Gabrielle Pouchelon
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View article: Context-dependent presynaptic inhibition of somatostatin interneuron inputs to Layer 1 of the visual cortex
Context-dependent presynaptic inhibition of somatostatin interneuron inputs to Layer 1 of the visual cortex Open
Layer 1 of the cortex is a critical site for integrating top-down inputs onto the distal dendrites of pyramidal neurons, where inhibitory neurons modulate these inputs to enable context-dependent sensory processing. Yet, it remains unclear…
View article: Restoring transient connectivity during development improves dysfunctions in fragile X mice
Restoring transient connectivity during development improves dysfunctions in fragile X mice Open
Early-generated circuits are critical for the maturation of cortical network activity and the formation of excitation/inhibition (E/I) balance. This process involves the maturation of specific populations of inhibitory neurons. While parva…
View article: Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development
Metabotropic signaling within somatostatin interneurons controls transient thalamocortical inputs during development Open
During brain development, neural circuits undergo major activity-dependent restructuring. Circuit wiring mainly occurs through synaptic strengthening following the Hebbian “fire together, wire together” precept. However, select connections…
View article: A versatile viral toolkit for functional discovery in the nervous system
A versatile viral toolkit for functional discovery in the nervous system Open
The ability to precisely control transgene expression is essential for basic research and clinical applications. Adeno-associated viruses (AAVs) are non-pathogenic and can be used to drive stable expression in virtually any tissue, cell ty…
View article: The organization and development of cortical interneuron presynaptic circuits are area specific
The organization and development of cortical interneuron presynaptic circuits are area specific Open
Parvalbumin and somatostatin inhibitory interneurons gate information flow in discrete cortical areas that compute sensory and cognitive functions. Despite the considerable differences between areas, individual interneuron subtypes are gen…
View article: A transient postnatal quiescent period precedes emergence of mature cortical dynamics
A transient postnatal quiescent period precedes emergence of mature cortical dynamics Open
Mature neural networks synchronize and integrate spatiotemporal activity patterns to support cognition. Emergence of these activity patterns and functions is believed to be developmentally regulated, but the postnatal time course for neura…
View article: Author response: A transient postnatal quiescent period precedes emergence of mature cortical dynamics
Author response: A transient postnatal quiescent period precedes emergence of mature cortical dynamics Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Mature neural networks synchr…
View article: A transient postnatal quiescent period precedes emergence of mature cortical dynamics
A transient postnatal quiescent period precedes emergence of mature cortical dynamics Open
Mature neural networks synchronize and integrate spatiotemporal activity patterns to support cognition. Emergence of these activity patterns and functions is believed to be developmentally regulated, but the postnatal time course for neura…
View article: The organization and developmental establishment of cortical interneuron presynaptic circuits
The organization and developmental establishment of cortical interneuron presynaptic circuits Open
Sensory and cognitive functions are processed in discrete cortical areas and depend upon the integration of long range cortical and subcortical inputs. PV and SST inhibitory interneurons (cINs) gate these inputs and failure to do so proper…