Gaiping Zhang
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View article: A novel 3A-based indirect enzyme-linked immunosorbent assay for serological testing of Senecavirus A
A novel 3A-based indirect enzyme-linked immunosorbent assay for serological testing of Senecavirus A Open
Senecavirus A (SVA) can cause a contagious porcine disease characterized by vesicular lesions on the mouth and feet. Its clinical symptoms are extremely similar to those of porcine foot-and-mouth disease, swine vesicular disease, and vesic…
View article: Genetic stability, environmental safety and field adaptation assessment of transgenic rice with chicken Newcastle disease HN protein
Genetic stability, environmental safety and field adaptation assessment of transgenic rice with chicken Newcastle disease HN protein Open
Based on the previously verified head-to-tail dimer vaccine model, a dimer of the HN protein (defined as Osr2HN) expressed in rice endosperm was designed. In previous immunization experiments in chickens, immunization with two doses (0.5 µ…
View article: Outer membrane vesicles-based nano-regulator for cancer immunotherapy by modulating neutrophils N1 polarization and hitchhiking delivery
Outer membrane vesicles-based nano-regulator for cancer immunotherapy by modulating neutrophils N1 polarization and hitchhiking delivery Open
Efficient eradication of cancer cells and enhanced tumor accumulation of drug via immune cells represent promising strategies for cancer treatment, yet they remain significant challenges. Inspired by neutrophils (NEs), we designed a novel …
View article: Design and development of a bispecific antibody targeting BAFF and IL-17 for systemic lupus erythematosus treatment
Design and development of a bispecific antibody targeting BAFF and IL-17 for systemic lupus erythematosus treatment Open
The bsscFv exhibited potent neutralizing activity in vitro and therapeutic efficacy in vivo, suggesting it as a promising bispecific therapeutic agent for the treatment of SLE. Further studies are warranted to explore its clinical potentia…
View article: A one-pot Cas12i3/Cas13d-based assay for rapid portable identification of genotypes I and II African swine fever viruses
A one-pot Cas12i3/Cas13d-based assay for rapid portable identification of genotypes I and II African swine fever viruses Open
View article: ERK-METTL3 axis acts as a novel regulator of antiviral innate immunity combating pseudorabies virus infection
ERK-METTL3 axis acts as a novel regulator of antiviral innate immunity combating pseudorabies virus infection Open
The ERK-mediated phosphorylation of the core m 6 A methyltransferase METTL3 has been linked to the regulation of embryonic stem cell differentiation and tumorigenesis. However, its role in the antiviral innate immune response remains uncle…
View article: PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation
PEDV Nsp14 induces mitophagy-mediated degradation of MAVS to antagonize host innate immunity and facilitate viral proliferation Open
Porcine epidemic diarrhea virus (PEDV) leads to a high mortality in neonatal piglets and causes serious harm to the global swine industry. PEDV has been shown to exploit diverse strategies for antagonism of host innate immunity and promoti…
View article: Correction: Ma et al. A Plant-Produced Recombinant Fusion Protein-Based Newcastle Disease Subunit Vaccine and Rapid Differential Diagnosis Platform. Vaccines 2020, 8, 122
Correction: Ma et al. A Plant-Produced Recombinant Fusion Protein-Based Newcastle Disease Subunit Vaccine and Rapid Differential Diagnosis Platform. Vaccines 2020, 8, 122 Open
The authors would like to make the following correction to this published paper [...]
View article: A novel fluorescence immunoassay for the quantitative detection of HPV16 L1 antibodies in human serum samples using ZnCdSe/ZnS quantum dot-labeled antibodies
A novel fluorescence immunoassay for the quantitative detection of HPV16 L1 antibodies in human serum samples using ZnCdSe/ZnS quantum dot-labeled antibodies Open
Human papillomavirus type 16 (HPV16) is a high-risk virus linked to cervical cancer, primarily through its oncogenic proteins E6 and E7. The HPV16-L1 protein, the major capsid component, plays a key role in capsid formation and immune resp…
View article: The S273R protein of African swine fever virus antagonizes the canonical NF- <i>κ</i> B signaling pathway by I <i>κ</i> B <i>α</i>
The S273R protein of African swine fever virus antagonizes the canonical NF- <i>κ</i> B signaling pathway by I <i>κ</i> B <i>α</i> Open
African swine fever virus (ASFV) is a large double-stranded DNA virus, which is the causative agent of African swine fever (ASF), a devastating disease of suids epidemic in many countries. The virus has developed multiple strategies to eva…
View article: Self‐Activatable Multi‐Module Nanoelectrode Triggering Electro‐Driven Pyroptosis in Cancer Cells Boost Anti‐Tumor Immunity
Self‐Activatable Multi‐Module Nanoelectrode Triggering Electro‐Driven Pyroptosis in Cancer Cells Boost Anti‐Tumor Immunity Open
Pyroptosis holds significant promise in facilitating tumor immunotherapy, but its efficiency is hindered by the indiscriminate pyroptotic killing of cells within cancer tissues and inadequate expression of gasdermin in cancer cells. Herein…
View article: Identification of linear B-cell epitopes of Senecavirus A VP2 protein using monoclonal antibodies
Identification of linear B-cell epitopes of Senecavirus A VP2 protein using monoclonal antibodies Open
Introduction Senecavirus A (SVA) is an emerging vesicular pathogen in swine with clinical signs similar to those of foot-and-mouth disease, porcine vesicular disease and vesicular stomatitis, making the control of swine vesicular disease o…
View article: Genomic characterization and evolutionary analysis of a Getah virus variant from piglets in central China
Genomic characterization and evolutionary analysis of a Getah virus variant from piglets in central China Open
Introduction As a re-emerging mosquito-borne virus, Getah virus (GETV) has been found in more than 10 countries surrounded by the Pacific Ocean and shows a broadly host tropism, raising concerns for the potential risk to public health. Hor…
View article: Analysis on the adjustment of transportation structure and the logistics transformation of railway freight
Analysis on the adjustment of transportation structure and the logistics transformation of railway freight Open
Purpose This paper aims to provide a comprehensive analysis of the strategic adjustments in China's transportation structure, with a particular focus on the pivotal role of railway freight and its integration into the modern logistics syst…
View article: The UL23 thymidine kinase of Marek's disease virus is a target for anti-HSV drug development
The UL23 thymidine kinase of Marek's disease virus is a target for anti-HSV drug development Open
View article: Quantum Dot-Based Fluorescence-Linked Immunosorbent Assay for the Detection of Medroxyprogesterone Acetate in Milk
Quantum Dot-Based Fluorescence-Linked Immunosorbent Assay for the Detection of Medroxyprogesterone Acetate in Milk Open
View article: Quantitative fluorescent detection of tetracycline in animal-derived foods using quantum dots
Quantitative fluorescent detection of tetracycline in animal-derived foods using quantum dots Open
Tetracycline (Tc) antibiotics, a class of synthetically produced broad-spectrum antimicrobial drugs, have been widely used in animal husbandry, leading to their widespread presence in animal-derived foods. However, misuse, overuse, and non…
View article: Preparation and evaluation of peptide-Poly (lactic-co-glycolic ancid) nanoparticle on porcine epidemic diarrhea virus infection
Preparation and evaluation of peptide-Poly (lactic-co-glycolic ancid) nanoparticle on porcine epidemic diarrhea virus infection Open
Porcine epidemic diarrhea virus (PEDV) can result in diarrhea, dehydration and death in suckling piglets, which has a great side effect on pig-breeding industry in China. Therefore, it is important to find an economical and effective treat…
View article: Antibacterial mechanism analysis of resveratrol against Salmonella typhimurium via metabolomics
Antibacterial mechanism analysis of resveratrol against Salmonella typhimurium via metabolomics Open
View article: Identification and characterization of linear B-cell epitopes on African swine fever virus H171R protein
Identification and characterization of linear B-cell epitopes on African swine fever virus H171R protein Open
African swine fever virus (ASFV) is a highly contagious and often fatal pathogen that poses a significant threat to the swine industry worldwide. The H171R protein, a structural component of ASFV, plays crucial roles in viral assembly, hos…
View article: Peptide-directed interference of PD-1/PD-L1 binding increases B lymphocyte function after infectious bursal disease viral infection
Peptide-directed interference of PD-1/PD-L1 binding increases B lymphocyte function after infectious bursal disease viral infection Open
View article: Integrin αVβ3 mediates porcine deltacoronavirus infection and inflammatory response through activation of the FAK-PI3K-AKT-nf-κB signalling pathway
Integrin αVβ3 mediates porcine deltacoronavirus infection and inflammatory response through activation of the FAK-PI3K-AKT-nf-κB signalling pathway Open
Porcine deltacoronavirus (PDCoV) is an emerging porcine enteropathogenic coronavirus that causes acute watery diarrhoea in piglets, resulting in significant economic losses to the global swine industry. However, the underlying mechanism of…
View article: Screening and Mechanism Study of Three Antagonistic Drugs, Oxysophoridine, Rutin, and Phellodendrine, against Zearalenone-Induced Reproductive Toxicity in Ovine Oocytes
Screening and Mechanism Study of Three Antagonistic Drugs, Oxysophoridine, Rutin, and Phellodendrine, against Zearalenone-Induced Reproductive Toxicity in Ovine Oocytes Open
Zearalenone (ZEN) is a common fungal toxin with reproductive toxicity in various grains. It poses a serious threat to ovine and other animal husbandry industries, as well as human reproductive health. Therefore, investigating the mechanism…
View article: Plug-and-display nanoparticle immunization of the core epitope domain induces potent neutralizing antibody and cellular immune responses against PEDV
Plug-and-display nanoparticle immunization of the core epitope domain induces potent neutralizing antibody and cellular immune responses against PEDV Open
Porcine epidemic diarrhea virus (PEDV), an enteric coronavirus, is widely spread worldwide and causes huge economic losses. The effective measure to control the viral infection is to develop ideal vaccines. Here, the collagenase equivalent…
View article: Preparation and evaluation of peptide-PLGA nanoparticles on porcine epidemic diarrhea virus infection
Preparation and evaluation of peptide-PLGA nanoparticles on porcine epidemic diarrhea virus infection Open
Background Porcine epidemic diarrhea virus (PEDV) can cause diarrhea, dehydration and death in suckling piglets, which seriously affects the economic benefits of the production line. Therefore, it is urgent to find an economical and effect…
View article: FADD promotes type I interferon production to suppress porcine reproductive and respiratory syndrome virus infection
FADD promotes type I interferon production to suppress porcine reproductive and respiratory syndrome virus infection Open
Porcine reproductive and respiratory syndrome (PRRS) is an epidemic animal infectious disease worldwide, causing huge economic losses to the global swine industry. Fas-associated death domain (FADD) was previously reported to be an adaptor…
View article: Nanovaccine Confers Dual Protection Against Influenza a Virus and Porcine Circovirus Type 2 [Retraction]
Nanovaccine Confers Dual Protection Against Influenza a Virus and Porcine Circovirus Type 2 [Retraction] Open
[This retracts the article DOI: 10.2147/IJN.S218057.].
View article: On-site detection and differentiation of African swine fever virus variants using an orthogonal CRISPR-Cas12b/Cas13a-based assay
On-site detection and differentiation of African swine fever virus variants using an orthogonal CRISPR-Cas12b/Cas13a-based assay Open
The African swine fever virus (ASFV) and its variants have induced substantial economic losses in China, prompting a critical need for efficient detection methods. Several PCR-based methods have been developed to discriminate between wild-…
View article: The multi-kingdom microbiome catalog of the chicken gastrointestinal tract
The multi-kingdom microbiome catalog of the chicken gastrointestinal tract Open
View article: Inhalable hybrid nanovaccines with virus-biomimetic structure boost protective immune responses against SARS-CoV-2 variants
Inhalable hybrid nanovaccines with virus-biomimetic structure boost protective immune responses against SARS-CoV-2 variants Open
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with different antigenic variants, has posed a significant threat to public health. It is urgent to develop inhalable vaccines, instead of injectable vaccines, to eli…