Gaël Runel
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View article: Influence of Aging and Diabetes on the Mechanical Properties of Mouse Skin
Influence of Aging and Diabetes on the Mechanical Properties of Mouse Skin Open
Background: Diabetics accumulate Advanced Glycation End products (AGEs) such as Nε-(carboxymethyl)lysine (CML) in their skin, which can provoke changes in the skin’s biomechanical properties. The same changes are also observed during aging…
View article: Comparative efficacy of multi micro-stimulation alveolar (MMSA) and traditional vacuum therapy on skin biomechanics integrity, and inflammation
Comparative efficacy of multi micro-stimulation alveolar (MMSA) and traditional vacuum therapy on skin biomechanics integrity, and inflammation Open
This study compares the effects of Multi Micro-Stimulation Alveolar (MMSA) therapy and traditional vacuum therapy on human skin explants, focusing on skin elasticity, collagen organization, and inflammatory responses. Advanced imaging moda…
View article: Anas barbariae 200K Modulates Cell Stiffness and Oxidative Stress in Microglial Cells In Vitro
Anas barbariae 200K Modulates Cell Stiffness and Oxidative Stress in Microglial Cells In Vitro Open
Anas barbariae 200K, a homeopathic medicine, is traditionally used for influenza-like illnesses. We investigated the effects of Anas barbariae 200K on microglial cells, a subpopulation of macrophages specific to the central nervous system …
View article: Cancer Cell Biomechanical Properties Accompany Tspan8-Dependent Cutaneous Melanoma Invasion
Cancer Cell Biomechanical Properties Accompany Tspan8-Dependent Cutaneous Melanoma Invasion Open
The intrinsic biomechanical properties of cancer cells remain poorly understood. To decipher whether cell stiffness modulation could increase melanoma cells’ invasive capacity, we performed both in vitro and in vivo experiments exploring c…
View article: EASYSTIFF<sup>®</sup>, a portable and innovative device able to separately analyze each skin compartment for the evaluation of mechanical properties
EASYSTIFF<sup>®</sup>, a portable and innovative device able to separately analyze each skin compartment for the evaluation of mechanical properties Open
Human skin is submitted to various factors leading to either extrinsic or intrinsic aging. In addition to inducing molecular and morphological changes, skin aging is characterized by modifications in skin biomechanical properties modificat…
View article: Rôle des forces mécaniques au sein de l’épiderme durant la croissance du mélanome cutané
Rôle des forces mécaniques au sein de l’épiderme durant la croissance du mélanome cutané Open
In recent years, many studies have sought to unravel the molecular mechanisms of cutaneous melanoma progression and to find new biomarkers for a better prognosis. However, the current data do not allow a complete understanding of melanoma …
View article: Biomechanical Properties of Cancer Cells
Biomechanical Properties of Cancer Cells Open
Since the crucial role of the microenvironment has been highlighted, many studies have been focused on the role of biomechanics in cancer cell growth and the invasion of the surrounding environment. Despite the search in recent years for m…
View article: Gradient in cytoplasmic pressure in germline cells controls overlying epithelial cell morphogenesis
Gradient in cytoplasmic pressure in germline cells controls overlying epithelial cell morphogenesis Open
It is unknown how growth in one tissue impacts morphogenesis in a neighboring tissue. To address this, we used the Drosophila ovarian follicle, in which a cluster of 15 nurse cells and a posteriorly located oocyte are surrounded by a layer…