Gabriel Mbalaviele YOU? Author Swipe

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Activation of the noncanonical inflammasome-GSDMD pathway triggers pyroptosis in bone marrow and promotes periosteal bone formation Open

Wei Zou, Chun Wang, Yongjia Li, Wentong Jia, Steven L. Teitelbaum , et al. · 2025

Evidence indicating that inflammation is commonly associated with ectopic osteogenesis in certain autoimmune and infectious conditions challenges the dogma that inflammatory responses always suppress bone formation. In this study, we find …

Staphylococcus aureus inhibits the NLRP3 inflammasome in macrophages during the early phases of intracellular infection, but not the late phases Open

Saumya Bhagat, Khushpreet Kaur, Luke D O'Connor, Chun Wang, Yongjia Li , et al. · 2025

Staphylococcus aureus (S. aureus) is a highly virulent pathogen responsible for chronic infections such as osteomyelitis. Although its interaction with the host immune system has been widely studied, the specific role of inflammasomes in r…

NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype Open

Inés Muela‐Zarzuela, Juan M. Suárez-Rivero, Andrea Gallardo-Orihuela, Chun Wang, Kumi Izawa , et al. · 2024

Background Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as senescence-associated secretory phenotype (SASP), some of which are…

Editorial: Inflammasomes in human diseases and metabolism Open

Gabriel Mbalaviele, Bernhard Ryffel · 2024

Citation: Mbalaviele G and Ryffel B (2024) Editorial: Inflammasomes in human diseases and metabolism. Front. Immunol. 15:1420303. doi: 10.3389/fimmu.2024.1420303

Author response: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open

Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu‐Amer, Gabriel Mbalaviele · 2024

Author Response: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open

Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu‐Amer, Gabriel Mbalaviele · 2024

Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open

Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu‐Amer, Gabriel Mbalaviele · 2024

Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…

Author Response: Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open

Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu‐Amer, Gabriel Mbalaviele · 2024

Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open

Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu‐Amer, Gabriel Mbalaviele · 2024

Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open

Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu‐Amer, Gabriel Mbalaviele · 2024

Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss Open

Chun Wang, Khushpreet Kaur, Canxin Xu, Yousef Abu‐Amer, Gabriel Mbalaviele · 2023

Chemotherapy is a widely used treatment for a variety of solid and hematological malignancies. Despite its success in improving the survival rate of cancer patients, chemotherapy causes significant toxicity to multiple organs, including th…

Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss Open

Bhavna Murali, Qihao Ren, Xianmin Luo, Douglas V. Faget, Chun Wang , et al. · 2023

The role of the stromal compartment in tumor progression is best illustrated in breast cancer bone metastases, where the stromal compartment supports tumor growth, albeit through poorly defined mechanisms. p38MAPKα is frequently expressed …

Supplementary Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss Open

Bhavna Murali, Qihao Ren, Xianmin Luo, Douglas V. Faget, Chun Wang , et al. · 2023

Supplementary Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss

Supplementary Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss Open

Bhavna Murali, Qihao Ren, Xianmin Luo, Douglas V. Faget, Chun Wang , et al. · 2023

Supplementary Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss

Data from Inhibition of the Stromal p38MAPK/MK2 Pathway Limits Breast Cancer Metastases and Chemotherapy-Induced Bone Loss Open

Bhavna Murali, Qihao Ren, Xianmin Luo, Douglas V. Faget, Chun Wang , et al. · 2023

The role of the stromal compartment in tumor progression is best illustrated in breast cancer bone metastases, where the stromal compartment supports tumor growth, albeit through poorly defined mechanisms. p38MAPKα is frequently expressed …

Tmem178 negatively regulates IL-1β production through inhibition of the NLRP3 inflammasome Open

Kunjan Khanna, Hui Yan, Muneshwar Mehra, Nidhi Rohatgi, Gabriel Mbalaviele , et al. · 2023

Objective Inflammasomes modulate the release of bioactive IL-1β. Excessive IL-1β levels are detected in patients with systemic juvenile idiopathic arthritis (sJIA) and cytokine storm syndrome (CSS) with mutated and unmutated inflammasome c…

NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype Open

Inés Muela‐Zarzuela, Juan M. Suárez-Rivero, Andrea Gallardo-Orihuela, Wan Chun, Kumi Izawa , et al. · 2023

Senescence is a cellular aging-related process triggered by different stresses and characterized by the secretion of various inflammatory factors referred to as the senescence-associated secretory phenotype (SASP). Here, we present evidenc…

NEK7 activates the NLRP1 Inflammasome Open

Inés Muela‐Zarzuela, Andrea Gallardo-Orihuela, Almudena Pino‐Ángeles, Juan M. Suárez-Rivero, Daniel Boy‐Ruiz , et al. · 2022

Inflammasomes including those assembled by NLRP1 and NLRP3 regulate the innate immune system by inducing interleukin (IL)-1β and IL-18 maturation. Inflammasomes are functionally regulated by post-translational modifications such as phospho…

Author response: Glutamine metabolism modulates chondrocyte inflammatory response Open

Manoj Arra, Gaurav Swarnkar, Naga Suresh Adapala, Syeda Kanwal Naqvi, Lei Cai , et al. · 2022

Glutamine metabolism modulates chondrocyte inflammatory response Open

Manoj Arra, Gaurav Swarnkar, Naga Suresh Adapala, Syeda Kanwal Naqvi, Lei Cai , et al. · 2022

Osteoarthritis is the most common joint disease in the world with significant societal consequences, but lacks effective disease modifying interventions. The pathophysiology consists of a prominent inflammatory component that can be target…

IL-1β expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function Open

Sidan Li, Juo-Chin Yao, Karolyn A. Oetjen, Joseph R. Krambs, Jun Xia , et al. · 2022

Hematopoietic stem/progenitor cells (HSPCs) reside in localized microenvironments, or niches, in the bone marrow that provide key signals regulating their activity. A fundamental property of hematopoiesis is the ability to respond to envir…

Author response: Fracture healing is delayed in the absence of gasdermin-interleukin-1 signaling Open

Kai Sun, Chun Wang, Jianqiu Xiao, Michael D. Brodt, Luorongxin Yuan , et al. · 2022

Fracture healing is delayed in the absence of gasdermin signaling Open

Kai Sun, Chun Wang, Jianqiu Xiao, Michael D. Brodt, Luorongxin Yuan , et al. · 2021

Amino-terminal fragments from proteolytically cleaved gasdermins (GSDMs) form plasma membrane pores that enable the secretion of interleukin-1β (IL-1β) and IL-18. Excessive GSDM- mediated pore formation can compromise the integrity of the …

NLRP3 inflammasome activation triggers gasdermin D–independent inflammation Open

Chun Wang, Tong Yang, Jianqiu Xiao, Canxin Xu, Yael Alippe , et al. · 2021

Sustained stimulation of the NLRP3 inflammasome causes inflammation in the absence of GSDMD.

Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy Open

Chun Wang, Tong Yang, Jianqiu Xiao, Canxin Xu, Yael Alippe , et al. · 2021

The D301N NLRP3 mutation in mice (D303N in humans) causes severe multi-organ damage and early death driven by the constitutively activated NLRP3 (NLRP3 ca ) inflammasome. Triggered inflammasomes activate caspase-1 to process IL-1 family cy…

NF-κB-mediated effects on behavior and cartilage pathology in a non-invasive loading model of post-traumatic osteoarthritis Open

Ian M. Berke, Era Jain, Burçin Yavuz, Thomas McGrath, L. Chen , et al. · 2020

These findings underscore the development of behavioral changes in this non-invasive loading model of PTOA and their relationships to NF-κB activation and pathology. They also highlight the potential chondroprotective effects of NF-κB inhi…

Issue Information Open

Patricia Ducy, Julia Chairperson, Maureen Charles, Amel Devlin, Michael Dudakovic , et al. · 2020

fitness for a particular purpose, or non-

Inhibition of the NLRP3 inflammasome prevents ovarian aging Open

José M. Navarro‐Pando, Elísabet Alcocer‐Gómez, Beatriz Castejón‐Vega, Jordi Muntané, Pedro Bullón , et al. · 2020

Inflammation is a hallmark of many processes during aging and reproductive physiology, negatively affecting female fertility. The goal of this study was to evaluate the role of the NLRP3 inflammasome in ovarian aging and female fertility. …

Author response: Inflammatory osteolysis is regulated by site-specific ISGylation of the scaffold protein NEMO Open

Naga Suresh Adapala, Gaurav Swarnkar, Manoj Arra, Jie Shen, Gabriel Mbalaviele , et al. · 2020

Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Inflammatory osteolysis is go…

Issue Information Open

Teresita Bellido, B.L. Clarke, Suzanne De Beur, Juliet Compston, Johannes Van Leeuwen , et al. · 2020

loss or damage arising out of, or in connection with, the use of or inability to use the

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