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View article: Respiratory Syncytial Virus and COVID‐19 in Hospitalized Adults in Spain: Clinical, Radiological Features and Antimicrobial Use
Respiratory Syncytial Virus and COVID‐19 in Hospitalized Adults in Spain: Clinical, Radiological Features and Antimicrobial Use Open
Background Lower respiratory tract infections (LRTIs) impose a significant global burden, with over 400 million cases annually. This study compares the clinical features of adults hospitalized with respiratory syncytial virus (RSV) and COV…
View article: Changes in HIV‐1 Reservoir Dynamics After Mpox Infection
Changes in HIV‐1 Reservoir Dynamics After Mpox Infection Open
In May 2022, a large outbreak of monkeypox virus (MPXV) occurred in several non‐endemic regions worldwide. Another outbreak in 2024 raised global concerns, particularly for immunocompromised individuals like people with HIV (PWH). Since th…
View article: Screening for asymptomatic mpox in at-risk populations: A cross-sectional study
Screening for asymptomatic mpox in at-risk populations: A cross-sectional study Open
Background Mpox is a viral disease caused by an orthopoxvirus called monkeypox virus. It experienced a significant increase in cases in 2022 worldwide, mostly with sexual transmission. The possibility of hidden circulation of this infectio…
View article: Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults with HIV (INSTINCT/GESIDA10918 Study)
Comparable Inflammatory and Metabolic Outcomes After Switching to Bictegravir/Emtricitabine/Tenofovir Alafenamide Versus Continuing Dolutegravir/Lamivudine in Virologically Suppressed Adults with HIV (INSTINCT/GESIDA10918 Study) Open
Background Dual antiretroviral therapy (ART) with dolutegravir/lamivudine (DTG/3TC) is widely used in virologically suppressed individuals. However, data remain limited on potential differential effects of ART regimens on mid-term systemic…
View article: Prognostic Value of Blood Epigenetic Biomarkers of Aging in Persons With Well-Controlled Human Immunodeficiency Virus (HIV-1) Infection
Prognostic Value of Blood Epigenetic Biomarkers of Aging in Persons With Well-Controlled Human Immunodeficiency Virus (HIV-1) Infection Open
Background Epigenetic age acceleration (EAA) predicts morbidity and mortality in the general population, but its prognostic utility in people with human immunodeficiency virus (HIV) (PWH) on suppressive antiretroviral therapy remains uncle…
View article: Early versus deferred antiretroviral therapy initiation and long-term cardiovascular disease outcomes in people with HIV: The START study
Early versus deferred antiretroviral therapy initiation and long-term cardiovascular disease outcomes in people with HIV: The START study Open
Background It is unknown whether delayed antiretroviral therapy (ART) initiation worsens CVD outcomes in people with HIV (PHIV). This study compared CVD event rates between PHIV who were randomized to receive immediate versus deferred ART.…
View article: Low Specific T‐Cell Immunity Against Mpox Elicited in People With HIV‐1 and PrEP Users After Subcutaneous Vaccination Compared to Natural Infection
Low Specific T‐Cell Immunity Against Mpox Elicited in People With HIV‐1 and PrEP Users After Subcutaneous Vaccination Compared to Natural Infection Open
In August 2024, the World Health Organization declared mpox infection a Public Health Emergency of International Concern for second time since 2022 and recommended vaccinating all people at‐risk, such as people with HIV‐1 (PWH) and prophyl…
View article: Underutilization of nirmatrelvir/ritonavir in eligible COVID-19 patients
Underutilization of nirmatrelvir/ritonavir in eligible COVID-19 patients Open
View article: Enfermedades crónicas y multisistémicas comorbilidad entre diabetes mellitus tipo 2 e hipertensión arterial: implicaciones terapéuticas. Una revisión sistemática
Enfermedades crónicas y multisistémicas comorbilidad entre diabetes mellitus tipo 2 e hipertensión arterial: implicaciones terapéuticas. Una revisión sistemática Open
La comorbilidad entre la diabetes mellitus tipo 2 (DM2) y la hipertensión arterial (HTA) se ha convertido en un reto creciente para los sistemas de salud, gracias a su alta prevalencia y las complicaciones terapéuticas que conlleva. Esta r…
View article: Clinical Characterization and Outcomes of Human Clade IIb Mpox Virus Disease: A European Multicenter Mpox Observational Cohort Study (MOSAIC)
Clinical Characterization and Outcomes of Human Clade IIb Mpox Virus Disease: A European Multicenter Mpox Observational Cohort Study (MOSAIC) Open
Background The global mpox outbreak that started in May 2022 was caused by a novel clade IIb variant of the mpox virus (Orthopoxvirus monkeypox, MPXV). It differed from the traditional Western and Central Africa disease in transmission pat…
View article: Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia
Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia Open
Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19. To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia. This multicenter, phase 3, placebo…
View article: Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia
Fostamatinib for Hospitalized Adults With COVID-19 and Hypoxemia Open
Importance Fostamatinib, a spleen tyrosine kinase inhibitor, has been reported to improve outcomes of COVID-19. Objective To evaluate the efficacy and safety of fostamatinib in adults hospitalized with COVID-19 and hypoxemia. Design, Setti…
View article: PP4.11 – 00077 Long-term antiretroviral treatment reduces the reactivation capacity of HIV-1 reservoir
PP4.11 – 00077 Long-term antiretroviral treatment reduces the reactivation capacity of HIV-1 reservoir Open
View article: PP4.16 – 00014 Reduction of HIV-1 reservoir following mpox infection
PP4.16 – 00014 Reduction of HIV-1 reservoir following mpox infection Open
View article: Impact of soluble epoxide hydrolase inhibition on silica-induced pulmonary fibrosis, ectopic lymphoid neogenesis, and autoantibody production in lupus-prone mice
Impact of soluble epoxide hydrolase inhibition on silica-induced pulmonary fibrosis, ectopic lymphoid neogenesis, and autoantibody production in lupus-prone mice Open
cSiO2 evoked robust pulmonary inflammation and fibrosis in NZBWF1 mice that was evident at 7 days PI and progressed to ELS development and autoimmunity by 28 days PI. sEH inhibition by TPPU modestly suppressed cSiO2-i…
View article: Subclinical atherosclerosis burden in carotid and femoral territories in HIV subjects: relationships with HIV and non-HIV related factors
Subclinical atherosclerosis burden in carotid and femoral territories in HIV subjects: relationships with HIV and non-HIV related factors Open
Background Cardiovascular disease is a major cause of morbidity in an aging HIV population. However, risk estimation with the most frequent equations usually classifies HIV patients as having a low or moderate risk. Several studies have de…
View article: A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19
A Phase III Randomized Controlled Trial of Plitidepsin, a Marine-Derived Compound, in Hospitalized Adults With Moderate COVID-19 Open
Background Plitidepsin has shown potent preclinical activity against severe acute respiratory syndrome coronavirus 2 and was generally well tolerated in a phase I trial of hospitalized patients with coronavirus disease 2019 (COVID-19). NEP…
View article: T Cell Homeostasis Disturbances in a Cohort of Long-Term Elite Controllers of HIV Infection
T Cell Homeostasis Disturbances in a Cohort of Long-Term Elite Controllers of HIV Infection Open
Elite controllers (ECs) are people living with HIV (PLWH) able to control HIV replication without antiretroviral therapy and have been proposed as a model of a functional HIV cure. Much evidence suggests that this spontaneous control of HI…
View article: Monkeypox virus genomic accordion strategies
Monkeypox virus genomic accordion strategies Open
The 2023 monkeypox (mpox) epidemic was caused by a subclade IIb descendant of a monkeypox virus (MPXV) lineage traced back to Nigeria in 1971. Person-to-person transmission appears higher than for clade I or subclade IIa MPXV, possibly cau…
View article: Mpox, herpes, and enteroviruses: Differential diagnosis
Mpox, herpes, and enteroviruses: Differential diagnosis Open
Mpox (formerly monkeypox) disease has been reported in Central and West Africa for years until May 2022 when the United Kingdom reported several cases with no evidence of epidemiological links to travel to endemic areas, nor any imports of…
View article: Antimicrobial and Antiviral Materials a Review of Applications, and Mechanism of Action
Antimicrobial and Antiviral Materials a Review of Applications, and Mechanism of Action Open
View article: Differences in the inflammatory response among hospitalized patients with distinct variants of SARS-CoV-2
Differences in the inflammatory response among hospitalized patients with distinct variants of SARS-CoV-2 Open
The SARS-CoV-2 variants demonstrate diverse transmission patterns, modifications in infectivity, and immune response. Changes in disease manifestation may be attributed to vaccination and the virus’s reduced capacity to induce inflammation…
View article: Bacterial nanocellulose spheres coated with meta acrylic copolymer: Vaccinium meridionale swartz extract delivery for colorectal cancer chemoprevention
Bacterial nanocellulose spheres coated with meta acrylic copolymer: Vaccinium meridionale swartz extract delivery for colorectal cancer chemoprevention Open
Bacterial nanocellulose, a natural hydrocolloid traditionally used as a food ingredient, has demonstrated potential as a non-soluble dietary fiber and functional material. Moreover, its properties can further be potentialized whether coupl…
View article: TRPC6 inhibitor (BI 764198) to reduce risk and severity of ARDS due to COVID-19: a phase II randomised controlled trial
TRPC6 inhibitor (BI 764198) to reduce risk and severity of ARDS due to COVID-19: a phase II randomised controlled trial Open
Background Despite the availability of COVID-19 vaccinations, there remains a need to investigate treatments to reduce the risk or severity of potentially fatal complications of COVID-19, such as acute respiratory distress syndrome (ARDS).…
View article: Specific Cellular and Humoral Immune Responses to the Neoantigen RBD of SARS-CoV-2 in Patients with Primary and Secondary Immunodeficiency and Healthy Donors
Specific Cellular and Humoral Immune Responses to the Neoantigen RBD of SARS-CoV-2 in Patients with Primary and Secondary Immunodeficiency and Healthy Donors Open
Patients with antibody deficiency disorders, such as primary immunodeficiency (PID) or secondary immunodeficiency (SID) to B-cell lymphoproliferative disorder (B-CLPD), are two groups vulnerable to developing the severe or chronic form of …
View article: Plitidepsin in adult patients with COVID-19 requiring hospital admission: A long-term follow-up analysis
Plitidepsin in adult patients with COVID-19 requiring hospital admission: A long-term follow-up analysis Open
Introduction The APLICOV-PC study assessed the safety and preliminary efficacy of plitidepsin in hospitalized adult patients with COVID-19. In this follow-up study (E-APLICOV), the incidence of post-COVID-19 morbidity was evaluated and any…
View article: Use of Monoclonal Antibodies in Immunocompromised Patients Hospitalized with Severe COVID-19: A Retrospective Multicenter Cohort
Use of Monoclonal Antibodies in Immunocompromised Patients Hospitalized with Severe COVID-19: A Retrospective Multicenter Cohort Open
Objective: We aim to describe the safety and efficacy of sotrovimab in severe cases of COVID-19 in immunocompromised hosts. Methods: We used a retrospective multicenter cohort including immunocompromised hospitalized patients with severe C…
View article: Faster lung function decline in people living with HIV despite adequate treatment: a longitudinal matched cohort study
Faster lung function decline in people living with HIV despite adequate treatment: a longitudinal matched cohort study Open
Introduction Chronic lung disease is common among people living with HIV (PLWH). We hypothesised that PLWH receiving antiretroviral therapy (ART) have faster lung function decline than matched controls. Methods We performed a prospective m…
View article: Referee report. For: Effect of atorvastatin on subclinical atherosclerosis in virally-suppressed HIV-infected patients with CMV seropositivity: a randomized double-blind placebo-controlled trial [version 2; peer review: 2 approved]
Referee report. For: Effect of atorvastatin on subclinical atherosclerosis in virally-suppressed HIV-infected patients with CMV seropositivity: a randomized double-blind placebo-controlled trial [version 2; peer review: 2 approved] Open
View article: Monitoring monkeypox virus in saliva and air samples in Spain: a cross-sectional study
Monitoring monkeypox virus in saliva and air samples in Spain: a cross-sectional study Open