Gabrielle Quickstad
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View article: A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB)
A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB) Open
SOX9 and RUNX2 are lineage defining transcription factors that drive differentiation of chondrocyte and osteoblast lineages respectively from osteochondral progenitors. In limb development, these progenitors are specified first by SOX9 exp…
View article: KMT2C and KMT2D regulate skeletal development through stage-specific epigenetic control of chondrogenesis
KMT2C and KMT2D regulate skeletal development through stage-specific epigenetic control of chondrogenesis Open
Many craniofacial disorders linked to mutations in enhancer-associated chromatin-modifying enzymes, including Kabuki syndrome (KS), present with a wide range of skeletal abnormalities. KS is a craniofacial development disorder characterize…
View article: KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression
KMT2D coordinates antiviral CD4+ T cell responses through opposing effects on T follicular helper and cytotoxic gene expression Open
T follicular helper (TFH) cells are essential for protective antibody responses. Histone modifications direct TFH development and function; however, the role of specific chromatin modifiers in this process is not well understood. Lysine me…
View article: A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB)
A RUNX2 GFP reporter is expressed prior to osteochondral differentiation and models Metaphyseal Dysplasia with Maxillary Hypoplasia and Brachydactyly (MDMHB) Open
SOX9 and RUNX2 are lineage defining transcription factors that drive differentiation of chondrocyte and osteoblast lineages respectively from osteochondral progenitors. In limb development, these progenitors are specified first by SOX9 exp…
View article: KDM6A regulates immune response genes in multiple myeloma
KDM6A regulates immune response genes in multiple myeloma Open
The histone H3 at lysine 27 (H3K27) demethylase lysine demethylase 6A (KDM6A) is a tumor suppressor in multiple cancers, including multiple myeloma (MM). We created isogenic MM cells disrupted for KDM6A and tagged the endogenous protein to…
View article: KDM6A Regulates Immune Response Genes in Multiple Myeloma
KDM6A Regulates Immune Response Genes in Multiple Myeloma Open
The histone H3K27 demethylase KDM6A is a tumor suppressor in multiple cancers, including multiple myeloma (MM). We created isogenic MM cells disrupted for KDM6A and tagged the endogenous protein to facilitate genome wide studies. KDM6A bin…
View article: BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation
BRD4 binds to active cranial neural crest enhancers to regulate RUNX2 activity during osteoblast differentiation Open
Cornelia de Lange syndrome (CdLS) is a congenital disorder featuring facial dysmorphism, postnatal growth deficits, cognitive disability and upper limb abnormalities. CdLS is genetically heterogeneous, with cases arising from mutation of B…
View article: <scp>SETting</scp> up the genome: <scp>KMT2D</scp> and <scp>KDM6A</scp> genomic function in the Kabuki syndrome craniofacial developmental disorder
<span>SETting</span> up the genome: <span>KMT2D</span> and <span>KDM6A</span> genomic function in the Kabuki syndrome craniofacial developmental disorder Open
Background Kabuki syndrome is a congenital developmental disorder that is characterized by distinctive facial gestalt and skeletal abnormalities. Although rare, the disorder shares clinical features with several related craniofacial syndro…