Gabriela D. García Nores
YOU?
Author Swipe
View article: Topical captopril: a promising treatment for secondary lymphedema
Topical captopril: a promising treatment for secondary lymphedema Open
View article: Keratinocytes coordinate inflammatory responses and regulate development of secondary lymphedema
Keratinocytes coordinate inflammatory responses and regulate development of secondary lymphedema Open
Epidermal changes are histological hallmarks of secondary lymphedema, but it is unknown if keratinocytes contribute to its pathophysiology. Using clinical lymphedema specimens and mouse models, we show that keratinocytes play a primary rol…
View article: Strategies for prevention and management of partial flap loss or fat necrosis in microvascular autologous breast reconstruction
Strategies for prevention and management of partial flap loss or fat necrosis in microvascular autologous breast reconstruction Open
Partial flap loss (skin involved) or fat necrosis following autologous breast reconstruction remains a dreaded postoperative complication despite significant advances in microsurgical techniques. Several strategies have been proposed in th…
View article: The Impact of Bilateral Suprazygomatic Maxillary Nerve Blocks on Postoperative Pain Control in Patients Undergoing Orthognathic Surgery
The Impact of Bilateral Suprazygomatic Maxillary Nerve Blocks on Postoperative Pain Control in Patients Undergoing Orthognathic Surgery Open
Aims: The mainstay of analgesia in orthognathic interventions for maxillary hypoplasia is perioperative opioids, however, the side effect profile is broad with the potential for well-described deleterious effects. The suprazygomatic maxill…
View article: CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema
CD4+ T cells are activated in regional lymph nodes and migrate to skin to initiate lymphedema Open
T cell-mediated responses have been implicated in the development of fibrosis, impaired lymphangiogenesis, and lymphatic dysfunction in secondary lymphedema. Here we show that CD4 + T cells are necessary for lymphedema pathogenesis by util…
View article: Regulatory T Cells Mediate Local Immunosuppression in Lymphedema
Regulatory T Cells Mediate Local Immunosuppression in Lymphedema Open
View article: Abstract 1: Topical Tacrolimus for the Treatment of Lymphedema
Abstract 1: Topical Tacrolimus for the Treatment of Lymphedema Open
PURPOSE: Lymphedema is a common, life-long complication of cancer treatment that currently has no cure. Patients with lymphedema have decreased quality of life and suffer recurrent infections, while current treatments are merely palliative…
View article: Abstract 9: Th2 Deficiency Attenuates The Pathologic Findings Of Lymphedema
Abstract 9: Th2 Deficiency Attenuates The Pathologic Findings Of Lymphedema Open
PURPOSE: Lymphedema is a progressive disease that is regulated by CD4+ cells. However, while it is clear that CD4+ cells are important, the effect of cellular differentiation is less clear. Therefore, this study sought to evaluate the role…
View article: Topical tacrolimus for the treatment of secondary lymphedema
Topical tacrolimus for the treatment of secondary lymphedema Open
View article: Lymph Node Transplantation Decreases Swelling and Restores Immune Responses in a Transgenic Model of Lymphedema
Lymph Node Transplantation Decreases Swelling and Restores Immune Responses in a Transgenic Model of Lymphedema Open
LNT decreases pathological changes of lymphedema and was shown to potently induce lymphangiogenesis. Lymphatic vessels induced by LNT were abnormal in appearance, but were functional and able to transport antigen-presenting cells. Animals …
View article: Diphtheria toxin–mediated ablation of lymphatic endothelial cells results in progressive lymphedema
Diphtheria toxin–mediated ablation of lymphatic endothelial cells results in progressive lymphedema Open
Development of novel treatments for lymphedema has been limited by the fact that the pathophysiology of this disease is poorly understood. It remains unknown, for example, why limb swelling resulting from surgical injury resolves initially…
View article: Obesity‐induced lymphatic dysfunction is reversible with weight loss
Obesity‐induced lymphatic dysfunction is reversible with weight loss Open
Key points Obesity induces lymphatic leakiness, decreases initial lymphatic vessel density, impairs collecting vessel pumping and decreases transport of macromolecules. Obesity results in perilymphatic inducible nitric oxide synthase (iNOS…
View article: Obesity but not high-fat diet impairs lymphatic function
Obesity but not high-fat diet impairs lymphatic function Open
Collectively, our studies suggest that HFD-induced obesity decreases lymphatic function by increasing perilymphatic inflammation and altering LEC gene expression. Reversal of diminished VEGFR-3 signaling may rescue this phenotype and impro…
View article: Exercise training improves obesity‐related lymphatic dysfunction
Exercise training improves obesity‐related lymphatic dysfunction Open
Key points Obesity results in perilymphatic inflammation and lymphatic dysfunction. Lymphatic dysfunction in obesity is characterized by decreased lymphatic vessel density, decreased collecting lymphatic vessel pumping frequency, decreased…
View article: Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity
Inhibition of Inflammation and iNOS Improves Lymphatic Function in Obesity Open
View article: Lymphatic Function Regulates Contact Hypersensitivity Dermatitis in Obesity
Lymphatic Function Regulates Contact Hypersensitivity Dermatitis in Obesity Open
View article: Th2 Cytokines Inhibit Lymphangiogenesis
Th2 Cytokines Inhibit Lymphangiogenesis Open
Lymphangiogenesis is the process by which new lymphatic vessels grow in response to pathologic stimuli such as wound healing, inflammation, and tumor metastasis. It is well-recognized that growth factors and cytokines regulate lymphangioge…