Gabriela Tonini Peterle
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View article: Nicotine exposure increases PIK3CA, AKT1, HIF-1α, GLUT1, CA9 and VEGF expression in oral potentially malignant lesions
Nicotine exposure increases PIK3CA, AKT1, HIF-1α, GLUT1, CA9 and VEGF expression in oral potentially malignant lesions Open
Background: Oral squamous cell carcinoma (OSCC) is a highly aggressive malignancy often arising from oral potentially malignant lesions (OPMD). Nicotine triggers pathways associated with tumor progression, angiogenesis, and metastasis, not…
View article: Comparison of the chondrogenic differentiation potential of bone marrow mesenchymal stem cells between female and male Wistar rats
Comparison of the chondrogenic differentiation potential of bone marrow mesenchymal stem cells between female and male Wistar rats Open
This study aimed to compare the chondrogenic differentiation potential between bone marrow mesenchymal stem cells from female (fBMSCs) and male (mBMSCs) Wistar rats. For this purpose, female and male BMSCs were subjected to chondrogenic di…
View article: The participation of tumor residing pericytes in oral squamous cell carcinoma
The participation of tumor residing pericytes in oral squamous cell carcinoma Open
Pericytes are perivascular cells related to vessel structure and angiogenesis that can interact with neoplastic cells, interfering with cancer progression and outcomes. This study focused on the characterization of pericytes in oral squamo…
View article: Effects of the juçara fruit (Euterpe edulis Martius) pulp and lyophilized extract on NRF2, KEAP1, SOD1, and GPX2 expression in human colorectal cancer cell lines
Effects of the juçara fruit (Euterpe edulis Martius) pulp and lyophilized extract on NRF2, KEAP1, SOD1, and GPX2 expression in human colorectal cancer cell lines Open
We investigated the effects of the juçara fruit (Euterpe edulis Martius) pulp and lyophilized extract on the expression of cytoprotective genes nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2), kelch-like ECH-associated protein 1…
View article: Effects of the juçara fruit (Euterpe edulis Martius) pulp and lyophilized extract on NRF2, KEAP1, SOD1, and GPX2 expression in human colorectal cancer cell lines
Effects of the juçara fruit (Euterpe edulis Martius) pulp and lyophilized extract on NRF2, KEAP1, SOD1, and GPX2 expression in human colorectal cancer cell lines Open
We investigated the effects of the juçara fruit (Euterpe edulis Martius) pulp and lyophilized extract on the expression of cytoprotective genes nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2), kelch-like ECH-associated protein 1…
View article: PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: A cross-sectional study
PAI-1 expression in intratumoral inflammatory infiltrate contributes to lymph node metastasis in oral cancer: A cross-sectional study Open
Our results suggest that the strong PAI-1 expression in intratumoral inflammatory infiltrate is an indicator of a better prognosis for patients diagnosed with oral squamous cell carcinoma.
View article: PAI‐1, CAIX, and VEGFA expressions as prognosis markers in oral squamous cell carcinoma
PAI‐1, CAIX, and VEGFA expressions as prognosis markers in oral squamous cell carcinoma Open
Background In oral squamous cell carcinoma ( OSCC ), the HIF ‐1 complex promotes the expression of genes involved in specific mechanisms of cell survival under hypoxic conditions, such as plasminogen activator inhibitor‐1 ( PAI ‐1), carbon…
View article: JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma
JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma Open
JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets.
View article: Alcoolismo, tabagismo e exposição aos agrotóxicos: avaliação epidemiológica e molecular como auxiliar na prevenção e questões de saúde
Alcoolismo, tabagismo e exposição aos agrotóxicos: avaliação epidemiológica e molecular como auxiliar na prevenção e questões de saúde Open
Objetivos: Realizar medidas de educação visando a prevenção em saúde e melhor qualidade de vida, e obter dados através de levantamento epidemiológico que poderão ser fornecidos ao SUS como um modelo de região rural que poderá ser utilizado…
View article: <i>ATM</i>,<i>BCL2</i>, and<i>TGFβ</i>Gene Polymorphisms as Radiotherapy Outcome Biomarkers in Head and Neck Squamous Cell Carcinoma Patients
<i>ATM</i>,<i>BCL2</i>, and<i>TGFβ</i>Gene Polymorphisms as Radiotherapy Outcome Biomarkers in Head and Neck Squamous Cell Carcinoma Patients Open
These results can help individualize treatment according to a patient's genetic markers. We demonstrated that ATM IVS62 + 60G>A, TGFβ 29C>T, TGFβ-509C>T, and BCL2-938C>A can function as biomarkers of tumor radiosensitivity, being candidate…
View article: Research Article Alcohol metabolizing gene polymorphisms and their relationship with oral cancer risk and clinicopathological features
Research Article Alcohol metabolizing gene polymorphisms and their relationship with oral cancer risk and clinicopathological features Open
Oral cancer incidence is higher in individuals between the fifth and seventh decades of life, but some studies indicate a decreasing age trend. From the epidemiological point of view, alcohol consumption is associated with the emergence of…
View article: DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity
DAP1 high expression increases risk of lymph node metastases in squamous cell carcinoma of the oral cavity Open
Death-associated protein 1 (DAP1) is a member of the DAP family. Its expression is associated with cell growth and normal death of the neoplastic cells, regulated by the mammalian target of the rapamycin protein. Activated DAP1 negatively …
View article: Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism
Prognostic significance of head and neck squamous cell carcinoma repair gene polymorphism Open
The aims of this study were to analyze the polymorphisms XRCC1 Arg194Trp, XRCC1 Arg399Gln, XRCC3 Thr241Met, XPC Lys939Gln, ERCC1 Asn118Asn, and RAD51 -98G>C and to verify their influence on radiotherapy response and prognosis of patients w…
View article: FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma
FAS ligand expression in inflammatory infiltrate lymphoid cells as a prognostic marker in oral squamous cell carcinoma Open
Currently, the most important prognostic factor in oral squamous cell carcinoma (OSCC) is the presence of regional lymph node metastases, which correlates with a 50% reduction in life expectancy. We have previously observed that expression…
View article: Keratins 17 and 19 expression as prognostic markers in oral squamous cell carcinoma
Keratins 17 and 19 expression as prognostic markers in oral squamous cell carcinoma Open
Five-year survival rates for oral squamous cell carcinoma (OSCC) are 30% and the mortality rate is 50%. Immunohistochemistry panels are used to evaluate proliferation, vascularization, apoptosis, HPV infection, and keratin expression, whic…
View article: MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma
MTHFR C677T and A1298C polymorphisms as predictors of radiotherapy response in head and neck squamous cell carcinoma Open
The C677T and A1298C polymorphisms in methylene-tetrahydrofolate reductase (MTHFR), which regulates the release of active folate in the body, may have reduced activity. Given that folate participates in important intracellular pathways, su…
View article: Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer
Leptin receptor expression and Gln223Arg polymorphism as prognostic markers in oral and oropharyngeal cancer Open
The leptin gene product is released into the blood stream, passes through the blood-brain barrier, and finds the leptin receptor (LEPR) in the central nervous system. This hormone regulates food intake, hematopoiesis, inflammation, immunit…