Gail Horan
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View article: Metastatic Bifocal Germinoma With Dramatic Early Steroid Response, Utility of Circulating miR‐371a‐3p and Vinblastine Monotherapy Prior to Definitive Craniospinal Irradiation
Metastatic Bifocal Germinoma With Dramatic Early Steroid Response, Utility of Circulating miR‐371a‐3p and Vinblastine Monotherapy Prior to Definitive Craniospinal Irradiation Open
View article: Combination Cytoreductive Surgery, Radiotherapy, or Ablation for De Novo Metastatic Prostate Cancer: The IP2-ATLANTA Internal Pilot, Phase 2, Randomised Controlled Trial
Combination Cytoreductive Surgery, Radiotherapy, or Ablation for De Novo Metastatic Prostate Cancer: The IP2-ATLANTA Internal Pilot, Phase 2, Randomised Controlled Trial Open
Randomisation to combination cytoreductive surgery, radiotherapy, and ablation was feasible. Cytoreductive treatment combinations were well tolerated and deserve further evaluation. The majority of patients still have viable residual prost…
View article: A diagnosis of Noonan syndrome through routine whole genome sequencing in a child with an intracranial nongerminomatous germ cell tumor
A diagnosis of Noonan syndrome through routine whole genome sequencing in a child with an intracranial nongerminomatous germ cell tumor Open
Intracranial germ cell tumors (GCTs) comprise both pure germinoma and nongerminomatous GCTs (NGGCTs)1, the latter representing about one-third of GCTs2,3. In Europe, typical clinical and radiological presentation along with alpha-fetoprote…
View article: Introduction and impact of routine whole genome sequencing in the diagnosis and management of sarcoma
Introduction and impact of routine whole genome sequencing in the diagnosis and management of sarcoma Open
View article: Patients’ Preferences for Cytoreductive Treatments in Newly Diagnosed Metastatic Prostate Cancer: The IP5-MATTER Study
Patients’ Preferences for Cytoreductive Treatments in Newly Diagnosed Metastatic Prostate Cancer: The IP5-MATTER Study Open
We performed a large study to ascertain how patients diagnosed with advanced (metastatic) prostate cancer at their first diagnosis made decisions regarding additional available treatments for their prostate and cancer deposits (metastases)…
View article: The Role of Multiparametric MRI and MRI–targeted Biopsy in the Diagnosis of Radiorecurrent Prostate Cancer: An Analysis from the FORECAST Trial
The Role of Multiparametric MRI and MRI–targeted Biopsy in the Diagnosis of Radiorecurrent Prostate Cancer: An Analysis from the FORECAST Trial Open
After radiotherapy, magnetic resonance imaging (MRI) is accurate for detecting recurrent prostate cancer, with missed cancer being smaller and of lower grade. Targeting a biopsy to suspicious areas on MRI results in a diagnosis of cancer i…
View article: Thromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial
Thromboxane biosynthesis in cancer patients and its inhibition by aspirin: a sub-study of the Add-Aspirin trial Open
View article: External validation of a risk model predicting failure of salvage focal ablation for prostate cancer
External validation of a risk model predicting failure of salvage focal ablation for prostate cancer Open
Objectives To externally validate a published model predicting failure within 2 years after salvage focal ablation in men with localised radiorecurrent prostate cancer using a prospective, UK multicentre dataset. Patients and methods Patie…
View article: Radiotherapy quality assurance in paediatric clinical trials: first report from six QUARTET-affiliated trials
Radiotherapy quality assurance in paediatric clinical trials: first report from six QUARTET-affiliated trials Open
View article: Corrigendum to “Magnetic Resonance Imaging and targeted biopsies compared to transperineal mapping biopsies prior to salvage focal therapy/ablation in localised and metastatic recurrent prostate cancer after radiotherapy. Primary Outcomes from the FORECAST Trial” [Eur Urol 2022;81(6):598–605]
Corrigendum to “Magnetic Resonance Imaging and targeted biopsies compared to transperineal mapping biopsies prior to salvage focal therapy/ablation in localised and metastatic recurrent prostate cancer after radiotherapy. Primary Outcomes from the FORECAST Trial” [Eur Urol 2022;81(6):598–605] Open
View article: Embryonal tumor with multilayered rosettes: Overview of diagnosis and therapy
Embryonal tumor with multilayered rosettes: Overview of diagnosis and therapy Open
View article: Magnetic Resonance Imaging and Targeted Biopsies Compared to Transperineal Mapping Biopsies Before Focal Ablation in Localised and Metastatic Recurrent Prostate Cancer After Radiotherapy
Magnetic Resonance Imaging and Targeted Biopsies Compared to Transperineal Mapping Biopsies Before Focal Ablation in Localised and Metastatic Recurrent Prostate Cancer After Radiotherapy Open
View article: Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group)
Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group) Open
Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy®, proton pencil beam scanning [PBS]) are applied in a limited number of centers. For a 14-year…
View article: Metastatic prostate cancer men’s attitudes towards treatment of the local tumour and metastasis evaluative research (IP5-MATTER): protocol for a prospective, multicentre discrete choice experiment study
Metastatic prostate cancer men’s attitudes towards treatment of the local tumour and metastasis evaluative research (IP5-MATTER): protocol for a prospective, multicentre discrete choice experiment study Open
Introduction Systemic therapy with androgen deprivation therapy (ADT) and intensification with agents such as docetaxel, abiraterone acetate and enzalutamide has resulted in improved overall survival in men with de novo synchronous metasta…
View article: Additional Treatments to the Local tumour for metastatic prostate cancer-Assessment of Novel Treatment Algorithms (IP2-ATLANTA): protocol for a multicentre, phase II randomised controlled trial
Additional Treatments to the Local tumour for metastatic prostate cancer-Assessment of Novel Treatment Algorithms (IP2-ATLANTA): protocol for a multicentre, phase II randomised controlled trial Open
Introduction Survival in men diagnosed with de novo synchronous metastatic prostate cancer has increased following the use of upfront systemic treatment, using chemotherapy and other novel androgen receptor targeted agents, in addition to …
View article: MRI and Targeted Biopsies Compared to Transperineal Mapping Biopsies Prior to Focal Ablation in Recurrent Prostate Cancer after Radiotherapy
MRI and Targeted Biopsies Compared to Transperineal Mapping Biopsies Prior to Focal Ablation in Recurrent Prostate Cancer after Radiotherapy Open
View article: Clinical Outcomes of a Randomized Trial of Adaptive Plan-of-the-Day Treatment in Patients Receiving Ultra-hypofractionated Weekly Radiation Therapy for Bladder Cancer
Clinical Outcomes of a Randomized Trial of Adaptive Plan-of-the-Day Treatment in Patients Receiving Ultra-hypofractionated Weekly Radiation Therapy for Bladder Cancer Open
View article: Brain tumors: Medulloblastoma, ATRT, ependymoma
Brain tumors: Medulloblastoma, ATRT, ependymoma Open
Children with medulloblastoma, atypical teratoid rhabdoid tumor (ATRT), and ependymoma are treated with a multidisciplinary approach including surgery, radiotherapy, and chemotherapy. Lower doses of craniospinal irradiation and tumor bed b…
View article: A rapid review of evidence and recommendations from the SIOPE radiation oncology working group to help mitigate for reduced paediatric radiotherapy capacity during the COVID-19 pandemic or other crises
A rapid review of evidence and recommendations from the SIOPE radiation oncology working group to help mitigate for reduced paediatric radiotherapy capacity during the COVID-19 pandemic or other crises Open
View article: Assembling the brain trust: the multidisciplinary imperative in neuro-oncology
Assembling the brain trust: the multidisciplinary imperative in neuro-oncology Open
View article: Toxicity and Patient-Reported Outcomes of a Phase 2 Randomized Trial of Prostate and Pelvic Lymph Node Versus Prostate only Radiotherapy in Advanced Localised Prostate Cancer (PIVOTAL)
Toxicity and Patient-Reported Outcomes of a Phase 2 Randomized Trial of Prostate and Pelvic Lymph Node Versus Prostate only Radiotherapy in Advanced Localised Prostate Cancer (PIVOTAL) Open
PIVOTAL demonstrated that high-dose pelvic lymph node IMRT can be delivered at multiple centers with a modest side effect profile. Although safety data from the present study are encouraging, the impact of P&P IMRT on disease control remai…
View article: Uncommon low-grade brain tumors
Uncommon low-grade brain tumors Open
The 2016 World Health Organization (WHO) classification of primary central nervous system (CNS) tumors includes numerous uncommon (representing ≤1% of tumors) low-grade (grades I-II) brain neoplasms with varying clinical behaviors and outc…
View article: Contents
Contents Open
View article: Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group)
Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group) Open
The investigated modern radiotherapy techniques demonstrate superior dosimetric results compared to 3D-CRT. The lowest mean dose for organs at risk is obtained with proton therapy. However, for a large number of organs ranges in mean doses…
View article: Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group)<sup>*</sup>
Dosimetric comparison of five different techniques for craniospinal irradiation across 15 European centers: analysis on behalf of the SIOP-E-BTG (radiotherapy working group)<sup>*</sup> Open
Purpose: Conventional techniques (3D-CRT) for craniospinal irradiation (CSI) are still widely used. Modern techniques (IMRT, VMAT, TomoTherapy®, proton pencil beam scanning [PBS]) are applied in a limited number of center…
View article: OC-0345: Comparing cranio spinal irradiation planning for photon and proton techniques at 15 European centers
OC-0345: Comparing cranio spinal irradiation planning for photon and proton techniques at 15 European centers Open
View article: Prevention of radiotherapy-induced neurocognitive dysfunction in survivors of paediatric brain tumours: the potential role of modern imaging and radiotherapy techniques
Prevention of radiotherapy-induced neurocognitive dysfunction in survivors of paediatric brain tumours: the potential role of modern imaging and radiotherapy techniques Open
View article: MB-49INTENSIVE TREATMENT OF HIGH-RISK MEDULLOBLASTOMA (HR-MB): HOW TO LEARN FROM TOXICITIES IN AN EUROPEAN SETTING OF RADIOTHERAPISTS AND PHYSICISTS OF THE SIOP BRAIN TUMOR WORKING GROUP
MB-49INTENSIVE TREATMENT OF HIGH-RISK MEDULLOBLASTOMA (HR-MB): HOW TO LEARN FROM TOXICITIES IN AN EUROPEAN SETTING OF RADIOTHERAPISTS AND PHYSICISTS OF THE SIOP BRAIN TUMOR WORKING GROUP Open
View article: MB-07OUTCOME OF CRANIOSPINAL IRRADIATION (CSI) IN CHILDREN AND TEENAGERS: A SINGLE INSTITUTION EXPERIENCE
MB-07OUTCOME OF CRANIOSPINAL IRRADIATION (CSI) IN CHILDREN AND TEENAGERS: A SINGLE INSTITUTION EXPERIENCE Open
View article: A Comprehensive Single Institutional Review of 2 Years in a Designated Fast-Track Sarcoma Diagnostic Clinic Linked with a Sarcoma Specialist Advisory Group: Meeting the Target but Failing the Task?
A Comprehensive Single Institutional Review of 2 Years in a Designated Fast-Track Sarcoma Diagnostic Clinic Linked with a Sarcoma Specialist Advisory Group: Meeting the Target but Failing the Task? Open
Background . National guidelines prompted the implementation of a designated two-week wait referral pathway to facilitate the early diagnosis of sarcomas, to improve treatment outcomes. Methods . Patients referred to the Cambridge Sarcoma …