restoration of<i>Pomc</i>Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network
Selective Restoration of<i>Pomc</i>Expression in Glutamatergic POMC Neurons: Evidence for a Dynamic Hypothalamic Neurotransmitter Network Open
Hypothalamic POMC deficiency leads to obesity and metabolic deficiencies, largely due to the loss of melanocortin peptides. However, POMC neurons in the arcuate nucleus (ARC) are comprised of glutamatergic and GABAergic subpopulations. The…
View article: YY1 Upregulates Checkpoint Receptors and Downregulates Type I Cytokines in Exhausted, Chronically Stimulated Human T Cells
YY1 Upregulates Checkpoint Receptors and Downregulates Type I Cytokines in Exhausted, Chronically Stimulated Human T Cells Open
T cells infiltrate affected organs in chronic infections and malignancy, but they may fail to eradicate virus-infected cells or tumor because of exhaustion. This report describes a Yin Yang-1 (YY1)-centered mechanism for diverse components…
View article: Variable proopiomelanocortin expression in tanycytes of the adult rat hypothalamus and pituitary stalk
Variable proopiomelanocortin expression in tanycytes of the adult rat hypothalamus and pituitary stalk Open
It is generally believed that proopiomelanocortin (POMC) is expressed exclusively by neurons in the adult rodent brain. Unbeknownst to most researchers, however, Pomc in situ hybridization studies in the rat show specific labeling in the v…