Explanipedia

Metabolism-weighted brain connectome reveals synaptic integration and vulnerability to neurodegeneration Open

Mahnaz Ashrafi, Laura Fraticelli, Gabriel Castrillón, Valentin Riedl · 2025

The brain’s capacity for integration arises from both its structural wiring and energetically demanding electrochemical signaling. Yet current connectome analyses treat network nodes as functionally homogeneous, ignoring that neural commun…

The control costs of human brain dynamics Open

Eric G. Ceballos, Andrea I. Luppi, Gabriel Castrillón, Manish Saggar, Bratislav Mišić , et al. · 2024

The human brain is a complex system with high metabolic demands and extensive connectivity that requires control to balance energy consumption and functional efficiency over time. How this control is manifested on a whole-brain scale is la…

Simultaneous quantification of oxygen and glucose consumption during visual stimulation in the human cortex Open

Antonia Bose, Samira Epp, Roman Belenya, Katarzyna Kurcyus, Eric G. Ceballos , et al. · 2024

The brain relies on oxidized glucose as its primary fuel. Despite robust coupling of cerebral oxygen and glucose consumption during rest, the oxygen to glucose index (OGI) has been suggested to drop significantly during neuronal activation…

The control costs of human brain dynamics Open

Eric G Ceballos, Andrea I. Luppi, Gabriel Castrillón, Manish Saggar, Bratislav Mišić , et al. · 2024

The human brain is a complex system with high metabolic demands and extensive connectivity that requires control to balance energy consumption and functional efficiency over time. How this control is manifested on a whole-brain scale is la…

An energy costly architecture of neuromodulators for human brain evolution and cognition Open

Gabriel Castrillón, Samira Epp, Antonia Bose, Laura Fraticelli, André Hechler , et al. · 2023

In comparison to other species, the human brain exhibits one of the highest energy demands relative to body metabolism. It remains unclear whether this heightened energy demand uniformly supports an enlarged brain or if specific signaling …

BOLD signal changes can oppose oxygen metabolism across the human cortex Open

Samira Epp, Gabriel Castrillón, Baohua Yuan, Jessica R. Andrews-Hanna, Christine Preibisch , et al. · 2023

Functional MRI measures brain activity by monitoring changes in blood oxygen levels, known as the blood-oxygen-level-dependent (BOLD) signal, rather than measuring neuronal activity directly. This approach crucially relies on neurovascular…

Decreased functional integration in higher‐order association areas in individuals with autosomal‐dominant Alzheimer’s disease: Findings from the Colombia‐Boston (COLBOS) biomarker study Open

Gabriel Castrillón, Catalina Bustamante, Edmarie Guzmán‐Vélez, Stephanie Langella, Paula Aduen , et al. · 2023

Background The disruption of brain functional connections has been linked to cognitive impairment in Alzheimer’s disease. The functional architecture of the brain can be modeled using graph theory, which provides metrics to describe both l…

An energy costly architecture of neuromodulators for human brain evolution and cognition Open

Gabriel Castrillón, Samira Epp, Antonia Bose, Laura Fraticelli, André Hechler , et al. · 2023

Humans spend more energy on the brain than any other species. However, the high energy demand cannot be fully explained by brain size scaling alone. We hypothesized that energy-demanding signaling strategies may have contributed to human c…

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates Open

Jae Hoon Sul, Susan K. Service, Alden Huang, Vasily Ramensky, S S Hwang , et al. · 2020

The physiological effects of noninvasive brain stimulation fundamentally differ across the human cortex Open

Gabriel Castrillón, Nico Sollmann, Katarzyna Kurcyus, Adeel Razi, Sandro M. Krieg , et al. · 2020

Signaling pathways along the human cortex shape the effect of noninvasive brain stimulation.

Rostral Middle Frontal Volumetric Differences in Bipolar Offspring versus Community Controls Offspring Open

Juan David Palacio, María Alejandra Gómez-Valero, Paula Andrea Bustamante-Gómez, Pilar Arroyave-Sierra, Cristian Vargas-Upegui , et al. · 2019

Neuroanatomical findings in the anterior limbic network in bipolar disorder (BD) adults have not been replicated in other populations such as bipolar offspring (BO). The aim of this study was to compare some brain areas volumes between BO …

The physiological effects of non-invasive brain stimulation fundamentally differ across the human cortex Open

Gabriel Castrillón, Nico Sollmann, Katarzyna Kurcyus, Adeel Razi, Sandro M. Krieg , et al. · 2019

Non-invasive brain stimulation reliably modulates brain activity and symptoms of neuropsychiatric disorders. However, stimulation effects substantially vary across individuals and brain regions. We combined transcranial magnetic stimulatio…

Intra- and inter-network effects of navigated transcranial magnetic stimulation using low- and high-frequency pulse application to the dorsolateral prefrontal cortex – a combined rTMS-fMRI approach Open

Nico Sollmann, Haichao Zhang, Gabriel Castrillón, Katarzyna Kurcyus, Bernhard Meyer , et al. · 2019

Understanding the Hidden Complexity of Latin American Population Isolates Open

Jazlyn A. Mooney, Christian D. Huber, Susan K. Service, Jae Hoon Sul, Clare D. Marsden , et al. · 2018

Contribution of common and rare variants to bipolar disorder susceptibility in extended pedigrees from population isolates Open

Jae Hoon Sul, Susan K. Service, Alden Huang, Vasily Ramensky, Sun‐Goo Hwang , et al. · 2018

Current evidence from case/control studies indicates that genetic risk for psychiatric disorders derives primarily from numerous common variants, each with a small phenotypic impact. The literature describing apparent segregation of bipola…

Subjective memory complaints in preclinical autosomal dominant Alzheimer disease Open

Daniel Norton, Rebecca E. Amariglio, Hillary Protas, Kewei Chen, Daniel Camilo Aguirre‐Acevedo , et al. · 2017

Cognitively unimpaired PSEN-1 carriers have elevated SMC. Self-reported SMC may be a relatively early indicator of preclinical AD, while partner- reported SMC increases later in preclinical AD, closer to clinical onset.

[P1–434]: RELATIONSHIPS BETWEEN MEMORY FUNCTION, TAU PATHOLOGY AND FUNCTIONAL CONNECTIVITY IN THE DEFAULT MODE NETWORK IN AUTOSOMAL‐DOMINANT ALZHEIMER's DISEASE: A PRELIMINARY REPORT Open

Edmarie Guzmán‐Vélez, Gabriel Castrillón, Kewei Chen, Daniel Norton, Ana Baena , et al. · 2017

Disruption of the default-mode network (DMN) has been associated with memory dysfunction and beta-amyloid deposition in preclinical Alzheimer's disease (AD). However, the role of tau accumulation in the integrity of the DMN in AD is not we…

Increased hippocampal, thalamus and amygdala volume in long‐term lithium‐treated bipolar I disorder patients compared with unmedicated patients and healthy subjects Open

Carlos López‐Jaramillo, Cristian Vargas, Ana M. Díaz‐Zuluaga, Juan David Palacio, Gabriel Castrillón , et al. · 2017

Objective Magnetic resonance imaging ( MRI ) studies in bipolar I disorder ( BD ‐I) suggest that lithium is associated with increased volumes of cortico‐limbic structures. However, more rigorous control of confounding factors is needed to …

Metabolic connectivity mapping reveals effective connectivity in the resting human brain Open

Valentin Riedl, Lukas Utz, Gabriel Castrillón, Timo Grimmer, Josef P. Rauschecker , et al. · 2015

Significance Noninvasive brain imaging of humans identifies prominent networks related to sensory and cognitive functions in the resting state; however, the signaling hierarchy and directionality among these networks remain largely unknown…

Genetic contributions to circadian activity rhythm and sleep pattern phenotypes in pedigrees segregating for severe bipolar disorder Open

Lucia Pagani, Patricia A. St. Clair, Terri Teshiba, Susan K. Service, Scott C. Fears , et al. · 2015

Significance Characterizing the abnormalities in sleep and activity that are associated with bipolar disorder (BP) and identifying their causation are key milestones in unraveling the biological underpinnings of this severe and highly prev…

Evaluation of Multiband EPI Acquisitions for Resting State fMRI Open

Christine Preibisch, Gabriel Castrillón, Martin Bührer, Valentin Riedl · 2015

Functional magnetic resonance imaging (fMRI) and particularly resting state fMRI (rs-fMRI) is widely used to investigate resting state brain networks (RSNs) on the systems level. Echo planar imaging (EPI) is the state-of-the-art imaging te…

Successful Scene Encoding in Presymptomatic Early-Onset Alzheimer’s Disease Open

Yakeel T. Quiroz, Kim Willment, Gabriel Castrillón, Martha C. Muniz, Francisco Lopera , et al. · 2015

Hyperactivation in medial temporal lobe regions during scene encoding is seen in individuals genetically-determined to develop AD years before their clinical onset. Our findings will guide future research with the ultimate goal of using fu…

P3‐104: Associations between subjective memory complaints and hippocampal volume in preclinical early‐onset Alzheimer's disease Open

Yakeel T. Quiroz, Rebecca E. Amariglio, Daniel Camilo Aguirre‐Acevedo, Sandra M. Opoka, Brendan Pulsifer , et al. · 2015

There is increasing evidence that subjective memory complaints (SMC) may be one of the earliest clinical signs of preclinical Alzheimer's disease (AD) in late-onset AD. Understanding the relevance of SMC in early-onset AD is relatively und…

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