Explanipedia

Hematological and biochemical profiles, infection and habitat quality in an urban rat population Open

Ticiana S. A. Carvalho‐Pereira, Gabriel Pedra, Daiana S. de Oliveira, Fábio N. Souza, Caio Graco Zeppelini , et al. · 2025

Host condition is key in understanding disease dynamics. In this study, we investigated the relationship between infection with Leptospira interrogans and helminths, and the hematological and hormone-biochemical stress-related profiles of …

Impact of CFTR Modulators on Longitudinal Cystic Fibrosis Survival and Mortality: Review and Secondary Analysis Open

Jaime Rubin, Craig J. McKinnon, Gabriel Pedra, Devon A. Morgan, Kevin Zweig , et al. · 2025

Hematological and biochemical profiles, infection and habitat quality in an urban rat population Open

Ticiana S. A. Carvalho‐Pereira, Gabriel Pedra, Daiana S. de Oliveira, Fábio Neves Souza, Caio Graco Zeppelini , et al. · 2024

Host condition is key in understanding disease dynamics. In an urban population of Rattus norvegicus, we aimed to assess whether infection of Leptospira interrogans and helminths was associated with patterns of host hematological and hormo…

Risk factors for fibrosis progression in non-alcoholic steatohepatitis: Analysis of the European cohort in the real-world GAIN study Open

Anum Shaikh, Gabriel Pedra, Leonardo Ruiz‐Casas, Bethany Franks, Harpal Dhillon , et al. · 2023

Disease duration, NASH severity and presence of other metabolic comorbidities could help to assess risk of progression in patients with NASH.

Evaluation of the impact of chemical control on the ecology of Rattus norvegicus of an urban community in Salvador, Brazil Open

Arsinoê Cristina Pertile, Ricardo Lustosa, Ticiana S. A. Carvalho‐Pereira, Gabriel Pedra, Jesús Alonso Panti–May , et al. · 2022

Background The presence of synanthropic rodents, such as Rattus norvegicus , in urban environments generates high costs of prophylaxis and control, in large part due to the environmental transmission of the pathogenic spirochete Leptospira…

Evaluation of the impact of chemical control on the ecology of Rattus norvegicus of an urban community in Salvador, Brazil Open

Arsinoê Cristina Pertile, Ricardo Lustosa, Ticiana S. A. Carvalho‐Pereira, Gabriel Pedra, Jesús Alonso Panti–May , et al. · 2022

dataset of rodent trapping in a pre/post-intervention scheme. Check publication of the same name for details on the study design. File contains complete comprehensive codebook.

Evaluation of the impact of chemical control on the ecology of Rattus norvegicus of an urban community in Salvador, Brazil Open

Arsinoê Cristina Pertile, Ricardo Lustosa, Ticiana S. A. Carvalho‐Pereira, Gabriel Pedra, Jesús Alonso Panti–May , et al. · 2022

dataset of rodent trapping in a pre/post-intervention scheme. Check publication of the same name for details on the study design. File contains complete comprehensive codebook.

Clinical and sociodemographic determinants of disease progression in patients with nonalcoholic steatohepatitis in the United States Open

Leonardo Ruiz‐Casas, Gabriel Pedra, Anum Shaikh, Bethany Franks, Harpal Dhillon , et al. · 2021

One fifth of patients with nonalcoholic fatty liver disease (NAFLD) may progress to nonalcoholic steatohepatitis (NASH), which can increase the risk of cirrhosis, cancer, and death. To date, reported predictors of NASH progression have bee…

Correction to: The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe Open

Leonardo Ruiz‐Casas, Jonathan Evans, Alison Rose, Gabriel Pedra, Alan Lobo , et al. · 2021

The LUCID study: living with ulcerative colitis; identifying the socioeconomic burden in Europe Open

Leonardo Ruiz‐Casas, Jonathan Evans, Alison Rose, Gabriel Pedra, Alan Lobo , et al. · 2021

Background Ulcerative colitis (UC) is an inflammatory bowel disease with increasing prevalence worldwide. Current treatment strategies place considerable economic and humanistic burdens on patients. The aim of this study was to determine t…

Clinical attributes and treatment characteristics are associated with work productivity and activity impairment in people with severe haemophilia A Open

Jamie O’Hara, Declan Noone, Mohit Jain, Gabriel Pedra, Sarah Landis , et al. · 2021

Introduction Few studies have examined the real‐world impact of haemophilia on daily activities and work productivity in people with severe haemophilia A (PWSHA). Aim To determine clinical attributes and treatment characteristics associate…

The LUCID Study: Living With Ulcerative Colitis; Identifying the Socioeconomic Burden in Europe Open

Leonardo Ruiz Casas, Jonathan Evans, Alison Rose, Gabriel Pedra, Alan Lobo , et al. · 2020

BackgroundUlcerative Colitis (UC) is an inflammatory bowel disease with increasing prevalence worldwide. Current treatment strategies place considerable economic and humanistic burdens on patients. The aim of this study was to determine th…

Fibrosis progression in NASH: real-world data from the US population Open

Gabriel Pedra, Leonardo Ruiz Casas, Harpal Dhillon, Jörn M. Schattenberg, Manuel Romero‐Gómez · 2020

Cost of non-alcoholic steatohepatitis in Europe and the USA: The GAIN study. Open

Jamie O’Hara, Alan Finnegan, Harpal Dhillon, Leonardo Ruiz‐Casas, Gabriel Pedra , et al. · 2020

Cost of non-alcoholic steatohepatitis in Europe and the USA: The GAIN study Open

Jamie O’Hara, Alan Finnegan, Harpal Dhillon, Leonardo Ruiz‐Casas, Gabriel Pedra , et al. · 2020

The impact of factor infusion frequency on health-related quality of life in people with haemophilia Open

Gabriel Pedra, P Christoffersen, Kate Khair, Xin Ying Lee, Sonia O’Hara , et al. · 2020

Background Some studies suggest that people with haemophilia (PwH) who use prophylaxis value low frequency of clotting factor administration more than a lower risk of bleeding. However, more frequent infusions offer the potential of reduci…

PBI60 TRENDS AND UPTAKE OF PREDICTIVE BRCA TESTING Open

Antony P. Martin, Gabriel Pedra, Jennifer Downing, B. Godman, Ana Alfirevic , et al. · 2019

Coinfection modifies carriage of enzootic and zoonotic parasites in Norway rats from an urban slum Open

Ticiana S. A. Carvalho‐Pereira, Fábio N. Souza, Luana Ribeiro do Nascimento Santos, Gabriel Pedra, Amanda Minter , et al. · 2019

We examine coinfection between helminth species and the bacterium Leptospira interrogans in a natural population of the Norway rat, Rattus norvegicus . We ask whether coinfection can influence the probability and intensity of infection of …

Trends in BRCA testing and socioeconomic deprivation Open

Antony P. Martin, Gabriel Pedra, Jennifer Downing, Brendan Collins, Brian Godman , et al. · 2019

The Cost of Non-Alcoholic Steatohepatitis (NASH) in Europe and USA: The GAIN Study Open

Jamie O’Hara, Alan Finnegan, Harpal Dhillon, Leonardo Ruiz‐Casas, Gabriel Pedra , et al. · 2019

PAR volume 145 issue 6 Cover and Back matter Open

José Antonio Garrido-Cárdenas, Concepción Mesa-Valle, Francisco Manzano, Jérémy Gauthier, Jean‐Michel Drezen , et al. · 2018

An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Quantification of Leptospira interrogans Survival in Soil and Water Microcosms Open

Arnau Casanovas‐Massana, Gabriel Pedra, Elsio A. Wunder, Peter J. Diggle, Michael Begon , et al. · 2018

Leptospira interrogans is the etiological agent of leptospirosis, a globally distributed zoonotic disease. Human infection usually occurs through skin exposure with water and soil contaminated with the urine of chronically infected animals…

The helminth community of a population ofRattus norvegicusfrom an urban Brazilian slum and the threat of zoonotic diseases Open

Ticiana S. A. Carvalho‐Pereira, Fábio N. Souza, Luana R. N. Santos, Ruth Walker, Arsinoê Cristina Pertile , et al. · 2017

Urban slums provide suitable conditions for infestation by rats, which harbour and shed a wide diversity of zoonotic pathogens including helminths. We aimed to identify risk factors associated with the probability and intensity of infectio…

Using fine‐scale spatial genetics of Norway rats to improve control efforts and reduce leptospirosis risk in urban slum environments Open

Jonathan Richardson, Mary K. Burak, Christian Hernandez, James M. Shirvell, Carol Mariani , et al. · 2016

The Norway rat ( Rattus norvegicus ) is a key pest species globally and responsible for seasonal outbreaks of the zoonotic bacterial disease leptospirosis in the tropics. The city of Salvador, Brazil, has seen recent and dramatic increases…

Factors affecting carriage and intensity of infection of Calodium hepaticum within Norway rats (Rattus norvegicus) from an urban slum environment in Salvador, Brazil Open

Ruth Walker, Ticiana S. A. Carvalho‐Pereira, Soledad Serrano, Gabriel Pedra, Kathryn P. Hacker , et al. · 2016

SUMMARY Urban slum environments in the tropics are conducive to the proliferation and the spread of rodent-borne zoonotic pathogens to humans. Calodium hepaticum (Brancroft, 1893) is a zoonotic nematode known to infect a variety of mammali…

Leptospira in breast tissue and milk of urban Norway rats (Rattus norvegicus) Open

Daiana de Oliveira, Cláudio Pereira Figueira, L. ZHAN, Arsinoê Cristina Pertile, Gabriel Pedra , et al. · 2016

SUMMARY Leptospirosis is a zoonosis caused by bacteria of the genus Leptospira . The disease is globally distributed and a major public health concern. The Norway rat ( Rattus norvegicus ) is the main reservoir of the pathogen in urban slu…

A Two-Year Ecological Study of Norway Rats (Rattus norvegicus) in a Brazilian Urban Slum Open

Jesús Alonso Panti–May, Ticiana S. A. Carvalho‐Pereira, Soledad Serrano, Gabriel Pedra, J. E. Taylor , et al. · 2016

The Norway or brown rat (Rattus norvegicus) is among the most ubiquitous of rodents. However, the lack of studies describing Norway rat populations from tropical areas have limited our understanding regarding their demography and seasonal …

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