Gabriel Rosenfeld
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View article: Persistent immune dysregulation and metabolic alterations following SARS-CoV-2 infection
Persistent immune dysregulation and metabolic alterations following SARS-CoV-2 infection Open
SARS-CoV-2 can cause a variety of post-acute sequelae including Long COVID19 (LC), a complex, multisystem disease characterized by a broad range of symptoms including fatigue, cognitive impairment, and post-exertional malaise. The pathogen…
View article: Tuberculosis disease severity assessment using clinical variables and radiology enabled by artificial intelligence
Tuberculosis disease severity assessment using clinical variables and radiology enabled by artificial intelligence Open
Radiology can define tuberculosis (TB) severity and may guide duration of treatment, however the optimal radiological metric to use and which clinical variables to combine it with in the real-world is unclear. We systematically associated …
View article: Predictive capabilities of baseline radiological findings for early and late disease outcomes within sensitive and multi-drug resistant tuberculosis cases
Predictive capabilities of baseline radiological findings for early and late disease outcomes within sensitive and multi-drug resistant tuberculosis cases Open
Timika Score simplifies the usage of baseline CXR for prediction of early infectiousness of the case and shows comparable performance to using detailed, standardized radiologist observations. The score's utility diminishes for treatment ou…
View article: Analysis of a Large Patient-Level Dataset to Predict Outcome of Treatment for Drug-Resistant Tuberculosis
Analysis of a Large Patient-Level Dataset to Predict Outcome of Treatment for Drug-Resistant Tuberculosis Open
BACKGROUND Drug-resistant (DR) tuberculosis treatment is challenging and frequently leads to poor outcomes. An international collaboration, the National Institute of Allergy and Infectious Diseases (NIAID) TB Portals develops, maintains, a…
View article: Radiologist observations of chest X-rays (CXR) predict sputum smear microscopy status in TB Portals, a real-world database of tuberculosis (TB) cases
Radiologist observations of chest X-rays (CXR) predict sputum smear microscopy status in TB Portals, a real-world database of tuberculosis (TB) cases Open
The Tuberculosis (TB) Portals is an international program of 14 countries connecting clinical, genomic, and radiologist specialists to develop an openly available repository of deidentified TB cases with multi-modal data such as case clini…
View article: Current challenges in microbiome metadata collection
Current challenges in microbiome metadata collection Open
While the biomedical community has embraced data sharing (e.g. results, raw data) and supported establishment of large research consortia (e.g. the Human Microbiome Project) aimed to standardize the quality of important sets of microbiome …
View article: Estimating the scale of biomedical data generation using text mining
Estimating the scale of biomedical data generation using text mining Open
While the impact of biomedical research has traditionally been measured using bibliographic metrics such as citation or journal impact factor, the data itself is an output which can be directly measured to provide additional context about …