Gabriella C. Reeder
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View article: Evolutionarily guided transcription factor design programs novel T cell states
Evolutionarily guided transcription factor design programs novel T cell states Open
Protein-coding genes in the human genome evolved via modular rearrangement of domains from ancestral genes 1 . Here, we develop a scalable, evolutionarily guided method to assemble novel protein-coding genes from constituent domains within…
View article: Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia
Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia Open
View article: Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19
Distinct pulmonary and systemic effects of dexamethasone in severe COVID-19 Open
Dexamethasone is the standard of care for critically ill patients with COVID-19, but the mechanisms by which it decreases mortality and its immunological effects in this setting are not understood. Here we perform bulk and single-cell RNA …
View article: A Multiomics, Spatiotemporal, and Single Cell Atlas for Mapping Cell-Type-Specific Dysregulation at the Maternal-Fetal Interface
A Multiomics, Spatiotemporal, and Single Cell Atlas for Mapping Cell-Type-Specific Dysregulation at the Maternal-Fetal Interface Open
The placenta, the first organ to functionally mature, undergoes disordered development in many pregnancy complications. Molecular investigations have been hampered by the extreme cellular heterogeneity of the placenta, and this complexity …
View article: A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling
A myeloid program associated with COVID-19 severity is decreased by therapeutic blockade of IL-6 signaling Open
Altered myeloid inflammation and lymphopenia are hallmarks of severe infections. We identified the upregulated EN-RAGE gene program in airway and blood myeloid cells from patients with acute lung injury from SARS-CoV-2 or other causes acro…
View article: An evolved AAV variant enables efficient genetic engineering of murine T cells
An evolved AAV variant enables efficient genetic engineering of murine T cells Open
Precise targeting of large transgenes to T cells using homology-directed repair has been transformative for adoptive cell therapies and T cell biology. Delivery of DNA templates via adeno-associated virus (AAV) has greatly improved knockin…
View article: Discovering dominant tumor immune archetypes in a pan-cancer census
Discovering dominant tumor immune archetypes in a pan-cancer census Open
View article: Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium
Single-cell multiomics defines tolerogenic extrathymic Aire-expressing populations with unique homology to thymic epithelium Open
Extrathymic Aire-expressing cells are hematopoietic migratory DC–like populations with homology to medullary thymic epithelium.
View article: Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS
Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS Open
The immunological features that distinguish COVID-19-associated acute respiratory distress syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report the results of comparative lower respiratory tract transcript…
View article: Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19
Publisher Correction: Global absence and targeting of protective immune states in severe COVID-19 Open
View article: Active surveillance characterizes human intratumoral T cell exhaustion
Active surveillance characterizes human intratumoral T cell exhaustion Open
Intratumoral T cells that might otherwise control tumors are often identified in an "exhausted" state, defined by specific epigenetic modifications and upregulation of genes such as CD38, cytotoxic T-lymphocyte-associated protein 4 (CTLA4)…
View article: Active Surveillance Characterizes Human Intratumoral T Cell Exhaustion
Active Surveillance Characterizes Human Intratumoral T Cell Exhaustion Open
Intratumoral T cells that might otherwise control tumors are often identified in an ‘exhausted’ state, defined by specific epigenetic modifications as well as upregulation of genes such as CD38, CTLA-4 and PD-1. While the term might imply …
View article: Global absence and targeting of protective immune states in severe COVID-19
Global absence and targeting of protective immune states in severe COVID-19 Open
Although infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has pleiotropic and systemic effects in some individuals1-3, many others experience milder symptoms. Here, to gain a more comprehensive underst…
View article: A Pan-Cancer Census of Dominant Tumor Immune Archetypes
A Pan-Cancer Census of Dominant Tumor Immune Archetypes Open
View article: Global Absence and Targeting of Protective Immune States in Severe COVID-19
Global Absence and Targeting of Protective Immune States in Severe COVID-19 Open
While SARS-CoV-2 infection has pleiotropic and systemic effects in some patients, many others experience milder symptoms. We sought a holistic understanding of the severe/mild distinction in COVID-19 pathology, and its origins. We performe…
View article: Global Absence and Targeting of Protective Immune States in Severe COVID-19.
Global Absence and Targeting of Protective Immune States in Severe COVID-19. Open