Gabriele Guglielmetti
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View article: A prospective humoral immune monitoring study of kidney transplant recipients receiving three doses of SARS‐CoV‐2 mRNA vaccine
A prospective humoral immune monitoring study of kidney transplant recipients receiving three doses of SARS‐CoV‐2 mRNA vaccine Open
Kidney transplant recipients (KTRs), like other solid organ transplant recipients display a suboptimal response to mRNA vaccines, with only about half achieving seroconversion after two doses. However, the effectiveness of a booster dose, …
View article: MO208: De Novo Glomerulonephritides Following BNT162B2 COVID-19 Vaccine: A Case Series
MO208: De Novo Glomerulonephritides Following BNT162B2 COVID-19 Vaccine: A Case Series Open
BACKGROUND AND AIMS The development and massive use of mRNA COVID-19 vaccine BNT162b2 has raised new concerns on triggering de novo immune-mediated diseases, in particular rare diseases as glomerulonephritis (GN), even if the security prof…
View article: MO380INCREASED PREVALENCE OF ACUTE KIDNEY INJURY AND MORTALITY IN COVID-19 HOSPITALIZED PATIENTS
MO380INCREASED PREVALENCE OF ACUTE KIDNEY INJURY AND MORTALITY IN COVID-19 HOSPITALIZED PATIENTS Open
Background and Aims In 2020, SARS-CoV-2 pandemic had a devastating impact on individuals and on national health systems worldwide. Although being primarily a lung disease, COVID-19-associated systemic inflammation and activation of coagula…
View article: MO962EPIDEMIOLOGY AND CLINICAL RELEVANCE OF ACUTE KIDNEY INJURY IN KIDNEY TRANSPLANT RECIPIENTS
MO962EPIDEMIOLOGY AND CLINICAL RELEVANCE OF ACUTE KIDNEY INJURY IN KIDNEY TRANSPLANT RECIPIENTS Open
Background and Aims Very few information about COVID-19 in kidney transplant recipients (KTRs) are known and the available evidence are based on limited case series. In KTRs, Acute Kidney Injury (AKI) of different causes is known to be ass…
View article: Supplementary Material for: Ultrasonographic Intraparenchymal Renal Resistive Index Variation for Assessing Renal Functional Reserve in Patients Scheduled for Cardiac Surgery: A Pilot Study
Supplementary Material for: Ultrasonographic Intraparenchymal Renal Resistive Index Variation for Assessing Renal Functional Reserve in Patients Scheduled for Cardiac Surgery: A Pilot Study Open
Introduction: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common complication in patients undergoing cardiac surgery. Preoperative renal functional reserve (RFR) has been demonstrated to be highly predictive of CSA-AKI. W…
View article: A call to action to evaluate renal functional reserve in patients with COVID-19
A call to action to evaluate renal functional reserve in patients with COVID-19 Open
Coronavirus disease 2019 (COVID-19) poses an unprecedented challenge to world health systems, substantially increasing hospitalization and mortality rates in all affected countries. Being primarily a respiratory disease, COVID-19 is mainly…
View article: Recent Advances on Biomarkers of Early and Late Kidney Graft Dysfunction
Recent Advances on Biomarkers of Early and Late Kidney Graft Dysfunction Open
New biomarkers of early and late graft dysfunction are needed in renal transplant to improve management of complications and prolong graft survival. A wide range of potential diagnostic and prognostic biomarkers, measured in different biol…
View article: “War to the knife” against thromboinflammation to protect endothelial function of COVID-19 patients
“War to the knife” against thromboinflammation to protect endothelial function of COVID-19 patients Open
In this viewpoint, we summarize the relevance of thromboinflammation in COVID-19 and discuss potential mechanisms of endothelial injury as a key point for the development of lung and distant organ dysfunction, with a focus on direct viral …
View article: Extracellular Vesicles as Mediators of Cellular Crosstalk Between Immune System and Kidney Graft
Extracellular Vesicles as Mediators of Cellular Crosstalk Between Immune System and Kidney Graft Open
Extracellular vesicles (EVs) are known immune-modulators exerting a critical role in kidney transplantation (KT). EV bioactive cargo includes graft antigens, costimulatory/inhibitory molecules, cytokines, growth factors, and functional mic…
View article: Subclinical Contrast-Induced Acute Kidney Injury in Patients Undergoing Cerebral Computed Tomography
Subclinical Contrast-Induced Acute Kidney Injury in Patients Undergoing Cerebral Computed Tomography Open
Introduction: The nephrotoxicity of modern contrast media remains controversial. Novel biomarkers of kidney damage may help in identifying a subclinical structural renal injury not revealed by widely used markers of kidney function. Object…
View article: SaO061RADIOISOTOPIC EVALUATION OF RENAL FUNCTION IN KIDNEY DONORS AFTER NEPHRECTOMY FOR DETECTION OF EARLY AKI AND LONG TERM COMPENSATORY RENAL HYPERTROPHY
SaO061RADIOISOTOPIC EVALUATION OF RENAL FUNCTION IN KIDNEY DONORS AFTER NEPHRECTOMY FOR DETECTION OF EARLY AKI AND LONG TERM COMPENSATORY RENAL HYPERTROPHY Open
INTRODUCTION AND AIMS: Establish a register of individuals with an AKI warning test score and to estimate a population rate of AKI warning test score and thirty-day mortality.METHODS: In June 2014 NHS England issued a patient safety alert …
View article: Diagnosis and management of asymptomatic bacteriuria in kidney transplant recipients: a survey of current practice in Europe
Diagnosis and management of asymptomatic bacteriuria in kidney transplant recipients: a survey of current practice in Europe Open
Screening for and treating asymptomatic bacteriuria are common in KTRs despite uncertainties around the benefits and harms. In an era of antimicrobial resistance, further studies are needed to address the diagnosis and management of asympt…