Gabriella Orlando
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View article: Proactive antimicrobial stewardship with real-time microbiological alerts improves management of bloodstream infections
Proactive antimicrobial stewardship with real-time microbiological alerts improves management of bloodstream infections Open
Introduction This study aims to assess the impact of proactive Infectious Disease Specialist (IDS) interventions, in addition to standard antimicrobial stewardship (AMS) practices, triggered by real-time microbiological alerts, on improvin…
View article: Impact of vancomycin resistance on attributable mortality among <i>Enterococcus faecium</i> bloodstream infections: propensity score analysis of a large, multicentre retrospective study
Impact of vancomycin resistance on attributable mortality among <i>Enterococcus faecium</i> bloodstream infections: propensity score analysis of a large, multicentre retrospective study Open
Background Conflicting results exist about mortality risk of infections caused by vancomycin-susceptible Enterococcus faecium (VSEfm) and vancomycin-resistant Enterococcus faecium (VREfm). Our aim was to compare risk factors and clinical o…
View article: Central Nervous System Infections Caused by Bacillus Calmette–Guerin: Case Report and Narrative Literature Review
Central Nervous System Infections Caused by Bacillus Calmette–Guerin: Case Report and Narrative Literature Review Open
Bacillus Calmette–Guerin (BCG) central nervous system (CNS) infections are one of the rarest complications following BCG exposure. A 77-year-old male, with bladder cancer previously treated with BCG instillation, presented with fever, conf…
View article: P09. Clinical characteristics and outcomes of <i>Pseudomonas aeruginosa</i> community isolates from lower respiratory tract in intensive versus non- intensive care units: a 6-years retrospective cohort study
P09. Clinical characteristics and outcomes of <i>Pseudomonas aeruginosa</i> community isolates from lower respiratory tract in intensive versus non- intensive care units: a 6-years retrospective cohort study Open
Introduction Data about differences between patients infected or colonized with Pseudomonas aeruginosa (PA) isolate from lower respiratory tract at time of hospital admission are limited. This study aims to: compare susceptibility pattern,…
View article: P25. Characteristics, treatment options, and predictors of clinical failure among Pseudomonas aeruginosa infection with microbiologically confirmed intermediate or resistant carbapenem susceptibility profile: a multicenter clinical experience on behalf of CASPER (CArbapenem-reSistant <i>Pseudomonas aERuginosa</i> during and after the COVID-19 pandemic) study group
P25. Characteristics, treatment options, and predictors of clinical failure among Pseudomonas aeruginosa infection with microbiologically confirmed intermediate or resistant carbapenem susceptibility profile: a multicenter clinical experience on behalf of CASPER (CArbapenem-reSistant <i>Pseudomonas aERuginosa</i> during and after the COVID-19 pandemic) study group Open
Background This study aims to assess the risk factors for clinical failure in carbapenem-intermediate-resistant Pseudomonas aeruginosa (CiRPA) infections, focusing on susceptibility profiles, prior treatments, and the effectiveness of curr…
View article: Comparison of Patients With or Without COVID-19 and Without Hematological Diseases Treated for Invasive Pulmonary Aspergillosis: A 5-Year Retrospective Cohort Study with Propensity-Based Adjustment
Comparison of Patients With or Without COVID-19 and Without Hematological Diseases Treated for Invasive Pulmonary Aspergillosis: A 5-Year Retrospective Cohort Study with Propensity-Based Adjustment Open
Background Our aim was to compare epidemiological, clinical and treatment characteristics, and outcomes between patients with diagnoses of coronavirus disease 2019–associated pulmonary aspergillosis (CAPA) or putative invasive pulmonary as…
View article: Intravenous fosfomycin in combination regimens as a treatment option for difficult-to-treat infections due to multi-drug-resistant Gram-negative organisms: A real-life experience
Intravenous fosfomycin in combination regimens as a treatment option for difficult-to-treat infections due to multi-drug-resistant Gram-negative organisms: A real-life experience Open
View article: Long-Term Suppressive Therapeutic-Drug-Monitoring-Guided Dalbavancin Therapy for Cardiovascular Prosthetic Infections
Long-Term Suppressive Therapeutic-Drug-Monitoring-Guided Dalbavancin Therapy for Cardiovascular Prosthetic Infections Open
Dalbavancin represents a promising treatment for cardiovascular prosthetic infections due to its prolonged half-life, bactericidal activity, large spectrum of activity, and excellent biofilm penetration. However, the use of dalbavancin in …
View article: Vancomycin resistant enterococcus risk factors for hospital colonization in hematological patients: a matched case-control study
Vancomycin resistant enterococcus risk factors for hospital colonization in hematological patients: a matched case-control study Open
Background Vancomycin-resistant enterococcus (VRE) was the fastest growing pathogen in Europe in 2022 (+ 21%) but its clinical relevance is still unclear. We aim to identify risk factors for acquired VRE rectal colonization in hematologica…
View article: Evaluating immunological and inflammatory changes of treatment-experienced people living with HIV switching from first-line triple cART regimens to DTG/3TC vs. B/F/TAF: the DEBATE trial
Evaluating immunological and inflammatory changes of treatment-experienced people living with HIV switching from first-line triple cART regimens to DTG/3TC vs. B/F/TAF: the DEBATE trial Open
Background The aim of this randomized clinical trial (RCT) was to compare immunological changes in virally suppressed people living with HIV (PLWH) switching from a three-drug regimen (3DR) to a two-drug regimen (2DR). Methods An open-labe…
View article: A Fatal Case of Pseudomonas aeruginosa Community-Acquired Pneumonia in an Immunocompetent Patient: Clinical and Molecular Characterization and Literature Review
A Fatal Case of Pseudomonas aeruginosa Community-Acquired Pneumonia in an Immunocompetent Patient: Clinical and Molecular Characterization and Literature Review Open
Rare cases of Pseudomonas aeruginosa community-acquired pneumonia (PA-CAP) were reported in non-immunocompromised patients. We describe a case of Pseudomonas aeruginosa (PA) necrotizing cavitary CAP with a fatal outcome in a 53-year-old ma…
View article: Is It Possible to Eradicate Carbapenem-Resistant Acinetobacter baumannii (CRAB) from Endemic Hospitals?
Is It Possible to Eradicate Carbapenem-Resistant Acinetobacter baumannii (CRAB) from Endemic Hospitals? Open
Background: Despite the global efforts to antagonize carbapenem-resistant Acinetobacter baumannii (CRAB) spreading, it remains an emerging threat with a related mortality exceeding 40% among critically ill patients. The purpose of this rev…
View article: Ceftazidime/Avibactam in Ventilator-Associated Pneumonia Due to Difficult-to-Treat Non-Fermenter Gram-Negative Bacteria in COVID-19 Patients: A Case Series and Review of the Literature
Ceftazidime/Avibactam in Ventilator-Associated Pneumonia Due to Difficult-to-Treat Non-Fermenter Gram-Negative Bacteria in COVID-19 Patients: A Case Series and Review of the Literature Open
Ventilator-associated pneumonia (VAP) in critically ill patients with COVID-19 represents a very huge global threat due to a higher incidence rate compared to non-COVID-19 patients and almost 50% of the 30-day mortality rate. Pseudomonas a…
View article: Long-Term Impact of the COVID-19 Pandemic on In-Hospital Antibiotic Consumption and Antibiotic Resistance: A Time Series Analysis (2015–2021)
Long-Term Impact of the COVID-19 Pandemic on In-Hospital Antibiotic Consumption and Antibiotic Resistance: A Time Series Analysis (2015–2021) Open
The coronavirus disease 2019 (COVID-19)-pandemic-related overload of health systems has compromised the application of antimicrobial stewardship (AS) models and infection prevention and control (IPC) programs. We aimed to evaluate the impa…
View article: Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality
Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality Open
View article: Development of post-COVID-19 cardiovascular events: an analysis of clinical features and risk factors from a single hospital retrospective study
Development of post-COVID-19 cardiovascular events: an analysis of clinical features and risk factors from a single hospital retrospective study Open
Cardiovascular complications after a SARS-CoV-2 infection are a phenomenon of relevant scientific interest. The aim of this study was to analyze the onset of post-COVID-19 cardiovascular events in patients hospitalized in a tertiary care c…
View article: Challenges to Antimicrobial Stewardship in the Countries of the Arab League: Concerns of Worsening Resistance during the COVID-19 Pandemic and Proposed Solutions
Challenges to Antimicrobial Stewardship in the Countries of the Arab League: Concerns of Worsening Resistance during the COVID-19 Pandemic and Proposed Solutions Open
The COVID-19 pandemic is expected to worsen the global problem of antimicrobial resistance (AMR). There is a heightened interest in understanding this effect and to develop antimicrobial stewardship (AMS) interventions accordingly to curb …
View article: Combined Resistance to Ceftolozane-Tazobactam and Ceftazidime-Avibactam in Extensively Drug-Resistant (XDR) and Multidrug-Resistant (MDR) Pseudomonas aeruginosa: Resistance Predictors and Impact on Clinical Outcomes Besides Implications for Antimicrobial Stewardship Programs
Combined Resistance to Ceftolozane-Tazobactam and Ceftazidime-Avibactam in Extensively Drug-Resistant (XDR) and Multidrug-Resistant (MDR) Pseudomonas aeruginosa: Resistance Predictors and Impact on Clinical Outcomes Besides Implications for Antimicrobial Stewardship Programs Open
A retrospective case-control study was conducted at Modena University Hospital from December 2017 to January 2019 to identify risk factors and predictors of MDR/XDR Pseudomonas aeruginosa (PA) isolation with resistance to ceftazidime/aviba…
View article: Real-life experience with compassionate use of cefiderocol for difficult-to-treat resistant <i>Pseudomonas aeruginosa</i> (DTR-P) infections
Real-life experience with compassionate use of cefiderocol for difficult-to-treat resistant <i>Pseudomonas aeruginosa</i> (DTR-P) infections Open
Objectives To describe our real-life experience with cefiderocol in XDR and difficult-to-treat resistant Pseudomonas aeruginosa (DTR-P) infections without any other available treatment options. Methods We included patients with a proven in…
View article: Herpes Simplex Virus Re-Activation in Patients with SARS-CoV-2 Pneumonia: A Prospective, Observational Study
Herpes Simplex Virus Re-Activation in Patients with SARS-CoV-2 Pneumonia: A Prospective, Observational Study Open
Background: Herpes simplex 1 co-infections in patients with COVID-19 are considered relatively uncommon; some reports on re-activations in patients in intensive-care units were published. The aim of the study was to analyze herpetic re-act…
View article: A five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unit
A five-component infection control bundle to permanently eliminate a carbapenem-resistant Acinetobacter baumannii spreading in an intensive care unit Open
Background Carbapenem-resistant Acinetobacter baumannii (CRAB) infection outbreaks are difficult to control and sometimes require cohorting of CRAB-positive patients or temporary ward closure for environmental cleaning. We aimed at control…
View article: The impact of tocilizumab on respiratory support states transition and clinical outcomes in COVID-19 patients. A Markov model multi-state study
The impact of tocilizumab on respiratory support states transition and clinical outcomes in COVID-19 patients. A Markov model multi-state study Open
Background The benefit of tocilizumab on mortality and time to recovery in people with severe COVID pneumonia may depend on appropriate timing. The objective was to estimate the impact of tocilizumab administration on switching respiratory…
View article: Bacterial and Fungal Co-Infections in Patients with COVID-19 Related Pneumonia: A Retrospective Cohort Study
Bacterial and Fungal Co-Infections in Patients with COVID-19 Related Pneumonia: A Retrospective Cohort Study Open
Background: The study analyzed risk factors for bacterial and fungal coinfection in patients with COVID-19 and the impact on mortality. Methods: This is a single-center retrospective study conducted on 387 patients with confirmed COVID-19 …
View article: The Impact of COVID-19 on UNAIDS 90–90–90 Targets: Calls for New HIV Care Models
The Impact of COVID-19 on UNAIDS 90–90–90 Targets: Calls for New HIV Care Models Open
We compared 90–90–90 targets in 2020, during the coronavirus disease 2019 (COVID-19) pandemic, with the targets across the period 2017–2019 in people with HIV. We observed a significant loss in the 90–90–90 objectives in 2020 when compared…
View article: Incidence, risk factors and outcome of acute kidney injury (AKI) in patients with COVID-19
Incidence, risk factors and outcome of acute kidney injury (AKI) in patients with COVID-19 Open
View article: Twenty-four-hour serum creatinine variation is associated with poor outcome in the novel coronavirus disease 2019 (COVID-19) patients
Twenty-four-hour serum creatinine variation is associated with poor outcome in the novel coronavirus disease 2019 (COVID-19) patients Open
COVID-19 patients with decreased kidney function within 24 hours of admission were at high risk of AKI and 30-day in-hospital mortality.
View article: Acid base disorders in patients with COVID-19
Acid base disorders in patients with COVID-19 Open
View article: Bacterial and Fungal Co-Infections in Patients with COVID-19 Related Pneumonia: A Retrospective Cohort Study
Bacterial and Fungal Co-Infections in Patients with COVID-19 Related Pneumonia: A Retrospective Cohort Study Open
Background : The study analysed risk factors for bacterial and fungal co-infection in patients with COVID-19 and the impact on mortality. Methods : This is a single-center retrospective study conducted on 387 patients with confirmed COVID-…
View article: Beauveria bassiana keratitis: Management of an atypical clinical presentation
Beauveria bassiana keratitis: Management of an atypical clinical presentation Open
View article: Risk factors for nosocomial rectal colonization with carbapenem-resistant Acinetobacter baumannii in hospital: a matched case–control study
Risk factors for nosocomial rectal colonization with carbapenem-resistant Acinetobacter baumannii in hospital: a matched case–control study Open