Gamze B. Bulut
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View article: 8TH GRADE STUDENTS' LEVEL OF KNOWLEDGE ABOUT BIODIVERSITY AND ITS CORRELATION WITH DIFFERENT VARIABLES
8TH GRADE STUDENTS' LEVEL OF KNOWLEDGE ABOUT BIODIVERSITY AND ITS CORRELATION WITH DIFFERENT VARIABLES Open
Nearly 14 million species are estimated to exist on Earth, of which 1.8 million have been identified, and new species are being added to the world of science every day. Therefore, scientists are aware that there are still unidentified spec…
View article: Neutrophil Elastase Targets Select Proteins on Human Blood-Monocyte-Derived Macrophage Cell Surfaces
Neutrophil Elastase Targets Select Proteins on Human Blood-Monocyte-Derived Macrophage Cell Surfaces Open
Neutrophil elastase (NE) has been reported to be a pro-inflammatory stimulus for macrophages. The aim of the present study was to determine the impact of NE exposure on the human macrophage proteome and evaluate its impact on pro-inflammat…
View article: IDENTIFICATION OF 8TH GRADE STUDENTS' COGNITIVE STRUCTURES RELATED TO THE CONCEPTS OF BIODIVERSITY, SPECIES AND ECOSYSTEM
IDENTIFICATION OF 8TH GRADE STUDENTS' COGNITIVE STRUCTURES RELATED TO THE CONCEPTS OF BIODIVERSITY, SPECIES AND ECOSYSTEM Open
Human beings have tried to investigate, explore, and define the environment they live in since the moment they came into existence. Humans have utilized these creatures to discover answers to their changing requirements and to further thei…
View article: IL-1β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice
IL-1β Inhibition Partially Negates the Beneficial Effects of Diet-Induced Atherosclerosis Regression in Mice Open
BACKGROUND: Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions is the global leading cause of death. The most common and effective means to reduce these major adverse cardiovascular events, including …
View article: Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages
Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages Open
Neutrophil elastase (NE) is taken up by macrophages, retains intracellular protease activity, and induces a pro-inflammatory phenotype. However, the mechanism of NE-induced pro-inflammatory polarization of macrophages is not well understoo…
View article: Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages
Neutrophil Elastase Degrades Histone Deacetylases and Sirtuin 1 in Primary Human Monocyte Derived Macrophages Open
Neutrophil elastase (NE) is taken up by macrophages, retains intracellular protease activity and induces a pro-inflammatory phenotype. However, the mechanism of NE-induced pro-inflammatory polarization of macrophages is not well understood…
View article: Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium
Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium Open
Using bulk and single-cell RNA sequencing on endothelial cells from adipose and mesentery, we found that an obesogenic diet induces a reduction in adipose endothelial oxidative phosphorylation gene expression, resulting in a phenotypic con…
View article: Neutrophil elastase activates the release of extracellular traps from COPD blood monocyte‐derived macrophages
Neutrophil elastase activates the release of extracellular traps from COPD blood monocyte‐derived macrophages Open
Neutrophil elastase (NE), a major inflammatory mediator in chronic obstructive pulmonary disease (COPD) airways, impairs macrophage function, contributing to persistence of airway inflammation. We hypothesized that NE activates a novel mec…
View article: IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering
IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering Open
Background Thromboembolic events secondary to rupture or erosion of advanced atherosclerotic lesions are the leading cause of death in the world. The most common and effective means to reduce these major adverse cardiovascular events (MACE…
View article: Loss of endothelial cell heterogeneity in arteries after obesogenic diet
Loss of endothelial cell heterogeneity in arteries after obesogenic diet Open
Background It is well recognized that obesity leads to arterial endothelial dysfunction and cardiovascular disease. However, the progression to endothelial dysfunction is not clear. Endothelial cells (ECs) adapt to the unique needs of thei…
View article: Supplementary Figure from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
Supplementary Figure from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis Open
Supplementary Figure from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
View article: Supplementary Figure from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
Supplementary Figure from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis Open
Supplementary Figure from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
View article: Data from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
Data from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis Open
Caspase 9 undergoes alternative splicing to produce two opposing isoforms: proapoptotic Caspase 9a and pro-survival Caspase 9b (C9b). Previously, our laboratory reported that C9b is expressed in majority of non–small cell lung cancer tumor…
View article: Data from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis
Data from Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis Open
Caspase 9 undergoes alternative splicing to produce two opposing isoforms: proapoptotic Caspase 9a and pro-survival Caspase 9b (C9b). Previously, our laboratory reported that C9b is expressed in majority of non–small cell lung cancer tumor…
View article: Supplemental Figure Legends from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Supplemental Figure Legends from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis Open
Supplemental Figure Legends for Supplemental Figures 1 through 12.
View article: Data from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Data from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis Open
Alternate RNA processing of caspase-9 generates the splice variants caspase 9a (C9a) and caspase 9b (C9b). C9b lacks a domain present in C9a, revealing a tumorigenic function that drives the phenotype of non–small cell lung cancer (NSCLC) …
View article: Data from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Data from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis Open
Alternate RNA processing of caspase-9 generates the splice variants caspase 9a (C9a) and caspase 9b (C9b). C9b lacks a domain present in C9a, revealing a tumorigenic function that drives the phenotype of non–small cell lung cancer (NSCLC) …
View article: Supplemental Methods from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Supplemental Methods from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis Open
Methods used for Supplemental Data only: WST-1 cell proliferation assay, Ki-67 mmunohistochemical analysis
View article: Supplemental Figures and Tables from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Supplemental Figures and Tables from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis Open
Supplemental Figure 1: Larger legend table for symbols in fig 1A. Supplemental Figure 2: The expression of BIRC5, CDKN1A, CXCL1 and IER3 correlates with expression of C9b, but not C9a, in human NSCLC tissues. Supplemental Figure 3: Down-re…
View article: Supplemental Figures and Tables from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Supplemental Figures and Tables from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis Open
Supplemental Figure 1: Larger legend table for symbols in fig 1A. Supplemental Figure 2: The expression of BIRC5, CDKN1A, CXCL1 and IER3 correlates with expression of C9b, but not C9a, in human NSCLC tissues. Supplemental Figure 3: Down-re…
View article: Supplemental Methods from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Supplemental Methods from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis Open
Methods used for Supplemental Data only: WST-1 cell proliferation assay, Ki-67 mmunohistochemical analysis
View article: Supplemental Figure Legends from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Supplemental Figure Legends from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis Open
Supplemental Figure Legends for Supplemental Figures 1 through 12.
View article: Transcriptional Profile of Human Pancreatic Acinar Ductal Metaplasia
Transcriptional Profile of Human Pancreatic Acinar Ductal Metaplasia Open
Our findings support the relevancy of human in vitro models to study pancreas cancer pathogenesis and exocrine cell plasticity.
View article: A New Autosomal <i> Myh11-CreER <sup>T2</sup> </i> Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model—Brief Report
A New Autosomal <i> Myh11-CreER <sup>T2</sup> </i> Smooth Muscle Cell Lineage Tracing and Gene Knockout Mouse Model—Brief Report Open
Background: The Myh11 promoter is extensively used as a smooth muscle cell (SMC) Cre-driver and is regarded as the most restrictive and specific promoter available to study SMCs. Unfortunately, in the existing Myh11-CreER T2 mouse, the tra…
View article: Endothelial OCT4 is atheroprotective by preventing metabolic and phenotypic dysfunction
Endothelial OCT4 is atheroprotective by preventing metabolic and phenotypic dysfunction Open
Aims Until recently, the pluripotency factor Octamer (ATGCAAAT)-binding transcriptional factor 4 (OCT4) was believed to be dispensable in adult somatic cells. However, our recent studies provided clear evidence that OCT4 has a critical ath…
View article: KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation
KLF4 (Kruppel-Like Factor 4)-Dependent Perivascular Plasticity Contributes to Adipose Tissue inflammation Open
Objective: Smooth muscle cells and pericytes display remarkable plasticity during injury and disease progression. Here, we tested the hypothesis that perivascular cells give rise to Klf4 -dependent macrophage-like cells that augment adipos…
View article: MEKK3-MEK5-ERK5 Signaling Promotes Mitochondrial Degradation
MEKK3-MEK5-ERK5 Signaling Promotes Mitochondrial Degradation Open
Mitochondria are vital organelles that coordinate cellular energy homeostasis and have important roles in cell death. Therefore, the removal of damaged or excessive mitochondria is critical for maintaining proper cellular function. The PIN…