Gabriel Hilario
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View article: NanoSSIEFARL polymeric nanoparticles-based immunotherapeutic for the treatment of genital herpes
NanoSSIEFARL polymeric nanoparticles-based immunotherapeutic for the treatment of genital herpes Open
This study aimed to investigate the therapeutic potential of a nanoparticle formulation containing the immunodominant peptide SSIEFARL from Herpes simplex virus 2 glycoprotein B A against genital herpes. A nanoparticle formulation (NanoSSI…
View article: Aedes aegypti salivary extracts exert immunomodulatory effects onmacrophages, dendritic cells, and T lymphocytes and increase Zikavirus production in vitro.
Aedes aegypti salivary extracts exert immunomodulatory effects onmacrophages, dendritic cells, and T lymphocytes and increase Zikavirus production in vitro. Open
Background This study delves into the complex interplay between Aedes aegypti salivary gland extract and immunological cells during Zika virus (ZIKV) infection. Focusing on key immune cells, including macrophages, dendritic cells, and mono…
View article: INTERFACES ENTRE SAÚDE E EDUCAÇÃO
INTERFACES ENTRE SAÚDE E EDUCAÇÃO Open
Estima-se que 56 milhões de crianças com menos de cinco anos venham a morrer entre 2018 e 2030, 80% dessas mortes devendo ocorrer no sul da Ásia e na África subsaariana. Desses 56 milhões de crianças, 28 milhões serão recém-nascidos (UNIGM…
View article: Production and Analysis of Babassu Oil Nanoparticles Containing an Immunogenic Peptide of Herpes Simplex Virus for Genital Mucosa Application 1
Production and Analysis of Babassu Oil Nanoparticles Containing an Immunogenic Peptide of Herpes Simplex Virus for Genital Mucosa Application 1 Open
View article: SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies
SARS-CoV-2 infected children form early immune memory responses dominated by nucleocapsid-specific CD8+ T cells and antibodies Open
This is the third year of the SARS-CoV-2 pandemic, and yet most children remain unvaccinated. COVID-19 in children manifests as mostly mild or asymptomatic, however high viral titers and strong cellular and humoral responses are observed u…
View article: Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses
Pediatric COVID-19 patients in South Brazil show abundant viral mRNA and strong specific anti-viral responses Open
COVID-19 manifests as a milder disease in children than adults, but the underlying mechanisms are not fully characterized. Here we assess the difference in cellular or humoral immune responses of pediatric and adult COVID-19 patients to se…
View article: RvD1 treatment during primary infection modulates memory response increasing viral load during respiratory viral reinfection
RvD1 treatment during primary infection modulates memory response increasing viral load during respiratory viral reinfection Open
Resolvin D1 (RvD1), which is biosynthesized from essential long-chain fatty acids, is involved in anti-inflammatory activity and modulation of T cell response. Memory CD8+ T cells are important for controlling tumor growth and viral infect…
View article: Strong specific anti-viral responses in pediatric COVID-19 patients in South Brazil
Strong specific anti-viral responses in pediatric COVID-19 patients in South Brazil Open
Epidemiological evidence that COVID-19 manifests as a milder disease in children compared to adults has been reported by numerous studies, but the mechanisms underlying this phenomenon have not been characterized. It is still unclear how f…
View article: Strong anti-viral responses in pediatric COVID-19 patients in South Brazil
Strong anti-viral responses in pediatric COVID-19 patients in South Brazil Open
Epidemiological evidence that COVID-19 manifests as a milder disease in children compared to adults has been reported by numerous studies, but the mechanisms underlying this phenomenon have not been characterized. It is still unclear how f…
View article: Hsp <scp>BP</scp> 1 and anti‐Hsp <scp>BP</scp> 1 levels in the serum of <scp>HIV</scp> ‐infected individuals are associated to the disease progression
Hsp <span>BP</span> 1 and anti‐Hsp <span>BP</span> 1 levels in the serum of <span>HIV</span> ‐infected individuals are associated to the disease progression Open
The discovery that HspBp1 and anti-HspBp1 are associated with progression of HIV infection is new and corroborates to validate the quantification of these proteins as an additional strategy in the management of the HIV infection.