Gabriella Nesi
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View article: Sutureless clampless partial nephrectomy: where do we stand? A narrative review
Sutureless clampless partial nephrectomy: where do we stand? A narrative review Open
This review aims to evaluate the current literature on sutureless clampless partial nephrectomy (sl-oc PN) and assess its potential advantages in terms of renal function preservation, oncological safety, and perioperative outcomes. We cond…
View article: Overlapping Extremes: An Analysis of Avelumab Maintenance and Pembrolizumab in Advanced Urothelial Carcinoma
Overlapping Extremes: An Analysis of Avelumab Maintenance and Pembrolizumab in Advanced Urothelial Carcinoma Open
OBSERVE-UC study; registration ID: CEAVC 25351.
View article: Ulcerative colitis and colorectal cancer: Pathogenic insights and precision strategies for prevention and treatment
Ulcerative colitis and colorectal cancer: Pathogenic insights and precision strategies for prevention and treatment Open
Ulcerative colitis (UC) is associated with an increased risk of developing colitis-associated colorectal cancer (caCRC), a major complication of long-standing disease. In this review, we examined the pathogenic association between UC and c…
View article: MON-505 Genetic Dissection by Whole Exome Analysis of Unilateral Coexisting Adrenal Cortical Adenoma and Carcinoma in the Context of MEN1 Syndrome
MON-505 Genetic Dissection by Whole Exome Analysis of Unilateral Coexisting Adrenal Cortical Adenoma and Carcinoma in the Context of MEN1 Syndrome Open
Disclosure: F. Cioppi: None. T. Orioli: None. G. Cantini: None. T. Ercolino: None. F. Cioppi: None. G. Assié: None. A. Jouinot: None. A.A. Dedonno: None. M. Maggi: None. M. Benelli: None. L. Canu: None. G. Nesi: None. M. Luconi: None. Mult…
View article: Targeting carbonic anhydrase <scp>IX</scp> / <scp>XII</scp> prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma
Targeting carbonic anhydrase <span>IX</span> / <span>XII</span> prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma Open
Ferroptosis is a form of regulated cell death dependent on iron‐driven phospholipid peroxidation and is controlled by both cell autonomous and non‐cell autonomous mechanisms. In prostate cancer (PCa), tumor cells engage in a metabolic cros…
View article: Functional and Oncologic Outcomes in Single-Kidney Patients Treated with Robot-Assisted Partial Nephrectomy for Renal Tumors: Results from a Prospectively Maintained Dataset of a Single Tertiary Referral Center
Functional and Oncologic Outcomes in Single-Kidney Patients Treated with Robot-Assisted Partial Nephrectomy for Renal Tumors: Results from a Prospectively Maintained Dataset of a Single Tertiary Referral Center Open
Background: Renal tumors in solitary kidneys require treatments that optimize both oncological and functional outcomes. Robot-assisted partial nephrectomy (RAPN) offers a balance between these needs and reduced morbidity. This study invest…
View article: Current practices in prostate pathology reporting: results from a survey of genitourinary and general pathologists
Current practices in prostate pathology reporting: results from a survey of genitourinary and general pathologists Open
Aims Standardizing pathology reporting protocols through peer consensus review is critical for the best quality of care metrics. Reporting heterogeneity due to discrepancies among professional societies and practice patterns may lead to he…
View article: CD44 Methylation Levels in Androgen-Deprived Prostate Cancer: A Putative Epigenetic Modulator of Tumor Progression
CD44 Methylation Levels in Androgen-Deprived Prostate Cancer: A Putative Epigenetic Modulator of Tumor Progression Open
Epigenetic changes have been reported to promote the development and progression of prostate cancer (PCa). Compared to normal prostate tissue, tumor samples from patients treated with androgen-deprivation therapy (ADT) show the hypermethyl…
View article: Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas
Emerging role of IGF1R and IR expression and localisation in adrenocortical carcinomas Open
View article: How Rudolph Virchow changed the approach to autopsy of the brain
How Rudolph Virchow changed the approach to autopsy of the brain Open
Anatomical studies of the brain and successive analyses of this organ were performed in ancient times. Indeed, notes found in the Edwin Smith Papyrus mention that the Egyptians identified the meninges and gyri millennia ago. Their successo…
View article: Hypoxia-Inducible Factor in Renal Cell Carcinoma: From Molecular Insights to Targeted Therapies
Hypoxia-Inducible Factor in Renal Cell Carcinoma: From Molecular Insights to Targeted Therapies Open
Mutations of the von Hippel–Lindau (VHL) tumor suppressor gene occur frequently in clear cell renal cell carcinoma (RCC), the predominant histology of kidney cancer, and have been associated with its pathogenesis and progression. Alteratio…
View article: Cell-Free Carbonic Anhydrase IX mRNA in Urine as Biomarker for Urogenital Cancers: The Relationship Between Urinary Extracellular RNA and Tumor-Cell-Associated RNA
Cell-Free Carbonic Anhydrase IX mRNA in Urine as Biomarker for Urogenital Cancers: The Relationship Between Urinary Extracellular RNA and Tumor-Cell-Associated RNA Open
Circulating tumor cells and cell-free nucleic acids are novel diagnostic, prognostic and predictive tools for non-invasive and cost-effective cancer detection in liquid biopsy. Carbonic anhydrase IX (CAIX) has been proposed as a biomarker …
View article: Medullary carcinomas of the nonampullary small intestine: association with coeliac disease, mismatch repair deficiency, PD‐L1 expression, and favourable prognosis
Medullary carcinomas of the nonampullary small intestine: association with coeliac disease, mismatch repair deficiency, PD‐L1 expression, and favourable prognosis Open
Aim Gastrointestinal medullary carcinoma is a rare histologic subtype of adenocarcinoma. As nonampullary small bowel medullary carcinomas (SB‐MCs) are poorly characterized, we aimed to analyse their clinicopathologic and immunohistochemica…
View article: Targeted Next Generation Sequencing molecular profiling and its clinical application in adrenocortical cancer
Targeted Next Generation Sequencing molecular profiling and its clinical application in adrenocortical cancer Open
Objective Adrenal cortical carcinoma (ACC) is a rare malignancy with a generally poor but heterogeneous prognosis, especially depending on the tumour stage at diagnosis. Identification of somatic gene alterations combined with clinical/his…
View article: Correction to: Differential HLA class I subunit (A, B, C heavy chain and β2-microglobulin) expression levels in normal tissues
Correction to: Differential HLA class I subunit (A, B, C heavy chain and β2-microglobulin) expression levels in normal tissues Open
View article: High Filamin a Expression in Adrenocortical Carcinomas Is Associated with a Favourable Tumour Behaviour: A European Multicentric Study
High Filamin a Expression in Adrenocortical Carcinomas Is Associated with a Favourable Tumour Behaviour: A European Multicentric Study Open
The insulin-like growth factor 2 (IGF2) promotes cell growth by overactivating the IGF system in an autocrine loop in adrenocortical carcinomas (ACCs). The cytoskeleton protein filamin A (FLNA) acts as a repressor of IGF2 mitogenic signall…
View article: Prophylactic Lymphadenectomy in Patients with Penile Cancer: Is Sooner Better?
Prophylactic Lymphadenectomy in Patients with Penile Cancer: Is Sooner Better? Open
Background: Management of penile cancer patients has its grey zones. In particular, no strong evidence or recommendations exist regarding the timing of prophylactic lymphadenectomy. Here, we aim to review the impact that the timing of ingu…
View article: Platinum-based chemotherapy in metastatic prostate cancer: what possibilities?
Platinum-based chemotherapy in metastatic prostate cancer: what possibilities? Open
View article: Correction to: Voices from the past: results of the ESP history of pathology working group survey on pathology museums
Correction to: Voices from the past: results of the ESP history of pathology working group survey on pathology museums Open
View article: Immunotherapy-related biomarkers: Confirmations and uncertainties
Immunotherapy-related biomarkers: Confirmations and uncertainties Open
Immunotherapy profoundly changed oncology treatment, becoming one of the main therapeutical strategies. Remarkable improvement has been achieved in survival outcomes, but the percentage of patients who benefit from immunotherapy is still l…
View article: Intratumour microbiota modulates adrenocortical cancer responsiveness to mitotane
Intratumour microbiota modulates adrenocortical cancer responsiveness to mitotane Open
The infiltrating microbiota represents a novel cellular component of the solid tumour microenvironment that can influence tumour progression and response to therapy. Adrenocortical carcinoma (ACC) is a rare and aggressive endocrine maligna…
View article: Gender and cystectomy for bladder cancer: A high-volume tertiary urologic care center experience
Gender and cystectomy for bladder cancer: A high-volume tertiary urologic care center experience Open
View article: Tyrosine kinase and immune checkpoints inhibitors in favorable risk metastatic renal cell carcinoma: Trick or treat?
Tyrosine kinase and immune checkpoints inhibitors in favorable risk metastatic renal cell carcinoma: Trick or treat? Open
Over the past decade, the management of metastatic renal cell carcinoma (RCC) has undergone rapid evolution, culminating in a significant improvement in prognosis with frontline immunotherapy. RCC is a highly immuno-genic and pro-angiogeni…
View article: A Guide to Perform 3D Histology of Biological Tissues with Fluorescence Microscopy
A Guide to Perform 3D Histology of Biological Tissues with Fluorescence Microscopy Open
The analysis of histological alterations in all types of tissue is of primary importance in pathology for highly accurate and robust diagnosis. Recent advances in tissue clearing and fluorescence microscopy made the study of the anatomy of…
View article: Prognostic Value of Microscopic Tumor Necrosis in Adrenal Cortical Carcinoma
Prognostic Value of Microscopic Tumor Necrosis in Adrenal Cortical Carcinoma Open
Adrenal cortical carcinoma (ACC) is an uncommon neoplasm with variable prognosis. Several histologic criteria have been identified as predictors of malignancy in adrenal cortical tumors. The Weiss score is the system most widely employed f…
View article: Adjuvant Therapy for Renal Cell Carcinoma: Hype or Hope?
Adjuvant Therapy for Renal Cell Carcinoma: Hype or Hope? Open
Renal cell carcinoma (RCC) is the third most common genitourinary cancer accounting for approximately 180,000 deaths worldwide in 2020. Although over two-thirds of patients initially present localized disease, up to 50% of them may progres…
View article: DNA repair deficiency as circulating biomarker in prostate cancer
DNA repair deficiency as circulating biomarker in prostate cancer Open
Deleterious aberrations in DNA repair genes are actionable in approximately 25% of metastatic castration-resistant prostate cancers (mCRPC) patients. Homology recombination repair (HRR) is the DNA damage repair (DDR) mechanism most frequen…
View article: Carbonic anhydrases III and IX are new players in the crosstalk between adrenocortical carcinoma and its altered adipose microenvironment
Carbonic anhydrases III and IX are new players in the crosstalk between adrenocortical carcinoma and its altered adipose microenvironment Open
View article: Inflammation in Urological Malignancies: The Silent Killer
Inflammation in Urological Malignancies: The Silent Killer Open
Several studies have investigated the role of inflammation in promoting tumorigenesis and cancer progression. Neoplastic as well as surrounding stromal and inflammatory cells engage in well-orchestrated reciprocal interactions to establish…
View article: Brief history of the who blue books on urinary and male genital tumours
Brief history of the who blue books on urinary and male genital tumours Open
The fifth edition of the World Health Organization (WHO) "Blue Book" on urinary and male genital tumours was published in 2022, but since when has the WHO been concerned about the classification of these neoplasms? It all began in 1952, wh…