Gabriella Guelfi
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View article: Sustainable Valorization of Grape Pomace in Sheep Through Systemic Health, Metabolic Safety, Milk and Meat Quality
Sustainable Valorization of Grape Pomace in Sheep Through Systemic Health, Metabolic Safety, Milk and Meat Quality Open
Grape pomace (GP), a by-product of winemaking, is rich in polyphenols and fiber, making it a promising and sustainable feed supplement for ruminants. This study evaluated the safety and productive impact of a 5% GP-supplemented diet (GP5) …
View article: MicroRNA Expression Profiling in Canine Myxomatous Mitral Valve Disease Highlights Potential Diagnostic Tool and Molecular Pathways
MicroRNA Expression Profiling in Canine Myxomatous Mitral Valve Disease Highlights Potential Diagnostic Tool and Molecular Pathways Open
Myxomatous mitral valve disease (MMVD) is the most common acquired cardiac disoder in dogs and a relevant model for human mitral valve disease. However, the molecular drivers of disease progression remain unclear, and reliable biomarkers f…
View article: Definition of Meat Quality Across Different Cattle Breeds to Support Consumer Choices Through an Accurate Labelling
Definition of Meat Quality Across Different Cattle Breeds to Support Consumer Choices Through an Accurate Labelling Open
Consumer preferences for beef are increasingly driven by a desire for hygienic and nutritious meat with excellent organoleptic qualities. This paper investigates the impact of cattle breed on key quality attributes—colour, marbling, and te…
View article: A miR-30 Guided Molecular Profiling of Canine Osteosarcoma and Extraskeletal Osteosarcoma Reveals Non-Seed Regulatory Divergence
A miR-30 Guided Molecular Profiling of Canine Osteosarcoma and Extraskeletal Osteosarcoma Reveals Non-Seed Regulatory Divergence Open
Osteosarcoma (OS) and extraskeletal osteosarcoma (EOS) in dogs exhibit histological similarities but differ in anatomical origin, which poses a challenge to diagnostic accuracy. We adopted a marker-first strategy to enhance molecular class…
View article: Do NGF and LPS Interact Synergistically to Modulate Inflammation in Sheep Endometrial Epithelial Cells?
Do NGF and LPS Interact Synergistically to Modulate Inflammation in Sheep Endometrial Epithelial Cells? Open
Neurotrophins and inflammatory mediators are known to influence endometrial function, but their interplay in luminal epithelial cells remains poorly characterized. In this study, sheep endometrial luminal epithelial cells (SELECs) were tre…
View article: The Emerging Role of Water Loss in Dog Aging
The Emerging Role of Water Loss in Dog Aging Open
Aging involves progressive physiological changes, including the dysregulation of water homeostasis, essential for cellular function, neuronal signaling, and musculoskeletal integrity. This review explores the emerging role of water loss as…
View article: The Autocrine Impact of Nerve Growth Factor on Sheep Uterine Epithelial Cells
The Autocrine Impact of Nerve Growth Factor on Sheep Uterine Epithelial Cells Open
Nerve growth factor (NGF) plays a critical role in reproduction through paracrine and endocrine mechanisms. However, its autocrine effects on uterine receptivity and inflammatory pathways remain unknown. This study is the first to demonstr…
View article: Diet Supplementation Influences Ghrelin System Expression in the Skin Appendages of the Sheep
Diet Supplementation Influences Ghrelin System Expression in the Skin Appendages of the Sheep Open
Ghrelin (GhRL) is an orexigenic hormone influenced by nutritional state. It plays a role in skin repair and diseases, though little information exists regarding its function in this organ. GhRL and its receptor were investigated in the ski…
View article: Dog Aging: A Comprehensive Review of Molecular, Cellular, and Physiological Processes
Dog Aging: A Comprehensive Review of Molecular, Cellular, and Physiological Processes Open
The aging process is a multifactorial biological phenomenon starting at birth and persisting throughout life, characterized by a decline in physiological functions and adaptability. This decline results in the diminished capacity of aging …
View article: From Gene to Protein: Unraveling the Reproductive Blueprint of Male Grey Squirrels via Nerve Growth Factor (NGF) and Cognate Receptors
From Gene to Protein: Unraveling the Reproductive Blueprint of Male Grey Squirrels via Nerve Growth Factor (NGF) and Cognate Receptors Open
The grey squirrel, an invasive species, threatens the Eurasian red squirrel’s conservation, particularly in Umbria, Italy. Understanding its reproductive biology is essential to limiting its reproductive success. This study investigates th…
View article: Interleukin-1 Beta (IL1B) and Nerve Growth Factor (NGF): Key Players in Rabbit Reproductive Regulation
Interleukin-1 Beta (IL1B) and Nerve Growth Factor (NGF): Key Players in Rabbit Reproductive Regulation Open
Several seminal plasma components, besides NGF, are implicated as ovulation-inducing factors in mammals. This study investigated the IL1B and its receptor IL1R1 in the testis (T), male accessory glands, prostate (P) and seminal vesicles (S…
View article: The Molecular Signature Related to Local Inflammatory and Immune Response in Canine Cutaneous Hypersensitivity Reactions: A Preliminary Study
The Molecular Signature Related to Local Inflammatory and Immune Response in Canine Cutaneous Hypersensitivity Reactions: A Preliminary Study Open
Cutaneous hypersensitivity reactions (CHRs) are complex inflammatory skin disorders that affect humans and dogs. This study examined the inflammatory and immune responses leading to skin damage, inflammation, and irritation by investigatin…
View article: Feline hypertrophic cardiomyopathy: Does the <scp>microRNA</scp>‐<scp>mRNA</scp> regulatory network contribute to heart sarcomeric protein remodelling?
Feline hypertrophic cardiomyopathy: Does the <span>microRNA</span>‐<span>mRNA</span> regulatory network contribute to heart sarcomeric protein remodelling? Open
Feline primary hypertrophic cardiomyopathy (HCM) is an intrinsic myocardial disease characterized by concentric hypertrophy of the left ventricle. In the present study, we investigated the microRNA‐mRNA regulatory network in feline myocard…
View article: Seasonal variation of NGF in seminal plasma and expression of NGF and its cognate receptors NTRK1 and p75NTR in the sex organs of rams
Seasonal variation of NGF in seminal plasma and expression of NGF and its cognate receptors NTRK1 and p75NTR in the sex organs of rams Open
Nerve growth factor (NGF) has long been known as the main ovulation-inducing factor in induced ovulation species, however, recent studies suggested the NGF role also in those with spontaneous ovulation. The first aim of this study was to e…
View article: Mimic miRNA and Anti-miRNA Activated Scaffolds as a Therapeutic Strategy to Promote Bone, Cartilage, and Skin Regeneration
Mimic miRNA and Anti-miRNA Activated Scaffolds as a Therapeutic Strategy to Promote Bone, Cartilage, and Skin Regeneration Open
MiRNA-based therapies represent an innovative and promising strategy applicable to various medical fields, such as tissue regeneration and the treatment of numerous diseases, including cancer, cardiovascular problems, and viral infections.…
View article: The Role of Genistein in Mammalian Reproduction
The Role of Genistein in Mammalian Reproduction Open
Genistein is a natural compound belonging to flavonoids, having antioxidant, anti-inflammatory, and anti-neoplastic properties. Genistein is considered a phytoestrogen. As such, genistein can bind estrogen receptors (ERα and ERβ), although…
View article: Identification of Appropriate Endogenous Controls for Circulating miRNA Quantification in Working Dogs under Physiological Stress Conditions
Identification of Appropriate Endogenous Controls for Circulating miRNA Quantification in Working Dogs under Physiological Stress Conditions Open
Cell-free miRNAs, called circulating miRNAs (cmiRNAs), can act in a paracrine manner by facilitating a diversity of signaling mechanisms between cells. Real-time qPCR is the most accepted method for quantifying miRNA expression levels. The…
View article: Editorial: Women in animal behavior and welfare: 2021
Editorial: Women in animal behavior and welfare: 2021 Open
The work of female scientists often does not receive the attention it deserves. To recognize and 14 promote the achievements of women in animal behavior and welfare science, this Research Topic 15 aims to highlight the scientific contribut…
View article: Interferon Tau (IFNt) and Interferon-Stimulated Genes (ISGs) Expression in Peripheral Blood Leukocytes and Correlation with Circulating Pregnancy-Associated Glycoproteins (PAGs) during Peri-Implantation and Early Pregnancy in Buffalo Cows
Interferon Tau (IFNt) and Interferon-Stimulated Genes (ISGs) Expression in Peripheral Blood Leukocytes and Correlation with Circulating Pregnancy-Associated Glycoproteins (PAGs) during Peri-Implantation and Early Pregnancy in Buffalo Cows Open
The objective of this study was to analyze interferon-stimulated genes (ISGs) and interferon tau (IFNt) gene expression in peripheral blood leukocytes during the peri-implantation period and until 40 days of pregnancy in buffalo cows. Rela…
View article: The Complex Interaction between P53 and miRNAs Joins New Awareness in Physiological Stress Responses
The Complex Interaction between P53 and miRNAs Joins New Awareness in Physiological Stress Responses Open
This review emphasizes the important role of cross-talk between P53 and microRNAs in physiological stress signaling. P53 responds to stress in a variety of ways ranging from activating survival-promotion pathways to triggering programmed c…
View article: Extracellular circulating miRNAs as stress-related signature to search and rescue dogs
Extracellular circulating miRNAs as stress-related signature to search and rescue dogs Open
Our research explores serum extracellular circulating miRNAs (ecmiRNAs) involved in dog stress response immediately after the search and rescue (SAR) of missing people. The experimental plan considers four arduous SAR simulations. The SAR …
View article: How Do Avalanche Dogs (and Their Handlers) Cope with Physical Exercise? Heart Rate Changes during Endurance in a Snowy Environment
How Do Avalanche Dogs (and Their Handlers) Cope with Physical Exercise? Heart Rate Changes during Endurance in a Snowy Environment Open
This study aimed to assess the heart rate (HR) responses of avalanche SAR dogs and handlers under working field conditions. Thirteen SAR units (dogs and handlers) performed an exercise (Endurance) consisting of approximately 5.5 km of roug…
View article: Omics Insights into Animal Resilience and Stress Factors
Omics Insights into Animal Resilience and Stress Factors Open
Resilience is conceived as a dynamic developmental process involving the achievement of positive adaptation within the context of significant adversity. Resilience is not a unique ability but rather a set of capacities of a system put in p…
View article: The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis
The Prophylactic Use of Bovine Colostrum in a Murine Model of TNBS-Induced Colitis Open
This study investigated the effects of a short-term administration of bovine colostrum (BC) in a TNBS model of induced colitis. Colitis was induced by TNBS treatment after seven days of BC (BC group, n = 12) or saline (control group, n = 1…
View article: Benefits of dietary supplements on the physical fitness of German Shepherd dogs during a drug detection training course
Benefits of dietary supplements on the physical fitness of German Shepherd dogs during a drug detection training course Open
A high standard of physical fitness is an essential characteristic of drug detection dogs because it affects not only their ability to sustain high activity levels but also their attention and olfaction efficiency. Nutritional supplements …
View article: A cross-talk between blood-cell neuroplasticity-related genes and environmental enrichment in working dogs
A cross-talk between blood-cell neuroplasticity-related genes and environmental enrichment in working dogs Open
This study aims to identify a panel of blood-cell neuroplasticity-related genes expressed following environmental enrichment stimulation (EE). The Drug detection (DD) training course was an excellent model for the study of EE in the workin…
View article: Validation of a qualitative behaviour score during the capture phase of stray dogs
Validation of a qualitative behaviour score during the capture phase of stray dogs Open
There are no studies on the capture phase of stray dogs, although this can be very stressful and have a significant impact on dogs’ welfare. In this preliminary study, we propose a simple qualitative evaluation system of the dog’s behaviou…
View article: Multi-Operator Qualitative Behavioural Assessment for dogs entering the shelter
Multi-Operator Qualitative Behavioural Assessment for dogs entering the shelter Open
View article: Investigation of PAG2 mRNA Expression in Water Buffalo Peripheral Blood Mononuclear Cells and Polymorphonuclear Leukocytes from Maternal Blood at the Peri-Implantation Period
Investigation of PAG2 mRNA Expression in Water Buffalo Peripheral Blood Mononuclear Cells and Polymorphonuclear Leukocytes from Maternal Blood at the Peri-Implantation Period Open
The main objective of this study was to assess PAG2 mRNA expression in maternal blood cells at the peri-implantation period in water buffalo; moreover, we wanted to evaluate the earliest time in which PAG-2 could be detected in maternal bl…
View article: Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice
Preventive effects of bovine colostrum supplementation in TNBS-induced colitis in mice Open
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder for which the current medical therapy is not completely effective. Bovine colostrum (BC) is a biological fluid rich in bioactive molecules that may have beneficial effects…