Gabriele Riva
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View article: TIP-13. Advancing Patient-Centered Neurological Trials in Canada through Scientific Innovation and Operational Excellence at The Clinical Research Unit at The Montreal Neurological Institute and Hospital
TIP-13. Advancing Patient-Centered Neurological Trials in Canada through Scientific Innovation and Operational Excellence at The Clinical Research Unit at The Montreal Neurological Institute and Hospital Open
The Clinical Research Unit (CRU) at the Montreal Neurological Institute-Hospital (MNI) represents Canada’s most comprehensive academic center for neurological clinical trials, offering industry partners unmatched scientific capabilities an…
View article: Phonon-Assisted Radiative Lifetimes and Exciton Dynamics from First Principles
Phonon-Assisted Radiative Lifetimes and Exciton Dynamics from First Principles Open
Exciton-phonon interactions play a fundamental role in phonon-assisted radiative recombination and exciton dynamics in solids. In this work, we present a first-principles framework for computing phonon-assisted radiative lifetimes and exci…
View article: Multichannel Dyson equations for even- and odd-order Green's functions: application to double excitations
Multichannel Dyson equations for even- and odd-order Green's functions: application to double excitations Open
We extend the concept of the multichannel Dyson equation that we have recently derived to model photoemission spectra by coupling the one- and the three-body Green's functions, to higher-order Green's functions and to other spectroscopies.…
View article: Multichannel Dyson equation: derivation and analysis
Multichannel Dyson equation: derivation and analysis Open
In a recent letter [Phys. Rev. Lett. 131, 216401] we presented the multichannel Dyson equation (MCDE) in which two or more many-body Green's functions are coupled. In this work we will give further details of the MCDE approach. In particul…
View article: Glioblastoma scRNA-seq shows treatment-induced, immune-dependent increase in mesenchymal cancer cells and structural variants in distal neural stem cells
Glioblastoma scRNA-seq shows treatment-induced, immune-dependent increase in mesenchymal cancer cells and structural variants in distal neural stem cells Open
Background Glioblastoma is a treatment-resistant brain cancer. Its hierarchical cellular nature and its tumor microenvironment (TME) before, during, and after treatments remain unresolved. Methods Here, we used single-cell RNA sequencing t…
View article: Report on scipost_202110_00015v1
Report on scipost_202110_00015v1 Open
We present an original approach for the calculation of direct and inverse photo-emission spectra from first principles.The main goal is to go beyond the standard Green's function approaches, such as the GW method, in order to find a good d…
View article: Photoemission spectroscopy from the three-body Green's function
Photoemission spectroscopy from the three-body Green's function Open
We present an original approach for the calculation of direct and inverse photo-emission spectra from first principles. The main goal is to go beyond the standard Green's function approaches, such as the $GW$ method, in order to find a goo…
View article: Photoemission spectral functions from the three-body Green's function
Photoemission spectral functions from the three-body Green's function Open
We present an original strategy for the calculation of direct and inverse photo-emission spectra from first principles. The main goal is to go beyond the standard Green's function approaches, such as the $GW$ method, in order to find a goo…
View article: A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition
A Ploidy Increase Promotes Sensitivity of Glioma Stem Cells to Aurora Kinases Inhibition Open
Glioma stem cells account for glioblastoma relapse and resistance to conventional therapies, and protein kinases, involved in the regulation of the mitotic machinery (i.e., Aurora kinases), have recently emerged as attractive therapeutic t…
View article: Abstract 3778: Uncovering the role of glioma stem cells in glioblastoma chemo-resistance and recurrence
Abstract 3778: Uncovering the role of glioma stem cells in glioblastoma chemo-resistance and recurrence Open
Glioblastoma (GBM) is the most common malignant brain tumor. Despite multimodal aggressive therapies, the median survival after diagnosis is 14 months. The failure of current therapies is due to the presence within the tumor of a subpopula…
View article: Specific Expression of a New Bruton Tyrosine Kinase Isoform (p65BTK) in the Glioblastoma Gemistocytic Histotype
Specific Expression of a New Bruton Tyrosine Kinase Isoform (p65BTK) in the Glioblastoma Gemistocytic Histotype Open
Bruton's tyrosine-kinase (BTK) is a non-receptor tyrosine kinase recently associated with glioma tumorigenesis and a novel prognostic marker for poor survival in patients with glioma. The p65BTK is a novel BTK isoform involved in different…
View article: COMP-06. GLIOBLASTOMA DEVELOPMENT MIRRORS THE DEVELOPING BRAIN
COMP-06. GLIOBLASTOMA DEVELOPMENT MIRRORS THE DEVELOPING BRAIN Open
Intratumoral and interpatient heterogeneity are characteristics of glioblastoma and constitute important challenges in overcoming treatment resistance and developing new, more effective therapies. Using single-cell RNA sequencing, we chara…
View article: Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation
Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation Open
Glioblastoma is the most common malignant brain tumour in adults. The failure of current therapies can be ascribed to glioma stem cells (GSCs), which can rapidly repopulate the tumour following the initial treatment. The study of histone d…
View article: Single-cell RNA-seq reveals that glioblastoma recapitulates normal brain development
Single-cell RNA-seq reveals that glioblastoma recapitulates normal brain development Open
Summary Cancer stem cells are critical for cancer initiation, development, and resistance to treatments. Our understanding of these processes, and how they relate to glioblastoma heterogeneity, is limited. To overcome these limitations, we…
View article: Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway
Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway Open
Glioblastoma multiforme (GBM) is a grade IV astrocytoma and the most common form of malignant brain tumor in adults. GBM remains one of the most fatal and least successfully treated solid tumors: current therapies provide a median survival…
View article: Thyrospheres from B-CPAP Cell Line with <i>BRAF</i> and <i>TERT</i> Promoter Mutations have Different Functional and Molecular Features than Parental Cells
Thyrospheres from B-CPAP Cell Line with <i>BRAF</i> and <i>TERT</i> Promoter Mutations have Different Functional and Molecular Features than Parental Cells Open
Human thyroid cancer derived cell lines are widely used to study the mechanisms involved in thyroid carcinogenesis. However, there is limited availability of non-cross-contaminated cancer cell lines derived from papillary thyroid carcinoma…
View article: Epigenetic targeting of glioma stem cells: Short-term and long-term treatments with valproic acid modulate DNA methylation and differentiation behavior, but not temozolomide sensitivity
Epigenetic targeting of glioma stem cells: Short-term and long-term treatments with valproic acid modulate DNA methylation and differentiation behavior, but not temozolomide sensitivity Open
Glioblastoma (GBM) is the most aggressive tumor of the central nervous system. GBM is a fatal tumor, incurable by conventional therapies. One of the factors underlying tumor recurrence and poor long-term survival is the presence of a cance…
View article: The Effect of Culture on Human Bone Marrow Mesenchymal Stem Cells: Focus on DNA Methylation Profiles
The Effect of Culture on Human Bone Marrow Mesenchymal Stem Cells: Focus on DNA Methylation Profiles Open
Human bone marrow mesenchymal stem cells (hBM‐MSCs) are the best characterized multipotent adult stem cells. Their self‐renewal capacity, multilineage differentiation potential, and immunomodulatory properties have indicated that they can …
View article: Glioblastoma multiforme: a multidisciplinary approach to overcome chemoresistance and find new therapeutic strategies
Glioblastoma multiforme: a multidisciplinary approach to overcome chemoresistance and find new therapeutic strategies Open
Objectives: Glioblastoma multiforme is the most frequent malignant brain tumor. Patients die within 15 months after diagnosis. The failure of current therapies is ascribed to a subpopulation of cells with stem-like properties, called gliom…
View article: Pioglitazone Effect on Glioma Stem Cell Lines: Really a Promising Drug Therapy for Glioblastoma?
Pioglitazone Effect on Glioma Stem Cell Lines: Really a Promising Drug Therapy for Glioblastoma? Open
Glioblastoma multiforme (GBM) represents one of the most frequent malignant brain tumors. Current therapies do not provide real solutions to this pathology. Their failure can be ascribed to a cell subpopulation with stem-like properties ca…