Explanipedia

Association between Elastic Modulus of Foot Soft Tissues and Gait Characteristics in Young Individuals with Flatfoot Open

Xin Jiao, Tianyi Hu, Yongjin Li, Binbin Wang, Mirabel Ewura Esi Acquah , et al. · 2024

Flatfoot is a common foot deformity, causing foot pain, osteoarthritis of the midfoot, and even knee and hip dysfunction. The elastic modulus of foot soft tissues and its association with gait biomechanics still remain unclear. For this st…

Verapamil Attenuates the Severity of Tendinopathy by Mitigating Mitochondrial Dysfunction through the Activation of the Nrf2/HO-1 Pathway Open

Zengguang Wang, Zhenglin Dong, Yiming Li, Xin Jiao, Yihao Liu , et al. · 2024

Tendinopathy is a prevalent condition in orthopedics patients, exerting a profound impact on tendon functionality. However, its underlying mechanism remains elusive and the efficacy of pharmacological interventions continues to be suboptim…

A finite element analysis of the carpal arch with various locations of carpal tunnel release Open

Lu Yu, Jingyi Jia, Kishor Lakshminarayanan, Yiming Li, Yaokai Gan , et al. · 2023

Objective The purpose of this study was to investigate the effects of the location of transverse carpal ligament (TCL) transection on the biomechanical property of the carpal arch structure. It was hypothesized that carpal tunnel release w…

The effect of thickness and elastic modulus of the anterior talofibular ligament on anterior ankle joint stiffness: A subject-specific finite element study Open

Linjing Peng, Lu Yu, Jingyi Jia, Yaokai Gan, Angang Ding , et al. · 2023

Ankle sprain is a frequent type of sports injury leading to lateral ligament injury. The anterior talofibular ligament (ATFL) is a primary ligamentous stabilizer of the ankle joint and typically the most vulnerable ligament injured in a la…

Fullerenol inhibits tendinopathy by alleviating inflammation Open

Xin Jiao, Zengguang Wang, Yiming Li, Tianchang Wang, Xu Chen , et al. · 2023

Tendinopathy is a common disease in orthopaedics, seriously affecting tendon functions. However, the effects of non-surgical treatment on tendinopathy are not satisfactory and surgical treatments possibly impair the function of tendons. Bi…

A Retrospective Comparative Study of Endoscopic Treatment of Gastrocnemius Contracture using the Modified Soft Tissue Release Kit Open

Yiming Li, Zengguang Wang, Yaokai Gan, Xin Jiao, Xu Chen , et al. · 2023

Background and Objectives: This study aimed to evaluate the effectiveness and safety of endoscopic gastrocnemius recession using the self-developed Modified Soft Tissue Release Kit. Materials and Methods: This retrospective review followed…

A Retrospective Clinical Study of Endoscopic Treatment of Carpal Tunnel Syndrome using the Modified Soft Tissue Release kit Open

Yiming Li, Xin Jiao, Yaokai Gan, Dingwei Shi, Zengguang Wang , et al. · 2022

Objective Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy, and endoscopic carpal tunnel release (ECTR) is one of the minimally invasive procedures for the treatment of CTS. Based on the shortcomings of ECTR…

Outcomes of V‐cut Osteotomy on the First Metatarsal Head Combined with Fixation in Mortise‐shaped Bone Groove‐Plasty and Akin Osteotomy on the First Toe for Hallux Valgus Correction Open

Xin Jiao, Yaokai Gan, Yiming Li, Xu Chen, Zengguang Wang , et al. · 2022

Objective Hallux valgus (HV) is a common foot deformity, and recurrence is one of the most serious complications after HV correction. As a result, the surgical technique with a lower recurrence rate is a dream. The purpose of the article s…

3D-Printed β-Tricalcium Phosphate Scaffolds Promote Osteogenic Differentiation of Bone Marrow-Deprived Mesenchymal Stem Cells in an N6-methyladenosineDependent Manner Open

Xin Jiao, Xin Sun, Wentao Li, Wenxiang Chu, Yuxin Zhang , et al. · 2022

Bone defect is a serious orthopedic disease which has been studied for a long time. Alternative degradable biomaterials are required for bone repairing and regeneration to address the limitation of autogenous bone. β-tricalcium phosph…

Bone marrow mesenchymal stem cells loaded β-tricalcium phosphate promote lumbar intervertebral fusion: a randomized controlled clinical trial Open

Jie Zhao, Baozhi Ding, Xin Wang, Yaokai Gan, Xiaojiang Sun , et al. · 2022

BackgroundAs current stem cell tissue engineering always requires in vitro cell culture, it is subject to restrictions such as extra time cost, ethical problems, and contamination. A novel device named the bone mesenchymal stem cells scree…

The Relationship between Shear Wave Velocity in Transverse Carpal Ligament and Carpal Tunnel Pressure: A Finite Element Analysis Open

Linjing Peng, Yu Wu, Aili Zhang, Kishor Lakshminarayanan, Yaokai Gan , et al. · 2022

A clinical study on bone defect reconstruction and functional recovery in benign bone tumors of the lower extremity, treated by bone marrow mesenchymal stem cell rapid screening–enrichment–composite system Open

Lei Wang, Dinghao Luo, Junxiang Wu, Kai Xie, Yu Guo , et al. · 2021

Use of a novel Screen–Enrich–Combine(-biomaterials) Circulating System to fill a 3D-printed open Ti6Al4V frame with mesenchymal stem cells/β-tricalcium phosphate to repair complex anatomical bone defects in load-bearing areas Open

Wenxiang Chu, Zhiqing Liu, Yaokai Gan, Yongyun Chang, Xin Jiao , et al. · 2021

Filling the 3D-printed Ti6Al4V large-aperture frame with osteogenic materials achieved biological reconstruction over a larger area of regenerated bone to repair complex anatomical weight-bearing bone defects under the condition of early f…

A Clinical Study on Bone Defect Reconstruction and Functional Recovery in Benign Bone Tumors of the Lower Extremity, Treated by Bone Marrow Mesenchymal Stem Cell Rapid Screening–enrichment–composite System Open

Lei Wang, Dinghao Luo, Junxiang Wu, Kai Xie, Yu Guo , et al. · 2020

Background: With the development of medical technology, credible options for defect reconstructions after the resection of benign bone tumors of the lower extremities has become a high priority. As the current reconstructive methods common…

Use of a novel Screen–Enrich–Combine(-biomaterials) Circulating System for filling of a 3D-printed open Ti6Al4V frame with mesenchymal stem cells/β-tricalcium phosphate to repair complex anatomical bone defects in load-bearing areas Open

Wenxiang Chu, Zhiqing Liu, Yaokai Gan, Yongyun Chang, Xin Jiao , et al. · 2020

Background: Repairing complex anatomical load-bearing bone defects is difficult because it requires restoration of load-bearing function, reconstruction of anatomical shape and repair by regenerated bone. We previously developed a Screen–E…

Varisized 3D‐Printed Lunate for Kienböck's Disease in Different Stages: Preliminary Results Open

Zhenjiang Ma, Zi‐fan Liu, Qing‐song Shi, Tao Li, Zhiyuan Liu , et al. · 2020

Objective To evaluate the feasibility of arthroplasty with varisized three‐dimensional(3D) printing lunate prosthesis for the treatment of advanced Kienböck's disease (KD). Methods From 2016 November to 2018 September, a retrospective stud…

Huge aneurysmal bone cyst secondary to giant cell tumor of the hand phalanx: a case report and related literature Open

Mingzhuo Li, Yaokai Gan, Dingwei Shi, Jie Zhao · 2020

IL-23, but not IL-12, plays a critical role in inflammation-mediated bone disorders Open

Jiajia Xu, Jian Li, Yiming Hu, Kerong Dai, Yaokai Gan , et al. · 2020

Interleukin-12 (IL-12) and IL-23 are thought to have central roles in inflammation and are critical to pathologies associated with inflammation-induced bone disorders. The deletion of IL-12p40 (a common subunit of IL-12 and IL-23) can impr…

Comparison and characterization of enriched mesenchymal stem cells obtained by the repeated filtration of autologous bone marrow through porous biomaterials Open

Wenxiang Chu, Yifu Zhuang, Yaokai Gan, Xin Wang, Tingting Tang , et al. · 2019

Bone Mesenchymal Stem Cell-Enriched β-Tricalcium Phosphate Scaffold Processed by the Screen-Enrich-Combine Circulating System Promotes Regeneration of Diaphyseal Bone Non-Union Open

Xin Wang, Wenxiang Chu, Yifu Zhuang, Dingwei Shi, Hairong Tao , et al. · 2018

Bone non-union after fracture, considered a therapeutic challenge for orthopedics, always needs a reversion surgery, including autograft transplantation (AGT). However, adverse events related to autograft harvest cannot be ignored. Our gro…

Mesenchymal stem cells and porous β-tricalcium phosphate composites prepared through stem cell screen-enrich-combine(−biomaterials) circulating system for the repair of critical size bone defects in goat tibia Open

Wenxiang Chu, Yaokai Gan, Yifu Zhuang, Xin Wang, Jie Zhao , et al. · 2018

The MSCs/β-TCP prepared through SECCS demonstrated significant therapeutic efficacy in goat models of critical size bone defect. This provides a novel therapeutic strategy for critical size bone defects caused by severe injury, infection, …

Molecular pathogenesis of fracture nonunion Open

Zichuan Ding, Yi-kai Lin, Yaokai Gan, Tingting Tang · 2018

A better understanding of nonunion molecular pathogenesis may provide better approaches for its prevention, diagnosis and treatment in clinical practice.

A successful treatment of necrotizing fasciitis following the surgery of distal radius plate removal Open

Yuchen Cai, Yaokai Gan, Chao Yu, Jian Tang, Yuehua Sun · 2018

NF can occur during the perioperative period for routine clean radius plate removal operation in patients with no risk factor for NF. The objective is to remind the physicians to stay aware of this disease, especially its early clinical si…

Double Plating for the Treatment of Comminuted Distal Femur Fractures with Medial Instability Open

Yifu Zhuang, Yaokai Gan, Dingwei Shi, Jian Tang, Jie Zhao , et al. · 2018

Improving Bone Regeneration Using Chordin siRNA Delivered by pH-Responsive and Non-Toxic Polyspermine Imidazole-4,5-Imine Open

Chuandong Wang, Fei Xiao, Yaokai Gan, Weien Yuan, Zhanjing Zhai , et al. · 2018

Background/Aims: Bone nonunion remains a challenge for orthopaedists. The technological advancements that have been made in precisely silencing target genes have provided promising methods to address this challenge. Methods: We detected th…

A novel cytotherapy device for rapid screening, enriching and combining mesenchymal stem cells into a biomaterial for promoting bone regeneration Open

Yifu Zhuang, Yaokai Gan, Dingwei Shi, Jie Zhao, Tingting Tang , et al. · 2017

Biscarbamate Cross-Linked Low-Molecular-Weight Polyethylenimine for Delivering Anti-chordin siRNA into Human Mesenchymal Stem Cells for Improving Bone Regeneration Open

Chuandong Wang, Weien Yuan, Fei Xiao, Yaokai Gan, Xiaotian Zhao , et al. · 2017

Small-interfering RNA (siRNA) provides a rapid solution for drug design and provides new methods to develop customizable medicines. Polyethyleneimine 25 kDa (PEI25kDa) is an effective transfection agent used in siRNA delivery. However, the…

P53 functional abnormality in mesenchymal stem cells promotes osteosarcoma development Open

Tania Velletri, N Xie, Ying Wang, Yin Huang, Qinqin Yang , et al. · 2016

It has been shown that p53 has a critical role in the differentiation and functionality of various multipotent progenitor cells. P53 mutations can lead to genome instability and subsequent functional alterations and aberrant transformation…

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