Gail Marracci
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<i>TREM2</i> is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor Open
Triggering receptor expressed on myeloid cells-2 (TREM2) is a cell surface receptor on macrophages and microglia that senses and responds to disease associated signals to regulate the phenotype of these innate immune cells. The TREM2 signa…
A microwave method for plastic embedding of nervous tissue for light and electron microscopy Open
This new method is fast, reliable and an effective way to embed CNS tissue in resin.
Myelin repair stimulated by CNS-selective thyroid hormone action Open
Oligodendrocyte processes wrap axons to form neuroprotective myelin sheaths, and damage to myelin in disorders, such as multiple sclerosis (MS), leads to neurodegeneration and disability. There are currently no approved treatments for MS t…
Oral lipoic acid as a treatment for acute optic neuritis: a blinded, placebo controlled randomized trial Open
Background Lipoic acid, an antioxidant, has beneficial effects in experimental acute optic neuritis and autoimmune encephalomyelitis. Optical coherence tomography can detect retinal nerve fiber layer thinning, representing axonal degenerat…
Low-fat, plant-based diet in multiple sclerosis: A randomized controlled trial Open
While a very-low fat, plant-based diet was well adhered to and tolerated, it resulted in no significant improvement on brain MRI, relapse rate or disability as assessed by EDSS scores in subjects with RRMS over one year. The diet group how…
Omega-3 Fatty Acids for Depression in Multiple Sclerosis: A Randomized Pilot Study Open
ClinicalTrials.gov NCT00122954.