Gabriella Aviello
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View article: Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice
Dysregulated NOX1-NOS2 activity as hallmark of ileitis in mice Open
Inflammation of the ileum, or ileitis, is commonly caused by Crohn's disease (CD) but can also accompany ulcerative colitis (backwash ileitis), infections or drug-related damage. Oxidative tissue injury triggered by reactive oxygen species…
View article: Alkalihalobacillus clausii (formerly Bacillus clausii) spores lessen antibiotic-induced intestinal injury and reshape gut microbiota composition in mice
Alkalihalobacillus clausii (formerly Bacillus clausii) spores lessen antibiotic-induced intestinal injury and reshape gut microbiota composition in mice Open
The antibiotic-induced intestinal injury (AIJ) is associated with diarrhoea and gastrointestinal discomfort. However, the pathological intestinal mechanisms and related side effects associated with antibiotic use/misuse may be counteracted…
View article: Editorial: Advances in inflammatory bowel disease: Mucosal defense mechanisms against gut inflammation
Editorial: Advances in inflammatory bowel disease: Mucosal defense mechanisms against gut inflammation Open
EDITORIAL article Front. Pharmacol., 21 February 2023Sec. Gastrointestinal and Hepatic Pharmacology Volume 14 - 2023 | https://doi.org/10.3389/fphar.2023.1147936
View article: Hypothalamic AgRP neurons exert top-down control on systemic TNF-α release during endotoxemia
Hypothalamic AgRP neurons exert top-down control on systemic TNF-α release during endotoxemia Open
Loss of appetite and negative energy balance are common features of endotoxemia in all animals and are thought to have protective roles by reducing nutrient availability to host and pathogen metabolism. Accordingly, fasting and caloric res…
View article: Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction
Oral sodium butyrate supplementation ameliorates paclitaxel-induced behavioral and intestinal dysfunction Open
View article: Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation
Anorectic and aversive effects of GLP-1 receptor agonism are mediated by brainstem cholecystokinin neurons, and modulated by GIP receptor activation Open
In addition to disclosing a neuronal population required for the full appetite- and body weight-lowering effect of GLP-1RAs, our data also provide a novel framework for understanding and ameliorating GLP-1RA-induced nausea - a major factor…
View article: Therapeutic management of a symptomatic Kaposi’s sarcoma patient with renal failure undergoing haemodialysis: A case report
Therapeutic management of a symptomatic Kaposi’s sarcoma patient with renal failure undergoing haemodialysis: A case report Open
Kaposi’s sarcoma (KS) is a rare inflammation- based vascular cancer involving the skin. The viral aetiology of KS is the Human Herpesvirus 8. KS may be frequently diagnosed in immunosuppressed kidneytransplanted patients, while is less com…
View article: Analgesic and Anti-Inflammatory Effects of Perampanel in Acute and Chronic Pain Models in Mice: Interaction With the Cannabinergic System
Analgesic and Anti-Inflammatory Effects of Perampanel in Acute and Chronic Pain Models in Mice: Interaction With the Cannabinergic System Open
Pain conditions, such as neuropathic pain (NP) and persistent inflammatory pain are therapeutically difficult to manage. Previous studies have shown the involvement of glutamate receptor in pain modulation and in particular same of these s…
View article: NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation
NADPH oxidase 4 is protective and not fibrogenic in intestinal inflammation Open
View article: Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects
Colitis susceptibility in mice with reactive oxygen species deficiency is mediated by mucus barrier and immune defense defects Open
View article: Schistosoma mansoni Worm Infection Regulates the Intestinal Microbiota and Susceptibility to Colitis
Schistosoma mansoni Worm Infection Regulates the Intestinal Microbiota and Susceptibility to Colitis Open
Infection with parasite helminths induces potent modulation of the immune system of the host. Epidemiological and animal studies have shown that helminth infections can suppress or exacerbate unrelated autoimmune, allergic, and other infla…
View article: ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism
ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism Open
The A20-binding inhibitor of NF-κB 2 (ABIN2) interacts with Met1-linked ubiquitin chains and is an integral component of the tumor progression locus 2 (Tpl2) kinase complex. We generated a knock-in mouse expressing the ubiquitin-binding–de…
View article: Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N
Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N Open
View article: NADPH oxidases and ROS signaling in the gastrointestinal tract
NADPH oxidases and ROS signaling in the gastrointestinal tract Open
View article: Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis
Pharmacological inhibition of MAGL attenuates experimental colon carcinogenesis Open
View article: DOP085 Tight NADPH oxidase regulation is a prerequisite for gut health
DOP085 Tight NADPH oxidase regulation is a prerequisite for gut health Open
Background: Tight control of reactive oxygen species (ROS) production is vital in chronic inflammatory disorders. Overproduction of ROS can lead to oxidative stress, but likewise insufficient ROS compromises the host's antimicrobial…
View article: Cellular ROS imaging with hydro-Cy3 dye is strongly influenced by mitochondrial membrane potential
Cellular ROS imaging with hydro-Cy3 dye is strongly influenced by mitochondrial membrane potential Open
View article: Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection
Defensive Mutualism Rescues NADPH Oxidase Inactivation in Gut Infection Open
View article: Tools for Controlling Activity of Neural Circuits Can Boost Gastrointestinal Research
Tools for Controlling Activity of Neural Circuits Can Boost Gastrointestinal Research Open
We thank Prof U. G. Knaus and T. C. Collin for critical reading of the manuscript. GA is supported by the European Crohn's and Colitis Organization (ECCO) (J/15/2) and by the National Childrens' Research Centre (K/12/1). GD is supported by…
View article: Defects in Nicotinamide-adenine Dinucleotide Phosphate Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease
Defects in Nicotinamide-adenine Dinucleotide Phosphate Oxidase Genes NOX1 and DUOX2 in Very Early Onset Inflammatory Bowel Disease Open