Gabriel Hancu
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View article: Distinctive mineral and physicochemical parameters assessment of carob honey (Mallorca Island) from Spanish honeys exploiting dimensionality reduction tools and cluster analysis
Distinctive mineral and physicochemical parameters assessment of carob honey (Mallorca Island) from Spanish honeys exploiting dimensionality reduction tools and cluster analysis Open
This study applied dimensionality reduction tools, including Uniform Manifold Approximation and Projection (UMAP) and Principal Component Analysis (PCA), and cluster analysis to explore and classify the physicochemical parameters and miner…
View article: Exploring the interconnected properties of cannabidiol suspensions and orodispersible films
Exploring the interconnected properties of cannabidiol suspensions and orodispersible films Open
In this study, orodispersible films (ODFs) were developed as fast-releasing formulations for pediatric patients suffering from Lennox-Gastaut or Dravet syndrome, with cannabidiol (CBD) selected as the active pharmaceutical ingredient (API)…
View article: Recent Preclinical Evidence on Phytocannabinoids in Neurodegenerative Disorders: A Focus on Parkinson’s and Alzheimer’s Disease
Recent Preclinical Evidence on Phytocannabinoids in Neurodegenerative Disorders: A Focus on Parkinson’s and Alzheimer’s Disease Open
The endocannabinoid system (ECS) is a vital biological network essential for maintaining homeostasis and supporting various physiological functions. It comprises cannabinoid receptors, endogenous lipid-based ligands, known as endocannabino…
View article: Chitosan-Based Gel Development: Extraction, Gelation Mechanisms, and Biomedical Applications
Chitosan-Based Gel Development: Extraction, Gelation Mechanisms, and Biomedical Applications Open
Chitosan (CS), a versatile biopolymer obtained through the deacetylation of chitin, has gained significant interest in biomedical and pharmaceutical applications due to its biocompatibility, biodegradability, and unique gel-forming capabil…
View article: Current Understanding of Microneedling Procedures for Acne Skin: A Narrative Review
Current Understanding of Microneedling Procedures for Acne Skin: A Narrative Review Open
Acne vulgaris, the most prevalent skin disorder among teenagers and young adults, is often perceived as a moderate skin condition; however, it imposes a substantial economic and psychological burden on individuals and society. Microneedlin…
View article: Analyzing the Chiral Purity of Pharmaceuticals: The Application of Cyclodextrin-Based Chiral Selectors in Capillary Electrophoresis
Analyzing the Chiral Purity of Pharmaceuticals: The Application of Cyclodextrin-Based Chiral Selectors in Capillary Electrophoresis Open
The current review provides a focused analysis of the application of capillary electrophoresis (CE) techniques to determine the chiral purity of pharmaceuticals, with a specific emphasis on cyclodextrin- (CD) based chiral selectors (CSs), …
View article: Chirality in Modern Antidepressants: A Comprehensive Review of Stereochemical Impacts on Pharmacology and Therapeutics
Chirality in Modern Antidepressants: A Comprehensive Review of Stereochemical Impacts on Pharmacology and Therapeutics Open
The review explores the critical role of chirality in the pharmacology of antidepressant drugs, focusing on how the stereochemistry of these compounds influences their biological activity and therapeutic outcomes. Antidepressants, especial…
View article: Determination of caffeine by micellar electrokinetic chromatography in different beverages
Determination of caffeine by micellar electrokinetic chromatography in different beverages Open
A fast, simple and cost-effective capillary electrophoresis (CE) method was developed for caffeine determination in different beverages (energy drinks, soft drinks). Because caffeine is neutral from electrophoretic point of view and migrat…
View article: Applications of Capillary Electrophoresis for the Detection of Adulterants in Dietary Supplements
Applications of Capillary Electrophoresis for the Detection of Adulterants in Dietary Supplements Open
In recent years, the consumption of dietary supplements, particularly those incorporating plant-based ingredients, has increased greatly, driven by the perception of their natural origins and purported minimal health risks. However, one si…
View article: Analytical quality by design-based development of a capillary electrophoresis method for Omeprazole impurity profiling
Analytical quality by design-based development of a capillary electrophoresis method for Omeprazole impurity profiling Open
Omeprazole (OME) is a proton pump inhibitor used to treat gastroesophageal reflux disease associated conditions. The current study presents an Analytical Quality by Design-based approach for the development of a CE method for OME impurity …
View article: Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use
Phytocannabinoids: Exploring Pharmacological Profiles and Their Impact on Therapeutical Use Open
Phytocannabinoids, a diverse group of naturally occurring compounds extracted from the Cannabis plant, have attracted interest due to their potential pharmacological effects and medicinal uses. This comprehensive review presents the intric…
View article: Comprehensive Review on Chiral Stationary Phases in Single-Column Simultaneous Chiral–Achiral HPLC Separation Methods
Comprehensive Review on Chiral Stationary Phases in Single-Column Simultaneous Chiral–Achiral HPLC Separation Methods Open
This comprehensive review explores the utilization of chiral stationary phases (CSPs) in the context of single-column simultaneous chiral–achiral high-performance liquid chromatography (HPLC) separation methods. While CSPs have traditional…
View article: Chiral Separation of Vildagliptin by Capillary Electrophoresis—The Study of Enantiomeric Complexation
Chiral Separation of Vildagliptin by Capillary Electrophoresis—The Study of Enantiomeric Complexation Open
Vildagliptin (VIL) is a dipeptidyl peptidase-4 inhibitor used in the treatment of type 2 diabetes mellitus; in therapy, it is available as the enantiomerically pure S-VIL, the other enantiomer R-VIL being considered as an enantiomeric impu…
View article: Psychotherapy, pharmacotherapy, and their combination in the treatment of major depressive disorder: How well are we making use of available therapies?
Psychotherapy, pharmacotherapy, and their combination in the treatment of major depressive disorder: How well are we making use of available therapies? Open
Major depressive disorder stands as a profound challenge in the realm of psychiatric illnesses disrupting the well-being and daily existence of affected individuals. This heterogeneous condition continues to baffle researchers due to the e…
View article: Quality by design‐guided development of a capillary electrophoresis method for the simultaneous chiral purity determination and impurity profiling of tamsulosin
Quality by design‐guided development of a capillary electrophoresis method for the simultaneous chiral purity determination and impurity profiling of tamsulosin Open
Analytical Quality by Design principles using the design of experiments were applied for the development of a capillary electrophoresis method for the determination of enantiomeric purity and chemically related impurities of tamsulosin. Fr…
View article: The Role of Five-Membered Heterocycles in the Molecular Structure of Antibacterial Drugs Used in Therapy
The Role of Five-Membered Heterocycles in the Molecular Structure of Antibacterial Drugs Used in Therapy Open
Five-membered heterocycles are essential structural components in various antibacterial drugs; the physicochemical properties of a five-membered heterocycle can play a crucial role in determining the biological activity of an antibacterial…
View article: A Comprehensive Bibliographic Review Concerning the Efficacy of Organic Acids for Chemical Peels Treating Acne Vulgaris
A Comprehensive Bibliographic Review Concerning the Efficacy of Organic Acids for Chemical Peels Treating Acne Vulgaris Open
Acne vulgaris stands out as the most prevalent skin disorder among teenagers and young adults, causing physical discomfort and considerable economic and psychological burdens on individuals and society. A wide range of topical and systemic…
View article: Applications of Capillary Electrophoresis for the Determination of Cannabinoids in Different Matrices
Applications of Capillary Electrophoresis for the Determination of Cannabinoids in Different Matrices Open
Cannabinoids, terpenophenolic chemicals found only in cannabis, are primarily responsible for cannabis pharmacologic effects; nearly 150 distinct cannabinoids have been identified thus far. Among these, the main psychoactive molecule, tetr…
View article: New Trends in the Quality Control of Enantiomeric Drugs: Quality by Design-Compliant Development of Chiral Capillary Electrophoresis Methods
New Trends in the Quality Control of Enantiomeric Drugs: Quality by Design-Compliant Development of Chiral Capillary Electrophoresis Methods Open
Capillary electrophoresis (CE) is a potent method for analyzing chiral substances and is commonly used in the enantioseparation and chiral purity control of pharmaceuticals from different matrices. The adoption of Quality by Design (QbD) c…
View article: Chiral Discrimination of Mexiletine Enantiomers by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors and Experimental Design Method Optimization
Chiral Discrimination of Mexiletine Enantiomers by Capillary Electrophoresis Using Cyclodextrins as Chiral Selectors and Experimental Design Method Optimization Open
Mexiletine (MXL) is a class IB antiarrhythmic agent, acting as a non-selective voltage-gated sodium channel blocker, used in therapy as a racemic mixture R,S-MXL hydrochloride. The aim of the current study was the development of a new, fas…
View article: Development and Evaluation of Cannabidiol Orodispersible Tablets Using a 23-Factorial Design
Development and Evaluation of Cannabidiol Orodispersible Tablets Using a 23-Factorial Design Open
Orodispersible tablets (ODTs) are pharmaceutical formulations used to obtain fast therapeutic effects, usually recommended for geriatric and pediatric patients due to their improved compliance, bioavailability, ease of administration, and …
View article: The Use of Antibiotics as Chiral Selectors in Capillary Electrophoresis: A Review
The Use of Antibiotics as Chiral Selectors in Capillary Electrophoresis: A Review Open
Chirality is becoming an essential issue in modern pharmaceutical research as regulatory agencies emphasize the safety and efficiency of enantiomers in drug development. The development of efficient and reliable chiral separation methods b…
View article: Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode
Determination of Chiral Impurity of Naproxen in Different Pharmaceutical Formulations Using Polysaccharide-Based Stationary Phases in Reversed-Phased Mode Open
A novel, validated, reversed-phase (RP), chiral high performance liquid chromatography (HPLC) method was developed for the enantiopurity control analysis of naproxen, a frequently used non-steroidal anti-inflammatory agent using polysaccha…
View article: Chiral Switch: Between Therapeutical Benefit and Marketing Strategy
Chiral Switch: Between Therapeutical Benefit and Marketing Strategy Open
Chirality of pharmaceutical substances is an important aspect in drug research because it determines how enantiomers will interact with chiral biological targets. Enantiomers of a chiral drug can have different pharmacokinetic and pharmaco…
View article: Simultaneous determination of atorvastatin and ezetimibe from combined pharmaceutical products by micellar electrokinetic capillary chromatography
Simultaneous determination of atorvastatin and ezetimibe from combined pharmaceutical products by micellar electrokinetic capillary chromatography Open
A rapid and sensitive micellar electrokinetic capillary chromatography method with UV photodiode-array detection was developed for the simultaneous determination of atorvastatin and ezetimibe in fixed dose drug combination. Experimental co…
View article: Presence of pesticide residues in cannabis products
Presence of pesticide residues in cannabis products Open
The literature addressing the cannabis use for medical purposes provides scientific evidence that both cannabis and cannabinoids have potential therapeutic effects. The Cannabis plant has gained substantial attention in recent years due to…
View article: Simultaneous determination of amoxicillin and clavulanic acid in pharmaceutical preparations by capillary zone electrophoresis
Simultaneous determination of amoxicillin and clavulanic acid in pharmaceutical preparations by capillary zone electrophoresis Open
Clavulanic acid enhances the antibacterial spectrum of amoxicillin by rendering most β-lactamase producing isolates susceptible to the drug. A fast, simple and efficient capillary electrophoresis method was developed for the simultaneous d…
View article: Development of a Chiral Capillary Electrophoresis Method for the Enantioseparation of Verapamil Using Cyclodextrins as Chiral Selectors and Experimental Design Optimization
Development of a Chiral Capillary Electrophoresis Method for the Enantioseparation of Verapamil Using Cyclodextrins as Chiral Selectors and Experimental Design Optimization Open
Chirality is a property of asymmetry which determines the pharmacokinetic and pharmacological profiles of optically active pharmaceuticals. Verapamil (VER), a calcium channel blocker phenylalkylamine derivative used in the treatment of car…
View article: Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation
Structural Characterization of the Millennial Antibacterial (Fluoro)Quinolones—Shaping the Fifth Generation Open
The evolution of the class of antibacterial quinolones includes the introduction in therapy of highly successful compounds. Although many representatives were withdrawn due to severe adverse reactions, a few representatives have proven the…
View article: Application of Experimental Design Methodologies in the Enantioseparation of Pharmaceuticals by Capillary Electrophoresis: A Review
Application of Experimental Design Methodologies in the Enantioseparation of Pharmaceuticals by Capillary Electrophoresis: A Review Open
Chirality is one of the major issues in pharmaceutical research and industry. Capillary electrophoresis (CE) is an interesting alternative to the more frequently used chromatographic techniques in the enantioseparation of pharmaceuticals, …