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View article: Emergence of endothelial subtypes and role of cell cycle control in arterial-venous specification during embryonic vascular development
Emergence of endothelial subtypes and role of cell cycle control in arterial-venous specification during embryonic vascular development Open
During vascular development, endothelial cells (ECs) specify into arterial, capillary, and venous subtypes to form a circulatory network. While the cell cycle state enables postnatal arterial-venous specification in a flow- and tissue-spec…
View article: From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations
From bench to bedside: murine models of inherited and sporadic brain arteriovenous malformations Open
Brain arteriovenous malformations are abnormal vascular structures in which an artery shunts high pressure blood directly to a vein without an intervening capillary bed. These lesions become highly remodeled over time and are prone to rupt…
View article: Characterization of protein isoform diversity in human umbilical vein endothelial cells via long-read proteogenomics
Characterization of protein isoform diversity in human umbilical vein endothelial cells via long-read proteogenomics Open
Endothelial cells (ECs) comprise the lumenal lining of all blood vessels and are critical for the functioning of the cardiovascular system. Their phenotypes can be modulated by alternative splicing of RNA to produce distinct protein isofor…
View article: Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia
Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia Open
BACKGROUND: Distinct endothelial cell cycle states (early G1 versus late G1) provide different “windows of opportunity” to enable the differential expression of genes that regulate venous versus arterial specification, respectively. Endoth…
View article: Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest
Connexin 37 sequestering of activated-ERK in the cytoplasm promotes p27-mediated endothelial cell cycle arrest Open
Connexin37-mediated regulation of cell cycle modulators and, consequently, growth arrest lack mechanistic understanding. We previously showed that arterial shear stress up-regulates Cx37 in endothelial cells and activates a Notch/Cx37/p27 …
View article: Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests
Ephrin-B1 regulates the adult diastolic function through a late postnatal maturation of cardiomyocyte surface crests Open
The rod-shaped adult cardiomyocyte (CM) harbors a unique architecture of its lateral surface with periodic crests, relying on the presence of subsarcolemmal mitochondria (SSM) with unknown role. Here, we investigated the development and fu…
View article: Characterization of protein isoform diversity in human umbilical vein endothelial cells via long-read proteogenomics
Characterization of protein isoform diversity in human umbilical vein endothelial cells via long-read proteogenomics Open
Endothelial cells (ECs) comprise the lumenal lining of all blood vessels and are critical for the functioning of the cardiovascular system. Their phenotypes can be modulated by alternative splicing of RNA to produce distinct protein isofor…
View article: Connexin 43-mediated Neurovascular Interactions Regulate Neurogenesis in the Adult Brain Subventricular Zone
Connexin 43-mediated Neurovascular Interactions Regulate Neurogenesis in the Adult Brain Subventricular Zone Open
The subventricular zone (SVZ) is the largest neural stem cell (NSC) niche in the adult brain; herein, the blood-brain barrier is leaky, allowing direct interactions between NSCs and endothelial cells (ECs). Mechanisms by which direct NSC-E…
View article: Crest maturation at the cardiomyocyte surface contributes to a new late postnatal development stage that controls the diastolic function of the adult heart
Crest maturation at the cardiomyocyte surface contributes to a new late postnatal development stage that controls the diastolic function of the adult heart Open
RATIONALE In addition to its typical rod-shape, the mammalian adult cardiomyocyte (CM) harbors a unique lateral membrane surface architecture with periodic crests, relying on the presence of subsarcolemmal mitochondria (SSM) the role of wh…
View article: Characterization of protein isoform diversity in human umbilical vein endothelial cells via long-read proteogenomics
Characterization of protein isoform diversity in human umbilical vein endothelial cells via long-read proteogenomics Open
Endothelial cells (ECs) comprise the lumenal lining of all blood vessels and are critical for the functioning of the cardiovascular system. Their phenotypes can be modulated by alternative splicing of RNA to produce distinct protein isofor…
View article: Vascular endothelial cell specification in health and disease
Vascular endothelial cell specification in health and disease Open
There are two vascular networks in mammals that coordinately function as the main supply and drainage systems of the body. The blood vasculature carries oxygen, nutrients, circulating cells, and soluble factors to and from every tissue. Th…
View article: Endothelial Cell Cycle State Determines Propensity for Arterial-Venous Fate
Endothelial Cell Cycle State Determines Propensity for Arterial-Venous Fate Open
Summary Formation and maturation of a functional blood vascular system is required for the development and maintenance of all tissues in the body. During the process of blood vessel development, primordial endothelial cells are formed and …
View article: Ephrin-B1 blocks adult cardiomyocyte proliferation and heart regeneration
Ephrin-B1 blocks adult cardiomyocyte proliferation and heart regeneration Open
Aims Deciphering the innate mechanisms governing the blockade of proliferation in adult cardiomyocytes (CMs) is challenging for mammalian heart regeneration. Despite the exit of CMs from the cell cycle during the postnatal maturation perio…
View article: Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis
Endophilin-A2 dependent VEGFR2 endocytosis promotes sprouting angiogenesis Open
Endothelial cell migration, proliferation and survival are triggered by VEGF-A activation of VEGFR2. However, how these cell behaviors are regulated individually is still unknown. Here we identify Endophilin-A2 (ENDOA2), a BAR-domain prote…
View article: Lacteal junction zippering protects against diet-induced obesity
Lacteal junction zippering protects against diet-induced obesity Open
Zipping up obesity Chylomicrons are specialized particles that carry dietary fats from the intestine to the bloodstream for absorption into the body. Lacteals are lymphatic vessels that act as the highway for chylomicron transport, but it …
View article: SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2
SMAD4 Prevents Flow Induced Arteriovenous Malformations by Inhibiting Casein Kinase 2 Open
Background: Hereditary hemorrhagic telangiectasia (HHT) is an inherited vascular disorder that causes arteriovenous malformations (AVMs). Mutations in the genes encoding Endoglin ( ENG ) and activin-receptor-like kinase 1 ( AVCRL1 encoding…
View article: The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization
The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization Open
Vascular permeability and neovascularization are implicated in many diseases including retinopathies and diabetic wound healing. Robo4 is an endothelial-specific transmembrane receptor that stabilizes the vasculature, as shown in Robo4 −/−…