Explanipedia

Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function Open

B. Jenkins, Yasmin R Jenkins, Fernando M. Ponce-Garcia, Chloe Moscrop, Iain Perry , et al. · 2025

Conserved lipid metabolic reprogramming confers hypoxic and aging resilience Open

Wei I. Jiang, Gonçalo Vale, Quentinn Pearce, Kyoung Ae Kong, Wenbin Zhou , et al. · 2025

The Arctic ground squirrel (AGS, Urocitellus parryii ), an extreme hibernator, exhibits remarkable resilience to stressors like hypoxia and hypothermia, making it an ideal model for studying cellular metabolic adaptation. The underlying me…

Publisher Correction: ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27 Open

Yong Wang, Yanan Wang, Lei Bao, Gonçalo Vale, Jeffrey G. McDonald , et al. · 2025

Molecular insights into human phosphatidylserine synthase 2 and its regulation of SREBP pathways Open

Dongyu Li, Hongwen Chen, Gonçalo Vale, Nadia Elghobashi‐Meinhardt, Aurélie Hatton , et al. · 2025

Homologous proteins share similar sequences, enabling them to work together in cells to support normal physiological functions. Phosphatidylserine synthases 1 and 2 (PSS1 and PSS2) are homologous enzymes that catalyze the synthesis of phos…

ZMYND8 drives HER2 antibody resistance in breast cancer via lipid control of IL-27 Open

Yong Wang, Yanan Wang, Lei Bao, Gonçalo Vale, Jeffrey G. McDonald , et al. · 2025

Anti-HER2 antibodies are effective but often lead to resistance in patients with HER2+ breast cancer. Here, we report an epigenetic crosstalk with aberrant glycerophospholipid metabolism and inflammation as a key resistance mechanism of an…

ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity Open

Benjamin Jenkins, Yasmin R Jenkins, Fernando M. Ponce-Garcia, Chloe Moscrop, I PERRY , et al. · 2025

Chronic inflammation in autoimmunity is driven by T cell hyperactivation. This unregulated response to self is fuelled by heightened metabolic programmes, which offers a promising new direction to uncover novel treatment strategies. α/β-hy…

CLSTN3B promotes lipid droplet maturation and lipid storage in mouse adipocytes Open

Chuanhai Zhang, Mengchen Ye, Kamran Melikov, Dengbao Yang, Gonçalo Vale , et al. · 2024

Interaction between the gut microbiota and colonic enteroendocrine cells regulates host metabolism Open

Shuai Tan, Jacobo L. Santolaya, Tiffany Freeney Wright, Qi Liu, Teppei Fujikawa , et al. · 2024

LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in C. elegans Open

Taruna Pandey, Bingying Wang, Changnan Wang, Jenny Zu, Huichao Deng , et al. · 2024

Insulin-mechanistic target of rapamycin (mTOR) signaling drives anabolic growth during organismal development; its late-life dysregulation contributes to aging and limits lifespans. Age-related regulatory mechanisms and functional conseque…

DGAT2 inhibition blocks SREBP-1 cleavage and improves hepatic steatosis by increasing phosphatidylethanolamine in the ER Open

Shunxing Rong, Mingfeng Xia, Gonçalo Vale, Simeng Wang, Chai-Wan Kim , et al. · 2024

Paraoxonase-like APMAP maintains endoplasmic reticulum-associated lipid and lipoprotein homeostasis Open

Blessy Paul, Holly Merta, Rupali Ugrankar, Monica R. Hensley, Son Tran , et al. · 2024

Summary Oxidative stress perturbs lipid homeostasis and contributes to metabolic diseases. Though ignored compared to mitochondrial oxidation, the endoplasmic reticulum (ER) generates reactive oxygen species requiring antioxidant quality c…

CLSTN3B enhances adipocyte lipid droplet structure and function via endoplasmic reticulum contact Open

Chuanhai Zhang, Mengchen Ye, Kamran Melikov, Dengbao Yang, Gonçalo Vale , et al. · 2024

Interorganelle contacts facilitate material exchanges and sustain the structural and functional integrity of organelles. Lipid droplets (LDs) of adipocytes are responsible for energy storage and mobilization responding to body needs. LD bi…

Paraoxonase-Like APMAP Maintains Endoplasmic Reticulum-Associated Lipid and Lipoprotein Homeostasis Open

Blessy Paul, Holly Merta, Rupali Ugrankar, Monica R. Hensley, Son Tran , et al. · 2024

CLSTN3B Enhances Adipocyte Lipid Droplet Structure and Function via Endoplasmic Reticulum Contact Open

Chuanhai Zhang, Mengchen Ye, Kamran Melikov, Dengbao Yang, Gonçalo Vale , et al. · 2024

Adipose-specific overexpression of human AGPAT2 in mice causes increased adiposity and mild hepatic dysfunction Open

Anil K. Agarwal, Katie Tunison, Gonçalo Vale, Jeffrey G. McDonald, Xilong Li , et al. · 2023

AGPAT2, a critical enzyme involved in the biosynthesis of phospholipids and triacylglycerol (TAG), is highly expressed in adipose tissue (AT). Whether overexpression of AGPAT2 in AT will result in increased TAG synthesis (obesity) and its …

Regulated adipose tissue-specific expression of human AGPAT2 in lipodystrophic Agpat2-null mice results in regeneration of adipose tissue Open

Anil K. Agarwal, Katie Tunison, Gonçalo Vale, Jeffrey G. McDonald, Xilong Li , et al. · 2023

Genetic loss of Agpat2 in humans and mice results in congenital generalized lipodystrophy with near-total loss of adipose tissue and predisposition to develop insulin resistance, diabetes mellitus, hepatic steatosis, and hypertrigly…

An enteroendocrine-microbial axis in the large intestine controls host metabolism Open

Ezra Burstein, Shuai Tan, Jacobo L. Santolaya, Tiffany Wright, Qi Liu , et al. · 2023

Nutrient handling is an essential function of the gastrointestinal tract. Most nutrient absorption occurs in the small intestine and is coordinated by hormone-producing intestinal epithelial cells known as enteroendocrine cells (EECs). In …

Limiting mitochondrial plasticity by targeting DRP1 induces metabolic reprogramming and reduces breast cancer brain metastases Open

Pravat Kumar Parida, Mauricio Marquez-Palencia, Suvranil Ghosh, Nitin Khandelwal, Kangsan Kim , et al. · 2023

LPD-3 as a megaprotein brake for aging and insulin-mTOR signaling in<i>C. elegans</i> Open

Taruna Pandey, Bingying Wang, Changnan Wang, Jenny Zu, Huichao Deng , et al. · 2023

Insulin-mTOR signaling drives anabolic growth during organismal development, while its late-life dysregulation may detrimentally contribute to aging and limit lifespans. Age-related regulatory mechanisms and functional consequences of insu…

Repeated trans-arterial treatments of LDL-DHA nanoparticles induce multiple pathways of tumor cell death in hepatocellular carcinoma bearing rats Open

Yuzhu Wang, Junjie Li, Gonçalo Vale, Jaideep Chaudhary, Arnida Anwar , et al. · 2022

Introduction Repeated hepatic arterial delivery of therapeutic agents to the liver by percutaneously implanted port-catheter systems has been widely used to treat unresectable liver cancer. This approach is applied to assess the therapeuti…

A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience Open

Changnan Wang, Bingying Wang, Taruna Pandey, Yong Long, Jianxiu Zhang , et al. · 2022

Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through conserved homeostatic mechanisms. Here we report an exceptionally large and evolutionarily conserved protein LPD-3 in C. elegans that media…

A megaprotein-based molecular bridge critical for lipid trafficking and cold resilience Open

Changnan Wang, Bingying Wang, Taruna Pandey, Yong Long, Jianxiu Zhang , et al. · 2022

Cells adapt to cold by increasing levels of unsaturated phospholipids and membrane fluidity through homeostatic mechanisms conserved in nearly all forms of life. As most eukaryotic enzymes for lipid synthesis and desaturation localize on e…

Author Correction: Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer Open

Caterina Bartolacci, Cristina Andreani, Gonçalo Vale, Stefano Berto, Margherita Melegari , et al. · 2022

Targeting de novo lipogenesis and the Lands cycle induces ferroptosis in KRAS-mutant lung cancer Open

Caterina Bartolacci, Cristina Andreani, Gonçalo Vale, Stefano Berto, Margherita Melegari , et al. · 2022

FAF1 blocks ferroptosis by inhibiting peroxidation of polyunsaturated fatty acids Open

Shaojie Cui, Glenn Simmons, Gonçalo Vale, Yaqin Deng, Jungyeon Kim , et al. · 2022

Significance The current study reveals the functions of FAF1 in protecting cells from ferroptosis, a novel cell death pathway triggered by PUFA peroxidation. In the absence of FAF1, cultured cells and mice are extremely sensitive to ferrop…

CLSTN3B enhances lipid droplet function via endoplasmic reticulum contacts Open

Xing Zeng, Chuanhai Zhang, Gonçalo Vale, Kaitlyn M. Eckert, J. Ken McDonald , et al. · 2022

Inter-organellar contact sites facilitate material exchanges between membrane-bound intracellular compartments and sustain the structural and functional integrity of organelles1-3. The endoplasmic reticulum (ER)-lipid droplet (LD) contact …

Interplay between Asters/GRAMD1s and phosphatidylserine in intermembrane transport of LDL cholesterol Open

Michael N. Trinh, Michael S. Brown, Joachim Seemann, Gonçalo Vale, Jeffrey G. McDonald , et al. · 2022

Significance Cholesterol constitutes 50% of lipids in the plasma membrane (PM) of animal cells. Sensors in the endoplasmic reticulum (ER) maintain this level by adjusting cholesterol uptake, synthesis, and storage. Uptake is mediated by LD…

Contents Open

Maria Eugenia Guicciardi, Gregory J. Gores, Albert Meyer, Matthew S. Brown, Patrick J. McGrath , et al. · 2022

Transcriptional Integration of Distinct Microbial and Nutritional Signals by the Small Intestinal Epithelium Open

Colin R. Lickwar, James M. Davison, Cecelia Kelly, Gilberto Padilla Mercado, Jia Wen , et al. · 2022

Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and Rats Open

Fei Luo, Ēriks Šmagris, Sarah A. Martin, Gonçalo Vale, Jeffrey G. McDonald , et al. · 2021

Gonçalo Vale YOU? Author Swipe