Gabriela Delevati Colpo
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View article: Ifi27l2a acts as a cytokine that promotes a pro-inflammatory phenotype in microglia and enhances neuroinflammation
Ifi27l2a acts as a cytokine that promotes a pro-inflammatory phenotype in microglia and enhances neuroinflammation Open
Interferon alpha-inducible protein 27 like 2A (Ifi27l2a) was initially identified as an interferon-stimulated gene (Isg) involved in host-dependent mechanisms during viral invasion. We have recently shown that the Ifi27l2a protein also pla…
View article: Benefits of equilibrium between microbiota- and host-derived ligands of the aryl hydrocarbon receptor after stroke in aged male mice
Benefits of equilibrium between microbiota- and host-derived ligands of the aryl hydrocarbon receptor after stroke in aged male mice Open
View article: Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism
Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism Open
Alzheimer's disease (AD) affects more women than men. Although women live longer than men, it is not longevity alone, but other factors, including metabolic changes, that contribute to the higher risk of AD in women. Metabolic pathways hav…
View article: Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism
Serum metabolome profiling in patients with mild cognitive impairment reveals sex differences in lipid metabolism Open
Alzheimer’s disease (AD) affects more women than men. Although women live longer than men, it is not longevity alone, but other factors, including metabolic changes, that contribute to the higher risk of AD in women. Metabolic pathways hav…
View article: Abstract 299: Implications of Age on Post Stroke Depression in Intracerebral Hemorrhage Patients
Abstract 299: Implications of Age on Post Stroke Depression in Intracerebral Hemorrhage Patients Open
Introduction Risk Factors for stroke consistently have been researched regarding ischemic strokes, but unfortunately are overlooked in respect to hemorrhagic strokes. Intracerebral Hemorrhages (ICH) are a critical disease consistently asso…
View article: Abstract 422: The Impact of Household Composition on Acute Ischemic Strokes: Acute and Chronic Implications
Abstract 422: The Impact of Household Composition on Acute Ischemic Strokes: Acute and Chronic Implications Open
Introduction Stroke presents a significant global health challenge, impacting physical and mental well‐being. Social Isolation (SI) is a known risk factor and common complication affecting functional outcomes and impeding recovery. In this…
View article: Abstract 419: The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID‐19 Related Vascular Thrombosis
Abstract 419: The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID‐19 Related Vascular Thrombosis Open
Introduction Coronavirus disease 2019 is caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and has been associated with hypercoagulability and an increased incidence of thrombotic events as compared to other viral resp…
View article: The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis
The Contribution of Neutrophil Extracellular Traps to Coagulopathy in Patients with COVID-19-Related Thrombosis Open
COVID-19 is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is associated with hypercoagulability and increased incidence of thrombotic events. In this study, we investigated the levels of neutrophil extracellula…
View article: Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity
Aromatase, testosterone, TMPRSS2: determinants of COVID-19 severity Open
Background Male sex has been identified as a risk factor for worse COVID-19 outcomes. This sex difference has been mostly attributed to the complex role of sex hormones. Cell surface entry of SARS-CoV-2 is mediated by the transmembrane pro…
View article: Stabilizing histamine release in gut mast cells mitigates peripheral and central inflammation after stroke
Stabilizing histamine release in gut mast cells mitigates peripheral and central inflammation after stroke Open
Stroke is the most common cause of long-term disability and places a high economic burden on the global healthcare system. Functional outcomes from stroke are largely determined by the extent of ischemic injury, however, there is growing r…
View article: Restoring a balanced pool of host-derived and microbiota-derived ligands of the aryl hydrocarbon receptor is beneficial after stroke
Restoring a balanced pool of host-derived and microbiota-derived ligands of the aryl hydrocarbon receptor is beneficial after stroke Open
Background: Stroke is a major cause of morbidity and mortality, and its incidence increases with age. While acute therapies for stroke are currently limited to intravenous thrombolytics and endovascular thrombectomy, recent studies have im…
View article: Accelerated epigenetic aging in older adults with HIV disease: associations with serostatus, HIV clinical factors, and health literacy
Accelerated epigenetic aging in older adults with HIV disease: associations with serostatus, HIV clinical factors, and health literacy Open
View article: Leucine-Rich Alpha-2-Glycoprotein 1 is a Systemic Biomarker of Early Brain Injury and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage
Leucine-Rich Alpha-2-Glycoprotein 1 is a Systemic Biomarker of Early Brain Injury and Delayed Cerebral Ischemia After Subarachnoid Hemorrhage Open
View article: Renin-Angiotensin System in Huntington′s Disease: Evidence from Animal Models and Human Patients
Renin-Angiotensin System in Huntington′s Disease: Evidence from Animal Models and Human Patients Open
The Renin-Angiotensin System (RAS) is expressed in the central nervous system and has important functions that go beyond blood pressure regulation. Clinical and experimental studies have suggested that alterations in the brain RAS contribu…
View article: Sex differences in global metabolomic profiles of COVID-19 patients
Sex differences in global metabolomic profiles of COVID-19 patients Open
View article: Blood Biomarkers of Neuronal/Axonal and Glial Injury in Human Immunodeficiency Virus-Associated Neurocognitive Disorders
Blood Biomarkers of Neuronal/Axonal and Glial Injury in Human Immunodeficiency Virus-Associated Neurocognitive Disorders Open
Introduction: Approximately half of the people living with HIV (PLWH) experience HIV-associated neurocognitive disorders (HANDs). However, the neuropathogenesis of HAND is complex, and identifying reliable biomarkers has been challenging. …
View article: Sex differences in the immune response to acute COVID-19 respiratory tract infection
Sex differences in the immune response to acute COVID-19 respiratory tract infection Open
View article: Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19
Brain injury, endothelial injury and inflammatory markers are elevated and express sex-specific alterations after COVID-19 Open
Objective Although COVID-19 is a respiratory disease, all organs can be affected including the brain. To date, specific investigations of brain injury markers (BIM) and endothelial injury markers (EIM) have been limited. Additionally, a ma…
View article: Pain and Other Neurological Symptoms Are Present at 3 Months After Hospitalization in COVID-19 Patients
Pain and Other Neurological Symptoms Are Present at 3 Months After Hospitalization in COVID-19 Patients Open
COVID-19 is an ongoing pandemic with a devastating impact on public health. Acute neurological symptoms have been reported after a COVID-19 diagnosis, however, the long-term neurological symptoms including pain is not well established. Usi…
View article: Apathy is not associated with a panel of biomarkers in older adults with HIV disease
Apathy is not associated with a panel of biomarkers in older adults with HIV disease Open
View article: The effect of transcranial direct current stimulation on beta-endorphin in older adults with knee osteoarthritis pain
The effect of transcranial direct current stimulation on beta-endorphin in older adults with knee osteoarthritis pain Open
View article: Inflammatory Markers Profile in Older Adolescents During Treatment with Selective Serotonin Reuptake Inhibitors
Inflammatory Markers Profile in Older Adolescents During Treatment with Selective Serotonin Reuptake Inhibitors Open
Objective: This study aimed to investigate the serum levels of inflammatory markers in adolescents with major depressive disorder (MDD) using selective serotonin reuptake inhibitors. Methods: This was an 8-month…
View article: The Relationship Between Plasma BDNF and Pain in Older Adults With Knee Osteoarthritis
The Relationship Between Plasma BDNF and Pain in Older Adults With Knee Osteoarthritis Open
Osteoarthritis (OA) is the most prevalent cause of chronic pain and disability in people aged ≥45 years, with the knee being the most affected joint. Neurotrophic factors like brain-derived neurotrophic factor (BDNF), which promotes neurog…
View article: Microglia Activation in Basal Ganglia Is a Late Event in Huntington Disease Pathophysiology
Microglia Activation in Basal Ganglia Is a Late Event in Huntington Disease Pathophysiology Open
Altogether, our data demonstrate that microglial activation is involved in HD pathophysiology and is associated with disease progression.
View article: Decreased Plasma Levels of Angiotensin-Converting Enzyme Among Patients With Bipolar Disorder
Decreased Plasma Levels of Angiotensin-Converting Enzyme Among Patients With Bipolar Disorder Open
Background Dysfunctions in the renin-angiotensin system (RAS) seem to be involved in the pathophysiology of several mental illness, including schizophrenia and mood disorders. We carried out a cross-sectional study assessing the levels of …
View article: Peripheral Levels of Renin-Angiotensin System Components Are Associated With Cognitive Performance in Huntington’s Disease
Peripheral Levels of Renin-Angiotensin System Components Are Associated With Cognitive Performance in Huntington’s Disease Open
The renin-angiotensin system (RAS) has proven to be involved in the pathophysiology of neurodegenerative diseases, such as Parkinson’s disease (PD) and Alzheimer’s disease (AD), serving as a potential therapeutic target and a disease burde…
View article: Gene Expression Profiling in Huntington’s Disease: Does Comorbidity with Depressive Symptoms Matter?
Gene Expression Profiling in Huntington’s Disease: Does Comorbidity with Depressive Symptoms Matter? Open
Huntington’s disease (HD) is an inherited neurodegenerative disease. Besides the well-characterized motor symptoms, HD is marked by cognitive impairment and behavioral changes. In this study, we analyzed the blood of HD gene carries using …
View article: Three-month outcomes in hospitalized COVID-19 patients
Three-month outcomes in hospitalized COVID-19 patients Open
COVID-19 is an ongoing pandemic with a devastating impact on public health. Acute neurological symptoms have been reported after a COVID-19 diagnosis, however there is no data available on the long-term neurological symptoms. Using a prosp…
View article: The anti-aging effects of lithium in lymphoblastoid cell lines from patients with bipolar disorder and controls
The anti-aging effects of lithium in lymphoblastoid cell lines from patients with bipolar disorder and controls Open
View article: Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells
Clozapine Prevents Poly (I:C) Induced Inflammation by Modulating NLRP3 Pathway in Microglial Cells Open
Schizophrenia is a complex psychiatric disorder that exhibits an interconnection between the immune system and the brain. Experimental and clinical studies have suggested the presence of neuroinflammation in schizophrenia. In the present s…