Gabriel R. Titchiner
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View article: Discovery of iridoid cyclase completes the iridoid pathway in asterids
Discovery of iridoid cyclase completes the iridoid pathway in asterids Open
Iridoids are specialized monoterpenes ancestral to asterid flowering plants 1,2 that play key roles in defence and are also essential precursors for pharmacologically important alkaloids 3,4 . The biosynthesis of all iridoids involves the …
View article: Enzymatic epimerization of monoterpene indole alkaloids in kratom
Enzymatic epimerization of monoterpene indole alkaloids in kratom Open
Monoterpene indole alkaloids (MIAs) are a large, structurally diverse class of bioactive natural products. These compounds are biosynthetically derived from a stereoselective Pictet–Spengler condensation that generates a tetrahydro-β-carbo…
View article: Discovery of iridoid cyclase completes the iridoid pathway in asterids
Discovery of iridoid cyclase completes the iridoid pathway in asterids Open
Iridoids are specialized monoterpenes ancestral to asterid flowering plants (Albach et al , 2001; Stull et al , 2018). Iridoids play key roles in plant defense and are also essential precursors for pharmacologically important alkaloids (Do…
View article: Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation
Biosynthesis of Pyrrole-2-carbaldehyde via Enzymatic CO2 Fixation Open
The use of CO2 as a chemical building block is of considerable interest. To achieve carbon fixation at ambient conditions, (de)carboxylase enzymes offer an attractive route but frequently require elevated [CO2] levels to yield the acid pro…
View article: Enzymatic <i>N</i>-Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases
Enzymatic <i>N</i>-Allylation of Primary and Secondary Amines Using Renewable Cinnamic Acids Enabled by Bacterial Reductive Aminases Open
Allylic amines are a versatile class of synthetic precursors of many valuable nitrogen-containing organic compounds, including pharmaceuticals. Enzymatic allylic amination methods provide a sustainable route to these compounds but are ofte…
View article: Prenylated flavins: structures and mechanisms
Prenylated flavins: structures and mechanisms Open
The UbiX/UbiD system is widespread in microbes and responsible for the reversible decarboxylation of unsaturated carboxylic acids. The UbiD enzyme catalyzes this unusual reaction using a prenylated flavin (prFMN) as cofactor, the latter fo…
View article: Synthetic Enzyme‐Catalyzed CO<sub>2</sub> Fixation Reactions
Synthetic Enzyme‐Catalyzed CO<sub>2</sub> Fixation Reactions Open
In recent years, (de)carboxylases that catalyze reversible (de)carboxylation have been targeted for application as carboxylation catalysts. This has led to the development of proof‐of‐concept (bio)synthetic CO 2 fixation routes for chemica…
View article: Uncoupled activation and cyclisation in catmint reductive terpenoid biosynthesis
Uncoupled activation and cyclisation in catmint reductive terpenoid biosynthesis Open
Terpene synthases typically form complex molecular scaffolds by concerted activation and cyclization of linear starting materials in a single enzyme active site. Here we show that iridoid synthase, an atypical reductive terpene synthase, c…