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View article: Experimental Ischemic Stroke–Induced Alpha-Synuclein Pathology Enhances Endothelial Inflammatory Response and Impairs Angiogenesis
Experimental Ischemic Stroke–Induced Alpha-Synuclein Pathology Enhances Endothelial Inflammatory Response and Impairs Angiogenesis Open
BACKGROUND: α-Syn (alpha-synuclein) increases and oligomerization contributes to ischemic brain damage. Nevertheless, the exact mechanisms of ischemia-induced α-Syn pathology after stroke are understudied. In this exploratory and hypothesi…
View article: A novel stable transgenic zebrafish line expressing mCherry-tagged human alpha-synuclein in the nervous system and exhibiting all the key features of Lewy body disorders at larval stage
A novel stable transgenic zebrafish line expressing mCherry-tagged human alpha-synuclein in the nervous system and exhibiting all the key features of Lewy body disorders at larval stage Open
View article: Alpha-synuclein pathological deposition alters functional homeostasis and connectivity of striatal dopaminergic synapses and results in microglia activation, pathology spreading, muscle stiffness, whole brain atrophy and metabolic changes before producing frank nigral neuron deafferentation
Alpha-synuclein pathological deposition alters functional homeostasis and connectivity of striatal dopaminergic synapses and results in microglia activation, pathology spreading, muscle stiffness, whole brain atrophy and metabolic changes before producing frank nigral neuron deafferentation Open
The progressive accumulation of α-synuclein (α-Syn) aggregates is believed to contribute to Parkinson’s disease (PD) pathogenesis. Nevertheless, the earliest pre-degenerative molecular, functional, neuroinflammatory and metabolic changes a…
View article: Alpha-synuclein aggregation and dopaminergic neuron death in a new mouse model of Parkinson’s disease expressing human full-length and C-terminally truncated 1- 120 alpha-synuclein
Alpha-synuclein aggregation and dopaminergic neuron death in a new mouse model of Parkinson’s disease expressing human full-length and C-terminally truncated 1- 120 alpha-synuclein Open
Parkinson’s disease (PD) is neuropathologically characterized by the presence of Lewy bodies and Lewy neurites made of aggregated alpha-synuclein (aSyn). Several studies have shown that Lewy bodies contain C-terminally truncated aSyn which…
View article: Lewy pathology formation in patient-derived <i>GBA1</i> Parkinson’s disease midbrain organoids
Lewy pathology formation in patient-derived <i>GBA1</i> Parkinson’s disease midbrain organoids Open
Fibrillary aggregation of α-synuclein in Lewy body inclusions and nigrostriatal dopaminergic neuron degeneration define Parkinson’s disease neuropathology. Mutations in GBA1, encoding glucocerebrosidase, are the most frequent genetic risk …
View article: PROGRESSIVE PARKINSONIAN PHENOTYPE AND SYNUCLEINOPATHY ARE ASSOCIATED WITH NF-ΚB/C-REL DEFICIENCY IN MOUSE AND HUMAN SUBJECTS
PROGRESSIVE PARKINSONIAN PHENOTYPE AND SYNUCLEINOPATHY ARE ASSOCIATED WITH NF-ΚB/C-REL DEFICIENCY IN MOUSE AND HUMAN SUBJECTS Open
View article: NOVEL COMPOUNDS TARGETING SYNAPSIN III RESCUE ALPHA-SYNUCLEIN AGGREGATION AND NIGROSTRIATAL DYSFUNCTION AND DEGENERATION IN EXPERIMENTAL MODELS OF PARKINSON’S DISEASE
NOVEL COMPOUNDS TARGETING SYNAPSIN III RESCUE ALPHA-SYNUCLEIN AGGREGATION AND NIGROSTRIATAL DYSFUNCTION AND DEGENERATION IN EXPERIMENTAL MODELS OF PARKINSON’S DISEASE Open
View article: GUT-TO-BRAIN PROGRESSION OF SYNUCLEINOPATHY IN THE C-REL-/- MOUSE MODEL OF PARKINSON’S DISEASE
GUT-TO-BRAIN PROGRESSION OF SYNUCLEINOPATHY IN THE C-REL-/- MOUSE MODEL OF PARKINSON’S DISEASE Open
View article: Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease
Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease Open
Parkinson’s disease (PD) pathology is characterized by the loss of dopaminergic neurons of the nigrostriatal system and accumulation of Lewy bodies (LB) and Lewy neurites (LN), inclusions mainly composed of alpha-synuclein (α-Syn) fibrils.…
View article: Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy?
Alpha synuclein post translational modifications: potential targets for Parkinson’s disease therapy? Open
Parkinson’s disease (PD) is the most common neurodegenerative disorder with motor symptoms. The neuropathological alterations characterizing the brain of patients with PD include the loss of dopaminergic neurons of the nigrostriatal system…
View article: DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease
DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease Open
Dopamine dyshomeostasis has been acknowledged among the determinants of nigrostriatal neuron degeneration in Parkinson’s disease (PD). Several studies in experimental models and postmortem PD patients underlined increasing levels of the do…
View article: Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates
Synapsin III Regulates Dopaminergic Neuron Development in Vertebrates Open
Attention deficit and hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by alterations in the mesocorticolimbic and nigrostriatal dopaminergic pathways. Polymorphisms in the Synapsin III (Syn III) gene can associ…
View article: Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice
Methylphenidate Analogues as a New Class of Potential Disease-Modifying Agents for Parkinson’s Disease: Evidence from Cell Models and Alpha-Synuclein Transgenic Mice Open
Parkinson’s disease (PD) is characterized by dopaminergic nigrostriatal neurons degeneration and Lewy body pathology, mainly composed of α-synuclein (αSyn) fibrillary aggregates. We recently described that the neuronal phosphoprotein Synap…
View article: Alpha‐Synuclein is Involved in <scp>DYT1</scp> Dystonia Striatal Synaptic Dysfunction
Alpha‐Synuclein is Involved in <span>DYT1</span> Dystonia Striatal Synaptic Dysfunction Open
Background The neuronal protein alpha‐synuclein (α‐Syn) is crucially involved in Parkinson's disease pathophysiology. Intriguingly, torsinA (TA), the protein causative of DYT1 dystonia, has been found to accumulate in Lewy bodies and to in…
View article: Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson’s disease
Dopamine signaling modulates microglial NLRP3 inflammasome activation: implications for Parkinson’s disease Open
View article: Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype
Synapsin III gene silencing redeems alpha-synuclein transgenic mice from Parkinson's disease-like phenotype Open
Fibrillary aggregated α-synuclein (α-syn) deposition in Lewy bodies (LB) characterizes Parkinson's disease (PD) and is believed to trigger dopaminergic synaptic failure and a retrograde terminal-to-cell body neuronal degeneration. We descr…
View article: Synapsin III Controls Early Phases of Dopaminergic Neurons Development in Fishes and Mammals by Acting Upstream of BDNF and Cdk5 Signaling
Synapsin III Controls Early Phases of Dopaminergic Neurons Development in Fishes and Mammals by Acting Upstream of BDNF and Cdk5 Signaling Open
Polymorphisms in the Synapsin III (Syn III) gene can associate with attention deficits and hyperactivity disorder (ADHD), a neurodevelopmental disorder characterized by alterations in the mesocorticolimbic and nigrostriatal dopaminergic pa…
View article: The Association between α-Synuclein and α-Tubulin in Brain Synapses
The Association between α-Synuclein and α-Tubulin in Brain Synapses Open
α-synuclein is a small protein that is mainly expressed in the synaptic terminals of nervous tissue. Although its implication in neurodegeneration is well established, the physiological role of α-synuclein remains elusive. Given its involv…
View article: An updated reappraisal of synapsins: structure, function and role in neurological and psychiatric disorders
An updated reappraisal of synapsins: structure, function and role in neurological and psychiatric disorders Open
View article: Dopamine Signaling Modulates Microglial NLRP3 Inflammasome Activation: Implications for Parkinson’s Disease
Dopamine Signaling Modulates Microglial NLRP3 Inflammasome Activation: Implications for Parkinson’s Disease Open
Background: Parkinson’s disease (PD) is characterized by the loss of nigral dopaminergic neurons leading to impaired striatal dopamine signaling, α-synuclein- (α-syn-) rich inclusions, and neuroinflammation. Degenerating neurons are surrou…
View article: Dopamine Signaling Modulates Microglial NLRP3 Inflammasome Activation: Implications for Parkinson’s Disease
Dopamine Signaling Modulates Microglial NLRP3 Inflammasome Activation: Implications for Parkinson’s Disease Open
Background: Parkinson’s disease (PD) is characterized by the loss of nigral dopaminergic neurons leading to impaired striatal dopamine signaling, α-synuclein- (α-syn-) rich inclusions, and neuroinflammation. Degenerating neurons are surrou…
View article: Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives
Alpha-Synuclein in the Regulation of Brain Endothelial and Perivascular Cells: Gaps and Future Perspectives Open
Misfolded proteins, inflammation, and vascular alterations are common pathological hallmarks of neurodegenerative diseases. Alpha-synuclein is a small synaptic protein that was identified as a major component of Lewy bodies and Lewy neurit…
View article: Synapsin III Controls Early Phases of Dopaminergic Neurons Development in Fishes and Mammals by Acting Upstream of BDNF and Cdk5 Signaling
Synapsin III Controls Early Phases of Dopaminergic Neurons Development in Fishes and Mammals by Acting Upstream of BDNF and Cdk5 Signaling Open
View article: Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes
Extracellular clusterin limits the uptake of α‐synuclein fibrils by murine and human astrocytes Open
The progressive neuropathological damage seen in Parkinson's disease (PD) is thought to be related to the spreading of aggregated forms of α‐synuclein. Clearance of extracellular α‐synuclein released by degenerating neurons may be therefor…
View article: Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET‐Based Assay of Synapsin III Binding
Design and Synthesis of Fluorescent Methylphenidate Analogues for a FRET‐Based Assay of Synapsin III Binding Open
We previously described synapsin III (Syn III) as a synaptic phosphoprotein that controls dopamine release in cooperation with α‐synuclein (aSyn). Moreover, we found that in Parkinson's disease (PD), Syn III also participates in aSyn aggre…
View article: Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease
Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson’s Disease Open
The loss of dopaminergic neurons of the nigrostriatal system underlies the onset of the typical motor symptoms of Parkinson's disease (PD). Lewy bodies (LB) and Lewy neurites (LN), proteinaceous inclusions mainly composed of insoluble α-sy…
View article: Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate
Alpha-synuclein/synapsin III pathological interplay boosts the motor response to methylphenidate Open
View article: Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells
Alpha-Synuclein Preserves Mitochondrial Fusion and Function in Neuronal Cells Open
Dysregulations of mitochondria with alterations in trafficking and morphology of these organelles have been related to Parkinson’s disease (PD), a neurodegenerative disorder characterized by brain accumulation of Lewy bodies (LB), intraneu…
View article: The good and bad of therapeutic strategies that directly target α‐synuclein
The good and bad of therapeutic strategies that directly target α‐synuclein Open
Synucleinopathies are neurodegenerative diseases characterized by the accumulation of either neuronal/axonal or glial insoluble proteinaceous aggregates mainly composed of α‐synuclein (α‐syn). Among them, the most common disorders are Park…
View article: Study of alpha-synuclein fibrillation: state of the art and expectations
Study of alpha-synuclein fibrillation: state of the art and expectations Open
Since the discovery of the presence of fibrillary forms of α-synuclein (α-syn) in Lewy bodies (LB) and Lewy neurites in the brain of patients affected by Parkinson’s disease (PD) and dementia with LB, great effort has been dedicated to stu…